Variants of insulin-signaling inhibitor genes in type 2 diabetes and related metabolic abnormalities.

abstract：:Apicomplexan protist parasites utilize host sugars transported into the parasite by sugar transporter proteins for use as an energy source. We performed a phylum-wide phylogenetic analysis of the apicomplexan sugar transporter repertoire. Phylogenetic analyses revealed six major subfamilies of apicomplexan sugar trans...

journal_title：International journal of genomics

authors： Mahmud O,Kissinger JC

更新日期：2017-01-01 00:00:00

abstract：Background:Breast cancer development and progression involve both germline and somatic mutations. High-throughput genotyping and next-generation sequencing technologies have enabled discovery of genetic risk variants and acquired somatic mutations driving the disease. However, the possible oncogenic interactions betwee...

journal_title：International journal of genomics

authors： Wu J,Mamidi TKK,Zhang L,Hicks C

更新日期：2020-07-06 00:00:00

abstract：:To better understand the molecular functions of the master stress-response regulator AtfA in Aspergillus nidulans, transcriptomic analyses of the atfA null mutant and the appropriate control strains exposed to menadione sodium bisulfite- (MSB-), t-butylhydroperoxide- and diamide-induced oxidative stresses were perform...

journal_title：International journal of genomics

authors： Orosz E,Antal K,Gazdag Z,Szabó Z,Han KH,Yu JH,Pócsi I,Emri T

更新日期：2017-01-01 00:00:00

abstract：:Arabidopsis thaliana (L.) Heynh. is a model organism of plant molecular biology. More than 1,700 whole genome sequences have been sequenced, but no Korean isolate genomes have been sequenced thus far despite the fact that many A. thaliana isolated in Japan and China have been sequenced. To understand the genetic backg...

journal_title：International journal of genomics

authors： Park J,Xi H,Kim Y

更新日期：2020-09-05 00:00:00

abstract：:We characterized the male-specific region on the Y chromosome of rainbow trout, which contains both sdY (the sex-determining gene) and the male-specific genetic marker, OmyY1. Several clones containing the OmyY1 marker were screened from a BAC library from a YY clonal line and found to be part of an 800 kb BAC contig....

journal_title：International journal of genomics

authors： Phillips RB,Dekoning JJ,Brunelli JP,Faber-Hammond JJ,Hansen JD,Christensen KA,Renn SC,Thorgaard GH

更新日期：2013-01-01 00:00:00

abstract：:miRNAs are a class of noncoding RNAs important in posttranscriptional repressors and involved in the regulation of almost every biological process by base paring with target genes through sequence in their seed regions. Genetic variations in the seed regions have vital effects on gene expression, phenotypic variation,...

journal_title：International journal of genomics

authors： He S,Ou H,Zhao C,Zhang J

更新日期：2018-03-06 00:00:00

abstract：:Puberty is a transition period where a child transforms to an adult. Puberty can be affected by various genetic factors and environmental influences. In mammals, the regulation of puberty is enhanced by the hypothalamic-pituitary-gonadal axis (HPG axis). A number of genes such as GnRH, Kiss1, and GPR54 have been repor...

journal_title：International journal of genomics

authors： Omariba G,Xiao J

更新日期：2020-05-22 00:00:00

abstract：:The yellow color of inner leaves in Chinese cabbage depends on its lutein and carotene content. To identify responsible genes for yellow pigmentation in leaves, the transcriptome profiles of white (Kenshin) and yellow leaves (Wheessen) were examined using the Br300K oligomeric chip in Chinese cabbage. In yellow leaves...

journal_title：International journal of genomics

authors： Jung HJ,Manoharan RK,Park JI,Chung MY,Lee J,Lim YP,Hur Y,Nou IS

更新日期：2014-01-01 00:00:00

abstract：Purpose:Airway epithelium acts as a protective barrier against the particles from the inhaled air. Damage to the epithelium may result in loss of the barrier function. Epithelial repair in response to injury requires complex mechanisms, such as microRNA, small noncoding molecules, to regulate the processes involved in ...

journal_title：International journal of genomics

authors： Narożna B,Langwiński W,Jackson C,Lackie PM,Holloway JW,Stachowiak Z,Dmitrzak-Węglarz M,Szczepankiewicz A

更新日期：2018-09-05 00:00:00

abstract：:The wild Rubus species R. coreanus, which is widely distributed in southwest China, shows great promise as a genetic resource for breeding. One of its outstanding properties is adaptation to high temperature and humidity. To facilitate its use in selection and breeding programs, we assembled de novo 179,738,287 R. cor...

journal_title：International journal of genomics

authors： Chen Q,Liu X,Hu Y,Sun B,Hu Y,Wang X,Tang H,Wang Y

更新日期：2018-04-01 00:00:00

abstract：:Severe gastroenteritis and foodborne illness caused by Noroviruses (NoVs) during the winter are a worldwide phenomenon. Vulnerable populations including young children and elderly and immunocompromised people often require hospitalization and may die. However, no efficient vaccine for NoVs exists because of their vari...

