Alterations of blood-brain barrier and associated factors in acute liver failure.

Abstract:

:Brain edema in acute liver failure (ALF) remains lethal. Cytotoxic mechanisms associated with brain edema have been well recognized, but the role of vasogenic mechanisms of brain edema has not been explored. Intact tight junctions (TJs) between brain capillary endothelial cells are critical for normal BBB function. Recent reports found significant alterations in the tight junction elements including occludin and claudin-5, suggesting a vasogenic injury in the blood-brain barrier (BBB) integrity. However, the role of TJ in ALF has not been completely understood. This paper reviews the role of the paracellular tight junction in the increased selective BBB permeability that leads to brain edema in ALF and furthermore explores the effect of systemic inflammatory cytokines on the tight junction dysfunction.

authors

Cui W,Sun CM,Liu P

doi

10.1155/2013/841707

subject

Has Abstract

pub_date

2013-01-01 00:00:00

pages

841707

eissn

1687-6121

issn

1687-630X

journal_volume

2013

pub_type

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