Meta-Analysis of Genome-Wide Association Studies Identifies Novel Functional CpG-SNPs Associated with Bone Mineral Density at Lumbar Spine.

abstract：:In recent years the human microbiome has become a growing area of research and it is becoming clear that the microbiome of humans plays an important role for human health. Extensive research is now going into cataloging and annotating the functional role of the human microbiome. The ability to explore and describe the...

journal_title：International journal of genomics

authors： Bahrndorff S,Alemu T,Alemneh T,Lund Nielsen J

更新日期：2016-01-01 00:00:00

abstract：:The Gene Ontology (GO) provides a resource for consistent annotation of genes and gene products that is extensively used by numerous large public repositories. The GO is constructed of three subontologies describing the cellular component of action, molecular function, and overall biological process of a gene or gene ...

journal_title：International journal of genomics

authors： Francis RW

更新日期：2013-01-01 00:00:00

abstract：:Puberty is a transition period where a child transforms to an adult. Puberty can be affected by various genetic factors and environmental influences. In mammals, the regulation of puberty is enhanced by the hypothalamic-pituitary-gonadal axis (HPG axis). A number of genes such as GnRH, Kiss1, and GPR54 have been repor...

journal_title：International journal of genomics

authors： Omariba G,Xiao J

更新日期：2020-05-22 00:00:00

abstract：:The wild Rubus species R. coreanus, which is widely distributed in southwest China, shows great promise as a genetic resource for breeding. One of its outstanding properties is adaptation to high temperature and humidity. To facilitate its use in selection and breeding programs, we assembled de novo 179,738,287 R. cor...

journal_title：International journal of genomics

authors： Chen Q,Liu X,Hu Y,Sun B,Hu Y,Wang X,Tang H,Wang Y

更新日期：2018-04-01 00:00:00

abstract：:Rett spectrum disorder is a progressive neurological disease and the most common genetic cause of intellectual disability in females. MECP2 is the major causative gene. In addition, CDKL5 and FOXG1 mutations have been reported in Rett patients, especially with the atypical presentation. Each gene and different mutatio...

journal_title：International journal of genomics

authors： Frullanti E,Papa FT,Grillo E,Clarke A,Ben-Zeev B,Pineda M,Bahi-Buisson N,Bienvenu T,Armstrong J,Roche Martinez A,Mari F,Nissenkorn A,Lo Rizzo C,Veneselli E,Russo S,Vignoli A,Pini G,Djuric M,Bisgaard AM,Ravn K,Bosn

更新日期：2019-03-27 00:00:00

abstract：:Photobacterium damselae subsp. damselae (PDD) is a Gram-negative bacterium that can infect a variety of aquatic organisms and humans. Based on an epidemiological investigation conducted over the past 3 years, PDD is one of the most important pathogens causing septic skin ulcer in deep-sea cage-cultured Sebastes schleg...

journal_title：International journal of genomics

authors： Yu Y,Zhang Z,Wang Y,Liao M,Rong X,Li B,Wang K,Chen J,Zhang H

更新日期：2019-04-10 00:00:00

abstract：:Deep-sea fishes provide a unique opportunity to study the physiology and evolutionary adaptation to extreme environments. We carried out a high throughput sequencing analysis on a 454 GS-FLX titanium plate using unnormalized cDNA libraries from six tissues of A. carbo. Assemblage and annotations were performed by Newb...

journal_title：International journal of genomics

authors： Stefanni S,Bettencourt R,Pinheiro M,Moro GD,Bongiorni L,Pallavicini A

更新日期：2014-01-01 00:00:00

abstract：:To explore heat response mechanisms of mircoRNAs (miRNAs) in rice post-meiosis panicle, microarray analysis was performed on RNA isolated from rice post-meiosis panicles which were treated at 40°C for 0 min, 10 min, 20 min, 60 min, and 2 h. By integrating paired differentially expressed (DE) miRNAs and mRNA expression...

journal_title：International journal of genomics

authors： Peng Y,Zhang X,Liu Y,Chen X

更新日期：2020-09-17 00:00:00

abstract：:In general, mutation frequencies are context-dependent: specific adjacent nucleotides may influence the probability to observe a specific type of mutation in a genome. Recently, several hypermutable motifs were identified in the human genome. Namely, there is an increased frequency of T>C mutations in the second posit...

journal_title：International journal of genomics

authors： Medvedeva SA,Panchin AY,Alexeevski AV,Spirin SA,Panchin YV

更新日期：2013-01-01 00:00:00

abstract：:Taxol is one of the most potent and effective anticancer drugs and is originally isolated from Taxus species. To investigate the specific regulatory mechanisms of taxol synthesis in Taxus wallichiana var. mairei, RNA-seq was conducted to reveal the differences in transcriptional levels between wild type (WT) and "Jinx...

