Abstract：
:Severe gastroenteritis and foodborne illness caused by Noroviruses (NoVs) during the winter are a worldwide phenomenon. Vulnerable populations including young children and elderly and immunocompromised people often require hospitalization and may die. However, no efficient vaccine for NoVs exists because of their variable genome sequences. This study investigates the infection processes in protein-protein interactions between hosts and NoVs. Protein-protein interactions were collected from related Pfam NoV domains. The related Pfam domains were accumulated incrementally from the protein domain interaction database. To examine the influence of domain intimacy, the 7 NoV domains were grouped by depth. The number of domain-domain interactions increased exponentially as the depth increased. Many protein-protein interactions were relevant; therefore, cloud techniques were used to analyze data because of their computational capacity. The infection relationship between hosts and NoVs should be used in clinical applications and drug design.
journal_name
Int J Genomicsjournal_title
International journal of genomicsauthors
Huang CC,Tang CYdoi
10.1155/2013/456356subject
Has Abstractpub_date
2013-01-01 00:00:00pages
456356eissn
2314-436Xissn
2314-4378journal_volume
2013pub_type
杂志文章abstract：:Rheumatoid arthritis (RA) is an autoimmune disease characterized by the presence of antibodies against cyclic citrullinated peptide (anti-CCP), a consequence of the breakdown of immune tolerance. The lymphoid tyrosine phosphatase (Lyp) protein has significant effects on maintenance of peripheral immune tolerance. Two ...
journal_title：International journal of genomics
pub_type： 杂志文章
doi：10.1155/2017/8753498
更新日期：2017-01-01 00:00:00
abstract：:The Chinese Kunming (KM) mouse is a widely used outbred mouse stock in China. However, its genetic structure remains unclear. In this study, we sequenced the genome of the C57BL/6J-Chr1KM (B6-Chr1KM) strain, the chromosome 1 (Chr 1) of which was derived from one KM mouse. With 36.6× average coverage of the entire geno...
journal_title：International journal of genomics
pub_type： 杂志文章
doi：10.1155/2017/1712530
更新日期：2017-01-01 00:00:00
abstract：:Taxol is one of the most potent and effective anticancer drugs and is originally isolated from Taxus species. To investigate the specific regulatory mechanisms of taxol synthesis in Taxus wallichiana var. mairei, RNA-seq was conducted to reveal the differences in transcriptional levels between wild type (WT) and "Jinx...
journal_title：International journal of genomics
pub_type： 杂志文章
doi：10.1155/2019/1596895
更新日期：2019-05-02 00:00:00
abstract：:Kivircik sheep is an important local Turkish sheep according to its meat quality and milk productivity. The aim of this study was to analyze gene expression profiles of both prenatal and postnatal stages for the Kivircik sheep. Therefore, two different cDNA libraries, which were taken from the same Kivircik sheep mamm...
journal_title：International journal of genomics
pub_type： 杂志文章
doi：10.1155/2017/9604762
更新日期：2017-01-01 00:00:00
abstract：:To better understand the molecular functions of the master stress-response regulator AtfA in Aspergillus nidulans, transcriptomic analyses of the atfA null mutant and the appropriate control strains exposed to menadione sodium bisulfite- (MSB-), t-butylhydroperoxide- and diamide-induced oxidative stresses were perform...
journal_title：International journal of genomics
pub_type： 杂志文章
doi：10.1155/2017/6923849
更新日期：2017-01-01 00:00:00
abstract：:Calmodulin II (CALM2) gene polymorphism might be responsible for the variation in the left ventricular mass amongst healthy individuals. The aim was to evaluate the correlation between left ventricular mass (LVM) and g.474955027G>A (rs7565161) polymorphism adjacent to the CALM2 gene. Healthy Polish newborns (n = 206) ...
journal_title：International journal of genomics
pub_type： 杂志文章
doi：10.1155/2013/410407
更新日期：2013-01-01 00:00:00
abstract：:Sweet sorghum (Sorghum bicolor) is one of the most important cereal crops in the world with colorful seeds. To study the diversity and cultivar-specificity of phytochemicals in sweet sorghum seeds, widely targeted metabolomics was used to analyze the metabolic profiles of the white, red, and purple seeds from three sw...
journal_title：International journal of genomics
pub_type： 杂志文章
doi：10.1155/2020/6247429
更新日期：2020-03-04 00:00:00
abstract：:Cardiovascular disease is a leading cause of death in both humans and dogs. Dilated cardiomyopathy (DCM) accounts for a large number of these cases, reported to be the third most common form of cardiac disease in humans and the second most common in dogs. In human studies of DCM there are more than 50 genetic loci ass...
