Abstract：
:The term endozepines designates a family of astroglia-secreted proteins including the diazepambinding inhibitor (DBI) and its processing products, which have been originally isolated and characterized as endogenous ligands of benzodiazepine receptors. It is now clearly established that the octadecaneuropeptide ODN (DBI33-50), acting through the central-type benzodiazepine receptor or a metabotropic receptor, exerts important functions such as proconflict behavior, induction of anxiety, inhibition of pentobarbital-provoked sleep, decrease of water consumption and reduction of food intake. To mediate its effects, ODN regulates both glial cell and neuronal activities by acting on neurosteroid biosynthesis and/or neuropeptide expression. In addition, ODN stimulates astrocyte proliferation and protects both neurons and astrocytes from oxidative stress-induced cell death. The antiapoptotic effect of ODN on neural cells is mediated through activation of the ODN metabotropic receptor positively coupled to PKA, PKC and MAPK/ERK transduction pathways, which ultimately reduces the pro-apoptotic gene Bax and stimulates Bcl-2 expressions, and inhibits intracellular reactive oxygen species accumulation. The imbalance in favor of Bcl2 promotes mitochondria functions and blocks in turn caspases activation while at the same time, ODN also activates the endogenous antioxidant system i.e. glutathione biosynthesis, and expression and activities of antioxidant enzymes. In cultured astrocytes, DBI expression is up-regulated during moderate oxidative stress, and authentic ODN production is increased, suggesting that ODN may act as a paracrine factor protecting neighboring neurons. Taken together, the remarkable effect of ODN on the apoptotic cascade suggests that innovative ODN derivatives could potentially be useful for treatment of cerebral injuries involving oxidative stress and neurodegeneration.
journal_name
Curr Pharm Desjournal_title
Current pharmaceutical designauthors
Masmoudi-Kouki O,Hamdi Y,Ghouili I,Bahdoudi S,Kaddour H,Leprince J,Castel H,Vaudry H,Amri M,Vaudry D,Tonon MCdoi
10.2174/1381612824666181112111746subject
Has Abstractpub_date
2018-01-01 00:00:00pages
3918-3925issue
33eissn
1381-6128issn
1873-4286pii
CPD-EPUB-94431journal_volume
24pub_type
杂志文章,评审abstract：:The typical way of judging about either the efficacy of a new treatment or, on the contrary, the damage of a pollutant agent is through a test of hypothesis having its ineffectiveness as null hypothesis. This is the typical operational field of Kolmogorov's statistical framework where wastes of data (for instance non ...
journal_title：Current pharmaceutical design
pub_type： 杂志文章,评审
doi：10.2174/138161207780765891
更新日期：2007-01-01 00:00:00
abstract：:Today, in spite of being older than a century (born in 1911), the Pictet-Spengler two component reaction (PS-2CR) is still one of the most popular reactions, not only for the synthesis of tetrahydroisoquinolines (THIQs), tetrahydro-β-carbolines (THBCs), or more complex structures containing these two privileged moieti...
journal_title：Current pharmaceutical design
pub_type： 杂志文章,评审
doi：10.2174/1381612822666151231100247
更新日期：2016-01-01 00:00:00
abstract：:Vascular endothelial growth factor (VEGF) is one of the main endogenous pro-angiogenic cytokines. Inhibition of the VEGF signaling pathways is an effective treatment for cancer patients. In addition, local anti- VEGF therapy was developed and established to treat proliferative diabetic retinopathy, age-related macular...
journal_title：Current pharmaceutical design
pub_type： 杂志文章,评审
doi：10.2174/1381612821666150225120314
更新日期：2015-01-01 00:00:00
abstract：:Risk reduction and the attainment of good outcomes in contemporary cataract surgery depend in part on patient compliance with a postoperative regimen of topical eye drops. Topical drops are expensive and challenging to instill properly for patients. The consequences of noncompliance or poor compliance can be significa...
