Abstract:
:Background and Aim. Crohn's disease is associated with gut microbiota (GM) dysbiosis. Treatment with the anti-IL-12p40 monoclonal antibody (12p40-mAb) has therapeutic effect in Crohn's disease patients. This study addresses whether a 12p40-mAb treatment influences gut microbiota (GM) composition in mice with adoptive transfer colitis (AdTr-colitis). Methods. AdTr-colitis mice were treated with 12p40-mAb or rat-IgG2a or NaCl from days 21 to 47. Disease was monitored by changes in body weight, stool, endoscopic and histopathology scores, immunohistochemistry, and colonic cytokine/chemokine profiles. GM was characterized through DGGE and 16S rRNA gene-amplicon high-throughput sequencing. Results. Following 12p40-mAb treatment, most clinical and pathological parameters associated with colitis were either reduced or absent. GM was shifted towards a higher Firmicutes-to-Bacteroidetes ratio compared to rat-IgG2a treated mice. Significant correlations between 17 bacterial genera and biological markers were found. The relative abundances of the RF32 order (Alphaproteobacteria) and Akkermansia muciniphila were positively correlated with damaged histopathology and colonic inflammation. Conclusions. Shifts in GM distribution were observed with clinical response to 12p40-mAb treatment, whereas specific GM members correlated with colitis symptoms. Our study implicates that specific changes in GM may be connected with positive clinical outcomes and suggests preventing or correcting GM dysbiosis as a treatment goal in inflammatory bowel disease.
journal_name
Gastroenterol Res Practjournal_title
Gastroenterology research and practiceauthors
Castro-Mejía J,Jakesevic M,Krych Ł,Nielsen DS,Hansen LH,Sondergaard BC,Kvist PH,Hansen AK,Holm TLdoi
10.1155/2016/4953120subject
Has Abstractpub_date
2016-01-01 00:00:00pages
4953120eissn
1687-6121issn
1687-630Xjournal_volume
2016pub_type
杂志文章abstract::Background. The problems of fungal infections in edentulous have been discussed in literature. Findings show that oral mycosis has an influence on the mycosis of oesophageal mucosa. Based on this we started to follow from 2007 in patients who wear dentures mycological examination, to evaluate changes of yeasts numbers...
journal_title:Gastroenterology research and practice
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journal_title:Gastroenterology research and practice
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doi:10.1155/2016/1973086
更新日期:2016-01-01 00:00:00
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journal_title:Gastroenterology research and practice
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journal_title:Gastroenterology research and practice
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