Association Study of Puberty-Related Candidate Genes in Chinese Female Population.

Abstract:

:Puberty is a transition period where a child transforms to an adult. Puberty can be affected by various genetic factors and environmental influences. In mammals, the regulation of puberty is enhanced by the hypothalamic-pituitary-gonadal axis (HPG axis). A number of genes such as GnRH, Kiss1, and GPR54 have been reported as key regulators of puberty onset. In this study, we have conducted an association study of puberty-related candidate genes in Chinese female population. Gene variations reported to be related with some traits in a population may not exist in others due to different genetic and ethnic backgrounds, hence the need for this kind of study. The genotyping of SNPs was based on multiplex PCR and the next-generation sequencing (NGS) platform of Illumina. We finally performed association study using PLINK software. Our results confirmed that SNPs rs34787247 in LIN28, rs74795793 and rs9347389 in OCT-1, and rs379202 and rs10491080 in ZEB1 genes showed a significant association with puberty. With the result, it is reasonable to conclude that these genes affect the process of puberty in Shanghai Chinese female population, yet the mechanism remains to be investigated by further study.

journal_name

Int J Genomics

authors

Omariba G,Xiao J

doi

10.1155/2020/1426761

subject

Has Abstract

pub_date

2020-05-22 00:00:00

pages

1426761

eissn

2314-436X

issn

2314-4378

journal_volume

2020

pub_type

杂志文章
  • Analysis of the Phenotypes in the Rett Networked Database.

    abstract::Rett spectrum disorder is a progressive neurological disease and the most common genetic cause of intellectual disability in females. MECP2 is the major causative gene. In addition, CDKL5 and FOXG1 mutations have been reported in Rett patients, especially with the atypical presentation. Each gene and different mutatio...

    journal_title:International journal of genomics

    pub_type: 杂志文章

    doi:10.1155/2019/6956934

    authors: Frullanti E,Papa FT,Grillo E,Clarke A,Ben-Zeev B,Pineda M,Bahi-Buisson N,Bienvenu T,Armstrong J,Roche Martinez A,Mari F,Nissenkorn A,Lo Rizzo C,Veneselli E,Russo S,Vignoli A,Pini G,Djuric M,Bisgaard AM,Ravn K,Bosn

    更新日期:2019-03-27 00:00:00

  • SSR Mapping of QTLs Conferring Cold Tolerance in an Interspecific Cross of Tomato.

    abstract::A population of 146 RILs (Recombinant Inbred Line) was derived from the cross between a cold-sensitive cultivated Solanum lycopersicum L. XF98-7 and a cold-tolerant wild Solanum pimpinellifolium LA2184. Relative germination ratio (RGR) and chilling index (CI) were used to evaluate the cold tolerance of the parental li...

    journal_title:International journal of genomics

    pub_type: 杂志文章

    doi:10.1155/2016/3219276

    authors: Liu Y,Zhou T,Ge H,Pang W,Gao L,Ren L,Chen H

    更新日期:2016-01-01 00:00:00

  • The Complete Chloroplast Genome of Arabidopsis thaliana Isolated in Korea (Brassicaceae): An Investigation of Intraspecific Variations of the Chloroplast Genome of Korean A. thaliana.

    abstract::Arabidopsis thaliana (L.) Heynh. is a model organism of plant molecular biology. More than 1,700 whole genome sequences have been sequenced, but no Korean isolate genomes have been sequenced thus far despite the fact that many A. thaliana isolated in Japan and China have been sequenced. To understand the genetic backg...

    journal_title:International journal of genomics

    pub_type: 杂志文章

    doi:10.1155/2020/3236461

    authors: Park J,Xi H,Kim Y

    更新日期:2020-09-05 00:00:00

  • The Microbiome of Animals: Implications for Conservation Biology.

    abstract::In recent years the human microbiome has become a growing area of research and it is becoming clear that the microbiome of humans plays an important role for human health. Extensive research is now going into cataloging and annotating the functional role of the human microbiome. The ability to explore and describe the...

    journal_title:International journal of genomics

    pub_type: 杂志文章,评审

    doi:10.1155/2016/5304028

    authors: Bahrndorff S,Alemu T,Alemneh T,Lund Nielsen J

    更新日期:2016-01-01 00:00:00

  • GOLink: Finding Cooccurring Terms across Gene Ontology Namespaces.