journal_title：International journal of genomics

authors： Wang T,Chen Y,Zhuang W,Zhang F,Shu X,Wang Z,Yang Q

更新日期：2019-05-02 00:00:00

abstract：Background:Breast cancer development and progression involve both germline and somatic mutations. High-throughput genotyping and next-generation sequencing technologies have enabled discovery of genetic risk variants and acquired somatic mutations driving the disease. However, the possible oncogenic interactions betwee...

journal_title：International journal of genomics

authors： Wu J,Mamidi TKK,Zhang L,Hicks C

更新日期：2020-07-06 00:00:00

abstract：:Rice grain shape and nutritional quality traits have high economic value for commercial production of rice and largely determine the market price, besides influencing the global food demand for high-quality rice. In order to understand the genetic components of grain appearance traits in paddy, brown, and head rice, 1...

journal_title：International journal of genomics

authors： Bazrkar-Khatibani L,Fakheri BA,Hosseini-Chaleshtori M,Mahender A,Mahdinejad N,Ali J

更新日期：2019-02-25 00:00:00

abstract：:TSEN54 encodes a subunit of the tRNA-splicing endonuclease complex, which catalyzes the identification and cleavage of introns from precursor tRNAs. Previously, we identified an AluSx-derived alternative transcript in TSEN54 of cynomolgus monkey. Reverse transcription-polymerase chain reaction (RT-PCR) amplification a...

journal_title：International journal of genomics

authors： Lee JR,Kim YH,Park SJ,Choe SH,Cho HM,Lee SR,Kim SU,Kim JS,Sim BW,Song BS,Jeong KJ,Lee Y,Jin YB,Kang P,Huh JW,Chang KT

更新日期：2016-01-01 00:00:00

abstract：:We characterized the male-specific region on the Y chromosome of rainbow trout, which contains both sdY (the sex-determining gene) and the male-specific genetic marker, OmyY1. Several clones containing the OmyY1 marker were screened from a BAC library from a YY clonal line and found to be part of an 800 kb BAC contig....

journal_title：International journal of genomics

authors： Phillips RB,Dekoning JJ,Brunelli JP,Faber-Hammond JJ,Hansen JD,Christensen KA,Renn SC,Thorgaard GH

更新日期：2013-01-01 00:00:00

abstract：:The urinary metabolomic study based on gas chromatography-mass spectrometry (GC-MS) had been developed to investigate the possible antidepressant mechanism of chlorogenic acid (CGA) in a rat model of sleep deprivation (SD). According to pattern recognition analysis, there was a clear separation among big platform grou...

journal_title：International journal of genomics

authors： Ma WN,Zhou MM,Gou XJ,Zhao L,Cen F,Xu Y,Shen HY

更新日期：2018-02-11 00:00:00

abstract：:The yellow color of inner leaves in Chinese cabbage depends on its lutein and carotene content. To identify responsible genes for yellow pigmentation in leaves, the transcriptome profiles of white (Kenshin) and yellow leaves (Wheessen) were examined using the Br300K oligomeric chip in Chinese cabbage. In yellow leaves...

journal_title：International journal of genomics

authors： Jung HJ,Manoharan RK,Park JI,Chung MY,Lee J,Lim YP,Hur Y,Nou IS

更新日期：2014-01-01 00:00:00

abstract：Purpose:Next-generation sequencing (NGS) has become more accessible, leading to an increasing number of genetic studies of familial bradycardia being reported. However, most of the variants lack full evaluation. The relationship between genetic factors and bradycardia should be summarized and reevaluated. Methods:We s...

journal_title：International journal of genomics

authors： Cheng L,Li X,Zhao L,Wang Z,Zhang J,Liang Z,Wu Y

更新日期：2020-02-25 00:00:00

abstract：:The threat of heat stress on crop production increased dramatically due to global warming leading to the rise on the demand of heat-tolerant crops and understanding their tolerance. The leguminous forage crop Guar [Cyamopsis tetragonoloba (L.) Taub] is a high-temperature tolerant plant with numerous works on its toler...

journal_title：International journal of genomics

authors： Alshameri A,Al-Qurainy F,Gaafar AR,Khan S,Nadeem M,Alansi S

更新日期：2020-06-19 00:00:00

abstract：:Sweet sorghum (Sorghum bicolor) is one of the most important cereal crops in the world with colorful seeds. To study the diversity and cultivar-specificity of phytochemicals in sweet sorghum seeds, widely targeted metabolomics was used to analyze the metabolic profiles of the white, red, and purple seeds from three sw...

journal_title：International journal of genomics

authors： Zhou Y,Wang Z,Li Y,Li Z,Liu H,Zhou W

更新日期：2020-03-04 00:00:00

abstract：Background:Nonalcoholic fatty liver disease (NAFLD) has become a leading cause of liver transplantation. Lingguizhugan decoction (LGZG), a classical Chinese herbal formula, has beneficial effects on NAFLD animal models. Our study examined the impact of LGZG on hepatic global transcriptome of high-fat-diet-induced NAFLD...

