Abstract:
:Copper (Cu) in trace amounts is essential for biological organisms. However, dysregulation of the redox-active metal has been implicated in different neurological disorders such as Wilson's, Menkes', Alzheimer's, and Parkinson's diseases. Since many households use Cu tubing in the plumbing system, and corrosion causes the metal to leach into the drinking water, there may be adverse effects on the central nervous system connected with low-level chronic exposure. The present study demonstrates that treatment with a biologically relevant concentration of Cu for 3 months significantly increases activation of the redox-modulated transcription factor AP-1 in mouse brains. This was independent of an upstream kinase indicated in AP-1 activation. Another redox-active transcription factor, NF-κB, was not significantly modified by the Cu exposure. These results indicate that the effect of Cu on AP-1 is unique and may involve direct modulation of DNA binding.
journal_name
Toxicol Ind Healthjournal_title
Toxicology and industrial healthauthors
Lung S,Li H,Bondy SC,Campbell Adoi
10.1177/0748233713491805subject
Has Abstractpub_date
2015-12-01 00:00:00pages
1178-84issue
12eissn
0748-2337issn
1477-0393pii
0748233713491805journal_volume
31pub_type
杂志文章abstract::Many episodes of low back pain are disabling, thus making it one of the costly occupational health problem. The proper alignment and lifting operations during drilling process frequently exposed the oil-drilling workers to unusual strain on the spine and thus make them susceptible for developing low back pain. The pre...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233712451771
更新日期:2014-02-01 00:00:00
abstract::The reporting of physical symptoms is influenced to a large degree by psychological processes. Individuals are more likely to notice subtle sensations in environments lacking in stimulation than those demanding external attention. The beliefs or schemas that people hold dictate where and how they attend to their bodie...
journal_title:Toxicology and industrial health
pub_type: 杂志文章,评审
doi:
更新日期:1994-07-01 00:00:00
abstract::At the present time, the following parameters can be recommended for "early diagnosis" of phosgene overexposure: Phosgene indicator paper badges, to be worn by all persons involved in handling phosgene (these badges permit immediate estimation of the exposure dose in each individual case); Observation of the initial i...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/074823378500100208
更新日期:1985-10-01 00:00:00
abstract::Mercury has been used in many domains of human activities for many years, although in any form mercury is reported to be toxic. On the other hand, lichens have been used in the treatment of several diseases such as tuberculosis, hemorrhoids, ulcer, dysentery and cancer. Animal investigations on some common lichen spec...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233711404036
更新日期:2012-02-01 00:00:00
abstract::Aflatoxin B1 (AFB1) is a toxic compound commonly found as a contaminant in human food. It is carcinogenic due its potential in inducing the oxidative stress and distortion of the most antioxidant enzymes. Since black tea possesses strong antioxidant activity, it protects cells and tissues against oxidative stress. Cur...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233713491807
更新日期:2015-12-01 00:00:00
abstract::We report two cases of formaldehyde-containing hair straighteners causing new onset asthma. Formaldehyde has been reported to cause asthma in other settings. The purpose of this article is to examine two cases of asthma in hairdressers exposed to hair smoothing products and to review the relevant literature on formald...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233717750982
更新日期:2018-04-01 00:00:00
abstract::In this study, we investigated the protective effect of pentoxifilline (PTX) on smoking-induced damage in rat kidney tissues. Twenty-seven male Wistar rats were used in the study. Animals were divided into three equal groups as follows: Group 1: control group with only normal saline (NS; 0.9% NaCl) injection for 8 wee...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233710387006
更新日期:2011-05-01 00:00:00
abstract::A meta-analysis of epidemiologic studies for textile industry workers was undertaken in an attempt to evaluate whether the cancer risk varies within the textile industry in relation to the job held or the textile fiber used. We combined studies published up until 1990, when an ad hoc IARC Monograph was issued, and tho...
