Lingguizhugan Decoction Protects against High-Fat-Diet-Induced Nonalcoholic Fatty Liver Disease by Alleviating Oxidative Stress and Activating Cholesterol Secretion.

abstract：:The HIV-1 virus (human immunodeficiency virus) affects 36.9 million people worldwide, with approximately 900000 deaths in 2017. The virus carrier can develop severe immunodeficiency since CD4+ T lymphocytes are the main target, leading to acquired immunodeficiency syndrome (AIDS). Despite advances in pharmacological t...

journal_title：International journal of genomics

authors： Sanches-da-Silva GN,Medeiros LFS,Lima FM

更新日期：2019-08-21 00:00:00

abstract：:Paeonia lactiflora is a herbaceous flower in the family Paeoniaceae with both hypocotyl and epicotyl dormant seeds. We used high-throughput transcriptome sequencing on two different developmental stages of P. lactiflora seeds to identify seed dormancy and germination-related genes. We performed de novo assembly and an...

journal_title：International journal of genomics

authors： Ma Y,Cui J,Lu X,Zhang L,Chen Z,Fei R,Sun X

更新日期：2017-01-01 00:00:00

abstract：:Severe gastroenteritis and foodborne illness caused by Noroviruses (NoVs) during the winter are a worldwide phenomenon. Vulnerable populations including young children and elderly and immunocompromised people often require hospitalization and may die. However, no efficient vaccine for NoVs exists because of their vari...

journal_title：International journal of genomics

authors： Huang CC,Tang CY

更新日期：2013-01-01 00:00:00

abstract：:Identifying differentially variable (DV) genomic probes is becoming a new approach to detect novel genomic risk factors for complex human diseases. The F test is the standard equal-variance test in statistics. For high-throughput genomic data, the probe-wise F test has been successfully used to detect biologically rel...

journal_title：International journal of genomics

authors： Li X,Fu Y,Wang X,DeMeo DL,Tantisira K,Weiss ST,Qiu W

更新日期：2018-07-12 00:00:00

abstract：:The purpose of this work was to study changes in the level of cell-free DNA (cfDNA) in the blood of young and old rats in the normal state and with induced benign prostatic hyperplasia (BPH). Male Wistar rats were divided into 4 groups-young (3 months), old (20 months), intact, or with testosterone-induced BPH. Groups...

journal_title：International journal of genomics

authors： Vasilyeva IN,Bespalov VG,Von JD,Semenov AL,Tochilnikov GV,Romanov VA,Alvovsky IK,Baranenko DA

更新日期：2019-06-02 00:00:00

abstract：:Puberty is a transition period where a child transforms to an adult. Puberty can be affected by various genetic factors and environmental influences. In mammals, the regulation of puberty is enhanced by the hypothalamic-pituitary-gonadal axis (HPG axis). A number of genes such as GnRH, Kiss1, and GPR54 have been repor...

journal_title：International journal of genomics

authors： Omariba G,Xiao J

更新日期：2020-05-22 00:00:00

abstract：:High throughput genomic assays empower us to study the entire human genome in short time with reasonable cost. Formalin fixed-paraffin-embedded (FFPE) tissue processing remains the most economical approach for longitudinal tissue specimen storage. Therefore, the ability to apply high throughput genomic applications to...

journal_title：International journal of genomics

authors： Zhang P,Lehmann BD,Shyr Y,Guo Y

更新日期：2017-01-01 00:00:00

abstract：:Drought is the main environmental factor impairing hemp growth and yield. In order to decipher the molecular responses of hemp to drought stress, transcriptome changes of drought-stressed hemp (DS1 and DS2), compared to well-watered control hemp (CK1 and CK2), were studied with RNA-Seq technology. RNA-Seq generated 9....

journal_title：International journal of genomics

authors： Gao C,Cheng C,Zhao L,Yu Y,Tang Q,Xin P,Liu T,Yan Z,Guo Y,Zang G

更新日期：2018-05-15 00:00:00

abstract：:Rett spectrum disorder is a progressive neurological disease and the most common genetic cause of intellectual disability in females. MECP2 is the major causative gene. In addition, CDKL5 and FOXG1 mutations have been reported in Rett patients, especially with the atypical presentation. Each gene and different mutatio...

journal_title：International journal of genomics

authors： Frullanti E,Papa FT,Grillo E,Clarke A,Ben-Zeev B,Pineda M,Bahi-Buisson N,Bienvenu T,Armstrong J,Roche Martinez A,Mari F,Nissenkorn A,Lo Rizzo C,Veneselli E,Russo S,Vignoli A,Pini G,Djuric M,Bisgaard AM,Ravn K,Bosn

更新日期：2019-03-27 00:00:00

abstract：:In recent years the human microbiome has become a growing area of research and it is becoming clear that the microbiome of humans plays an important role for human health. Extensive research is now going into cataloging and annotating the functional role of the human microbiome. The ability to explore and describe the...

