Modulation of the intrinsic properties of motoneurons by serotonin.

abstract：:The pivotal therapeutic role of myocardial metabolic modulation in ischemic heart disease (IHD) is increasingly recognized. Among the others, inhibitors of free fatty acids (FFA) oxidation have been consistently shown to play an important role in the therapeutic strategy of IHD patients. Additionally, abnormalities of...

journal_title：Current pharmaceutical design

authors： Fragasso G,Salerno A,Spoladore R,Cera M,Montanaro C,Margonato A

更新日期：2009-01-01 00:00:00

abstract：:CHD is one of the most common serious chronic conditions in postmenopausal women and leads to extremely high risk for recurrent myocardial infarction and death. On the basis of the currently available randomized clinical-trial results the role of conventional HRT for treatment and prevention of CHD is rapidly evolving...

journal_title：Current pharmaceutical design

authors： Francucci CM,Camilletti A,Boscaro M

更新日期：2005-01-01 00:00:00

abstract：:The disappointing results in long-term survival of patients affected by non-small cell lung cancer (NSCLC) may be attributed, at least in part, to the lack of knowledge on the way by which genetic characteristics in normal and neoplastic cells affect responsiveness as well as metabolism of chemotherapy and new targete...

journal_title：Current pharmaceutical design

authors： Galvani E,Toffalorio F,Peters GJ,De Pas T,Giovannetti E

更新日期：2014-01-01 00:00:00

abstract：:Regeneration of bone requires the coordinated processes of angiogenesis and osteogenesis. These repair mechanisms are closely linked through both direct cell-cell contact and indirect paracrine signaling among osteoblasts, endothelial cells, and other cell types. The vasculature provides a source of nutrients, oxygen,...

journal_title：Current pharmaceutical design

authors： Segar CE,Ogle ME,Botchwey EA

更新日期：2013-01-01 00:00:00

abstract：:Drug design based on the structure of specific enzymes playing a role in carcinogenesis, e.g. tyrosine kinases, has been successful at identifying novel effective anticancer drugs. In contrast, no success has been achieved in drug design attempts, in which transcription factors or DNA-transcription factor complexes in...

journal_title：Current pharmaceutical design

authors： D'Incalci M,Brunelli D,Marangon E,Simone M,Tavecchio M,Gescher A,Mantovani R

更新日期：2007-01-01 00:00:00

abstract：:The human herpesviruses herpes simplex virus types 1 and 2 (HSV-1 and HSV-2) can cause severe recurrent disease in humans and establish lifelong infection in their hosts. Several antiviral therapies are available to control disease and spread, but these are not completely effective and do not affect latent virus. The ...

journal_title：Current pharmaceutical design

authors： Ramachandran S,Kinchington PR

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:Spice and spice-derived compounds have been identified and explored for their health benefits since centuries. One of the spice long pepper has been traditionally used to treat chronic bronchitis, asthma, constipation, gonorrhea, paralysis of the tongue, diarrhea, cholera, malaria, viral hepatitis, respirato...

journal_title：Current pharmaceutical design

authors： Prasad S,Tyagi AK

更新日期：2016-01-01 00:00:00

abstract：:Myelodysplastic syndromes (MDS) are a group of aquired hematopoietic disorders characterized by ineffective hematopoiesis, and increased risk of progression of acute myeloid leukemia. For a long period of time, the standard therapy for MDS was hematopoietic stem cell transplantation, however DNA methyltransferase inhi...

journal_title：Current pharmaceutical design

authors： Tsujioka T,Matsuoka A,Tohyama Y,Tohyama K

更新日期：2012-01-01 00:00:00

abstract：:Gene therapy, currently, represents one of the new therapies that have emerged for the treatment of different diseases. Between the different approaches that can be chosen concerning this therapy, gene delivery with non-viral systems has focused the attention during the past decades, because of the reduced toxicity co...

journal_title：Current pharmaceutical design

authors： Urbiola K,Blanco-Fernandez L,de Ilarduya CT

更新日期：2015-01-01 00:00:00

abstract：:Transient left ventricular dysfunction in patients under emotional stress, also known as Takotsubo cardiomyopathy, has been recognized as a distinct clinical entity. Recent studies have supported the concept notion that the cardiovascular system is regulated by cortical modulation. A network consisting of the insular ...

journal_title：Current pharmaceutical design

authors： Nagai M,Dote K,Kato M,Sasaki S,Oda N,Kagawa E,Nakano Y,Yamane A,Higashihara T,Miyauchi S,Tsuchiya A,Harada W,Kario K