journal_title:Toxicology and industrial health
pub_type: 杂志文章,meta分析
doi:10.1191/0748233702th139rr
更新日期:2002-05-01 00:00:00
abstract::This study was designed to determine if long-term exposure to high doses of methoxychlor (M) would alter pituitary or testicular endocrine functions in either an estrogenic or antiandrogenic manner. Weanling male Long-Evans hooded rats were dosed daily with M (po) at 0, 200, 300, or 400 mg kg-1 day-1 for 10 months. Me...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/074823379901500105
更新日期:1999-01-01 00:00:00
abstract::1,2-Dichloropropane (1,2-DCP), a solvent, which is the main component of the cleaner used in the offset printing companies in Japan, is suspected to be the causative agent of bile duct cancer, which has been recently reported at high incidence in those offset printing workplaces. While there are some reports about the...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233714568801
更新日期:2016-09-01 00:00:00
abstract::Diazinon (DZN) is one of the most widely used insecticides in agricultural pest control. Previous studies have shown that DZN may induce hepatotoxicity. Reactive oxygen species and apoptosis pathways are involved in the toxicity of DZN. Crocin, a constituent of saffron, has hepatoprotective effects due to its antioxid...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233713475519
更新日期:2015-04-01 00:00:00
abstract::This study on the effect of genetically modified (GM) and non-GM canola on soybean was carried out for physiological and biochemical biosafety assessment of GM canola. Methanolic extracts of GM and non-GM canola were assessed on seed germination and growth of soybean (Glycine max L.) under sterilized conditions. The e...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233713501366
更新日期:2016-03-01 00:00:00
abstract::Acrylamide has been discovered in foods cooked at high temperature. A potentially harmful effect of this dietary component has been suggested by data indicating its association with increased breast cancer. This study investigated the potential effects of acrylamide in nontumorigenic breast cells by assessing expressi...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233710380217
更新日期:2011-02-01 00:00:00
abstract::Atmospheric acid precursor emissions in Asia are increasing at a significant rate. This is expected to continue for the next several years. This main purpose for this study is to observe the concentration variations of PM(2.5), PM(2.5-10), PM(10), total suspended particulates (TSP), atmospheric particulates, and dry d...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233710375950
更新日期:2010-10-01 00:00:00
abstract:BACKGROUND:Hydrogen sulfide poisoning can cause severe myocardial injury, but the damage is subtle and can be easily misdiagnosed. This report presents the dynamic observation of myocardial injury associated with hydrogen sulfide poisoning. CASE REPORT:Two young men presented with symptoms of "lightning-like" death im...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233720945184
更新日期:2020-10-01 00:00:00
abstract::The hypolipidemic effect of 10% fruit fibers in rats fed with high-fat diet (HFD) was evaluated. This study was conducted on a total of 50 male Albino rats divided into 10 equal groups fed with different types of dietary fruits. The feeding period lasted for 24 weeks. Fasting blood samples were collected and sera sepa...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233712472526
更新日期:2015-03-01 00:00:00
abstract::The effects of different methylmercury (MeHg) forms on the immune system and the hypothalamic pituitary adrenal (HPA) axis were assessed. The lymphocyte response to Concanavalin A (Con A) stimulation, blood levels of interleukin-6 (IL-6), adrenocorticotrophin hormone (ACTH), and corticosterone in the presence of diffe...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/074823379701300105
更新日期:1997-01-01 00:00:00
abstract:OBJECTIVE:Printing workers experience a high rate of musculoskeletal disorders (MSDs). This study aims to determine the prevalence of MSDs, estimate serum biomarkers denoting musculoskeletal tissue changes, and determine some individual risk factors for MSDs among Egyptian printing workers. METHODS:Eighty-five male pr...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233720977399
更新日期:2021-01-01 00:00:00
abstract::Kinetic interactions among chemicals present in a mixture can influence the relationship between administered and delivered or effective dose; these interactions are distinct from dynamic interactions such as, for example, competition between two chemicals for receptor binding sites. The relationship between administe...