journal_title：International journal of genomics

authors： Bahrndorff S,Alemu T,Alemneh T,Lund Nielsen J

更新日期：2016-01-01 00:00:00

abstract：:Rheumatoid arthritis (RA) is an autoimmune disease characterized by the presence of antibodies against cyclic citrullinated peptide (anti-CCP), a consequence of the breakdown of immune tolerance. The lymphoid tyrosine phosphatase (Lyp) protein has significant effects on maintenance of peripheral immune tolerance. Two ...

journal_title：International journal of genomics

authors： Ruiz-Noa Y,Padilla-Gutiérrez JR,Hernández-Bello J,Palafox-Sánchez CA,Valle Y,Oregón-Romero E,Pereira-Suárez AL,Bernard-Medina AG,Muñoz-Valle JF

更新日期：2017-01-01 00:00:00

abstract：Background:Chronic kidney disease (CKD) is characterized by progressive renal function loss, which may finally lead to end-stage renal disease (ESRD). The study is aimed at identifying crucial genes related to CKD progressive and constructing a disease prediction model to investigate risk factors. Methods:GSE97709 and...

journal_title：International journal of genomics

authors： Xin G,Zhou G,Zhang W,Zhang X

更新日期：2020-11-12 00:00:00

abstract：:Photobacterium damselae subsp. damselae (PDD) is a Gram-negative bacterium that can infect a variety of aquatic organisms and humans. Based on an epidemiological investigation conducted over the past 3 years, PDD is one of the most important pathogens causing septic skin ulcer in deep-sea cage-cultured Sebastes schleg...

journal_title：International journal of genomics

authors： Yu Y,Zhang Z,Wang Y,Liao M,Rong X,Li B,Wang K,Chen J,Zhang H

更新日期：2019-04-10 00:00:00

abstract：:Rice grain shape and nutritional quality traits have high economic value for commercial production of rice and largely determine the market price, besides influencing the global food demand for high-quality rice. In order to understand the genetic components of grain appearance traits in paddy, brown, and head rice, 1...

journal_title：International journal of genomics

authors： Bazrkar-Khatibani L,Fakheri BA,Hosseini-Chaleshtori M,Mahender A,Mahdinejad N,Ali J

更新日期：2019-02-25 00:00:00

abstract：:The threat of heat stress on crop production increased dramatically due to global warming leading to the rise on the demand of heat-tolerant crops and understanding their tolerance. The leguminous forage crop Guar [Cyamopsis tetragonoloba (L.) Taub] is a high-temperature tolerant plant with numerous works on its toler...

journal_title：International journal of genomics

authors： Alshameri A,Al-Qurainy F,Gaafar AR,Khan S,Nadeem M,Alansi S

更新日期：2020-06-19 00:00:00

abstract：:Taxol is one of the most potent and effective anticancer drugs and is originally isolated from Taxus species. To investigate the specific regulatory mechanisms of taxol synthesis in Taxus wallichiana var. mairei, RNA-seq was conducted to reveal the differences in transcriptional levels between wild type (WT) and "Jinx...

journal_title：International journal of genomics

authors： Wang T,Chen Y,Zhuang W,Zhang F,Shu X,Wang Z,Yang Q

更新日期：2019-05-02 00:00:00

abstract：:Deep-sea fishes provide a unique opportunity to study the physiology and evolutionary adaptation to extreme environments. We carried out a high throughput sequencing analysis on a 454 GS-FLX titanium plate using unnormalized cDNA libraries from six tissues of A. carbo. Assemblage and annotations were performed by Newb...

journal_title：International journal of genomics

authors： Stefanni S,Bettencourt R,Pinheiro M,Moro GD,Bongiorni L,Pallavicini A

更新日期：2014-01-01 00:00:00

abstract：:Goat plays a crucial role in human livelihoods, being a major source of meat, milk, fiber, and hides, particularly under adverse climatic conditions. The goat genomics related to the candidate gene approach is now being used to recognize molecular mechanisms that have different expressions of growth, reproductive, mil...

journal_title：International journal of genomics

authors： Zonaed Siddiki AMAM,Miah G,Islam MS,Kumkum M,Rumi MH,Baten A,Hossain MA

更新日期：2020-08-18 00:00:00

abstract：:The genera Actinobacillus, Haemophilus, and Pasteurella exhibit extensive polyphyletic branching in phylogenetic trees and do not represent coherent clusters of species. In this study, we have utilized molecular signatures identified through comparative genomic analyses in conjunction with genome based and multilocus ...

journal_title：International journal of genomics

authors： Naushad S,Adeolu M,Goel N,Khadka B,Al-Dahwi A,Gupta RS

更新日期：2015-01-01 00:00:00

abstract：:The Chinese Kunming (KM) mouse is a widely used outbred mouse stock in China. However, its genetic structure remains unclear. In this study, we sequenced the genome of the C57BL/6J-Chr1KM (B6-Chr1KM) strain, the chromosome 1 (Chr 1) of which was derived from one KM mouse. With 36.6× average coverage of the entire geno...

