Abstract:
:Objective. To establish a standardized animal model for liver fibrosis with the same assessment criteria for liver fibrosis studies that have been established on a unified platform. Methods. The standardized liver fibrosis model was established using Sprague-Dawley (SD) rats that either received an intraperitoneal injection of carbon tetrachloride (CCl(4)) in small dosages or ingested an ethanol solution. Results. The definite corresponding rules among modeling of different weeks and corresponding serology indices as well as different pathological staging can be observed by modeling with small dosages and slow, individualized, and combined administrations. Conclusion. This method can be used for the standardized establishment of a liver fibrosis model in rats across 5 pathological stages, ranging from S0 to S4, with a high success rate (89.33%) and low death rate (17.3%) because of the application of multiple hypotoxic chemicals for modeling. We refer to the criteria of Histological Grading and Staging of Chronic Hepatitis for Fibrosis established by the 10th World Digestive Disease Academic Conference in Los Angeles in September 1994 (revised in November 2000).
journal_name
Gastroenterol Res Practjournal_title
Gastroenterology research and practiceauthors
Li L,Hu Z,Li W,Hu M,Ran J,Chen P,Sun Qdoi
10.1155/2012/560345subject
Has Abstractpub_date
2012-01-01 00:00:00pages
560345eissn
1687-6121issn
1687-630Xjournal_volume
2012pub_type
杂志文章abstract::Purpose. Endoscopic ultrasound-guided biliary drainage (EUS-BD) has been increasingly reported worldwide. However, studies concerning EUS-BD from Mainland China are sporadic. This study aims to investigate the feasibility, efficacy, and safety of EUS-BD using SEMS in a single center from Mainland China. Methods. Betwe...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
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journal_title:Gastroenterology research and practice
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journal_title:Gastroenterology research and practice
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journal_title:Gastroenterology research and practice
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journal_title:Gastroenterology research and practice
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journal_title:Gastroenterology research and practice
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journal_title:Gastroenterology research and practice
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journal_title:Gastroenterology research and practice
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journal_title:Gastroenterology research and practice
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doi:10.1155/2012/897678
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journal_title:Gastroenterology research and practice
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journal_title:Gastroenterology research and practice
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journal_title:Gastroenterology research and practice
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journal_title:Gastroenterology research and practice
pub_type: 杂志文章,评审
doi:10.1155/2017/2808235
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abstract::[This corrects the article DOI: 10.1155/2014/904307.]. ...
journal_title:Gastroenterology research and practice
pub_type: 已发布勘误
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journal_title:Gastroenterology research and practice
pub_type: 杂志文章,评审
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abstract::Background and Aim. EUS-guided intervention (EGI) for biliary therapy has been increasingly used in recent years. This report aims to describe the spectrum and experience of EUS-guided interventions in biliary diseases in a single-tertiary center. Methods. All patients with EGI were analyzed retrospectively by retriev...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2012/680753
更新日期:2012-01-01 00:00:00
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journal_title:Gastroenterology research and practice
pub_type: 杂志文章,评审
doi:10.1155/2015/930157
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abstract::Myeloproliferative neoplasms (MPNs) are the leading cause of Budd-Chiari syndrome (BCS), and the C allele of JAK2 rs4495487 was reported to be an additional candidate locus that contributed to MPNs. In the present study, we examined the role of JAK2 rs4495487 in the etiology and clinical presentation of Chinese BCS pa...
journal_title:Gastroenterology research and practice
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journal_title:Gastroenterology research and practice
pub_type: 杂志文章,评审
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journal_title:Gastroenterology research and practice
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journal_title:Gastroenterology research and practice
pub_type: 杂志文章
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更新日期:2016-01-01 00:00:00
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journal_title:Gastroenterology research and practice
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doi:10.1155/2011/739347
更新日期:2011-01-01 00:00:00
abstract::Evodiamine (Evo) is an indole alkaloid extracted from the traditional Chinese medicinal herb Evodia rutaecarpa. Evo may regulate gastrointestinal motility, but the evidence is insufficient, and the mechanisms remain unknown. The aim of this study was to investigate the effect of Evo on colonic motility of rats and the...
journal_title:Gastroenterology research and practice
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doi:10.1155/2020/8610653
更新日期:2020-04-03 00:00:00
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journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2018/2824139
更新日期:2018-07-17 00:00:00
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journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2011/631461
更新日期:2011-01-01 00:00:00
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journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2012/247309
更新日期:2012-01-01 00:00:00
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journal_title:Gastroenterology research and practice
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更新日期:2015-01-01 00:00:00
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journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2017/2676513
更新日期:2017-01-01 00:00:00