更新日期：2017-01-01 00:00:00

abstract：:Methicillin-resistant Staphylococcus aureus (MRSA) remains the single biggest challenge in infectious disease in the civilized world. Moreover, vancomycin resistance is also spreading, leading to fears of untreatable infections as were common in ancient times. Molecular microbiology and bioinformatics have revealed ma...

journal_title：Current pharmaceutical design

authors： Magana M,Ioannidis A,Magiorkinis E,Ursu O,Bologa CG,Chatzipanagiotou S,Hamblin MR,Tegos GP

更新日期：2015-01-01 00:00:00

abstract：:Post-traumatic stress disorder (PTSD) is an anxiety disorder that develops after experiencing trauma. Actual therapies do not help majority of patients with PTSD. Moreover, extinguished fear memories usually reappear in the individuals when exposed to trauma cues. New drugs to reduce the impact of conditioned cues in ...

journal_title：Current pharmaceutical design

authors： Barreto GE,Yarkov A,Avila-Rodriguez M,Aliev G,Echeverria V

更新日期：2015-01-01 00:00:00

abstract：:Fibrates are widely prescribed lipid-lowering drug in the treatment of dyslipidemia. Their main clinical effects, mediated by peroxisome proliferative activated receptor (PPAR) alpha activation, are a moderate reduction in total cholesterol and low-density lipoprotein cholesterol (LDL-C) levels, a marked reduction in ...

journal_title：Current pharmaceutical design

authors： Ansquer JC,Foucher C,Aubonnet P,Le Malicot K

更新日期：2009-01-01 00:00:00

abstract：:The chemical structure of polyphenols consisting of aromatic rings, capable of quenching free radicals, makes them ideal candidates to protect against oxidation. Polyphenols are present in a variety of foods including grapes, berries, dark chocolate, coffee and tea to mention a few. A number of studies have shown that...

journal_title：Current pharmaceutical design

authors： Murillo AG,Fernandez ML

更新日期：2017-01-01 00:00:00

abstract：:Macrophage migration inhibitory factor (MIF) is a pro-inflammatory cytokine released from T-cells and macrophages, and is a key molecule in inflammation. Although a detailed understanding of the biological functions of MIF has not yet been found, it is known that MIF catalyzes the tautomerization of phenylpyruvate and...

journal_title：Current pharmaceutical design

authors： Orita M,Yamamoto S,Katayama N,Fujita S

更新日期：2002-01-01 00:00:00

abstract：:A growing body of evidence shows that gamma-hydroxybutyric acid (GHB) is an addictive substance. Its precursors gammabutyrolactone (GBL) and 1,4-butanediol (1,4-BD) show the same properties and may pose even more risks due to different pharmacokinetics. There are indications that problematic GHB use is increasing in t...

journal_title：Current pharmaceutical design

authors： Brunt TM,van Amsterdam JG,van den Brink W

更新日期：2014-01-01 00:00:00

abstract：:Erectile function is determined by tight regulation of relaxation or contraction of corpus cavernosal smooth muscle, which is the result of a long and complex chain of molecular events. Control of erectile function resides in signaling pathways of the central and peripheral nervous system, as well as intracellular eve...

journal_title：Current pharmaceutical design

authors： Seftel AD

更新日期：2005-01-01 00:00:00

abstract：:Prevention, improved screening, and better treatment regimens have improved cancer incidence and mortality in the last decade. Chemoradiation continues to cause high morbidity in patients undergoing treatment. DNA therapeutics have the potential to modify the genes that cause tumor progression in order to produce a re...

journal_title：Current pharmaceutical design

authors： Coppelli FM,Grandis JR

更新日期：2005-01-01 00:00:00

abstract：:In the last two decades a tremendous development has been noticed in our understanding of the purinergic system, consisting of heterogeneously expressed purinoceptor subtypes and its classical agonists: e.g., adenosine triphosphate, uridine triphosphate or complex dinucleoside polyphosphates. These agonists exert mult...

journal_title：Current pharmaceutical design

authors： Schuchardt M,Tölle M,van der Giet M

更新日期：2012-01-01 00:00:00

abstract：:The production of autoreactive antibodies from self-reactive B cells results in the formation of immune complexes that deposit in tissue and fix complement, contributing to the pathogenesis of rheumatoid arthritis (RA). Earlier mouse models emphasize the importance of autoreactive antibodies formed against "self" prot...

