Mouse models of autoimmune uveitis.

abstract：:The treatment of skin wounds represents an important research area due to the important physiological and aesthetic role of this tissue. During the last years, nanoparticles have emerged as important platforms to treat skin wounds. Silver, gold, and copper nanoparticles, as well as titanium and zinc oxide nanoparticle...

journal_title：Current pharmaceutical design

authors： Oyarzun-Ampuero F,Vidal A,Concha M,Morales J,Orellana S,Moreno-Villoslada I

更新日期：2015-01-01 00:00:00

abstract：:The oncoproteins MDM2 and MDMX negatively regulate the activity and stability of the p53 tumor suppressor, directly contributing to the development and progression of many tumors harboring wild type p53. Antagonizing MDM2 and MDMX to activate the p53 pathway has thus become an attractive new strategy for anticancer dr...

journal_title：Current pharmaceutical design

authors： Zhan C,Lu W

更新日期：2011-01-01 00:00:00

abstract：:Approximately half of patients with schizophrenia have a lifetime diagnosis of substance abuse disorders. These dual diagnosis patients are more likely to have poorer outcomes, including more severe psychiatric symptoms with increased hospitalizations, higher utilization of services and frequent homelessness. Assessme...

journal_title：Current pharmaceutical design

authors： Tsuang J,Fong TW

更新日期：2004-01-01 00:00:00

abstract：:Colorectal cancer (CRC) is one of the most common cancers globally and is associated with a high mortality rate. The transforming growth factor beta (TGF-β) signaling pathway plays an important role in normal intestinal tissue function, but has also been implicated in the development of CRC. MicroRNAs (miRNAs) have al...

journal_title：Current pharmaceutical design

authors： Moradi-Marjaneh R,Khazaei M,Ferns GA,Aghaee-Bakhtiari SH

更新日期：2018-01-01 00:00:00

abstract：:Rheumatoid arthritis (RA) is a chronic inflammatory disease associated with premature mortality, severe morbidity, and functional impairment leading to considerable financial burden for both patients and society. Since disease progression and complications can differ from one patient to another, genetic markers are of...

journal_title：Current pharmaceutical design

authors： Rodriguez-Rodriguez L,López-Mejias R,Fernández-Gutiérrez B,Balsa A,González-Gay MA,Martín J

更新日期：2015-01-01 00:00:00

abstract：:Tocotrienols, components belonging to vitamin E members, are used as potent therapeutics in the treatment of several diseases. Recent studies suggested tocotrienol to have better activity in many situations compared to tocopherols. Tocotrienols have been shown to lower the atherogenic apolipoprotein B and lipoprotein ...

journal_title：Current pharmaceutical design

authors： Catalgol B,Batirel S,Ozer NK

更新日期：2011-01-01 00:00:00

abstract：:DAP12 is a novel immunoreceptor tyrosine-based activation motifs (ITAM)-bearing transmembrane adapter molecule. This molecule, together with its partner receptor complex molecules including the killer cell activating receptors (KARs), myeloid DAP12 associating lectin-1 (MDL-1), triggering receptor expressed on myeloid...

journal_title：Current pharmaceutical design

authors： Aoki N,Kimura S,Xing Z

更新日期：2003-01-01 00:00:00

abstract：:DNA methylation, a major regulator of epigenetic modifications has been shown to alter the expression of genes that are involved in aspects of glucose metabolism such as glucose intolerance, insulin resistance, β-cell dysfunction and other conditions, and it ultimately leads to the pathogenesis of type 2 diabetes mell...

journal_title：Current pharmaceutical design

authors： Alam F,Islam MA,Gan SH,Mohamed M,Sasongko TH

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Mitochondria are cellular organelles responsible for energy production, calcium handling, controlled synthesis of reactive oxygen species (ROS), and regulation of apoptosis. All these functions are crucial for cardiac homeostasis, and may be impaired in chronic heart failure (CHF). Therefore, mitochondrial d...

journal_title：Current pharmaceutical design

authors： Aimo A,Borrelli C,Vergaro G,Piepoli MF,Caterina AR,Mirizzi G,Valleggi A,Raglianti V,Passino C,Emdin M,Giannoni A

更新日期：2016-01-01 00:00:00

abstract：:The phenomenon of blood serum atherogenicity was described as the ability of human serum to induce lipid accumulation in cultured cells. The results of recent two-year prospective study in asymptomatic men provided the evidence for association between the changes in serum atherogenicity and dynamics of carotid intima-...

