Orientation of Human Microprocessor on Primary MicroRNAs.

Abstract:

:Single-stranded microRNAs (miRNAs) regulate gene expression by triggering mRNA degradation and/or inhibiting mRNA translation. miRNAs play important roles in various critical cellular processes and are associated with numerous human diseases, including cancer and neurodegenerative diseases. miRNA sequences are embedded in the primary miRNA transcripts (pri-miRNAs) that are initially processed by the Microprocessor complex in the nucleus. Microprocessor can orient itself on pri-miRNAs in two ways: one orientation results in subsequent miRNA production, and the other leads to cleavage of the miRNA sequence. Therefore, orienting Microprocessor on pri-miRNAs is a fundamental mechanism for determining the accuracy and efficiency of pri-miRNA processing and, in turn, miRNA production. Multiple mechanisms controlling Microprocessor orientation on pri-miRNAs, involving both cis-acting RNA elements and trans-acting factors, have recently been revealed. In this review, we discuss these exciting mechanisms and consider potential unknown mechanisms that might regulate Microprocessor orientation on pri-miRNAs.

journal_name

Biochemistry

journal_title

Biochemistry

authors

Nguyen HM,Nguyen TD,Nguyen TL,Nguyen TA

doi

10.1021/acs.biochem.8b00944

subject

Has Abstract

pub_date

2019-01-29 00:00:00

pages

189-198

issue

4

eissn

0006-2960

issn

1520-4995

journal_volume

58

pub_type

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