Abstract:
BACKGROUND:Clioquinol was used in the 1950s-1970s as antimicrobial but its oral formulations were withdrawn from the market due to suspected neurotoxicity. Currently, there is possibility of repositioning of oral clioquinol formulations. OBJECTIVES:To evaluate the antifungal activity and toxicological parameters of clioquinol and the other two 8-hydroxyquinoline derivatives using alternative animal models and to study the interaction dynamic of clioquinol with Candida albicans. METHODS:We used Toll-deficient Drosophila melanogaster to test the protective effect of 8-hydroxyquinolines against C. albicans infection. Toxicological parameters were investigated in chicken embryo. A mathematical model-based analysis of the time-kill data of clioquinol was performed to obtain pharmacodynamic characteristics. RESULTS:Clioquinol fully protected D. melanogaster from the infection. The 8-hydroxyquinolines did not cause changes in opening of the beak and movement of the chicken embryo; however, clioquinol and compound 2 increased arterial pulsation. Compound 3 was lethal at 1 mg mL-1 . Effective concentration found in modelling indicated that clioquinol was highly effective against C. albicans (0.306 μg mL-1 ) in easily achievable serum levels; clioquinol rapidly achieved kill rate reaching the maximum effect after 13 hours. CONCLUSIONS:These results support the potential of clioquinol to be used as a systemic antifungal agent.
journal_name
Mycosesjournal_title
Mycosesauthors
Pippi B,Merkel S,Staudt KJ,Teixeira ML,de Araújo BV,Zanette RA,Andrade SF,Fuentefria AMdoi
10.1111/myc.12888subject
Has Abstractpub_date
2019-05-01 00:00:00pages
475-481issue
5eissn
0933-7407issn
1439-0507journal_volume
62pub_type
杂志文章相关文献
MYCOSES文献大全abstract::Mucor is a fungus, which give rise to opportunistic infection in immunocompromised patients. We described a 55-year-old immunocompetent woman with cutaneous mucormycosis after scorpion sting. Mucormycosis may happen in patients with intact immunity and is not allocated only to patients with immune deficiency. ...
journal_title:Mycoses
pub_type: 杂志文章
doi:10.1111/myc.12066
更新日期:2013-09-01 00:00:00
abstract::Among fungi, Curvularia inaequalis is a rare pathogen. We report the first case of non-invasive fungal rhinosinusitis caused by this species. Endoscopic sinus surgery revealed massive polyposis and the presence of viscous eosinophilic mucus that allowed the growth of the fungus. We diagnosed eosinophilic fungal rhinos...
journal_title:Mycoses
pub_type: 信件
doi:10.1111/j.1439-0507.2008.01671.x
更新日期:2010-01-01 00:00:00
abstract::A 36-year-old HIV-infected male patient presented with relapsing fever episodes to 39 degrees C, night sweats and weight loss. Computerized tomography of the abdomen showed enlarged multiple lymph nodes. After surgical resection of multiple lymph nodes, disseminated infection with Histoplasma capsulatum was diagnosed....
journal_title:Mycoses
pub_type: 信件
doi:10.1046/j.1439-0507.1999.00262.x
更新日期:1999-04-01 00:00:00
abstract::The wide spectrum of candidiasis and its clinical importance encourage the research with the purpose of clarifying the mechanisms of pathogenicity and identification of virulence factors of Candida sp. Therefore, the aim of this study was to verify the adhesion capacity, protease activity and genotypic diversity of or...
journal_title:Mycoses
pub_type: 杂志文章
doi:10.1111/j.1439-0507.2011.02125.x
更新日期:2012-05-01 00:00:00
abstract::It has always been difficult to treat onychomycosis due to decrease ability of topical agents to penetrate the nail and reach the affected nail bed. Oral antifungal have shown good response but due to longer duration course it has potential to cause systemic side effects, leading to patient non-adherence and adverse e...
journal_title:Mycoses
pub_type: 杂志文章,评审
doi:10.1111/myc.12225
更新日期:2014-12-01 00:00:00
abstract::Ultraviolet B light (UVB) can have negative phototropic effects on fungi. Candida albicans is often found on human skin exposed to UVB. Therefore, it is of medical interest to know whether a negative phototropic response to UVB irradiation can support an invasive growth of this potentially dangerous agent. In our stud...
journal_title:Mycoses
pub_type: 杂志文章
doi:10.1111/j.1439-0507.2005.01169.x
更新日期:2006-01-01 00:00:00
abstract::Orointestinal mycoses are localized mainly in the oral cavity and in the oesophagus. Candida oesophagitis is not only found in AIDS-patients, also in patients of risk admitted to intensive care units. Upper intestinoscopies were made in 124 patients. Oesophageal candidosis was found in 6 patients, two of them had also...
journal_title:Mycoses
pub_type: 杂志文章
doi:10.1111/j.1439-0507.1999.tb04531.x
更新日期:1999-01-01 00:00:00
abstract::We present four cases of interdigital tinea pedis in Italian tourists which was probably acquired in Turkish mosques and holy Muslim places. In all patients mycological examinations were positive for Trichophyton rubrum. All patients were successfully treated with bifonazole cream (one application/day for three weeks)...
