Computational fluid dynamics modelling of perfusion measurements in dynamic contrast-enhanced computed tomography: development, validation and clinical applications.


:Dynamic contrast-enhanced computed tomography (DCE-CT) is an imaging tool that aids in evaluating functional characteristics of tissue at different stages of disease management: diagnostic, radiation treatment planning, treatment effectiveness, and monitoring. Clinical validation of DCE-derived perfusion parameters remains an outstanding problem to address prior to perfusion imaging becoming a widespread standard as a non-invasive quantitative measurement tool. One approach to this validation process has been the development of quality assurance phantoms in order to facilitate controlled perfusion ex vivo. However, most of these systems fail to establish and accurately replicate physiologically relevant capillary permeability and exchange performance. The current work presents the first step in the development of a prospective suite of physics-based perfusion simulations based on coupled fluid flow and particle transport phenomena with the goal of enhancing the understanding of clinical contrast agent kinetics. Existing knowledge about a controllable, two-compartmental fluid exchange phantom was used to validate the computational fluid dynamics (CFD) simulation model presented herein. The sensitivity of CFD-derived contrast uptake curves to contrast injection parameters, including injection duration and flow rate, were quantified and found to be within 10% accuracy. The CFD model was employed to evaluate two commonly used clinical kinetic algorithms used to derive perfusion parameters: Fick's principle and the modified Tofts model. Neither kinetic model was able to capture the true transport phenomena it aimed to represent but if the overall contrast concentration after injection remained identical, then successive DCE-CT evaluations could be compared and could indeed reflect differences in regional tissue flow. This study sets the groundwork for future explorations in phantom development and pharmaco-kinetic modelling, as well as the development of novel contrast agents for DCE imaging.


Phys Med Biol


Peladeau-Pigeon M,Coolens C




Has Abstract


2013-09-07 00:00:00












  • A compact and high sensitivity positron detector using dual-layer thin GSO scintillators for a small animal PET blood sampling system.

    abstract::For quantitative measurements of small animals such as mice or rats, a compact and high sensitivity continuous blood sampling detector is required because their blood sampling volume is limited. For this purpose we have developed and tested a new positron detector. The positron detector uses a pair of dual-layer thin ...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章


    authors: Yamamoto S,Imaizumi M,Shimosegawa E,Kanai Y,Sakamoto Y,Minato K,Shimizu K,Senda M,Hatazawa J

    更新日期:2010-07-07 00:00:00

  • K x-ray fluorescence measurements of bone lead concentration: the analysis of low-level data.

    abstract::K line x-ray fluorescence (KXRF) measurements of bone lead have emerged as a promising new biological marker of internal lead dose in epidemiological studies. Some disagreements exist, however, over the analysis of data at low levels of bone lead concentration. In this study, we performed 30 serial measurements on eac...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章


    authors: Kim R,Aro A,Rotnitzky A,Amarasiriwardena C,Hu H

    更新日期:1995-09-01 00:00:00

  • Geometrically undistorted MRI in the presence of field inhomogeneities using compressed sensing accelerated broadband 3D phase encoded turbo spin-echo imaging.

    abstract::In this study, we explore the potential of compressed sensing (CS) accelerated broadband 3D phase-encoded turbo spin-echo (3D-PE-TSE) for the purpose of geometrically undistorted imaging in the presence of field inhomogeneities. To achieve this goal 3D-PE-SE and 3D-PE-TSE sequences with broadband rf pulses and dedicat...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章


    authors: van Gorp JS,Bakker CJ,Bouwman JG,Smink J,Zijlstra F,Seevinck PR

    更新日期:2015-01-21 00:00:00

  • Assessment of organ-specific neutron equivalent doses in proton therapy using computational whole-body age-dependent voxel phantoms.

    abstract::Proton beams used for radiotherapy will produce neutrons when interacting with matter. The purpose of this study was to quantify the equivalent dose to tissue due to secondary neutrons in pediatric and adult patients treated by proton therapy for brain lesions. Assessment of the equivalent dose to organs away from the...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章


    authors: Zacharatou Jarlskog C,Lee C,Bolch WE,Xu XG,Paganetti H

    更新日期:2008-02-07 00:00:00

  • Design of applicators for a 27 MHz multielectrode current source interstitial hyperthermia system; impedance matching and effective power.