journal_title：International journal of genomics

authors： Yang L,Lin W,Nugent CA,Hao S,Song H,Liu T,Zheng P

更新日期：2017-01-01 00:00:00

abstract：:Insulin resistance has a central role in the pathogenesis of several metabolic diseases, including type 2 diabetes, obesity, glucose intolerance, metabolic syndrome, atherosclerosis, and cardiovascular diseases. Insulin resistance and related traits are likely to be caused by abnormalities in the genes encoding for pr...

journal_title：International journal of genomics

authors： de Lorenzo C,Greco A,Fiorentino TV,Mannino GC,Hribal ML

更新日期：2013-01-01 00:00:00

abstract：:The genera Actinobacillus, Haemophilus, and Pasteurella exhibit extensive polyphyletic branching in phylogenetic trees and do not represent coherent clusters of species. In this study, we have utilized molecular signatures identified through comparative genomic analyses in conjunction with genome based and multilocus ...

journal_title：International journal of genomics

authors： Naushad S,Adeolu M,Goel N,Khadka B,Al-Dahwi A,Gupta RS

更新日期：2015-01-01 00:00:00

abstract：:Paeonia lactiflora is a herbaceous flower in the family Paeoniaceae with both hypocotyl and epicotyl dormant seeds. We used high-throughput transcriptome sequencing on two different developmental stages of P. lactiflora seeds to identify seed dormancy and germination-related genes. We performed de novo assembly and an...

journal_title：International journal of genomics

authors： Ma Y,Cui J,Lu X,Zhang L,Chen Z,Fei R,Sun X

更新日期：2017-01-01 00:00:00

abstract：:Calmodulin II (CALM2) gene polymorphism might be responsible for the variation in the left ventricular mass amongst healthy individuals. The aim was to evaluate the correlation between left ventricular mass (LVM) and g.474955027G>A (rs7565161) polymorphism adjacent to the CALM2 gene. Healthy Polish newborns (n = 206) ...

journal_title：International journal of genomics

authors： Gorący I,Gorący J,Skonieczna-Żydecka K,Kaczmarczyk M,Dawid G,Ciechanowicz A

更新日期：2013-01-01 00:00:00

abstract：:Severe gastroenteritis and foodborne illness caused by Noroviruses (NoVs) during the winter are a worldwide phenomenon. Vulnerable populations including young children and elderly and immunocompromised people often require hospitalization and may die. However, no efficient vaccine for NoVs exists because of their vari...

journal_title：International journal of genomics

authors： Huang CC,Tang CY

更新日期：2013-01-01 00:00:00

abstract：:High throughput genomic assays empower us to study the entire human genome in short time with reasonable cost. Formalin fixed-paraffin-embedded (FFPE) tissue processing remains the most economical approach for longitudinal tissue specimen storage. Therefore, the ability to apply high throughput genomic applications to...

journal_title：International journal of genomics

authors： Zhang P,Lehmann BD,Shyr Y,Guo Y

更新日期：2017-01-01 00:00:00

abstract：:Apicomplexan protist parasites utilize host sugars transported into the parasite by sugar transporter proteins for use as an energy source. We performed a phylum-wide phylogenetic analysis of the apicomplexan sugar transporter repertoire. Phylogenetic analyses revealed six major subfamilies of apicomplexan sugar trans...

journal_title：International journal of genomics

authors： Mahmud O,Kissinger JC

更新日期：2017-01-01 00:00:00

abstract：:Simple sequence repeats (SSRs) are among the most important markers for population analysis and have been widely used in plant genetic mapping and molecular breeding. Expressed sequence tag-SSR (EST-SSR) markers, located in the coding regions, are potentially more efficient for QTL mapping, gene targeting, and marker-...

journal_title：International journal of genomics

authors： Ding Q,Li J,Wang F,Zhang Y,Li H,Zhang J,Gao J

更新日期：2015-01-01 00:00:00

abstract：:Goat plays a crucial role in human livelihoods, being a major source of meat, milk, fiber, and hides, particularly under adverse climatic conditions. The goat genomics related to the candidate gene approach is now being used to recognize molecular mechanisms that have different expressions of growth, reproductive, mil...

journal_title：International journal of genomics

authors： Zonaed Siddiki AMAM,Miah G,Islam MS,Kumkum M,Rumi MH,Baten A,Hossain MA

更新日期：2020-08-18 00:00:00

abstract：:Cardiovascular disease is a leading cause of death in both humans and dogs. Dilated cardiomyopathy (DCM) accounts for a large number of these cases, reported to be the third most common form of cardiac disease in humans and the second most common in dogs. In human studies of DCM there are more than 50 genetic loci ass...

journal_title：International journal of genomics

authors： Simpson S,Edwards J,Ferguson-Mignan TF,Cobb M,Mongan NP,Rutland CS

更新日期：2015-01-01 00:00:00