    abstract::The Gene Ontology (GO) provides a resource for consistent annotation of genes and gene products that is extensively used by numerous large public repositories. The GO is constructed of three subontologies describing the cellular component of action, molecular function, and overall biological process of a gene or gene ...

    journal_title:International journal of genomics

    pub_type: 杂志文章

    doi:10.1155/2013/594528

    authors: Francis RW

    更新日期:2013-01-01 00:00:00

  • Urinary Metabolomic Study of Chlorogenic Acid in a Rat Model of Chronic Sleep Deprivation Using Gas Chromatography-Mass Spectrometry.

    abstract::The urinary metabolomic study based on gas chromatography-mass spectrometry (GC-MS) had been developed to investigate the possible antidepressant mechanism of chlorogenic acid (CGA) in a rat model of sleep deprivation (SD). According to pattern recognition analysis, there was a clear separation among big platform grou...

    journal_title:International journal of genomics

    pub_type: 杂志文章

    doi:10.1155/2018/1361402

    authors: Ma WN,Zhou MM,Gou XJ,Zhao L,Cen F,Xu Y,Shen HY

    更新日期:2018-02-11 00:00:00

  • Clustering Pattern and Functional Effect of SNPs in Human miRNA Seed Regions.

    abstract::miRNAs are a class of noncoding RNAs important in posttranscriptional repressors and involved in the regulation of almost every biological process by base paring with target genes through sequence in their seed regions. Genetic variations in the seed regions have vital effects on gene expression, phenotypic variation,...

    journal_title:International journal of genomics

    pub_type: 杂志文章

    doi:10.1155/2018/2456076

    authors: He S,Ou H,Zhao C,Zhang J

    更新日期:2018-03-06 00:00:00

  • Differential Methylation of Genomic Regions Associated with Heteroblasty Detected by M&M Algorithm in the Nonmodel Species Eucalyptus globulus Labill.

    abstract::Epigenetic regulation plays important biological roles in plants, including timing of flowering and endosperm development. Little is known about the mechanisms controlling heterochrony (the change in the timing or rate of developmental events during ontogeny) in Eucalyptus globulus. DNA methylation has been proposed a...

    journal_title:International journal of genomics

    pub_type: 杂志文章

    doi:10.1155/2016/4395153

    authors: Hasbún R,Iturra C,Bravo S,Rebolledo-Jaramillo B,Valledor L

    更新日期:2016-01-01 00:00:00

  • Human Genes Encoding Transcription Factors and Chromatin-Modifying Proteins Have Low Levels of Promoter Polymorphism: A Study of 1000 Genomes Project Data.

    abstract::The expression level of each gene is controlled by its regulatory regions, which determine the precise regulation in a tissue-specific manner, according to the developmental stage of the body and the necessity of a response to external stimuli. Nucleotide substitutions in regulatory gene regions may modify the affinit...

    journal_title:International journal of genomics

    pub_type: 杂志文章

    doi:10.1155/2015/260159

    authors: Ignatieva EV,Levitsky VG,Kolchanov NA

    更新日期:2015-01-01 00:00:00

  • The Potential Use of the CRISPR-Cas System for HIV-1 Gene Therapy.

    abstract::The HIV-1 virus (human immunodeficiency virus) affects 36.9 million people worldwide, with approximately 900000 deaths in 2017. The virus carrier can develop severe immunodeficiency since CD4+ T lymphocytes are the main target, leading to acquired immunodeficiency syndrome (AIDS). Despite advances in pharmacological t...

    journal_title:International journal of genomics

    pub_type: 杂志文章,评审

    doi:10.1155/2019/8458263

    authors: Sanches-da-Silva GN,Medeiros LFS,Lima FM

    更新日期:2019-08-21 00:00:00

  • Genome Sequencing of a Mung Bean Plant Growth Promoting Strain of P. aeruginosa with Biocontrol Ability.

    abstract::Pseudomonas aeruginosa PGPR2 is a mung bean rhizosphere strain that produces secondary metabolites and hydrolytic enzymes contributing to excellent antifungal activity against Macrophomina phaseolina, one of the prevalent fungal pathogens of mung bean. Genome sequencing was performed using the Ion Torrent Personal Gen...

