Abstract：
:The present study examines verbal working memory over time in boys with fragile X syndrome (FXS) compared to nonverbal mental-age (NVMA) matched, typically developing (TD) boys. Concomitantly, the relationship between cortisol-a physiological marker for stress-and verbal working memory performance over time is examined to understand the role of physiological mechanisms in cognitive development in FXS. Participants were assessed between one and three times over a 2-year time frame using two verbal working memory tests that differ in complexity: memory for words and auditory working memory with salivary cortisol collected at the beginning and end of each assessment. Multilevel modeling results indicate specific deficits over time on the memory for words task in boys with FXS compared to TD controls that is exacerbated by elevated baseline cortisol. Similar increasing rates of growth over time were observed for boys with FXS and TD controls on the more complex auditory working memory task, but only boys with FXS displayed an association of increased baseline cortisol and lower performance. This study highlights the benefit of investigations of how dynamic biological and cognitive factors interact and influence cognitive development over time.
journal_name
Brain Cognjournal_title
Brain and cognitionauthors
Scherr JF,Hahn LJ,Hooper SR,Hatton D,Roberts JEdoi
10.1016/j.bandc.2015.12.002subject
Has Abstractpub_date
2016-02-01 00:00:00pages
80-90eissn
0278-2626issn
1090-2147pii
S0278-2626(15)30041-5journal_volume
102pub_type
杂志文章abstract：:Individuals with autism demonstrate impairments on measures of executive function (EF) relative to typically developing comparison participants. EF is comprised of several processes including inhibition, working memory and set shifting that develop throughout the lifespan. Impairments in EF may appear early in develop...
journal_title：Brain and cognition
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pub_type： 临床试验,杂志文章
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journal_title：Brain and cognition
pub_type： 杂志文章
doi：10.1016/j.bandc.2008.01.010
更新日期：2008-08-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/0278-2626(90)90040-u
更新日期：1990-05-01 00:00:00
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journal_title：Brain and cognition
pub_type： 杂志文章
doi：10.1016/j.bandc.2017.08.007
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pub_type： 杂志文章
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journal_title：Brain and cognition
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pub_type： 杂志文章
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journal_title：Brain and cognition
pub_type： 杂志文章
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journal_title：Brain and cognition
pub_type： 杂志文章
doi：10.1016/j.bandc.2010.03.005
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journal_title：Brain and cognition
pub_type： 杂志文章
doi：10.1006/brcg.2000.1244
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pub_type： 杂志文章
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journal_title：Brain and cognition
pub_type： 杂志文章
doi：10.1006/brcg.1997.0916
更新日期：1997-07-01 00:00:00
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journal_title：Brain and cognition
pub_type： 杂志文章
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更新日期：2014-12-01 00:00:00
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pub_type： 杂志文章,随机对照试验
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