The self-composing brain: towards a glial-neuronal brain theory.

Abstract:

:A brain model is proposed which describes its structural organization and the related functions as compartments organized in time and space. On a molecular level the negative feedback loops of clock-controlled genes are interpreted as compartments. This spatio-temporal operational principle may also work on the cellular level as glial-neuronal interactions, wherein glia have a spatio-temporal boundary setting function. The synchronization of the multi-compartmental operations of the brain is compared to the harmonization in a symphony and appears as an integrated behavior of the whole organism, defined as modes of behavior. For explanation of the principle of harmonization, an example from Schubert's Symphony No. 8 has been chosen. While harmonization refers to the synchronization of diverse systems, it seems appropriate to select the brain of a composer and the structure of musical composition as a paradigm towards a glial-neuronal brain theory. Finally, some limitations of experimental brain research are discussed and robotics are proposed as a promising alternative.

journal_name

Brain Cogn

journal_title

Brain and cognition

authors

Mitterauer B,Kopp K

doi

10.1016/s0278-2626(03)00043-5

subject

Has Abstract

pub_date

2003-04-01 00:00:00

pages

357-67

issue

3

eissn

0278-2626

issn

1090-2147

pii

S0278262603000435

journal_volume

51

pub_type

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