journal_title：Current pharmaceutical design

authors： Sobenin IA,Myasoedova VA,Anisimova EV,Pavlova XN,Möhlenkamp S,Schmermund A,Seibel R,Berenbein S,Lehmann N,Moebus S,Jöckel K,Orekhov AN,Erbel R

更新日期：2014-01-01 00:00:00

abstract：:The prevalence of fungal infections of skin has increased rapidly, affecting approximately 40 million people across the globe. A wide variety of antifungal drugs has been utilized in the effective management of numerous dermatological infections. Topical treatment of fungal infections has proved to be quite advantageo...

journal_title：Current pharmaceutical design

authors： Akhtar N,Verma A,Pathak K

更新日期：2015-01-01 00:00:00

abstract：:Lysine acetylation plays an essential role in metabolism. Five individual studies have identified that a large number of cellular proteins are potentially acetylated. Notably, almost every enzyme involved in central metabolic pathways such as glycolysis, the TCA cycle, fat acid metabolism, urea cycle and glycogen meta...

journal_title：Current pharmaceutical design

authors： Lin R,Zhou X,Huang W,Zhao D,Lv L,Xiong Y,Guan KL,Lei QY

更新日期：2014-01-01 00:00:00

abstract：: ...

journal_title：Current pharmaceutical design

authors： Di Martino P

更新日期：2019-01-01 00:00:00

abstract：:Mast cells are important in the development of allergic and anaphylactic reactions, but also in acquired and innate immunity. There is also increasing evidence that mast cells participate in inflammatory diseases, where they can be activated by non-allergic triggers, such as neuropeptides and cytokines, often having s...

journal_title：Current pharmaceutical design

authors： Sismanopoulos N,Delivanis DA,Alysandratos KD,Angelidou A,Therianou A,Kalogeromitros D,Theoharides TC

更新日期：2012-01-01 00:00:00

abstract：:Mitochondria are involved in different physiological and pathological processes that are crucial for tumor cell physiology, growth and survival. Since cancer cells have frequently disrupted different cell death pathways that promote their survival, mitochondria may be key organelles to promote cell death in cancer cel...

journal_title：Current pharmaceutical design

authors： Ferrín G,Linares CI,Muntané J

更新日期：2011-01-01 00:00:00

abstract：:In recent years, nanosuspensions have been accepted as a valuable drug delivery system for poorly water-soluble drugs. Topdown and bottom-up technologies are the two main approaches for generating nanosuspensions. Several products manufactured by the top-down technologies have been successfully commercialized demonstr...

journal_title：Current pharmaceutical design

authors： Zhang X,Li LC,Mao S

更新日期：2014-01-01 00:00:00

abstract：:LIM (Lin-11, Isl-1, Mec-3), RING (Really interesting new gene), PHD (Plant homology domain) and MYND (myeloid, Nervy, DEAF-1) domains are all zinc-binding domains that ligate two zinc ions. Unlike the better known classical zinc fingers, these domains do not bind DNA, but instead mediate interactions with other protei...

journal_title：Current pharmaceutical design

authors： Matthews JM,Bhati M,Lehtomaki E,Mansfield RE,Cubeddu L,Mackay JP

更新日期：2009-01-01 00:00:00

abstract：:Quinone based bioreductive drugs have, potentially, a very versatile use in cancer chemotherapy. They can be activated by DT-diaphorase and hence can be used to target tumour types rich in this (O2)-independent reductase enzyme. Small molecular modifications can substantially reduce specificity for DT-diaphorase and u...

journal_title：Current pharmaceutical design

authors： McNally VA,Patterson AV,Williams KJ,Cowen RL,Stratford IJ,Jaffar M

更新日期：2002-01-01 00:00:00

abstract：:Cardiac ischemia, followed by reperfusion, often results in the development of cardiac contractile dysfunction that limits the recovery prognosis of patients. The current goal of pharmacological therapy in the course of ischemic heart disease is to improve the oxygen supply/demand ratio for the heart. Cardiac contract...

journal_title：Current pharmaceutical design

authors： Sawicki G

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:In the last decade, the development of anti-inflammatory strategies emerged as new trend in cardiovascular (CV) pharmacotherapy. Anti-inflammatory properties have been previously identified in different classes of drugs used in primary CV prevention. However, the extent to which the modification of inflammat...

