Protective effects of pituitary adenylate cyclase-activating polypeptide (PACAP) against apoptosis.

abstract：:In the mid seventies a drug design programme using the Amanita muscaria constituent muscimol (7) as a lead structure, led to the design of guvacine (23) and (R)-nipecotic acid (24) as specific GABA uptake inhibitors and the isomeric compounds isoguvacine (10) and isonipecotic acid (11) as specific GABAA receptor agoni...

journal_title：Current pharmaceutical design

authors： Krogsgaard-Larsen P,Frølund B,Frydenvang K

更新日期：2000-08-01 00:00:00

abstract：:Neuromuscular blocking agents are the leading drugs responsible for immediate hypersensitivity reactions during anaesthesia. Most hypersensitivity reactions represent IgE-mediated allergic reactions. Their incidence is estimated to be between 1 in 3,000 to 1 in 110,000 general anaesthetics. However striking variations...

journal_title：Current pharmaceutical design

authors： Mertes PM,Aimone-Gastin I,Guéant-Rodriguez RM,Mouton-Faivre C,Audibert G,O'Brien J,Frendt D,Brezeanu M,Bouaziz H,Guéant JL

更新日期：2008-01-01 00:00:00

abstract：:Methicillin-resistant Staphylococcus aureus (MRSA) remains the single biggest challenge in infectious disease in the civilized world. Moreover, vancomycin resistance is also spreading, leading to fears of untreatable infections as were common in ancient times. Molecular microbiology and bioinformatics have revealed ma...

journal_title：Current pharmaceutical design

authors： Magana M,Ioannidis A,Magiorkinis E,Ursu O,Bologa CG,Chatzipanagiotou S,Hamblin MR,Tegos GP

更新日期：2015-01-01 00:00:00

abstract：:Metabolic syndrome (MetS) which is caused by poor dietary habits and sedentary behavior is a serious global health problem. MetS is a cluster of risk factors, represented by central obesity, hyperglycemia, dyslipidemia, and hypertension. In the 21st century, MetS and associated comorbidities, including obesity, diabet...

journal_title：Current pharmaceutical design

authors： Korivi M,Liu BR

更新日期：2020-01-01 00:00:00

abstract：:Urological cancer refers to cancer in organs of the urinary system and the male reproductive system. It mainly includes prostate cancer, bladder cancer, renal cancer, etc., seriously threatening patients' survival. Although there are many advances in the treatment of urological cancer, approved targeted therapies ofte...

journal_title：Current pharmaceutical design

authors： Liu Q,Gu J,Zhang E,He L,Yuan ZX

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:A high dietary intake of polyphenols has been associated with a reduced cardiovascular mortality, due to their antioxidant properties. However, growing evidence suggests that counteracting oxidative stress in cardiovascular disease might also reduce sympathetic nervous system overactivity. METHODS:This arti...

journal_title：Current pharmaceutical design

authors： Bruno RM,Ghiadoni L

更新日期：2018-01-01 00:00:00

abstract：:This manuscript provides an overview for analysts, medical and scientific investigators, and laboratory administrators, the range of factors that should be considered to implement best practice forensic toxicology. These include laboratory influence over the collection of specimens, their proper transport and chain-of...

journal_title：Current pharmaceutical design

authors： Drummer OH

更新日期：2017-01-01 00:00:00

abstract：:The present review discusses the mechanism of late stent thrombosis and its distinction from restenosis and summarizes the advisory note issued by FDA on the proper usage of different treatments available for atherosclerosis. In light of the latest developments, a plethora of new stents have been and continue to be de...

journal_title：Current pharmaceutical design

authors： Rastogi A,Stavchansky S

更新日期：2008-01-01 00:00:00

abstract：:Circumstantial evidence has been provided of a role of the plasminogen/plasmin system in a variety of biological phenomena, including thrombolysis, vascular stenosis, reproduction, embryogenesis, cell invasion, angiogenesis, brain function and chronic lung or kidney inflammatory disorders. Inhibition of the system occ...

journal_title：Current pharmaceutical design

authors： Matsuno H

更新日期：2006-01-01 00:00:00

abstract：:Lou Gehrig's disease, a synonym of amyotrophic lateral sclerosis, is an adult-onset lethal neurodegenerative disorder. Irrespective of extensive efforts to elucidate the pathogenesis of the disease and searches for therapies, no favorable pharmacotherapeutic strategies have yet to be proposed. In a popular rodent mode...