journal_title：International journal of genomics

authors： Huang CC,Tang CY

更新日期：2013-01-01 00:00:00

abstract：:Pseudomonas aeruginosa PGPR2 is a mung bean rhizosphere strain that produces secondary metabolites and hydrolytic enzymes contributing to excellent antifungal activity against Macrophomina phaseolina, one of the prevalent fungal pathogens of mung bean. Genome sequencing was performed using the Ion Torrent Personal Gen...

journal_title：International journal of genomics

authors： Illakkiam D,Shankar M,Ponraj P,Rajendhran J,Gunasekaran P

更新日期：2014-01-01 00:00:00

abstract：:Determining protein-protein interaction (PPI) in biological systems is of considerable importance, and prediction of PPI has become a popular research area. Although different classifiers have been developed for PPI prediction, no single classifier seems to be able to predict PPI with high confidence. We postulated th...

journal_title：International journal of genomics

authors： Yao J,Guo H,Yang X

更新日期：2015-01-01 00:00:00

abstract：:Cancer is a multistep process characterized by various and different genetic lesions which cause the transformation of normal cells into tumor cells. To preserve the genomic integrity, eukaryotic cells need a complex DNA damage/repair response network of signaling pathways, involving many proteins, able to induce cell...

journal_title：International journal of genomics

authors： Tessitore A,Cicciarelli G,Del Vecchio F,Gaggiano A,Verzella D,Fischietti M,Vecchiotti D,Capece D,Zazzeroni F,Alesse E

更新日期：2014-01-01 00:00:00

abstract：Background:Nonalcoholic fatty liver disease (NAFLD) has become a leading cause of liver transplantation. Lingguizhugan decoction (LGZG), a classical Chinese herbal formula, has beneficial effects on NAFLD animal models. Our study examined the impact of LGZG on hepatic global transcriptome of high-fat-diet-induced NAFLD...

journal_title：International journal of genomics

authors： Yang L,Lin W,Nugent CA,Hao S,Song H,Liu T,Zheng P

更新日期：2017-01-01 00:00:00

abstract：:Auxin response factors (ARFs) have been reported to play vital roles during plant growth and development. In order to reveal specific functions related to vegetative organs in grasses, an in-depth study of the ARF gene family was carried out in switchgrass (Panicum virgatum L.), a warm-season C4 perennial grass that i...

journal_title：International journal of genomics

authors： Wang J,Wu Z,Shen Z,Bai Z,Zhong P,Ma L,Pan D,Zhang R,Li D,Zhang H,Fu C,Han G,Guo C

更新日期：2018-04-29 00:00:00

abstract：:Cardiovascular disease is a leading cause of death in both humans and dogs. Dilated cardiomyopathy (DCM) accounts for a large number of these cases, reported to be the third most common form of cardiac disease in humans and the second most common in dogs. In human studies of DCM there are more than 50 genetic loci ass...

journal_title：International journal of genomics

authors： Simpson S,Edwards J,Ferguson-Mignan TF,Cobb M,Mongan NP,Rutland CS

更新日期：2015-01-01 00:00:00

abstract：:In general, mutation frequencies are context-dependent: specific adjacent nucleotides may influence the probability to observe a specific type of mutation in a genome. Recently, several hypermutable motifs were identified in the human genome. Namely, there is an increased frequency of T>C mutations in the second posit...

journal_title：International journal of genomics

authors： Medvedeva SA,Panchin AY,Alexeevski AV,Spirin SA,Panchin YV

更新日期：2013-01-01 00:00:00

abstract：:The urinary metabolomic study based on gas chromatography-mass spectrometry (GC-MS) had been developed to investigate the possible antidepressant mechanism of chlorogenic acid (CGA) in a rat model of sleep deprivation (SD). According to pattern recognition analysis, there was a clear separation among big platform grou...

journal_title：International journal of genomics

authors： Ma WN,Zhou MM,Gou XJ,Zhao L,Cen F,Xu Y,Shen HY

更新日期：2018-02-11 00:00:00

abstract：Purpose:Next-generation sequencing (NGS) has become more accessible, leading to an increasing number of genetic studies of familial bradycardia being reported. However, most of the variants lack full evaluation. The relationship between genetic factors and bradycardia should be summarized and reevaluated. Methods:We s...

journal_title：International journal of genomics

authors： Cheng L,Li X,Zhao L,Wang Z,Zhang J,Liang Z,Wu Y

更新日期：2020-02-25 00:00:00

abstract：:Sweet sorghum (Sorghum bicolor) is one of the most important cereal crops in the world with colorful seeds. To study the diversity and cultivar-specificity of phytochemicals in sweet sorghum seeds, widely targeted metabolomics was used to analyze the metabolic profiles of the white, red, and purple seeds from three sw...