journal_title：Current pharmaceutical design
pub_type： 杂志文章,评审
doi：10.2174/1381612822666161129150628
更新日期：2017-01-01 00:00:00
abstract：:G-quadruplexes have found increasing potential in applications such as molecular therapeutics, diagnostics, and sensing. As a consequence, small molecules capable of selectively detecting G-quadruplexes have received significant attention in recent literature. Our review here addresses representative advances in the d...
journal_title：Current pharmaceutical design
pub_type： 杂志文章,评审
doi：10.2174/138161212799958314
更新日期：2012-01-01 00:00:00
abstract：:The essential nature of rapid radiotracer synthesis very early in drug discovery programs has driven the need for better and more varied tritium incorporation methods. This review presents a summary of recent advances for tritium introduction via tritiated water, tritium gas, complex tritides, and a range of recently ...
journal_title：Current pharmaceutical design
pub_type： 杂志文章,评审
doi：10.2174/1381612003399969
更新日期：2000-07-01 00:00:00
abstract：:With a 2030 projection of 23.6 million deaths per year the prevalence and severity of cardiovascular disease is at an astounding high. Thus, a definitive need for the identification of novel compounds with potential to prevent or treat the disease and associated states. Moreover, there is also an ever-increasing need ...
journal_title：Current pharmaceutical design
pub_type： 杂志文章
doi：10.2174/1381612826666200909125354
更新日期：2020-09-09 00:00:00
abstract：:Vascular smooth muscle cells (VSMC) respond to arterial wall injury by intimal proliferation and play a key role in atherogenesis by proliferating and migrating excessively in response to repeated injury, such as hypertension and atherosclerosis. In contrast, fully differentiated, quiescent VSMC allow arterial vasodil...
journal_title：Current pharmaceutical design
pub_type： 杂志文章
doi：10.2174/138161210794454987
更新日期：2010-01-01 00:00:00
abstract：:Molecular Mechanics (MM) force fields are the methods of choice for protein simulations, which are essential in the study of conformational flexibility. Given the importance of protein flexibility in drug binding, MM is involved in most if not all Computational Structure-Based Drug Discovery (CSBDD) projects. This pap...
journal_title：Current pharmaceutical design
pub_type： 杂志文章,评审
doi：10.2174/13816128113199990600
更新日期：2014-01-01 00:00:00
abstract：:Inhibition of carbonic anhydrase (CA, EC 4.2.1.1) isoforms present in the eyes (CA I, II, IV and XII), with sulfonamides such as acetazolamide, methazolamide, ethoxzolamide and dichlorophenamide, is still widely used for the systemic treatment of glaucoma. The mechanism of action of these drugs consists in inhibition ...
journal_title：Current pharmaceutical design
pub_type： 杂志文章,评审
doi：10.2174/138161208783877866
更新日期：2008-01-01 00:00:00
abstract：:DNA methyltransferase (DNMT) and histone deacetylase are key enzymes mediating the epigenetic regulation of gene expression. DNA hypermethylation and/or histone deacetylation in promoter regions is often associated with downregulation or silencing of transcription. Epigenetic silencing of tumor suppressor genes plays ...
journal_title：Current pharmaceutical design
pub_type： 杂志文章
doi：10.2174/13816128113199990527
更新日期：2014-01-01 00:00:00
abstract：:ATP-sensitive K+ channels, termed K(ATP) channels, provide a link between cellular metabolism and membrane electrical activity in a variety of tissues. Channel isoforms have been identified and are targets for compounds that both stimulate and inhibit their activity resulting in membrane hyperpolarization and depolari...
journal_title：Current pharmaceutical design
pub_type： 杂志文章,评审
doi：10.2174/1381612054546879
更新日期：2005-01-01 00:00:00
abstract：:This manuscript provides an overview for analysts, medical and scientific investigators, and laboratory administrators, the range of factors that should be considered to implement best practice forensic toxicology. These include laboratory influence over the collection of specimens, their proper transport and chain-of...