    journal_title:International journal of genomics

    pub_type: 杂志文章

    doi:10.1155/2014/123058

    authors: Illakkiam D,Shankar M,Ponraj P,Rajendhran J,Gunasekaran P

    更新日期:2014-01-01 00:00:00

  • Transcriptome-Based Modeling Reveals that Oxidative Stress Induces Modulation of the AtfA-Dependent Signaling Networks in Aspergillus nidulans.

    abstract::To better understand the molecular functions of the master stress-response regulator AtfA in Aspergillus nidulans, transcriptomic analyses of the atfA null mutant and the appropriate control strains exposed to menadione sodium bisulfite- (MSB-), t-butylhydroperoxide- and diamide-induced oxidative stresses were perform...

    journal_title:International journal of genomics

    pub_type: 杂志文章

    doi:10.1155/2017/6923849

    authors: Orosz E,Antal K,Gazdag Z,Szabó Z,Han KH,Yu JH,Pócsi I,Emri T

    更新日期:2017-01-01 00:00:00

  • Transcriptome of the Deep-Sea Black Scabbardfish, Aphanopus carbo (Perciformes: Trichiuridae): Tissue-Specific Expression Patterns and Candidate Genes Associated to Depth Adaptation.

    abstract::Deep-sea fishes provide a unique opportunity to study the physiology and evolutionary adaptation to extreme environments. We carried out a high throughput sequencing analysis on a 454 GS-FLX titanium plate using unnormalized cDNA libraries from six tissues of A. carbo. Assemblage and annotations were performed by Newb...

    journal_title:International journal of genomics

    pub_type: 杂志文章

    doi:10.1155/2014/267482

    authors: Stefanni S,Bettencourt R,Pinheiro M,Moro GD,Bongiorni L,Pallavicini A

    更新日期:2014-01-01 00:00:00

  • Detecting Differentially Variable MicroRNAs via Model-Based Clustering.

    abstract::Identifying differentially variable (DV) genomic probes is becoming a new approach to detect novel genomic risk factors for complex human diseases. The F test is the standard equal-variance test in statistics. For high-throughput genomic data, the probe-wise F test has been successfully used to detect biologically rel...

    journal_title:International journal of genomics

    pub_type: 杂志文章

    doi:10.1155/2018/6591634

    authors: Li X,Fu Y,Wang X,DeMeo DL,Tantisira K,Weiss ST,Qiu W

    更新日期:2018-07-12 00:00:00

  • Comparative analysis of context-dependent mutagenesis in humans and fruit flies.

    abstract::In general, mutation frequencies are context-dependent: specific adjacent nucleotides may influence the probability to observe a specific type of mutation in a genome. Recently, several hypermutable motifs were identified in the human genome. Namely, there is an increased frequency of T>C mutations in the second posit...

    journal_title:International journal of genomics

    pub_type: 杂志文章

    doi:10.1155/2013/173616

    authors: Medvedeva SA,Panchin AY,Alexeevski AV,Spirin SA,Panchin YV

    更新日期:2013-01-01 00:00:00

  • The Utilization of Formalin Fixed-Paraffin-Embedded Specimens in High Throughput Genomic Studies.

    abstract::High throughput genomic assays empower us to study the entire human genome in short time with reasonable cost. Formalin fixed-paraffin-embedded (FFPE) tissue processing remains the most economical approach for longitudinal tissue specimen storage. Therefore, the ability to apply high throughput genomic applications to...

    journal_title:International journal of genomics

    pub_type: 杂志文章,评审

    doi:10.1155/2017/1926304

    authors: Zhang P,Lehmann BD,Shyr Y,Guo Y

    更新日期:2017-01-01 00:00:00

  • Association of genetic variation in calmodulin and left ventricular mass in full-term newborns.

    abstract::Calmodulin II (CALM2) gene polymorphism might be responsible for the variation in the left ventricular mass amongst healthy individuals. The aim was to evaluate the correlation between left ventricular mass (LVM) and g.474955027G>A (rs7565161) polymorphism adjacent to the CALM2 gene. Healthy Polish newborns (n = 206) ...

    journal_title:International journal of genomics

    pub_type: 杂志文章

    doi:10.1155/2013/410407

    authors: Gorący I,Gorący J,Skonieczna-Żydecka K,Kaczmarczyk M,Dawid G,Ciechanowicz A

    更新日期:2013-01-01 00:00:00

  • Genetic Mapping and Validation of Quantitative Trait Loci (QTL) for the Grain Appearance and Quality Traits in Rice (Oryza sativa L.) by Using Recombinant Inbred Line (RIL) Population.