journal_title:Mycoses
pub_type: 杂志文章
doi:10.1111/myc.12775
更新日期:2018-11-01 00:00:00
abstract:BACKGROUND:Candida glabrata is the third leading cause of candidaemia in Turkey; however, the data regarding antifungal resistance mechanisms and genotypic diversity in association with their clinical implication are limited. OBJECTIVES:To assess genotypic diversity, antifungal susceptibility and mechanisms of drug re...
journal_title:Mycoses
pub_type: 杂志文章
doi:10.1111/myc.13104
更新日期:2020-09-01 00:00:00
abstract::The mould collection of the Centraalbureau voor Schimmelcultures, Baarn, The Netherlands, was screened for isolates originating from warm-blooded animals. The range of species indicates that distribution of clinically relevant, pathogenic or opportunistic strains over the fungal kingdom is non-random. Some opportunist...
journal_title:Mycoses
pub_type: 杂志文章,评审
doi:10.1111/j.1439-0507.1992.tb00849.x
更新日期:1992-09-01 00:00:00
abstract::Mycetoma is a chronic granulomatous, subcutaneous disease endemic in tropical and subtropical countries. It is currently a health problem in rural areas of Africa, Asia and South America. Nine cases of mycetoma were analysed in a retrospective study. All isolates were identified by morphological features. The level of...
journal_title:Mycoses
pub_type: 杂志文章
doi:10.1111/myc.12579
更新日期:2017-02-01 00:00:00
abstract::The MIC values of the antifungal drug ketoconazole were evaluated on 66 Candida albicans strains. These strains were isolated from 26 HIV-1 infected patients with oral recurrent candidosis. Each episode of oral candidosis observed in these patients was orally treated with ketoconazole (200 mg/day) until the clinical d...
journal_title:Mycoses
pub_type: 杂志文章
doi:10.1111/j.1439-0507.1992.tb00819.x
更新日期:1992-01-01 00:00:00
abstract::This short communication presents a review on the work of the mycological laboratory of the Institute of Microbiology and Epidemics, Hannover, Germany, concerning the mycological investigation on feeding stuff. Out of the routine diagnostic work, examining more than 4000 probes in the last 10 years, some selected inve...
journal_title:Mycoses
pub_type: 杂志文章
doi:
更新日期:2000-01-01 00:00:00
abstract::Among the genus Cunninghamella, so far C. bertholletiae is known to be the only clinically relevant species. Correct identification of C. bertholletiae is not possible with classical methods. PCR and sequencing of the internal transcribed spacer (ITS) region was used to identify seven of nine clinical isolates as C. b...
journal_title:Mycoses
pub_type: 杂志文章
doi:10.1111/j.1439-0507.2002.tb04543.x
更新日期:2002-01-01 00:00:00
abstract::A review is presented of the emerging problem of resistant and chronic vaginitis due to Candida glabrata. Although accurate numbers are lacking, several investigators report encountering increased numbers of women with vaginitis due to C. glabrata. Possible reasons for this apparent increase are discussed. Risk factor...
journal_title:Mycoses
pub_type: 杂志文章,评审
doi:10.1111/j.1439-0507.1998.tb00594.x
更新日期:1998-01-01 00:00:00
abstract::Screening of 217 soil samples of different habitats, such as PG study centre, garden, farmhouse, nursery, roadside, hostel, animal habitat, bird habitat, marriage garden, temple, vegetable market and house dust, was carried out for the presence of dermatophytes and related fungi in relation to soil pH. A total of 461 ...
journal_title:Mycoses
pub_type: 杂志文章
doi:10.1111/j.1439-0507.2009.01751.x
更新日期:2011-01-01 00:00:00
abstract::Detection of serum galactomannan (GM) and (1,3)-β-d-glucan (BG) is considered useful for non-culture diagnosis of invasive pulmonary aspergillosis (IPA) in neutropenic patients. Only few studies evaluated these seromarkers in non-neutropenic patients suspected of having IPA. The aim of this study was to evaluate both ...
journal_title:Mycoses
pub_type: 杂志文章,多中心研究
doi:10.1111/myc.12765
更新日期:2018-08-01 00:00:00
abstract::The annual incidence of cryptococcosis during 1981-2000 was determined in subscribers of a large integrated health care program in Northern California and in those among them who were HIV positive. The incidence of cryptococcosis had been measured in this setting in the previous decade. The 20-year incidence per milli...
journal_title:Mycoses
pub_type: 杂志文章
doi:10.1111/j.1439-0507.2004.01082.x
更新日期:2005-03-01 00:00:00
abstract::Cryptococcus neoformans is an encapsulated yeast-like fungus that causes life-threatening infections, particularly in immunocompromised patients. The formation of brown pigment on many media described in the literature, such as that in Niger seed (Guizotia abyssinica) agar, has been used to identify C. neoformans. The...