journal_title：Current pharmaceutical design

authors： Ono SI

更新日期：2017-01-01 00:00:00

abstract：:Over the last decade, much was learned about the biology of several types of stem and progenitor cells. It has become apparent that various cell sources may have the capacity to promote cardiomyogenesis and new blood vessel formation through different mechanisms, forming the rationale for cell-based therapy in patient...

journal_title：Current pharmaceutical design

authors： Rodrigo SF,Ramshorst Jv,Beeres SL,Bax JJ,Schalij MJ,Atsma DE

更新日期：2011-10-01 00:00:00

abstract：:Parkinson's disease (PD) is one of common neurodegenerative diseases, which shows motor symptoms including tremor, bradykinesia, rigidity and postural instability. It also involves non-motor symptoms such as cognitive impairment, mental manifestation, autonomic disorder and sensory disturbance. Although treatments to ...

journal_title：Current pharmaceutical design

authors： Miyazaki I,Asanuma M

更新日期：2017-01-01 00:00:00

abstract：:Increased visceral adiposity, is an emerging cardiovascular risk factor. There is now a compelling need to quantify visceral adipose tissue not only for diagnostic purposes, but also for therapeutic interventions with weight reduction drugs or pharmaceuticals targeted to adipose tissue, as well as anti-obesity medicat...

journal_title：Current pharmaceutical design

authors： Iacobellis G,Sharma AM

更新日期：2007-01-01 00:00:00

abstract：:The CCN family of growth factors is composed of six structurally related proteins including the cysteine-rich 61 (Cyr61), connective tissue growth factor (CTGF), nephroblastoma overexpressed (NOV), Wnt-1 induced secreted protein-1 (WISP-1), WISP-2 and WISP-3. Each family member consists of four conserved cysteine rich...

journal_title：Current pharmaceutical design

authors： Desnoyers L

更新日期：2004-01-01 00:00:00

abstract：:The state-of-the-art in the investigation of drugs release from Silica-based ordered Mesoporous Materials (SMMs) is reviewed. First, the SMM systems used like host matrixes are described. Then, the model drugs studied until now, including their pharmacological action, structure and the mesoporous matrix employed for e...

journal_title：Current pharmaceutical design

authors： Doadrio AL,Salinas AJ,Sánchez-Montero JM,Vallet-Regí M

更新日期：2015-01-01 00:00:00

abstract：:Human arylamine N-acetyltransferases 1 and 2 (NAT1 and NAT2) are polymorphic phase II xenobiotic-metabolising enzymes (XME) that acetylate arylamine compounds. They therefore play an important role in the detoxication and/or metabolic activation of certain therapeutic drugs, occupational chemicals and carcinogens. Alt...

journal_title：Current pharmaceutical design

authors： Rodrigues-Lima F,Dupret JM

更新日期：2004-01-01 00:00:00

abstract：:Pituitary adenylate cyclase-activating polypeptide (PACAP) is a novel member of the secretin/glucagon/vasoactive intestinal peptide (VIP) superfamily. In vertebrates, including avians, it occurs in two forms: PACAP(38) and PACAP(27). PACAP structure is well conserved during evolution, being identical in mammals, and s...

journal_title：Current pharmaceutical design

authors： Nowak JZ,Zawilska JB

更新日期：2003-01-01 00:00:00

abstract：BACKGROUND:Cardiac resynchronization therapy (CRT) is a valuable intracardiac device--based treatment option for a subgroup of patients with advanced heart failure (HF) and QRS prolongation. However, still a significant proportion of patients do not benefit from CRT implantation, labeled as non-responders. OBJECTIVES:...

journal_title：Current pharmaceutical design

authors： Debska-Kozlowska A,Ksiazczyk M,Warchol I,Lubinski A

更新日期：2019-01-01 00:00:00

abstract：:Free energy simulations are a powerful tool to study molecular recognition. The most rigorous variants can provide in depth understanding for a particular system, but are not suited for high throughput application to large libraries of compounds. Related, but less expensive methods are increasingly popular, including ...

journal_title：Current pharmaceutical design

authors： Simonson T

更新日期：2013-01-01 00:00:00

abstract：:Quinone based bioreductive drugs have, potentially, a very versatile use in cancer chemotherapy. They can be activated by DT-diaphorase and hence can be used to target tumour types rich in this (O2)-independent reductase enzyme. Small molecular modifications can substantially reduce specificity for DT-diaphorase and u...

