Appreciation of medical treatments through confidence intervals.

abstract：:Growth differentiation factor 5 (GDF5) is a member of the bone morphogenic protein (BMP) family and plays critical roles in organ development processes including bone, cartilage, ligament, and joint formation. GDF5 is expressed in the cartilage primordium in the early limb development, and in the interzone of joint fo...

journal_title：Current pharmaceutical design

authors： Jin L,Li X

更新日期：2013-01-01 00:00:00

abstract：:Stimulation of β-adrenergic receptors in the heart is the most effective endogenous way to increase the mechanical performance of cardiac tissues to meet the requirements of a fight-or-flight situation or stress. On the other hand, sustained activation of cardiac β-receptors initiates maladaptive remodeling of the myo...

journal_title：Current pharmaceutical design

authors： Szentmiklosi AJ,Szentandrássy N,Hegyi B,Horvath B,Magyar J,Bányász T,Nanasi PP

更新日期：2015-01-01 00:00:00

abstract：:The receptor for urokinase plasminogen activator (uPAR) is required in hematopoietic stem/progenitor cells (HSC, HPC) mobilization in the mouse. Indeed, uPAR Ko mice are deficient both in retention and mobilization of HSC and HPC, because uPAR causes their retention in the BM through its interaction with the α4β1 inte...

journal_title：Current pharmaceutical design

authors： Blasi F

更新日期：2011-01-01 00:00:00

abstract：:Research on Substance P (SP) has, until recently, focused on its role in pain and inflammation. However, a report that NK(1) receptor antagonists have utility in the treatment of depression has stimulated research into the function of SP and the NK(1)receptor in anxiety and depression. The distribution of SP and the N...

journal_title：Current pharmaceutical design

authors： McLean S

更新日期：2005-01-01 00:00:00

abstract：:Stroke is a leading cause of death and disability worldwide. Conventional treatment has a limitation of very narrow therapeutic time window and its devastating nature necessitate a novel regenerative approach. Transplanted stem cells resulted in functional recovery through multiple mechanisms including neuroprotection...

journal_title：Current pharmaceutical design

authors： Kwak KA,Kwon HB,Lee JW,Park YS

更新日期：2018-01-01 00:00:00

abstract：:Human heart has endogenous regenerative capability; however, the intrinsic repair mechanism is not sufficient to overcome the impact placed by adverse pathological conditions, such as myocardial infarction (MI). In such circumstances, the damaged tissue initiates a series of remodeling process which results in the det...

journal_title：Current pharmaceutical design

authors： Joshi J,Kothapalli CR

更新日期：2015-01-01 00:00:00

abstract：:Apoptosis is a regulated process leading to cell death, which is implicated both in normal development and in various pathologies including heart failure, stroke and neurodegenerative diseases. Caspase-3, a key enzyme of the apoptotic pathway, is considered as a major target for the treatment of abnormal cell death. M...

journal_title：Current pharmaceutical design

authors： Seaborn T,Masmoudi-Kouli O,Fournier A,Vaudry H,Vaudry D

更新日期：2011-01-01 00:00:00

abstract：:Immunosenescence is considered a major contributory factor to the increased frequency of morbidity and mortality among elderly. On the other hand centenarians are considered the best example of successful ageing. To gain insight into mechanisms of immunosenescence and its clinical relevance, a possible model is repres...

journal_title：Current pharmaceutical design

authors： Colonna-Romano G,Buffa S,Bulati M,Candore G,Lio D,Pellicanò M,Vasto S,Caruso C

更新日期：2010-01-01 00:00:00

abstract：:Lou Gehrig's disease, a synonym of amyotrophic lateral sclerosis, is an adult-onset lethal neurodegenerative disorder. Irrespective of extensive efforts to elucidate the pathogenesis of the disease and searches for therapies, no favorable pharmacotherapeutic strategies have yet to be proposed. In a popular rodent mode...

journal_title：Current pharmaceutical design

authors： Ono SI

更新日期：2017-01-01 00:00:00

abstract：:Parkinson's disease (PD) is a common neurodegenerative disorder characterized by cardinal features of tremor, bradykinesia, rigidity and postural instability. In addition to the motor symptoms patients experience cognitive decline eventually resulting in severe disability. Pathologically PD is characterized by neurode...