    abstract::In interstitial heating one of the main requirements for achieving a certain elevated temperature in a tumour is that the effective power per applicator (Peff), i.e. the power which is actually deposited in the tissue, is sufficiently high. In this paper this requirement is discussed for the applicators of the 27 MHz ...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章


    authors: Kaatee RS,Crezee J,Kanis AP,Lagendijk JJ,Levendag PC,Visser AG

    更新日期:1997-06-01 00:00:00

  • Leuco-crystal-violet micelle gel dosimeters: I. Influence of recipe components and potential sensitizers.

    abstract::Radiochromic leuco crystal violet (LCV) micelle gel dosimeters are promising three-dimensional radiation dosimeters because of their spatial stability and suitability for optical readout. The effects of surfactant type and surfactant concentration on dose sensitivity of LCV micelle gels are tested, demonstrating that ...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章


    authors: Nasr AT,Alexander K,Schreiner LJ,McAuley KB

    更新日期:2015-06-21 00:00:00

  • Quenching-free fluorescence signal from plastic-fibres in proton dosimetry: understanding the influence of Čerenkov radiation.

    abstract::The origin of photons emitted in optical fibres under proton irradiation has been attributed to either entirely Čerenkov radiation or light consisting of fluorescence with a substantial amount of Čerenkov radiation. The source of the light emission is assessed in order to understand why the signal from optical fibres ...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章


    authors: Brage Christensen J,Almhagen E,Nyström H,Andersen CE

    更新日期:2018-03-09 00:00:00

  • Accuracy of quantitative reconstructions in SPECT/CT imaging.

    abstract::The goal of this study was to determine the quantitative accuracy of our OSEM-APDI reconstruction method based on SPECT/CT imaging for Tc-99m, In-111, I-123, and I-131 isotopes. Phantom studies were performed on a SPECT/low-dose multislice CT system (Infinia-Hawkeye-4 slice, GE Healthcare) using clinical acquisition p...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章


    authors: Shcherbinin S,Celler A,Belhocine T,Vanderwerf R,Driedger A

    更新日期:2008-09-07 00:00:00

  • Predicting voxel-level dose distributions for esophageal radiotherapy using densely connected network with dilated convolutions.

    abstract::This work aims to develop a voxel-level dose prediction framework by integrating distance information between PTV and OARs, as well as image information, into a densely-connected network (DCNN). Firstly, a four-channel feature map, consisting of a PTV image, an OAR image, a CT image, and a distance image, is construct...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章


    authors: Zhang J,Liu S,Yan H,Li T,Mao R,Liu J

    更新日期:2020-10-21 00:00:00

  • Simulation study to improve the performance of a whole-body PbF2 Cherenkov TOF-PET scanner.

    abstract::Using Cherenkov radiation in positron emission tomography (PET) has the potential to improve the time of flight (TOF) resolution and reduce the cost of detectors. In previous studies promising TOF results were achieved when lead fluoride (PbF2) crystals were used instead of a scintillator. In this work, a whole-body P...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章


    authors: Consuegra D,Korpar S,Križan P,Pestotnik R,Razdevšek G,Dolenec R

    更新日期:2020-03-06 00:00:00

  • Modelling of the dielectric properties of normal and irradiated skin.

    abstract::We have shown that irradiation changes the dielectric properties of human skin at radiofrequencies. Both the dielectric constant and the conductivity of the irradiated skin decrease, especially at low frequencies. The experimental data were analysed using two bioelectric models. Relevant dielectric parameters were det...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章


    authors: Tamura T,Tenhunen M,Lahtinen T,Repo T,Schwan HP

    更新日期:1994-06-01 00:00:00

  • SpekCalc: a program to calculate photon spectra from tungsten anode x-ray tubes.

    abstract::A software program, SpekCalc, is presented for the calculation of x-ray spectra from tungsten anode x-ray tubes. SpekCalc was designed primarily for use in a medical physics context, for both research and education purposes, but may also be of interest to those working with x-ray tubes in industry. Noteworthy is the p...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章


    authors: Poludniowski G,Landry G,DeBlois F,Evans PM,Verhaegen F

    更新日期:2009-10-07 00:00:00

  • A breathing thorax phantom with independently programmable 6D tumour motion for dosimetric measurements in radiation therapy.

    abstract::Irradiation of moving targets using a scanned ion beam can cause clinically intolerable under- and overdosages within the target volume due to the interplay effect. Several motion mitigation techniques such as gating, beam tracking and rescanning are currently investigated to overcome this restriction. To enable detai...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章


    authors: Steidl P,Richter D,Schuy C,Schubert E,Haberer T,Durante M,Bert C

    更新日期:2012-04-21 00:00:00

  • Modelling the temporal region in patients with temporal lobe epilepsy.