journal_title：Current pharmaceutical design
pub_type： 杂志文章,评审
doi：10.2174/1381612823666170704123836
更新日期：2017-01-01 00:00:00
abstract：:Ghrelin as a human natural hormone is involved in fundamental regulatory processes of eating and energy balance. Ghrelin signals the nutrient availability from the gastrointestinal tract to the central nervous system, up-regulates food intake and lowers energy expenditure mainly through hypothalamic mediators acting b...
journal_title：Current pharmaceutical design
pub_type： 杂志文章,评审
doi：10.2174/138161212803216870
更新日期：2012-01-01 00:00:00
abstract：:Gene delivery, a process of introducing foreign functional nucleic acids into target cells, has proven to be a very promising tool for inducing specific gene expression in host cells. Many different technologies have been developed for efficient gene delivery. Among them, electroporation has been adopted in gene deliv...
journal_title：Current pharmaceutical design
pub_type： 杂志文章,评审
doi：10.2174/1381612821666151027152121
更新日期：2015-01-01 00:00:00
abstract：:Human tryptase is a structurally unique and mast cell specific trypsin-like serine protease. Recent biological and immunological investigations have implicated tryptase as a mediator in the pathology of numerous allergic and inflammatory conditions including rhinitis, conjunctivitis, and most notably asthma. A growing...
journal_title：Current pharmaceutical design
pub_type： 杂志文章,评审
doi：
更新日期：1998-10-01 00:00:00
abstract：:Regulation of cellular redox balances is important for the homeostasis of human health. Thus, many important human diseases, such as inflammation, diabetes, glaucoma, cancers, ischemia and neurodegenerative diseases, have been investigated in the field of reactive oxygen species (ROS) and oxidative stress. To overcome...
journal_title：Current pharmaceutical design
pub_type： 杂志文章,评审
doi：10.2174/138161211797052600
更新日期：2011-01-01 00:00:00
abstract：:Uveitis is a sight threatening intraocular inflammation accounting for approximately 10% of blindness worldwide. On the basis of aetiology, disease can be classified as infectious or non-infectious; and by anatomical localization of inflammation as anterior, posterior and panuveitis. Non-infectious uveitis is believed...
journal_title：Current pharmaceutical design
pub_type： 杂志文章,评审
doi：10.2174/1381612821666150316122928
更新日期：2015-01-01 00:00:00
abstract：:Serotonin (5-HT) is one of the main transmitters in the nervous system. Serotonergic neurons in the raphe nuclei in the brainstem innervate most parts of the central nervous system including motoneurons in the spinal cord and brainstem. This review will focus on the modulatory role that 5-HT exerts on motoneurons and ...
journal_title：Current pharmaceutical design
pub_type： 杂志文章,评审
doi：10.2174/13816128113199990341
更新日期：2013-01-01 00:00:00
abstract：:Dengue is one of the most important arboviral infections worldwide, infecting up to 390 million people and causing 25,000 deaths annually. Although a licensed dengue vaccine is available, it is not efficacious against dengue serotypes that infect people living in South East Asia, where dengue is an endemic disease. He...
journal_title：Current pharmaceutical design
pub_type： 杂志文章,评审
doi：10.2174/1381612823666170913163904
更新日期：2018-01-01 00:00:00
abstract：:Carboxylic acids are an important natural component as a final product or intermediates for syntheses. They are produced in plants, animals and also as products from biotechnological processes. This review presents the use of single hydroxide particles and layered double hydroxides as alternative adsorbents to remove ...
journal_title：Current pharmaceutical design
pub_type： 杂志文章,评审
doi：10.2174/1381612826666191226103623
更新日期：2020-01-01 00:00:00
abstract：:Naoxintong (NXT), a Chinese Materia Medica standardized product, extracted from 16 various kinds of Chinese traditional herbal medicines including Salvia miltiorrhiza, Angelica sinennsis, Astragali Radix, is clinically effective in treating atherosclerosisrelated diseases. Here, we tested the hypothesis that the anti-...