journal_title：International journal of genomics
pub_type： 杂志文章,评审
doi：10.1155/2015/204823
更新日期：2015-01-01 00:00:00
abstract：Purpose:Airway epithelium acts as a protective barrier against the particles from the inhaled air. Damage to the epithelium may result in loss of the barrier function. Epithelial repair in response to injury requires complex mechanisms, such as microRNA, small noncoding molecules, to regulate the processes involved in ...
journal_title：International journal of genomics
pub_type： 杂志文章
doi：10.1155/2018/9093785
更新日期：2018-09-05 00:00:00
abstract：:Pseudomonas aeruginosa PGPR2 is a mung bean rhizosphere strain that produces secondary metabolites and hydrolytic enzymes contributing to excellent antifungal activity against Macrophomina phaseolina, one of the prevalent fungal pathogens of mung bean. Genome sequencing was performed using the Ion Torrent Personal Gen...
journal_title：International journal of genomics
pub_type： 杂志文章
doi：10.1155/2014/123058
更新日期：2014-01-01 00:00:00
abstract：:Cancer is a multistep process characterized by various and different genetic lesions which cause the transformation of normal cells into tumor cells. To preserve the genomic integrity, eukaryotic cells need a complex DNA damage/repair response network of signaling pathways, involving many proteins, able to induce cell...
journal_title：International journal of genomics
pub_type： 杂志文章,评审
doi：10.1155/2014/820248
更新日期：2014-01-01 00:00:00
abstract：:Identifying differentially variable (DV) genomic probes is becoming a new approach to detect novel genomic risk factors for complex human diseases. The F test is the standard equal-variance test in statistics. For high-throughput genomic data, the probe-wise F test has been successfully used to detect biologically rel...
journal_title：International journal of genomics
pub_type： 杂志文章
doi：10.1155/2018/6591634
更新日期：2018-07-12 00:00:00
abstract：:In recent years the human microbiome has become a growing area of research and it is becoming clear that the microbiome of humans plays an important role for human health. Extensive research is now going into cataloging and annotating the functional role of the human microbiome. The ability to explore and describe the...
journal_title：International journal of genomics
pub_type： 杂志文章,评审
doi：10.1155/2016/5304028
更新日期：2016-01-01 00:00:00
abstract：:The purpose of this work was to study changes in the level of cell-free DNA (cfDNA) in the blood of young and old rats in the normal state and with induced benign prostatic hyperplasia (BPH). Male Wistar rats were divided into 4 groups-young (3 months), old (20 months), intact, or with testosterone-induced BPH. Groups...
journal_title：International journal of genomics
pub_type： 杂志文章
doi：10.1155/2019/8173630
更新日期：2019-06-02 00:00:00
abstract：:Apicomplexan protist parasites utilize host sugars transported into the parasite by sugar transporter proteins for use as an energy source. We performed a phylum-wide phylogenetic analysis of the apicomplexan sugar transporter repertoire. Phylogenetic analyses revealed six major subfamilies of apicomplexan sugar trans...
journal_title：International journal of genomics
pub_type： 杂志文章
doi：10.1155/2017/1707231
更新日期：2017-01-01 00:00:00
abstract：Purpose:Next-generation sequencing (NGS) has become more accessible, leading to an increasing number of genetic studies of familial bradycardia being reported. However, most of the variants lack full evaluation. The relationship between genetic factors and bradycardia should be summarized and reevaluated. Methods:We s...
journal_title：International journal of genomics
pub_type： 杂志文章
doi：10.1155/2020/2415850
更新日期：2020-02-25 00:00:00
abstract：:Drought is the main environmental factor impairing hemp growth and yield. In order to decipher the molecular responses of hemp to drought stress, transcriptome changes of drought-stressed hemp (DS1 and DS2), compared to well-watered control hemp (CK1 and CK2), were studied with RNA-Seq technology. RNA-Seq generated 9....
journal_title：International journal of genomics
pub_type： 杂志文章
doi：10.1155/2018/3057272
更新日期：2018-05-15 00:00:00
abstract：:The Gene Ontology (GO) provides a resource for consistent annotation of genes and gene products that is extensively used by numerous large public repositories. The GO is constructed of three subontologies describing the cellular component of action, molecular function, and overall biological process of a gene or gene ...
journal_title：International journal of genomics
pub_type： 杂志文章
doi：10.1155/2013/594528
更新日期：2013-01-01 00:00:00
abstract：:A population of 146 RILs (Recombinant Inbred Line) was derived from the cross between a cold-sensitive cultivated Solanum lycopersicum L. XF98-7 and a cold-tolerant wild Solanum pimpinellifolium LA2184. Relative germination ratio (RGR) and chilling index (CI) were used to evaluate the cold tolerance of the parental li...