    abstract::EEG interictal epileptiform discharges in temporal lobe epilepsy are associated with magnetic fields. The maxima of magnetic spikes recorded over the spherical portions of the head appear fairly symmetric, whereas those over the lower temporal region often have irregular shapes. Furthermore, their magnitude is often u...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章


    authors: Rose DF,Sato S,Smith PD,White J

    更新日期:1987-01-01 00:00:00

  • Investigation of detection limits for diffuse optical tomography systems: II. Analysis of slab and cup geometry for breast imaging.

    abstract::Using a statistical (chi-square) test on simulated data and a realistic noise model derived from the system's hardware we study the performance of diffuse optical tomography systems for fluorescence imaging. We compare the predicted smallest size of detectable lesions at various positions in slab and cup geometry and ...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章


    authors: Ziegler R,Brendel B,Rinneberg H,Nielsen T

    更新日期:2009-01-21 00:00:00

  • An analytical algorithm for skew-slit collimator SPECT with uniform attenuation correction.

    abstract::To replace the conventional pinhole (normal cone-beam) collimator, a novel skew-slit collimator was previously proposed and a Novikov-type algorithm developed to reconstruct images using the skew-slit geometry. The goal of this paper is to develop a reconstruction algorithm that has better noise control than the Novik...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章


    authors: Tang Q,Zeng GL,Huang Q

    更新日期:2006-12-07 00:00:00

  • Adaptation and applications of a realistic digital phantom based on patient lung tumor trajectories.

    abstract::Digital phantoms continue to play a significant role in modeling and characterizing medical imaging. The currently available XCAT phantom incorporates both the flexibility of mathematical phantoms and the realistic nature of voxelized phantoms. This phantom generates images based on a regular breathing pattern and can...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章


    authors: Mishra P,St James S,Segars WP,Berbeco RI,Lewis JH

    更新日期:2012-06-07 00:00:00

  • Investigation of practical approaches to evaluating cumulative dose for cone beam computed tomography (CBCT) from standard CT dosimetry measurements: a Monte Carlo study.

    abstract::A function called Gx(L) was introduced by the International Commission on Radiation Units and Measurements (ICRU) Report-87 to facilitate measurement of cumulative dose for CT scans within long phantoms as recommended by the American Association of Physicists in Medicine (AAPM) TG-111. The Gx(L) function is equal to t...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章


    authors: Abuhaimed A,Martin CJ,Sankaralingam M,Gentle DJ

    更新日期:2015-07-21 00:00:00

  • High resolution propagation-based imaging system for in vivo dynamic computed tomography of lungs in small animals.

    abstract::We have developed an x-ray imaging system for in vivo four-dimensional computed tomography (4DCT) of small animals for pre-clinical lung investigations. Our customized laboratory facility is capable of high resolution in vivo imaging at high frame rates. Characterization using phantoms demonstrate a spatial resolution...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章


    authors: Preissner M,Murrie RP,Pinar I,Werdiger F,Carnibella RP,Zosky GR,Fouras A,Dubsky S

    更新日期:2018-04-20 00:00:00

  • Development and evaluation of a deep learning based artificial intelligence for automatic identification of gold fiducial markers in an MRI-only prostate radiotherapy workflow.

    abstract::Identification of prostate gold fiducial markers in magnetic resonance imaging (MRI) images is challenging when CT images are not available, due to misclassifications from intra-prostatic calcifications. It is also a time consuming task and automated identification methods have been suggested as an improvement for bot...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章


    authors: Gustafsson CJ,Swärd J,Adalbjörnsson SI,Jakobsson A,Olsson LE

    更新日期:2020-11-12 00:00:00

  • Photon quality correction factors for ionization chambers in an epithermal neutron beam.

    abstract::Photon quality correction factors (kQy) for ionization chamber photon dosimetry in an epithermal neutron beam were determined according to a modified absorbed dose to water formalism which was extended to mixed radiation fields. We have studied two commercially available ionization chambers in the epithermal neutron b...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章


    authors: Munck af Rosenschöld PM,Ceberg CP,Giusti V,Andreo P

    更新日期:2002-07-21 00:00:00

  • Effects of tissue mechanical and acoustic anisotropies on the performance of a cross-correlation-based ultrasound strain imaging method.