journal_title：International journal of genomics

authors： Zhou Y,Wang Z,Li Y,Li Z,Liu H,Zhou W

更新日期：2020-03-04 00:00:00

abstract：:We screened bacteria that use E2 as its sole source of carbon and energy for growth and identified them as Rhodococcus, and we named them DSSKP-R-001. For a better understanding of the metabolic potential of the strain, whole genome sequencing of Rhodococcus DSSKP-R-001 and annotation of the functional genes were perf...

journal_title：International journal of genomics

authors： Zhao H,Tian K,Qiu Q,Wang Y,Zhang H,Ma S,Jin S,Huo H

更新日期：2018-10-28 00:00:00

abstract：:Drought is the main environmental factor impairing hemp growth and yield. In order to decipher the molecular responses of hemp to drought stress, transcriptome changes of drought-stressed hemp (DS1 and DS2), compared to well-watered control hemp (CK1 and CK2), were studied with RNA-Seq technology. RNA-Seq generated 9....

journal_title：International journal of genomics

authors： Gao C,Cheng C,Zhao L,Yu Y,Tang Q,Xin P,Liu T,Yan Z,Guo Y,Zang G

更新日期：2018-05-15 00:00:00

abstract：:Taxol is one of the most potent and effective anticancer drugs and is originally isolated from Taxus species. To investigate the specific regulatory mechanisms of taxol synthesis in Taxus wallichiana var. mairei, RNA-seq was conducted to reveal the differences in transcriptional levels between wild type (WT) and "Jinx...

journal_title：International journal of genomics

authors： Wang T,Chen Y,Zhuang W,Zhang F,Shu X,Wang Z,Yang Q

更新日期：2019-05-02 00:00:00

abstract：:The threat of heat stress on crop production increased dramatically due to global warming leading to the rise on the demand of heat-tolerant crops and understanding their tolerance. The leguminous forage crop Guar [Cyamopsis tetragonoloba (L.) Taub] is a high-temperature tolerant plant with numerous works on its toler...

journal_title：International journal of genomics

authors： Alshameri A,Al-Qurainy F,Gaafar AR,Khan S,Nadeem M,Alansi S

更新日期：2020-06-19 00:00:00

abstract：:Calmodulin II (CALM2) gene polymorphism might be responsible for the variation in the left ventricular mass amongst healthy individuals. The aim was to evaluate the correlation between left ventricular mass (LVM) and g.474955027G>A (rs7565161) polymorphism adjacent to the CALM2 gene. Healthy Polish newborns (n = 206) ...

journal_title：International journal of genomics

authors： Gorący I,Gorący J,Skonieczna-Żydecka K,Kaczmarczyk M,Dawid G,Ciechanowicz A

更新日期：2013-01-01 00:00:00

abstract：:High throughput genomic assays empower us to study the entire human genome in short time with reasonable cost. Formalin fixed-paraffin-embedded (FFPE) tissue processing remains the most economical approach for longitudinal tissue specimen storage. Therefore, the ability to apply high throughput genomic applications to...

journal_title：International journal of genomics

authors： Zhang P,Lehmann BD,Shyr Y,Guo Y

更新日期：2017-01-01 00:00:00

abstract：:Currently, protein interaction of Homo sapiens nucleotide binding domain (NBD) of heat shock 70 kDa protein (PDB: 1HJO) with p53 motif remains to be elucidated. The NBD-p53 motif complex enhances the p53 stabilization, thereby increasing the tumor suppression activity in cancer treatment. Therefore, we identified the ...

journal_title：International journal of genomics

authors： Elengoe A,Naser MA,Hamdan S

更新日期：2015-01-01 00:00:00

abstract：:Rett spectrum disorder is a progressive neurological disease and the most common genetic cause of intellectual disability in females. MECP2 is the major causative gene. In addition, CDKL5 and FOXG1 mutations have been reported in Rett patients, especially with the atypical presentation. Each gene and different mutatio...

journal_title：International journal of genomics

authors： Frullanti E,Papa FT,Grillo E,Clarke A,Ben-Zeev B,Pineda M,Bahi-Buisson N,Bienvenu T,Armstrong J,Roche Martinez A,Mari F,Nissenkorn A,Lo Rizzo C,Veneselli E,Russo S,Vignoli A,Pini G,Djuric M,Bisgaard AM,Ravn K,Bosn

更新日期：2019-03-27 00:00:00

abstract：:Epigenetic regulation plays important biological roles in plants, including timing of flowering and endosperm development. Little is known about the mechanisms controlling heterochrony (the change in the timing or rate of developmental events during ontogeny) in Eucalyptus globulus. DNA methylation has been proposed a...

journal_title：International journal of genomics

authors： Hasbún R,Iturra C,Bravo S,Rebolledo-Jaramillo B,Valledor L

更新日期：2016-01-01 00:00:00