journal_title：Current pharmaceutical design

authors： Thomas M,Le WD

更新日期：2004-01-01 00:00:00

abstract：:Multidrug resistance (MDR) is a phenomenon through which tumor cells develop resistance against the cytotoxic effects of various structurally and mechanistically unrelated chemotherapeutic agents. The most consistent feature in MDR is overexpression and/or overactivity of ATP-dependent drug efflux transporters. Other ...

journal_title：Current pharmaceutical design

authors： Ghandadi M,Sahebkar A

更新日期：2016-01-01 00:00:00

abstract：:Quinone based bioreductive drugs have, potentially, a very versatile use in cancer chemotherapy. They can be activated by DT-diaphorase and hence can be used to target tumour types rich in this (O2)-independent reductase enzyme. Small molecular modifications can substantially reduce specificity for DT-diaphorase and u...

journal_title：Current pharmaceutical design

authors： McNally VA,Patterson AV,Williams KJ,Cowen RL,Stratford IJ,Jaffar M

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND:Polyphenols are bioactive compounds that can be found mostly in foods like fruits, cereals, vegetables, dry legumes, chocolate and beverages such as coffee, tea and wine. They are extensively used in the prevention and treatment of cardiovascular disease (CVD) providing protection against many chronic illnes...

journal_title：Current pharmaceutical design

authors： Giglio RV,Patti AM,Cicero AFG,Lippi G,Rizzo M,Toth PP,Banach M

更新日期：2018-01-01 00:00:00

abstract：:Atherosclerosis is an inflammatory vascular disease that is characterized by progressive accumulation of cholesterol in the arterial walls and it is a major cause of cardiovascular disease. Issues related to the side effects of synthetic drugs have in recent times, led to the misuse of drugs, a lack of patient consult...

journal_title：Current pharmaceutical design

authors： Gholipour S,Sewell RDE,Lorigooini Z,Rafieian-Kopaei M

更新日期：2018-01-01 00:00:00

abstract：:Vasopressin (AVP) secretion and release are regulated by a number of central nervous system sites that receive peripheral signals from the osmoreceptors and baroreceptors. Aim of this paper is to review anatomical pathways and neurotransmitters involved as well as drugs affecting AVP secretion. ...

journal_title：Current pharmaceutical design

authors： Iovino M,Guastamacchia E,Giagulli VA,Licchelli B,Triggiani V

更新日期：2012-01-01 00:00:00

abstract：:Natural product drugs that target the tubulin/microtubule system remain an important component in the therapeutic arsenal to treat many types of malignancies. Agents such as the taxanes and vinca alkaloids bind to beta-tubulin and disrupt microtubule dynamics by inducing a potent mitotic block and subsequent cell deat...

journal_title：Current pharmaceutical design

authors： Verrills NM,Kavallaris M

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:Bacterial cellulose (BC) has recently attained greater interest in various research fields, including drug delivery for biomedical applications. BC has been studied in the field of drug delivery, such as tablet coating, controlled release systems and prodrug design. OBJECTIVE:In the current work, we tested ...

journal_title：Current pharmaceutical design

authors： Ullah H,Badshah M,Correia A,Wahid F,Santos HA,Khan T

更新日期：2019-01-01 00:00:00

abstract：:Proper understanding of blood-brain barrier (BBB) regulation is crucial to reduce/prevent its disruption during injury. Since high brain complexity makes interpretation of in vivo data challenging BBB studies are frequently performed using simplified in vitro models. Although such models represent an important and fre...

journal_title：Current pharmaceutical design

authors： Ogunshola OO

更新日期：2011-01-01 00:00:00

abstract：:Inhibition of carbonic anhydrase (CA, EC 4.2.1.1) isoforms present in the eyes (CA I, II, IV and XII), with sulfonamides such as acetazolamide, methazolamide, ethoxzolamide and dichlorophenamide, is still widely used for the systemic treatment of glaucoma. The mechanism of action of these drugs consists in inhibition ...