    abstract::The anisotropic mechanical properties (mechanical anisotropy) and view-dependent ultrasonic backscattering (acoustic anisotropy) of striated muscle due to the underlying myofiber arrangement have been well documented, but whether they impact on ultrasound strain imaging (USI) techniques remains unclear. The aim of thi...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章


    authors: Li H,Lee WN

    更新日期:2017-02-21 00:00:00

  • Development of a Si-PM-based high-resolution PET system for small animals.

    abstract::A Geiger-mode avalanche photodiode (Si-PM) is a promising photodetector for PET, especially for use in a magnetic resonance imaging (MRI) system, because it has high gain and is less sensitive to a static magnetic field. We developed a Si-PM-based depth-of-interaction (DOI) PET system for small animals. Hamamatsu 4 × ...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章


    authors: Yamamoto S,Imaizumi M,Watabe T,Watabe H,Kanai Y,Shimosegawa E,Hatazawa J

    更新日期:2010-10-07 00:00:00

  • Computed LET distributions in the build-up region of tissue for 14 MeV neutrons.

    abstract::Experimental radiobiological investigations of fast neutron beams involve irradiation of thin cell layers. The irradiation of cells is done either in free air or with a material such as graphite, TE plastic or bone-equivalent plastic covering the cells. This paper discusses the computed dose distributions in LET at sh...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章


    authors: Bhatia DP,Nagarajan PS

    更新日期:1979-09-01 00:00:00

  • Developing a new case based computer-aided detection scheme and an adaptive cueing method to improve performance in detecting mammographic lesions.

    abstract::The purpose of this study is to evaluate a new method to improve performance of computer-aided detection (CAD) schemes of screening mammograms with two approaches. In the first approach, we developed a new case based CAD scheme using a set of optimally selected global mammographic density, texture, spiculation, and st...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章


    authors: Tan M,Aghaei F,Wang Y,Zheng B

    更新日期:2017-01-21 00:00:00

  • Including robustness in multi-criteria optimization for intensity-modulated proton therapy.

    abstract::We present a method to include robustness in a multi-criteria optimization (MCO) framework for intensity-modulated proton therapy (IMPT). The approach allows one to simultaneously explore the trade-off between different objectives as well as the trade-off between robustness and nominal plan quality. In MCO, a database...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章


    authors: Chen W,Unkelbach J,Trofimov A,Madden T,Kooy H,Bortfeld T,Craft D

    更新日期:2012-02-07 00:00:00

  • Radiofrequency and microwave dielectric properties of aqueous cryoprotectant agents: dimethyl sulphoxide and 2,3-butanediol.

    abstract::Earlier work on the dielectric properties of cryoprotectant agents is extended using a modified measuring cell and method of data reduction yielding results more efficiently over a temperature range from -75 to +25 degrees C at frequencies from 27 MHz to 3 GHz. Dimethyl sulphoxide and butanediol are investigated at lo...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章


    authors: Evans S,bin Azeman A

    更新日期:1998-10-01 00:00:00

  • The first visualization of chemotherapy-induced tumor apoptosis via magnetic particle imaging in a mouse model.

    abstract::Imaging technologies that allow non-radiative visualization and quantification of apoptosis have a great potential for assessing therapy response, early diagnosis, and disease monitoring. Magnetic particle imaging (MPI), the direct imaging of magnetic nanoparticles as positive contrast agent and sole signal source, en...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章


    authors: Liang X,Wang K,Du J,Tian J,Zhang H

    更新日期:2020-09-24 00:00:00

  • Noninvasive reconstruction of cardiac transmembrane potentials using a kernelized extreme learning method.

    abstract::Non-invasively reconstructing the cardiac transmembrane potentials (TMPs) from body surface potentials can act as a regression problem. The support vector regression (SVR) method is often used to solve the regression problem, however the computational complexity of the SVR training algorithm is usually intensive. In t...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章


    authors: Jiang M,Zhang H,Zhu L,Cao L,Wang Y,Xia L,Gong Y

    更新日期:2015-04-21 00:00:00

  • A determination by an analysis of X-ray attenuation in aluminium of the intesity distribution at its point of origin in a thick tungsten target of bremsstrahlung excited by constant potentials of 60-140 kV.

    abstract::A recently described, computer aided method of attenuation analysis has been applied to free-air chamber measurements of the attenuation by up to 30mm A1 of the exposure rate of a narrow beam of X-radiation excited at a thick W target in a Be window tube by constant potentials of 60, 80, 100, 120 and 140 kV. It has ...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章


    authors: Soole BW

    更新日期:1977-03-01 00:00:00