journal_title：International journal of genomics

authors： Xu F,Chao T,Zhang Y,Hu S,Zhou Y,Xu H,Xiao J,Li K

更新日期：2017-01-01 00:00:00

abstract：Background:Breast cancer development and progression involve both germline and somatic mutations. High-throughput genotyping and next-generation sequencing technologies have enabled discovery of genetic risk variants and acquired somatic mutations driving the disease. However, the possible oncogenic interactions betwee...

journal_title：International journal of genomics

authors： Wu J,Mamidi TKK,Zhang L,Hicks C

更新日期：2020-07-06 00:00:00

abstract：:To better understand the molecular functions of the master stress-response regulator AtfA in Aspergillus nidulans, transcriptomic analyses of the atfA null mutant and the appropriate control strains exposed to menadione sodium bisulfite- (MSB-), t-butylhydroperoxide- and diamide-induced oxidative stresses were perform...

journal_title：International journal of genomics

authors： Orosz E,Antal K,Gazdag Z,Szabó Z,Han KH,Yu JH,Pócsi I,Emri T

更新日期：2017-01-01 00:00:00

abstract：:Epigenetic regulation plays important biological roles in plants, including timing of flowering and endosperm development. Little is known about the mechanisms controlling heterochrony (the change in the timing or rate of developmental events during ontogeny) in Eucalyptus globulus. DNA methylation has been proposed a...

journal_title：International journal of genomics

authors： Hasbún R,Iturra C,Bravo S,Rebolledo-Jaramillo B,Valledor L

更新日期：2016-01-01 00:00:00

abstract：:TSEN54 encodes a subunit of the tRNA-splicing endonuclease complex, which catalyzes the identification and cleavage of introns from precursor tRNAs. Previously, we identified an AluSx-derived alternative transcript in TSEN54 of cynomolgus monkey. Reverse transcription-polymerase chain reaction (RT-PCR) amplification a...

journal_title：International journal of genomics

authors： Lee JR,Kim YH,Park SJ,Choe SH,Cho HM,Lee SR,Kim SU,Kim JS,Sim BW,Song BS,Jeong KJ,Lee Y,Jin YB,Kang P,Huh JW,Chang KT

更新日期：2016-01-01 00:00:00

abstract：:Cardiovascular disease is a leading cause of death in both humans and dogs. Dilated cardiomyopathy (DCM) accounts for a large number of these cases, reported to be the third most common form of cardiac disease in humans and the second most common in dogs. In human studies of DCM there are more than 50 genetic loci ass...

journal_title：International journal of genomics

authors： Simpson S,Edwards J,Ferguson-Mignan TF,Cobb M,Mongan NP,Rutland CS

更新日期：2015-01-01 00:00:00

abstract：:Paulownia witches' broom caused by phytoplasma infection affects the production of Paulownia trees worldwide. Emerging evidence showed that long noncoding RNAs (lncRNA) play a protagonist role in regulating the expression of genes in plants. So far, the identification of lncRNAs has been limited to a few model plant s...

journal_title：International journal of genomics

authors： Fan G,Cao Y,Wang Z

更新日期：2018-02-21 00:00:00

abstract：:Auxin response factors (ARFs) have been reported to play vital roles during plant growth and development. In order to reveal specific functions related to vegetative organs in grasses, an in-depth study of the ARF gene family was carried out in switchgrass (Panicum virgatum L.), a warm-season C4 perennial grass that i...

journal_title：International journal of genomics

authors： Wang J,Wu Z,Shen Z,Bai Z,Zhong P,Ma L,Pan D,Zhang R,Li D,Zhang H,Fu C,Han G,Guo C

更新日期：2018-04-29 00:00:00

abstract：:Simple sequence repeats (SSRs) are among the most important markers for population analysis and have been widely used in plant genetic mapping and molecular breeding. Expressed sequence tag-SSR (EST-SSR) markers, located in the coding regions, are potentially more efficient for QTL mapping, gene targeting, and marker-...

journal_title：International journal of genomics

authors： Ding Q,Li J,Wang F,Zhang Y,Li H,Zhang J,Gao J

更新日期：2015-01-01 00:00:00

abstract：:A population of 146 RILs (Recombinant Inbred Line) was derived from the cross between a cold-sensitive cultivated Solanum lycopersicum L. XF98-7 and a cold-tolerant wild Solanum pimpinellifolium LA2184. Relative germination ratio (RGR) and chilling index (CI) were used to evaluate the cold tolerance of the parental li...

journal_title：International journal of genomics

authors： Liu Y,Zhou T,Ge H,Pang W,Gao L,Ren L,Chen H

更新日期：2016-01-01 00:00:00

abstract：:miRNAs are a class of noncoding RNAs important in posttranscriptional repressors and involved in the regulation of almost every biological process by base paring with target genes through sequence in their seed regions. Genetic variations in the seed regions have vital effects on gene expression, phenotypic variation,...

journal_title：International journal of genomics

authors： He S,Ou H,Zhao C,Zhang J

更新日期：2018-03-06 00:00:00