    abstract::Rice grain shape and nutritional quality traits have high economic value for commercial production of rice and largely determine the market price, besides influencing the global food demand for high-quality rice. In order to understand the genetic components of grain appearance traits in paddy, brown, and head rice, 1...

    journal_title:International journal of genomics

    pub_type: 杂志文章

    doi:10.1155/2019/3160275

    authors: Bazrkar-Khatibani L,Fakheri BA,Hosseini-Chaleshtori M,Mahender A,Mahdinejad N,Ali J

    更新日期:2019-02-25 00:00:00

  • A Novel Protein Interaction between Nucleotide Binding Domain of Hsp70 and p53 Motif.

    abstract::Currently, protein interaction of Homo sapiens nucleotide binding domain (NBD) of heat shock 70 kDa protein (PDB: 1HJO) with p53 motif remains to be elucidated. The NBD-p53 motif complex enhances the p53 stabilization, thereby increasing the tumor suppression activity in cancer treatment. Therefore, we identified the ...

    journal_title:International journal of genomics

    pub_type: 杂志文章

    doi:10.1155/2015/391293

    authors: Elengoe A,Naser MA,Hamdan S

    更新日期:2015-01-01 00:00:00

  • MicroRNAs in the DNA Damage/Repair Network and Cancer.

    abstract::Cancer is a multistep process characterized by various and different genetic lesions which cause the transformation of normal cells into tumor cells. To preserve the genomic integrity, eukaryotic cells need a complex DNA damage/repair response network of signaling pathways, involving many proteins, able to induce cell...

    journal_title:International journal of genomics

    pub_type: 杂志文章,评审

    doi:10.1155/2014/820248

    authors: Tessitore A,Cicciarelli G,Del Vecchio F,Gaggiano A,Verzella D,Fischietti M,Vecchiotti D,Capece D,Zazzeroni F,Alesse E

    更新日期:2014-01-01 00:00:00

  • Construction and Validation of Predictive Model to Identify Critical Genes Associated with Advanced Kidney Disease.

    abstract:Background:Chronic kidney disease (CKD) is characterized by progressive renal function loss, which may finally lead to end-stage renal disease (ESRD). The study is aimed at identifying crucial genes related to CKD progressive and constructing a disease prediction model to investigate risk factors. Methods:GSE97709 and...

    journal_title:International journal of genomics

    pub_type: 杂志文章

    doi:10.1155/2020/7524057

    authors: Xin G,Zhou G,Zhang W,Zhang X

    更新日期:2020-11-12 00:00:00

  • Genome Analysis of Rhodococcus Sp. DSSKP-R-001: A Highly Effective β-Estradiol-Degrading Bacterium.

    abstract::We screened bacteria that use E2 as its sole source of carbon and energy for growth and identified them as Rhodococcus, and we named them DSSKP-R-001. For a better understanding of the metabolic potential of the strain, whole genome sequencing of Rhodococcus DSSKP-R-001 and annotation of the functional genes were perf...

    journal_title:International journal of genomics

    pub_type: 杂志文章

    doi:10.1155/2018/3505428

    authors: Zhao H,Tian K,Qiu Q,Wang Y,Zhang H,Ma S,Jin S,Huo H

    更新日期:2018-10-28 00:00:00

  • Identification of Alternative Variants and Insertion of the Novel Polymorphic AluYl17 in TSEN54 Gene during Primate Evolution.

    abstract::TSEN54 encodes a subunit of the tRNA-splicing endonuclease complex, which catalyzes the identification and cleavage of introns from precursor tRNAs. Previously, we identified an AluSx-derived alternative transcript in TSEN54 of cynomolgus monkey. Reverse transcription-polymerase chain reaction (RT-PCR) amplification a...

    journal_title:International journal of genomics

    pub_type: 杂志文章

    doi:10.1155/2016/1679574

    authors: Lee JR,Kim YH,Park SJ,Choe SH,Cho HM,Lee SR,Kim SU,Kim JS,Sim BW,Song BS,Jeong KJ,Lee Y,Jin YB,Kang P,Huh JW,Chang KT

    更新日期:2016-01-01 00:00:00

  • Protein-Protein Interactions Inferred from Domain-Domain Interactions in Genogroup II Genotype 4 Norovirus Sequences.