journal_title:Toxicology and industrial health
pub_type: 杂志文章,评审
doi:10.1177/074823378900500507
更新日期:1989-10-01 00:00:00
abstract::Recent studies from the University of Arizona indicate that normal subjects, both college students and the elderly, can register the presence of low-intensity odors in the electroencephalogram (EEG) in the absence of conscious awareness of the odors. The experimental paradigm involves subjects sniffing pairs of bottle...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:
更新日期:1994-07-01 00:00:00
abstract::This study aimed to evaluate the extrapulmonary effects of exposure to cigarette smoke (CS) through the analysis of blood components and histopathological examinations of the trachea and diaphragm muscle (DM) in C57BL/6 mice. Thirty-six animals were exposed to six cigarettes per day for 5 days. The mice were divided i...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233717715187
更新日期:2017-09-01 00:00:00
abstract::This experiment is designed to investigate the positive effects of commercial nanosilver compound on blood parameters in experimental aflatoxicosis in broiler chickens. For this, 270 one-day-old broiler chickens were randomly divided into six treatment groups with three replicates. The experimental groups were group A...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233712452611
更新日期:2014-03-01 00:00:00
abstract::This study was realized to investigate the possible beneficial effect of thymoquinone (TQ), the major active component of volatile oil of Nigella sativa seeds, against lead (Pb)-induced inhibition of rat testicular functions. Adult rats were randomized into four groups: a control group receiving no treatment; a Pb gro...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233714548474
更新日期:2016-06-01 00:00:00
abstract::Endocrine disrupting chemicals (EDCs) are defined as exogenous substances that can alter the development and functioning of the endocrine system. The Wnt signaling pathway is an evolutionarily conserved pathway consisting of proteins that transmit cell-to-cell receptors through cell surface receptors, regulating impor...
journal_title:Toxicology and industrial health
pub_type: 杂志文章,评审
doi:10.1177/0748233719898989
更新日期:2020-01-01 00:00:00
abstract::The US Air Force has implemented the widespread use of JP-8 jet fuel in its operations, although a thorough understanding of its potential effects upon exposed personnel is unclear. Previous work has reported that JP-8 exposure is immunosuppressive. In the present study, the effects of in-utero JP-8 jet fuel exposure ...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233708089045
更新日期:2007-10-01 00:00:00
abstract::Trivalent chromium (Cr) is an environmental contaminant, which is extensively used in tanning industries throughout the world and causes various forms of health hazards in tannery workers. Therefore, a cross-sectional study design was used to evaluate the DNA damage and oxidative stress condition in tannery workers ex...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233712457447
更新日期:2014-06-01 00:00:00
abstract::In the recent years, there has been a growing interest in monitoring heavy metal contamination of spices/herbs. Spices and herbs are sources of many bioactive compounds that can improve the tastes of food as well as influence digestion and metabolism processes. In the present study, the levels of some essential and to...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233713500822
更新日期:2016-02-01 00:00:00
abstract::Methiocarb (MC) is a widely used carbamate pesticide in agriculture and health programs. Although the main molecular mechanism of carbamate toxicity involves acetylcholinesterase inhibition, studies have also implicated the induction of oxidative stress. Therefore, the present study was aimed to evaluate the effect of...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233712446719
更新日期:2013-02-01 00:00:00
abstract::Adult female Swiss Webster and B6C3F1 mice received distilled water only or water containing 0.1, 1.0, 10, 100 or 1000 ppb of aldicarb daily for 34 days. The target concentration of aldicarb present in the 10 ppb dosing solution was analytically verified on a daily basis as was its stability over a 48-hr period. To de...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/074823378800400310
更新日期:1988-09-01 00:00:00
abstract::Endothelial adhesion plays an important role in the process of atherosclerosis, which is regulated by endothelial adhesion molecules and chemoattractant molecules. In some areas of China, citreoviridin (CIT) is considered a risk factor for the development of atherosclerosis. Here, we investigated the role of CIT in ad...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233713483194
更新日期:2015-03-01 00:00:00