journal_title：Current pharmaceutical design

authors： Mincione F,Scozzafava A,Supuran CT

更新日期：2008-01-01 00:00:00

abstract：:The apoptosis inducing factor (AIF) was first discovered as a caspase-independent apoptosis effector that promoted cell death upon release from the mitochondria (triggered by pro-apoptotic stimuli) and relocalization into the nucleus, where it promotes chromatin condensation and DNA fragmentation. AIF is a mammalian m...

journal_title：Current pharmaceutical design

authors： Ferreira P,Villanueva R,Cabon L,Susín SA,Medina M

更新日期：2013-01-01 00:00:00

abstract：:From a complications standpoint, diabetes mellitus is a disease of the vasculature. Diabetics face a considerably higher risk of developing cardiovascular and cerebrovascular diseases. Both large and small blood vessels are susceptible to alterations from diabetes. Endothelial cell dysfunction associated with small ve...

journal_title：Current pharmaceutical design

authors： Huber JD

更新日期：2008-01-01 00:00:00

abstract：:Protozoan parasites, such as those responsible for malaria and African Sleeping Sickness, represent a huge burden to the developing world. Current chemotherapy to combat these diseases is inadequate: antiquated, toxic and increasingly ineffective due to drug resistance. In this article, the potential usefulness of tar...

journal_title：Current pharmaceutical design

authors： Grant KM

更新日期：2008-01-01 00:00:00

abstract：:Withdrawn by the publisher. ...

journal_title：Current pharmaceutical design

authors：

更新日期：2018-11-13 00:00:00

abstract：:Biodegradable particles have important applications in Drug Delivery Systems (DDS) of protein/peptide drugs. And recently, particle systems have also showed to be powerful for vaccine delivery (adjuvant) in order to solve the difficulties when conventional Alum adjuvant was used. However, in above applications, the pr...

journal_title：Current pharmaceutical design

authors： Wang L,Yang T,Ma G

更新日期：2015-01-01 00:00:00

abstract：:Ever since pure molecular entities have been adapted as drug, varied manifestations other than elimination of infections are frequently been acknowledged as side effects. Contemporary drug research focuses on these issues besides developing new molecules for the restoration of unnatural functional deviations in variou...

journal_title：Current pharmaceutical design

authors： Dutta RC

更新日期：2007-01-01 00:00:00

abstract：:Post-translational modification of histones is a primary mechanism through which epigenetic regulation of DNA transcription does occur. Among these modifications, regulation of histone acetylation state is an important tool to influence gene expression. Epigenetic regulation of neurodevelopment contributes to the stru...

journal_title：Current pharmaceutical design

authors： Contestabile A,Sintoni S

更新日期：2013-01-01 00:00:00

abstract：:The beneficial effect of antihypertensive treatment on the risk of major vascular events is well established. Several trials comparing older and newer drugs in the treatment of primary hypertension suggested that it is the blood pressure achieved, rather than choice of the drug that determines most of the primary outc...

journal_title：Current pharmaceutical design

authors： Karagiannis A,Mikhailidis DP,Kakafika AI,Tziomalos K,Athyros VG

更新日期：2007-01-01 00:00:00

abstract：:Cumulative scientific evidence gathered over the past ten years has confirmed the role of platelet GP IIb/IIIa inhibitors in reducing ischemic complications of patients undergoing percutaneous coronary intervention (PCI). Recently, mortality data available on more than 20,000 patients enrolled in randomized clinical t...

journal_title：Current pharmaceutical design

authors： Dery JP,Harrington RA,Tcheng JE

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND:Polyphenols widely distributed in plants, fruits and vegetables have received considerable attention on account of their physiological functions, including their antioxidant and anti-inflammatory properties. Some antioxidant components of cacao liquor prepared from fermented and roasted cacao beans, which is...

journal_title：Current pharmaceutical design

authors： Natsume M

更新日期：2018-01-01 00:00:00

abstract：:Mast cells, traditionally regarded as effector cells of the immune system, have more recently been demonstrated to be key figures in initiating, developing and sustaining complex pathophysiological processes underlying asthma and other allergic diseases. Asthma is characterised by airway inflammation alongside a distu...

journal_title：Current pharmaceutical design

authors： Carter RJ,Bradding P

更新日期：2011-01-01 00:00:00