journal_title：Current pharmaceutical design

authors： Carbone F,Liberale L,Bonaventura A,Cea M,Montecucco F

更新日期：2016-01-01 00:00:00

abstract：:The plants of the Colchicum family were known during the archaic period in Greece for their deleterious properties. Later on, they were used for the treatment of podagra. The treatment was introduced by the ancient Greek physicians and passed on to the Byzantine and Arabian physicians to endure until nowadays. The fir...

journal_title：Current pharmaceutical design

authors： Tsoucalas G,Papaioannou T,Panayiotakopoulos G,Saridaki Z,Vrachatis DA,Karamanou M

更新日期：2018-01-01 00:00:00

abstract：:Mechanical loading provides an anabolic stimulus for bone. More importantly, the mechanosensing apparatus in bone directs osteogenesis to where it is most needed for improving bone strength. The biological processes involved in bone mechanotransduction are poorly understood and further investigation of the molecular m...

journal_title：Current pharmaceutical design

authors： Turner CH,Robling AG

更新日期：2004-01-01 00:00:00

abstract：:The antimicrobial agents used in the treatment of mycobacterial infections have remained largely unchanged for several decades. Primary treatment of tuberculosis relies on four drugs, isoniazid, a rifamycin, pyrazinamide, and ethambutol (or streptomycin), and generally results in >95% cure in uncomplicated tuberculosi...

journal_title：Current pharmaceutical design

authors： Jacobs MR

更新日期：2004-01-01 00:00:00

abstract：:The role of polyphenols in the cardiovascular diseases prevention is still a matter of scientific discussion. However, recent clinical studies indicate that intake of anthocyanins and in a lesser extent procyanidins can participate in prevention of hypertension and type 2 diabetes. Fruits of Aronia melanocarpa (chokeb...

journal_title：Current pharmaceutical design

authors： Parzonko A,Naruszewicz M

更新日期：2016-01-01 00:00:00

abstract：:The prevalence of obesity is increasing globally. Rational perioperative anesthetic drug selection and administration require knowledge of how obesity interacts with those drugs. In this review, we summarize different aspects of the anesthetic agents, including pharmacokinetics (PK), pharmacodynamics (PD) and clinical...

journal_title：Current pharmaceutical design

authors： Dos Reis Falcão LF,Mc Loughlin S,Alvarez A

更新日期：2019-01-01 00:00:00

abstract：:Cystic fibrosis is caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene that lead to abnormalities in transepithelial ion transport in the airways of affected patients. Lung disease is the major contributor to morbidity and mortality in patients with cystic fibrosis but recommende...

journal_title：Current pharmaceutical design

authors： Ratjen F,Grasemann H

更新日期：2012-01-01 00:00:00

abstract：:Understanding of the roles of RNAs within the cell has changed and expanded dramatically during the past few years. Based on fundamentally new insights it is now increasingly possible to employ RNAs as highly valuable tools in molecular biology and medicine. At present, the most important therapeutic strategies are ba...

journal_title：Current pharmaceutical design

authors： Poller W,Fechner H

更新日期：2010-01-01 00:00:00

abstract：:Psoriasis is an immune-mediated, chronic and recurrent inflammatory skin disease, prevalent worldwide, and represents an important burden in life quality of patients. The most common clinical variant is termed as psoriasis vulgaris or plaque psoriasis, which with an individualized and carefully monitored therapy can d...

journal_title：Current pharmaceutical design

authors： Bruschi ML,da Silva JB,Rosseto HC

更新日期：2019-01-01 00:00:00

abstract：:The present mini review offers a brief overview on the preparation and modification of gold nanomaterials (AuNMs) designed for biomedical applications, including biosensors, bioimaging, phototherapy and importantly gene/drug delivery. As biocompatibility is a prerequisite for safe pharmaceutical application, the poten...

journal_title：Current pharmaceutical design

authors： Rossi M,Pina CD,Falletta E

更新日期：2016-01-01 00:00:00

abstract：:Chronic pain is a widespread healthcare problem affecting not only the patient but in many ways all the society. Chronic pain is a disease itself that endures for a long period of time and it is resistant to the majority of medical treatments that provide modest improvements in pain and minimum improvements in physica...

journal_title：Current pharmaceutical design

authors： Del Bufalo A,Cesario A,Salinaro G,Fini M,Russo P

更新日期：2014-01-01 00:00:00