MicroRNAs in the DNA Damage/Repair Network and Cancer.

abstract：:In recent years the human microbiome has become a growing area of research and it is becoming clear that the microbiome of humans plays an important role for human health. Extensive research is now going into cataloging and annotating the functional role of the human microbiome. The ability to explore and describe the...

journal_title：International journal of genomics

authors： Bahrndorff S,Alemu T,Alemneh T,Lund Nielsen J

更新日期：2016-01-01 00:00:00

abstract：Purpose:Airway epithelium acts as a protective barrier against the particles from the inhaled air. Damage to the epithelium may result in loss of the barrier function. Epithelial repair in response to injury requires complex mechanisms, such as microRNA, small noncoding molecules, to regulate the processes involved in ...

journal_title：International journal of genomics

authors： Narożna B,Langwiński W,Jackson C,Lackie PM,Holloway JW,Stachowiak Z,Dmitrzak-Węglarz M,Szczepankiewicz A

更新日期：2018-09-05 00:00:00

abstract：:Currently, protein interaction of Homo sapiens nucleotide binding domain (NBD) of heat shock 70 kDa protein (PDB: 1HJO) with p53 motif remains to be elucidated. The NBD-p53 motif complex enhances the p53 stabilization, thereby increasing the tumor suppression activity in cancer treatment. Therefore, we identified the ...

journal_title：International journal of genomics

authors： Elengoe A,Naser MA,Hamdan S

更新日期：2015-01-01 00:00:00

abstract：:The threat of heat stress on crop production increased dramatically due to global warming leading to the rise on the demand of heat-tolerant crops and understanding their tolerance. The leguminous forage crop Guar [Cyamopsis tetragonoloba (L.) Taub] is a high-temperature tolerant plant with numerous works on its toler...

journal_title：International journal of genomics

authors： Alshameri A,Al-Qurainy F,Gaafar AR,Khan S,Nadeem M,Alansi S

更新日期：2020-06-19 00:00:00

abstract：:Rice grain shape and nutritional quality traits have high economic value for commercial production of rice and largely determine the market price, besides influencing the global food demand for high-quality rice. In order to understand the genetic components of grain appearance traits in paddy, brown, and head rice, 1...

journal_title：International journal of genomics

authors： Bazrkar-Khatibani L,Fakheri BA,Hosseini-Chaleshtori M,Mahender A,Mahdinejad N,Ali J

更新日期：2019-02-25 00:00:00

abstract：:The HIV-1 virus (human immunodeficiency virus) affects 36.9 million people worldwide, with approximately 900000 deaths in 2017. The virus carrier can develop severe immunodeficiency since CD4+ T lymphocytes are the main target, leading to acquired immunodeficiency syndrome (AIDS). Despite advances in pharmacological t...

journal_title：International journal of genomics

authors： Sanches-da-Silva GN,Medeiros LFS,Lima FM

更新日期：2019-08-21 00:00:00

abstract：:Drought is the main environmental factor impairing hemp growth and yield. In order to decipher the molecular responses of hemp to drought stress, transcriptome changes of drought-stressed hemp (DS1 and DS2), compared to well-watered control hemp (CK1 and CK2), were studied with RNA-Seq technology. RNA-Seq generated 9....

journal_title：International journal of genomics

authors： Gao C,Cheng C,Zhao L,Yu Y,Tang Q,Xin P,Liu T,Yan Z,Guo Y,Zang G

更新日期：2018-05-15 00:00:00

abstract：Background:Chronic kidney disease (CKD) is characterized by progressive renal function loss, which may finally lead to end-stage renal disease (ESRD). The study is aimed at identifying crucial genes related to CKD progressive and constructing a disease prediction model to investigate risk factors. Methods:GSE97709 and...

journal_title：International journal of genomics

authors： Xin G,Zhou G,Zhang W,Zhang X

更新日期：2020-11-12 00:00:00

abstract：:The yellow color of inner leaves in Chinese cabbage depends on its lutein and carotene content. To identify responsible genes for yellow pigmentation in leaves, the transcriptome profiles of white (Kenshin) and yellow leaves (Wheessen) were examined using the Br300K oligomeric chip in Chinese cabbage. In yellow leaves...

journal_title：International journal of genomics

authors： Jung HJ,Manoharan RK,Park JI,Chung MY,Lee J,Lim YP,Hur Y,Nou IS

更新日期：2014-01-01 00:00:00

abstract：:Simple sequence repeats (SSRs) are among the most important markers for population analysis and have been widely used in plant genetic mapping and molecular breeding. Expressed sequence tag-SSR (EST-SSR) markers, located in the coding regions, are potentially more efficient for QTL mapping, gene targeting, and marker-...

