Progression-free survival, post-progression survival, and tumor response as surrogate markers for overall survival in patients with extensive small cell lung cancer.

Abstract:

OBJECTIVES:The effects of first-line chemotherapy on overall survival (OS) might be confounded by subsequent therapies in patients with small cell lung cancer (SCLC). We examined whether progression-free survival (PFS), post-progression survival (PPS), and tumor response could be valid surrogate endpoints for OS after first-line chemotherapies for patients with extensive SCLC using individual-level data. METHODS:Between September 2002 and November 2012, we analyzed 49 cases of patients with extensive SCLC who were treated with cisplatin and irinotecan as first-line chemotherapy. The relationships of PFS, PPS, and tumor response with OS were analyzed at the individual level. RESULTS:Spearman rank correlation analysis and linear regression analysis showed that PPS was strongly correlated with OS (r = 0.97, p < 0.05, R(2)= 0.94), PFS was moderately correlated with OS (r = 0.58, p < 0.05, R(2)= 0.24), and tumor shrinkage was weakly correlated with OS (r = 0.37, p < 0.05, R(2)= 0.13). The best response to second-line treatment, and the number of regimens employed after progression beyond first-line chemotherapy were both significantly associated with PPS ( p ≤ 0.05). CONCLUSION:PPS is a potential surrogate for OS in patients with extensive SCLC. Our findings also suggest that subsequent treatment after disease progression following first-line chemotherapy may greatly influence OS.

journal_name

Ann Thorac Med

authors

Imai H,Mori K,Wakuda K,Ono A,Akamatsu H,Shukuya T,Taira T,Kenmotsu H,Naito T,Kaira K,Murakami H,Endo M,Nakajima T,Yamamoto N,Takahashi T

doi

10.4103/1817-1737.146885

subject

Has Abstract

pub_date

2015-01-01 00:00:00

pages

61-6

issue

1

eissn

1817-1737

issn

1998-3557

pii

ATM-10-61

journal_volume

10

pub_type

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