journal_title:Mycoses
pub_type: 杂志文章
doi:10.1111/j.1439-0507.2010.01877.x
更新日期:2011-07-01 00:00:00
abstract::Candida albicans, the most important opportunistic fungal pathogen, is able to generate remarkable amounts of reactive oxygen species (ROS). Since ROS are highly cytotoxic, this mechanism may contribute to the pathogenicity of this yeast, including its invasiveness and the inflammatory response of the host. Terbinafin...
journal_title:Mycoses
pub_type: 杂志文章
doi:10.1046/j.1439-0507.2002.00756.x
更新日期:2002-06-01 00:00:00
abstract::Is non-response to maintenance treatment for recurrent vulvovaginal candidosis (RCVV) related to the impaired glucose metabolism? In the ReCiDiF trial, women with RCVV were given a degressive regimen with fluconazole according to their clinical, microscopic and mycologic response. Data obtained from optimal, suboptima...
journal_title:Mycoses
pub_type: 杂志文章
doi:10.1111/myc.12626
更新日期:2017-08-01 00:00:00
abstract::Scedosporium apiospermum is a ubiquitous filamentous fungus, commonly found in soil, sewage and polluted waters. It is rarely pathogenic but can cause a broad spectrum of clinical diseases, which can be localised or disseminate to distant organs. The disseminated form of the disease is mostly seen among immunocompromi...
journal_title:Mycoses
pub_type: 杂志文章,评审
doi:10.1111/myc.12739
更新日期:2018-06-01 00:00:00
abstract::The infection of the capillitium of an 8-year old child due to Microsporum canis is described. The child occasionally visited its mother working at an animal farm. The focus of the infection was found in farm rabbits infected by M. canis. A contamination of the environment (cages and floors) by the above mentioned der...
journal_title:Mycoses
pub_type: 杂志文章
doi:
更新日期:1989-02-01 00:00:00
abstract::The first case of a cutaneous cryptococcosis associated with systemic erythematous lupus (SLE) diagnosed in our Mycology Reference Centre is presented: a 24-year-old female patient diagnosed with SLE, nephrotic syndrome, arterial hypertension, renal insufficiency due to glomerulonephritis type IV and cellulitis in the...
journal_title:Mycoses
pub_type: 信件
doi:10.1046/j.1439-0507.2001.00661.x
更新日期:2001-11-01 00:00:00
abstract::Itraconazole is a lipophilic triazole antifungal with a broad spectrum of activity. Most of the important fungal pathogens respond to itraconazole concentrations of 100 ng/ml. Therefore, itraconazole is suitable for treatment of a variety of systemic mycoses, as aspergillosis, cryptococcosis, candidosis as well as non...
journal_title:Mycoses
pub_type: 杂志文章,评审
doi:
更新日期:1994-01-01 00:00:00
abstract::Different commercial enzyme-linked immunsorbent assays (ELISA) were evaluated in a preliminary study for diagnosis of systemic candidosis: Biomerica and Virotech GmbH, which allowed immunoglobulin G detection, and Platelia, which associated total antibody to antigen detection. They were tested with a home-made ELISA a...
journal_title:Mycoses
pub_type: 杂志文章
doi:10.1046/j.1439-0507.2002.00775.x
更新日期:2002-12-01 00:00:00
abstract::A commercially available antigen assay (Pastorex Aspergillus) was used to detect Aspergillus antigen in serial bronchoalveolar lavage (BAL) fluids and sera of patients undergoing bone marrow transplantation (six patients with autopsyproven aspergillosis and 10 control patients without evidence of fungal infection). As...
journal_title:Mycoses
pub_type: 杂志文章
doi:10.1111/j.1439-0507.1996.tb00155.x
更新日期:1996-09-01 00:00:00
abstract::This is an observational-retrospective study comparing the real-world outcomes associated with posaconazole vs itraconazole as prophylaxis treatments. Two hundred and ninety-three patient admissions attributable to 174 patients were included in the study. Patients were treated with itraconazole (n = 114 admissions; 39...
journal_title:Mycoses
pub_type: 杂志文章
doi:10.1111/myc.12728
更新日期:2018-03-01 00:00:00
abstract::The aim of the study was to determine zinc, copper and iron levels, erythrocyte oxidant/antioxidant status, vitamin C and β-carotene in dogs with dermatophytosis. A total of 23 dogs with clinically established diagnosis of dermatophytosis by trichogram and positive fungal culture and six dogs as control were included ...
journal_title:Mycoses
pub_type: 杂志文章
doi:10.1111/myc.12163
更新日期:2014-06-01 00:00:00
abstract::This is a retrospective study on the superficial mycoses due to Trichophyton violaceum in the greater Athens area for the last 15 years - 1989-2003. During this period 104 patients were found to have an infection due to T. violaceum- an incidence rate of 0.75% of all dermatophytosis. Of the patients 59 were Greeks, 15...
journal_title:Mycoses
pub_type: 杂志文章
doi:10.1111/j.1439-0507.2005.01159.x
更新日期:2005-11-01 00:00:00