Feasibility of using auditory event-related potentials to investigate learning and memory in nonverbal individuals with Angelman syndrome.

Abstract:

:The combination of intellectual, communicative, and motor deficits limit the use of standardized behavioral assessments of cognition in individuals with Angelman syndrome (AS). The current study is the first to objectively evaluate learning and memory in AS using auditory event-related potentials (ERP) during passive exposure to spoken stimuli. Fifteen nonverbal individuals with the deletion subtype of AS (age 4-45 years) completed the auditory incidental memory paradigm. Auditory ERPs were recorded in response to a sequence of unfamiliar nonwords, in which one randomly selected stimulus was repeated multiple times and the rest were presented once. Larger parietal responses within 200-500 ms for the repeated nonword compared to novel distracters were associated with caregiver reports of more adaptive communication skills. These findings demonstrate good tolerability of ERP procedures (94% success rate) and indicate that persons with AS can acquire new information following repeated auditory exposure, even in the absence of explicit memorization instructions. Strong associations between the caregiver reports of adaptive functioning and neural indices of auditory learning and memory support the utility of brain-based measures for objectively evaluating higher-order information processing in nonverbal persons with neurodevelopmental disorders.

journal_name

Brain Cogn

journal_title

Brain and cognition

authors

Key AP,Jones D,Peters S,Dold C

doi

10.1016/j.bandc.2018.11.001

subject

Has Abstract

pub_date

2018-12-01 00:00:00

pages

73-79

eissn

0278-2626

issn

1090-2147

pii

S0278-2626(18)30360-9

journal_volume

128

pub_type

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