journal_title：International journal of genomics

authors： Ding Q,Li J,Wang F,Zhang Y,Li H,Zhang J,Gao J

更新日期：2015-01-01 00:00:00

abstract：:Deep-sea fishes provide a unique opportunity to study the physiology and evolutionary adaptation to extreme environments. We carried out a high throughput sequencing analysis on a 454 GS-FLX titanium plate using unnormalized cDNA libraries from six tissues of A. carbo. Assemblage and annotations were performed by Newb...

journal_title：International journal of genomics

authors： Stefanni S,Bettencourt R,Pinheiro M,Moro GD,Bongiorni L,Pallavicini A

更新日期：2014-01-01 00:00:00

abstract：:Identifying differentially variable (DV) genomic probes is becoming a new approach to detect novel genomic risk factors for complex human diseases. The F test is the standard equal-variance test in statistics. For high-throughput genomic data, the probe-wise F test has been successfully used to detect biologically rel...

journal_title：International journal of genomics

authors： Li X,Fu Y,Wang X,DeMeo DL,Tantisira K,Weiss ST,Qiu W

更新日期：2018-07-12 00:00:00

abstract：:Paeonia lactiflora is a herbaceous flower in the family Paeoniaceae with both hypocotyl and epicotyl dormant seeds. We used high-throughput transcriptome sequencing on two different developmental stages of P. lactiflora seeds to identify seed dormancy and germination-related genes. We performed de novo assembly and an...

journal_title：International journal of genomics

authors： Ma Y,Cui J,Lu X,Zhang L,Chen Z,Fei R,Sun X

更新日期：2017-01-01 00:00:00

abstract：:The genera Actinobacillus, Haemophilus, and Pasteurella exhibit extensive polyphyletic branching in phylogenetic trees and do not represent coherent clusters of species. In this study, we have utilized molecular signatures identified through comparative genomic analyses in conjunction with genome based and multilocus ...

journal_title：International journal of genomics

authors： Naushad S,Adeolu M,Goel N,Khadka B,Al-Dahwi A,Gupta RS

更新日期：2015-01-01 00:00:00

abstract：:Calmodulin II (CALM2) gene polymorphism might be responsible for the variation in the left ventricular mass amongst healthy individuals. The aim was to evaluate the correlation between left ventricular mass (LVM) and g.474955027G>A (rs7565161) polymorphism adjacent to the CALM2 gene. Healthy Polish newborns (n = 206) ...

journal_title：International journal of genomics

authors： Gorący I,Gorący J,Skonieczna-Żydecka K,Kaczmarczyk M,Dawid G,Ciechanowicz A

更新日期：2013-01-01 00:00:00

abstract：:Taxol is one of the most potent and effective anticancer drugs and is originally isolated from Taxus species. To investigate the specific regulatory mechanisms of taxol synthesis in Taxus wallichiana var. mairei, RNA-seq was conducted to reveal the differences in transcriptional levels between wild type (WT) and "Jinx...

journal_title：International journal of genomics

authors： Wang T,Chen Y,Zhuang W,Zhang F,Shu X,Wang Z,Yang Q

更新日期：2019-05-02 00:00:00

abstract：:In general, mutation frequencies are context-dependent: specific adjacent nucleotides may influence the probability to observe a specific type of mutation in a genome. Recently, several hypermutable motifs were identified in the human genome. Namely, there is an increased frequency of T>C mutations in the second posit...

journal_title：International journal of genomics

authors： Medvedeva SA,Panchin AY,Alexeevski AV,Spirin SA,Panchin YV

更新日期：2013-01-01 00:00:00

abstract：:The Gene Ontology (GO) provides a resource for consistent annotation of genes and gene products that is extensively used by numerous large public repositories. The GO is constructed of three subontologies describing the cellular component of action, molecular function, and overall biological process of a gene or gene ...

journal_title：International journal of genomics

authors： Francis RW

更新日期：2013-01-01 00:00:00

abstract：:Osteoporosis is a serious public health issue, which is mostly characterized by low bone mineral density (BMD). To search for additional genetic susceptibility loci underlying BMD variation, an effective strategy is to focus on testing of specific variants with high potential of functional effects. Single nucleotide p...

journal_title：International journal of genomics

authors： Qiu C,Shen H,Fu X,Xu C,Deng H

更新日期：2018-08-07 00:00:00

abstract：:Background and Objectives. Chronic obstructive pulmonary disease (COPD) is a complex disease characterized by airflow limitation. Although airway inflammation and oxidative stress are known to be important in the pathogenesis of COPD, the mechanism underlying airflow obstruction is not fully understood. Gene expressio...

journal_title：International journal of genomics

authors： Kim WJ,Lim JH,Lee JS,Lee SD,Kim JH,Oh YM

更新日期：2015-01-01 00:00:00

abstract：:Pseudomonas aeruginosa PGPR2 is a mung bean rhizosphere strain that produces secondary metabolites and hydrolytic enzymes contributing to excellent antifungal activity against Macrophomina phaseolina, one of the prevalent fungal pathogens of mung bean. Genome sequencing was performed using the Ion Torrent Personal Gen...