journal_title：Current pharmaceutical design

authors： McNally VA,Patterson AV,Williams KJ,Cowen RL,Stratford IJ,Jaffar M

更新日期：2002-01-01 00:00:00

abstract：:Resveratrol (3,5,4'-trihydroxy-trans-stilbene) is a non-flavonoid polyphenol that may be present in a limited number of foodstuffs such as grapes and red wine. Resveratrol has been reported to exert a plethora of health benefits through many different mechanisms of action. This versatility and presence in the human di...

journal_title：Current pharmaceutical design

authors： Tomé-Carneiro J,Larrosa M,González-Sarrías A,Tomás-Barberán FA,García-Conesa MT,Espín JC

更新日期：2013-01-01 00:00:00

abstract：:Hypericin is a naturally occurring substance found in the common St. John's Wort (Hypericum species) and can also be synthesized from the anthraquinone derivative emodin. As the main component of Hypericum perforatum, it has traditionally been used throughout the history of folk medicine. In the last three decades, hy...

journal_title：Current pharmaceutical design

authors： Kubin A,Wierrani F,Burner U,Alth G,Grünberger W

更新日期：2005-01-01 00:00:00

abstract：:Interest in opioid drugs like morphine, as the oldest and most potent pain-killing agents known, has been maintained through the years. One of the most frequent chronic pain sensations people experience is associated with pathological conditions of the musculoskeletal system. Chronic musculoskeletal pain is a major he...

journal_title：Current pharmaceutical design

authors： Spetea M

更新日期：2013-01-01 00:00:00

abstract：:Diterpenes present complex structure and due to their unique carbon skeleton and interesting biological activities, have been the focus of continuous studies for the development of new anticancer agents. Phorbol esters have been known for their activity against skin malignancies since ancient times. Taxol was first st...

journal_title：Current pharmaceutical design

authors： Prieto JM,Silveira D

更新日期：2018-01-01 00:00:00

abstract：:Fusion proteins have been well-studied and widely applied in biopharmaceutics. Albumin fusion proteins are simple to construct, easy to purify, and stable to formulate. One main application of fusion protein is to extend the plasma half-life of therapeutic proteins and peptides. Albiglutide for diabetes treatment is t...

journal_title：Current pharmaceutical design

authors： Rogers B,Dong D,Li Z,Li Z

更新日期：2015-01-01 00:00:00

abstract：:This review is based on carriers of natural origin such as polysaccharides, proteins, and cell derived entities which have been used for delivery of siRNA. To realize the therapeutic potential of a delivery system, the role of the carrier is of utmost importance. Historical aspects of viral vectors, the first carriers...

journal_title：Current pharmaceutical design

authors： Karunaratne DN,Jafari M,Ranatunga RJ,Siriwardhana A

更新日期：2015-01-01 00:00:00

abstract：:Naturally occurring abietane diterpenoids have been studied over the years and have shown to display a wide range of biological activities. This review covers three main aspects of the abietane-type diterpenoids with hydroxy-p-quinone C ring, designated as royleanones. An overview of 1) the naturally occurrence, 2) ch...

journal_title：Current pharmaceutical design

authors： Ladeiras D,Monteiro CM,Pereira F,Reis CP,Afonso CA,Rijo P

更新日期：2016-01-01 00:00:00

abstract：:We set up two models of gastric bleeding in rats using low-dose aspirin (ASA) and the antiplatelet drug clopidogrel, a P2Y₁₂ receptor antagonist, and examined the effect of antiulcer drugs on gastric bleeding and ulcerogenic responses under such conditions. Under urethane anesthesia, two catheters were inserted into t...

journal_title：Current pharmaceutical design

authors： Takeuchi K,Izuhara C,Takayama S,Momode T,Kojo M,Hara D,Amagase K

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:R. Schofield (1978) proposed a hypothesis of hematopoietic stem cells (HSCs) niche (specialized cell microenvironment). An existence of osteoblastic and vascular niches for HSCs has been postulated since 2003. At the same time, the discussion about the existence and functioning of niche for multipotent mesen...

journal_title：Current pharmaceutical design

authors： Khlusov IA,Litvinova LS,Khlusova MY,Yurova KA

更新日期：2018-01-01 00:00:00

abstract：:Mitochondria are involved in different physiological and pathological processes that are crucial for tumor cell physiology, growth and survival. Since cancer cells have frequently disrupted different cell death pathways that promote their survival, mitochondria may be key organelles to promote cell death in cancer cel...

journal_title：Current pharmaceutical design

authors： Ferrín G,Linares CI,Muntané J

更新日期：2011-01-01 00:00:00