journal_title：International journal of genomics
pub_type： 杂志文章
doi：10.1155/2016/3219276
更新日期：2016-01-01 00:00:00
abstract：:Paeonia lactiflora is a herbaceous flower in the family Paeoniaceae with both hypocotyl and epicotyl dormant seeds. We used high-throughput transcriptome sequencing on two different developmental stages of P. lactiflora seeds to identify seed dormancy and germination-related genes. We performed de novo assembly and an...
journal_title：International journal of genomics
pub_type： 杂志文章
doi：10.1155/2017/8027626
更新日期：2017-01-01 00:00:00
abstract：:The urinary metabolomic study based on gas chromatography-mass spectrometry (GC-MS) had been developed to investigate the possible antidepressant mechanism of chlorogenic acid (CGA) in a rat model of sleep deprivation (SD). According to pattern recognition analysis, there was a clear separation among big platform grou...
journal_title：International journal of genomics
pub_type： 杂志文章
doi：10.1155/2018/1361402
更新日期：2018-02-11 00:00:00
abstract：:Background and Objectives. Chronic obstructive pulmonary disease (COPD) is a complex disease characterized by airflow limitation. Although airway inflammation and oxidative stress are known to be important in the pathogenesis of COPD, the mechanism underlying airflow obstruction is not fully understood. Gene expressio...
journal_title：International journal of genomics
pub_type： 杂志文章
doi：10.1155/2015/206937
更新日期：2015-01-01 00:00:00
abstract：:The yellow color of inner leaves in Chinese cabbage depends on its lutein and carotene content. To identify responsible genes for yellow pigmentation in leaves, the transcriptome profiles of white (Kenshin) and yellow leaves (Wheessen) were examined using the Br300K oligomeric chip in Chinese cabbage. In yellow leaves...
journal_title：International journal of genomics
pub_type： 杂志文章
doi：10.1155/2014/204969
更新日期：2014-01-01 00:00:00
abstract：:Goat plays a crucial role in human livelihoods, being a major source of meat, milk, fiber, and hides, particularly under adverse climatic conditions. The goat genomics related to the candidate gene approach is now being used to recognize molecular mechanisms that have different expressions of growth, reproductive, mil...
journal_title：International journal of genomics
pub_type： 杂志文章,评审
doi：10.1155/2020/5940205
更新日期：2020-08-18 00:00:00
abstract：:Inflorescence represents the highly specialized plant tissue producing the grains. Although key genes regulating flower initiation and development are conserved, the mechanism regulating fertility is still not well explained. To identify genes and gene network underlying inflorescence morphology and fertility of bread...
journal_title：International journal of genomics
pub_type： 杂志文章
doi：10.1155/2018/6897032
更新日期：2018-02-08 00:00:00
abstract：:High throughput genomic assays empower us to study the entire human genome in short time with reasonable cost. Formalin fixed-paraffin-embedded (FFPE) tissue processing remains the most economical approach for longitudinal tissue specimen storage. Therefore, the ability to apply high throughput genomic applications to...
journal_title：International journal of genomics
pub_type： 杂志文章,评审
doi：10.1155/2017/1926304
更新日期：2017-01-01 00:00:00
abstract：:Rett spectrum disorder is a progressive neurological disease and the most common genetic cause of intellectual disability in females. MECP2 is the major causative gene. In addition, CDKL5 and FOXG1 mutations have been reported in Rett patients, especially with the atypical presentation. Each gene and different mutatio...
journal_title：International journal of genomics
pub_type： 杂志文章
doi：10.1155/2019/6956934
更新日期：2019-03-27 00:00:00
abstract：Background:Breast cancer development and progression involve both germline and somatic mutations. High-throughput genotyping and next-generation sequencing technologies have enabled discovery of genetic risk variants and acquired somatic mutations driving the disease. However, the possible oncogenic interactions betwee...
journal_title：International journal of genomics
pub_type： 杂志文章
doi：10.1155/2020/2641370
更新日期：2020-07-06 00:00:00
abstract：:Arabidopsis thaliana (L.) Heynh. is a model organism of plant molecular biology. More than 1,700 whole genome sequences have been sequenced, but no Korean isolate genomes have been sequenced thus far despite the fact that many A. thaliana isolated in Japan and China have been sequenced. To understand the genetic backg...
journal_title：International journal of genomics
pub_type： 杂志文章
doi：10.1155/2020/3236461
更新日期：2020-09-05 00:00:00
abstract：:Osteoporosis is a serious public health issue, which is mostly characterized by low bone mineral density (BMD). To search for additional genetic susceptibility loci underlying BMD variation, an effective strategy is to focus on testing of specific variants with high potential of functional effects. Single nucleotide p...
journal_title：International journal of genomics
pub_type： 杂志文章
doi：10.1155/2018/6407257
更新日期：2018-08-07 00:00:00
