Algorithm-based prediction of HIV-1 subtype D coreceptor use.

Abstract:

:We compared the coreceptor tropism-predicting performance of a specific genotypic algorithm for HIV-1 subtype D and that of the geno2pheno algorithm with different cutoffs. The D-specific algorithm and geno2pheno with a false-positivity rate cutoff of 2.5% had the same concordance with the phenotypic determination. The geno2pheno algorithm with a false-positivity rate cutoff of 2.5%, more sensitive but slightly less specific, seems to be an appropriate alternative.

journal_name

J Clin Microbiol

authors

Dina J,Raymond S,Maillard A,Le Guillou-Guillemette H,Rodalec A,Beby-Defaux A,Giraudeau G,Vallet S,Mourez T,Payan C,Vabret A,Ruffault A,Ferre V,Izopet J,Plantier JC

doi

10.1128/JCM.00798-13

subject

Has Abstract

pub_date

2013-09-01 00:00:00

pages

3087-9

issue

9

eissn

0095-1137

issn

1098-660X

pii

JCM.00798-13

journal_volume

51

pub_type

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