Abstract：
:The combination of intellectual, communicative, and motor deficits limit the use of standardized behavioral assessments of cognition in individuals with Angelman syndrome (AS). The current study is the first to objectively evaluate learning and memory in AS using auditory event-related potentials (ERP) during passive exposure to spoken stimuli. Fifteen nonverbal individuals with the deletion subtype of AS (age 4-45 years) completed the auditory incidental memory paradigm. Auditory ERPs were recorded in response to a sequence of unfamiliar nonwords, in which one randomly selected stimulus was repeated multiple times and the rest were presented once. Larger parietal responses within 200-500 ms for the repeated nonword compared to novel distracters were associated with caregiver reports of more adaptive communication skills. These findings demonstrate good tolerability of ERP procedures (94% success rate) and indicate that persons with AS can acquire new information following repeated auditory exposure, even in the absence of explicit memorization instructions. Strong associations between the caregiver reports of adaptive functioning and neural indices of auditory learning and memory support the utility of brain-based measures for objectively evaluating higher-order information processing in nonverbal persons with neurodevelopmental disorders.
journal_name
Brain Cognjournal_title
Brain and cognitionauthors
Key AP,Jones D,Peters S,Dold Cdoi
10.1016/j.bandc.2018.11.001subject
Has Abstractpub_date
2018-12-01 00:00:00pages
73-79eissn
0278-2626issn
1090-2147pii
S0278-2626(18)30360-9journal_volume
128pub_type
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pub_type： 杂志文章
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pub_type： 临床试验,杂志文章
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