journal_title：Current pharmaceutical design

authors： Low JM,Moore TL

更新日期：2005-01-01 00:00:00

abstract：:There is now a large body of evidence that weight loss in older persons not only increases mortality, but also increases the incidence of hip fracture, functional deterioration and institutionalization. Weight loss is a central component of frailty. There is evidence that it is not only muscle, but also fat loss that ...

journal_title：Current pharmaceutical design

authors： Morley JE

更新日期：2007-01-01 00:00:00

abstract：:Inhibition of carbonic anhydrase (CA, EC 4.2.1.1) isoforms present in the eyes (CA I, II, IV and XII), with sulfonamides such as acetazolamide, methazolamide, ethoxzolamide and dichlorophenamide, is still widely used for the systemic treatment of glaucoma. The mechanism of action of these drugs consists in inhibition ...

journal_title：Current pharmaceutical design

authors： Mincione F,Scozzafava A,Supuran CT

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:Radix Stephaniae Tetrandrine (RST), known as FangJi (Pinyin name) in Chinese, is the dried root of Stephania tetrandra S.Moore, and has been prescribed in combination with other herbs to treat cardiovascular diseases and breast cancer in traditional Chinese medicine (TCM) clinical trials. OBJECTIVE:The aim ...

journal_title：Current pharmaceutical design

authors： Guo Y,Chen B,Pei X,Zhang D

更新日期：2020-01-01 00:00:00

abstract：:A recent meta-analysis showed that the mean age of onset of psychosis among cannabis users was almost three years earlier than that of non-cannabis users. However, because cannabis users usually smoke tobacco, the use of tobacco might independently contribute to the earlier onset of psychosis. We aimed to use meta-ana...

journal_title：Current pharmaceutical design

authors： Myles N,Newall H,Nielssen O,Large M

更新日期：2012-01-01 00:00:00

abstract：:Innate and adaptive immunity has been shown to be critically involved in the pathogenesis of atherosclerosis. In particular, immune suppression mediated by regulatory T cells (Tregs) or tolerogenic dendritic cells (DCs) serves as a vital mechanism for regulating pathogenic chronic inflammation in atherogensis, suggest...

journal_title：Current pharmaceutical design

authors： Sasaki N,Yamashita T,Kasahara K,Takeda M,Hirata K

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Lipid nanoparticles have attracted increased degree of scientific and commercial attention in the last decade. The lipidic nanoparticles have emerged as a potential alternative to other nano-scale systems due to their various advantages over them and also due to overcoming the shortcomings of the already ava...

journal_title：Current pharmaceutical design

authors： Pathak K,Shankar R,Joshi M

更新日期：2017-11-21 00:00:00

abstract：:Various growth factors such as the platelet derived growth factor (PDGF), insulin-like growth factor (IGF), epidermal growth factor (EGF), fibroblast growth factor (FGF), and vascular endothelial growth factor (VEGF) transduce their mitogenic signals through the activation of tyrosine kinase receptors (RTKs). Since en...

journal_title：Current pharmaceutical design

authors： Gouni-Berthold I,Sachinidis A

更新日期：2004-01-01 00:00:00

abstract：:Drug hypersensitivity reactions (DHRs) represent a major burden on the healthcare system since their diagnostic and management are complex. As they can be influenced by individual genetic background, it is conceivable that the identification of variants in genes potentially involved could be used in genetic testing fo...

journal_title：Current pharmaceutical design

authors： Mayorga C,Montañez MI,Jurado-Escobar R,Gil-Ocaña V,Cornejo-García JA

更新日期：2019-01-01 00:00:00

abstract：:Biochemical biomarkers are important candidates for the diagnosis and prognosis of neurological diseases of autoimmune etiology, since they may reflect the presence, nature and intensity of certain immune responses caused by both genetic and environmental processes. Different body fluids such as cerebrospinal fluid (C...

journal_title：Current pharmaceutical design

authors： Tumani H,Brettschneider J

更新日期：2012-01-01 00:00:00

abstract：:DNA methylation, a major regulator of epigenetic modifications has been shown to alter the expression of genes that are involved in aspects of glucose metabolism such as glucose intolerance, insulin resistance, β-cell dysfunction and other conditions, and it ultimately leads to the pathogenesis of type 2 diabetes mell...

journal_title：Current pharmaceutical design

authors： Alam F,Islam MA,Gan SH,Mohamed M,Sasongko TH

更新日期：2016-01-01 00:00:00