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Prognostic factors for bronchoscopic intervention in advanced lung or esophageal cancer patients with malignant airway obstruction.

Abstract：

CONTEXT:Bronchoscopic intervention can provide immediate relief from suffocation and an opportunity for additional treatment in patients with malignant airway obstruction. However, few studies have specifically identified prognostic factors affecting the survival of advanced lung or esophageal cancer patients receiving bronchoscopic intervention. AIMS:We aimed to investigate prognostic factors influencing survival in these patients. STUDY DESIGN:We conducted retrospective study. METHODS:The clinical parameters were retrospectively reviewed in 51 patients (lung cancer: n = 35; esophageal cancer: n = 16) who underwent palliative bronchoscopic interventions due to malignant airway. RESULTS:Bronchoscopic interventions, such as mechanical removal (n = 26), stenting (n = 31), laser cauterization (n = 19), and ballooning (n = 16), were performed on intraluminal (n = 21, 41%), extrinsic (n = 8, 16%), and combined lesions (n = 22, 43%). Tracheal invasion was found in 24 patients (47%). Successful palliation was achieved in 49 patients (96%). After the intervention, additional anti-cancer treatment was followed in 24 patients (47%). The median survival time and overall survival rate were 3.4 months and 4%. Survival was increased with selected conditions, including a treatment-naïve status (hazard ratio [HR], 0.359; confidence interval [CI], 0.158-0.815; P = 0.01), an intact proximal airway (HR, 0.265; CI, 0.095-0.738; P = 0.01), and post-procedural additional treatment (HR, 0.330; CI, 0.166-0.657; P < 0.01). CONCLUSIONS:Brochoscopic intervention could provide immediate relief and survival improvement in advanced lung or esophageal cancer patients with selected conditions such as a treatment-naïve status, an intact proximal airway, and available post-procedural additional treatment.

journal_name

Ann Thorac Med

journal_title

Annals of thoracic medicine

authors

Song JU,Park HY,Kim H,Jeon K,Um SW,Koh WJ,Suh GY,Chung MP,Kwon OJ

doi

10.4103/1817-1737.109818

subject

Has Abstract

pub_date

2013-04-01 00:00:00

pages

86-92

issue

eissn

1817-1737

issn

1998-3557

pii

ATM-8-86

journal_volume

pub_type

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Prognostic factors for bronchoscopic intervention in advanced lung or esophageal cancer patients with malignant airway obstruction.