journal_title：Current pharmaceutical design
pub_type： 杂志文章
doi：10.2174/1381612811319330008
更新日期：2013-01-01 00:00:00
abstract：:Over the last several years, it has become increasingly clear that dendritic cells (DC) are not only critical for the initiation of T cell immunity, but these cells also determine the course of the subsequent immune response (i.e. tolerance vs. immunity, Th1 vs. Th2). However, the mechanisms by which DC can influence ...
journal_title：Current pharmaceutical design
pub_type： 杂志文章,评审
doi：10.2174/1381612013397627
更新日期：2001-07-01 00:00:00
abstract：:In recent years several new drugs (oxcarbazepine, lamotrigine, topiramate, gabapentin, zonisamide, tiagabine, fosphenytoin, vigabatrin and felbamate) have been added to the therapeutic armamentarium against epilepsy. Some of these represent structural modifications of pre-existing compounds, others were developed with...
journal_title：Current pharmaceutical design
pub_type： 杂志文章,评审
doi：10.2174/1381612003400245
更新日期：2000-05-01 00:00:00
abstract：:Virtual screening, especially the structure-based virtual screening, has emerged as a reliable, cost-effective and time-saving technique for the discovery of lead compounds. Here, the basic ideas and computational tools for virtual screening have been briefly introduced, and emphasis is placed on aspects of recent dev...
journal_title：Current pharmaceutical design
pub_type： 杂志文章,评审
doi：10.2174/1381612043452721
更新日期：2004-01-01 00:00:00
abstract：:Colchicine is a lipophilic alkaloid drug, which exhibits ant-inflammatory and anti-fibrotic properties. Cardinal mechanisms of action of colchicine are the disruption of the microtubule system and the inhibition of neutrophil adhesion and recruitment. Colchicine is indicated in the prevention and treatment of gouty ar...
journal_title：Current pharmaceutical design
pub_type： 杂志文章,评审
doi：10.2174/1381612824666180123101313
更新日期：2018-01-01 00:00:00
abstract：:Preterm birth is the leading cause of perinatal morbidity and mortality. Pathological processes that have been linked with preterm birth infection and / or intrauterine inflammation are most frequently found associated with their induction. Studies in animal models and human research showed prior infections to the ind...
journal_title：Current pharmaceutical design
pub_type： 杂志文章,评审
doi：10.2174/1381612820666140130202224
更新日期：2014-01-01 00:00:00
abstract：:Rotaviruses are an important cause of human morbidity and mortality, representing the primary pathogens responsible for acute dehydrating diarrhea in children under the age of 3. The infectious rotavirus particle is made up of three concentric layers of protein, and contains a genome consisting of eleven segments of d...
journal_title：Current pharmaceutical design
pub_type： 杂志文章,评审
doi：10.2174/1381612043382620
更新日期：2004-01-01 00:00:00
abstract：BACKGROUND:Central serous chorioretinopathy (CSC) is the fourth most frequent retinal disorder in terms of prevalence. It typically occurs in young subjects and affects men more often than women. CSC is characterized by serous retinal detachment (SRD) involving mainly the macular area. The clinical course is usually se...
journal_title：Current pharmaceutical design
pub_type： 杂志文章,评审
doi：10.2174/1381612825666190123165914
更新日期：2018-01-01 00:00:00
abstract：:Hypertension is the most common medical disorder during pregnancy. Approximately 70 percent of women diagnosed with hypertension during pregnancy will have gestational hypertension-preeclampsia. The term gestational hypertension-preeclampsia is used to describe a wide spectrum of patients who may have only mild elevat...
journal_title：Current pharmaceutical design
pub_type： 杂志文章,评审
doi：10.2174/1381612053381864
更新日期：2005-01-01 00:00:00