journal_title：International journal of genomics

authors： Illakkiam D,Shankar M,Ponraj P,Rajendhran J,Gunasekaran P

更新日期：2014-01-01 00:00:00

abstract：:Severe gastroenteritis and foodborne illness caused by Noroviruses (NoVs) during the winter are a worldwide phenomenon. Vulnerable populations including young children and elderly and immunocompromised people often require hospitalization and may die. However, no efficient vaccine for NoVs exists because of their vari...

journal_title：International journal of genomics

authors： Huang CC,Tang CY

更新日期：2013-01-01 00:00:00

abstract：:Goat plays a crucial role in human livelihoods, being a major source of meat, milk, fiber, and hides, particularly under adverse climatic conditions. The goat genomics related to the candidate gene approach is now being used to recognize molecular mechanisms that have different expressions of growth, reproductive, mil...

journal_title：International journal of genomics

authors： Zonaed Siddiki AMAM,Miah G,Islam MS,Kumkum M,Rumi MH,Baten A,Hossain MA

更新日期：2020-08-18 00:00:00

abstract：:Puberty is a transition period where a child transforms to an adult. Puberty can be affected by various genetic factors and environmental influences. In mammals, the regulation of puberty is enhanced by the hypothalamic-pituitary-gonadal axis (HPG axis). A number of genes such as GnRH, Kiss1, and GPR54 have been repor...

journal_title：International journal of genomics

authors： Omariba G,Xiao J

更新日期：2020-05-22 00:00:00

abstract：:Rheumatoid arthritis (RA) is an autoimmune disease characterized by the presence of antibodies against cyclic citrullinated peptide (anti-CCP), a consequence of the breakdown of immune tolerance. The lymphoid tyrosine phosphatase (Lyp) protein has significant effects on maintenance of peripheral immune tolerance. Two ...

journal_title：International journal of genomics

authors： Ruiz-Noa Y,Padilla-Gutiérrez JR,Hernández-Bello J,Palafox-Sánchez CA,Valle Y,Oregón-Romero E,Pereira-Suárez AL,Bernard-Medina AG,Muñoz-Valle JF

更新日期：2017-01-01 00:00:00

abstract：:To explore heat response mechanisms of mircoRNAs (miRNAs) in rice post-meiosis panicle, microarray analysis was performed on RNA isolated from rice post-meiosis panicles which were treated at 40°C for 0 min, 10 min, 20 min, 60 min, and 2 h. By integrating paired differentially expressed (DE) miRNAs and mRNA expression...

journal_title：International journal of genomics

authors： Peng Y,Zhang X,Liu Y,Chen X

更新日期：2020-09-17 00:00:00

abstract：:The expression level of each gene is controlled by its regulatory regions, which determine the precise regulation in a tissue-specific manner, according to the developmental stage of the body and the necessity of a response to external stimuli. Nucleotide substitutions in regulatory gene regions may modify the affinit...

journal_title：International journal of genomics

authors： Ignatieva EV,Levitsky VG,Kolchanov NA

更新日期：2015-01-01 00:00:00

abstract：:Kivircik sheep is an important local Turkish sheep according to its meat quality and milk productivity. The aim of this study was to analyze gene expression profiles of both prenatal and postnatal stages for the Kivircik sheep. Therefore, two different cDNA libraries, which were taken from the same Kivircik sheep mamm...

journal_title：International journal of genomics

authors： Ozdemir Ozgenturk N,Omeroglu Ulu Z,Ulu S,Un C,Ozdem Oztabak K,Altunatmaz K

更新日期：2017-01-01 00:00:00

abstract：:The urinary metabolomic study based on gas chromatography-mass spectrometry (GC-MS) had been developed to investigate the possible antidepressant mechanism of chlorogenic acid (CGA) in a rat model of sleep deprivation (SD). According to pattern recognition analysis, there was a clear separation among big platform grou...

journal_title：International journal of genomics

authors： Ma WN,Zhou MM,Gou XJ,Zhao L,Cen F,Xu Y,Shen HY

更新日期：2018-02-11 00:00:00

abstract：:The purpose of this work was to study changes in the level of cell-free DNA (cfDNA) in the blood of young and old rats in the normal state and with induced benign prostatic hyperplasia (BPH). Male Wistar rats were divided into 4 groups-young (3 months), old (20 months), intact, or with testosterone-induced BPH. Groups...

journal_title：International journal of genomics

authors： Vasilyeva IN,Bespalov VG,Von JD,Semenov AL,Tochilnikov GV,Romanov VA,Alvovsky IK,Baranenko DA

更新日期：2019-06-02 00:00:00