    abstract::Severe gastroenteritis and foodborne illness caused by Noroviruses (NoVs) during the winter are a worldwide phenomenon. Vulnerable populations including young children and elderly and immunocompromised people often require hospitalization and may die. However, no efficient vaccine for NoVs exists because of their vari...

    journal_title:International journal of genomics

    pub_type: 杂志文章

    doi:10.1155/2013/456356

    authors: Huang CC,Tang CY

    更新日期:2013-01-01 00:00:00

  • Genetics of Human and Canine Dilated Cardiomyopathy.

    abstract::Cardiovascular disease is a leading cause of death in both humans and dogs. Dilated cardiomyopathy (DCM) accounts for a large number of these cases, reported to be the third most common form of cardiac disease in humans and the second most common in dogs. In human studies of DCM there are more than 50 genetic loci ass...

    journal_title:International journal of genomics

    pub_type: 杂志文章,评审

    doi:10.1155/2015/204823

    authors: Simpson S,Edwards J,Ferguson-Mignan TF,Cobb M,Mongan NP,Rutland CS

    更新日期:2015-01-01 00:00:00

  • Comprehensive Analysis of Transcriptome Sequencing Data in the Lung Tissues of COPD Subjects.

    abstract::Background and Objectives. Chronic obstructive pulmonary disease (COPD) is a complex disease characterized by airflow limitation. Although airway inflammation and oxidative stress are known to be important in the pathogenesis of COPD, the mechanism underlying airflow obstruction is not fully understood. Gene expressio...

    journal_title:International journal of genomics

    pub_type: 杂志文章

    doi:10.1155/2015/206937

    authors: Kim WJ,Lim JH,Lee JS,Lee SD,Kim JH,Oh YM

    更新日期:2015-01-01 00:00:00

  • Meta-Analysis of Genome-Wide Association Studies Identifies Novel Functional CpG-SNPs Associated with Bone Mineral Density at Lumbar Spine.

    abstract::Osteoporosis is a serious public health issue, which is mostly characterized by low bone mineral density (BMD). To search for additional genetic susceptibility loci underlying BMD variation, an effective strategy is to focus on testing of specific variants with high potential of functional effects. Single nucleotide p...

    journal_title:International journal of genomics

    pub_type: 杂志文章

    doi:10.1155/2018/6407257

    authors: Qiu C,Shen H,Fu X,Xu C,Deng H

    更新日期:2018-08-07 00:00:00

  • Transcriptome Analysis of Two Different Developmental Stages of Paeonia lactiflora Seeds.

    abstract::Paeonia lactiflora is a herbaceous flower in the family Paeoniaceae with both hypocotyl and epicotyl dormant seeds. We used high-throughput transcriptome sequencing on two different developmental stages of P. lactiflora seeds to identify seed dormancy and germination-related genes. We performed de novo assembly and an...

    journal_title:International journal of genomics

    pub_type: 杂志文章

    doi:10.1155/2017/8027626

    authors: Ma Y,Cui J,Lu X,Zhang L,Chen Z,Fei R,Sun X

    更新日期:2017-01-01 00:00:00

  • Variants of insulin-signaling inhibitor genes in type 2 diabetes and related metabolic abnormalities.

    abstract::Insulin resistance has a central role in the pathogenesis of several metabolic diseases, including type 2 diabetes, obesity, glucose intolerance, metabolic syndrome, atherosclerosis, and cardiovascular diseases. Insulin resistance and related traits are likely to be caused by abnormalities in the genes encoding for pr...

    journal_title:International journal of genomics

    pub_type: 杂志文章

    doi:10.1155/2013/376454

    authors: de Lorenzo C,Greco A,Fiorentino TV,Mannino GC,Hribal ML

    更新日期:2013-01-01 00:00:00

  • Identification of Wheat Inflorescence Development-Related Genes Using a Comparative Transcriptomics Approach.

    abstract::Inflorescence represents the highly specialized plant tissue producing the grains. Although key genes regulating flower initiation and development are conserved, the mechanism regulating fertility is still not well explained. To identify genes and gene network underlying inflorescence morphology and fertility of bread...

    journal_title:International journal of genomics

    pub_type: 杂志文章

    doi:10.1155/2018/6897032

    authors: Ma L,Ma SW,Deng Q,Yuan Y,Wei Z,Jia H,Ma Z

    更新日期:2018-02-08 00:00:00