Combination of statin plus renin angiotensin system inhibition for the prevention or the treatment of atherosclerotic cardiovascular disease.

abstract：:Inflammatory bowel disease (IBD), including Crohn's disease (CD) and ulcerative colitis (UC), are chronic relapsing conditions resulting from immune system activity in a genetically predisposed individual. IBD is based on progressive damage to the inflamed gut tissue. As its pathogenesis remains unknown, recent accumu...

journal_title：Current pharmaceutical design

authors： Alimohammadi N,Koosha F,Rafeian-Kopaei M

更新日期：2020-01-01 00:00:00

abstract：:The skin remains an attractive area for drug delivery. The skin, however, often limits the ingress of drugs, because of its very low permeability. Much research, focusing on employing a variety of physical and chemical methods, aimed at reversibly altering skin permeability in favour of compounds, has been reported. O...

journal_title：Current pharmaceutical design

authors： Kilian D,Shahzad Y,Fox L,Gerber M,Du Plessis J

更新日期：2015-01-01 00:00:00

abstract：:Reactive oxygen species (ROS), as well as reactive nitrogen species (RNS) play either harmful or beneficial role in biological systems. Beneficial effects of ROS include physiological roles in cellular responses against infectious agents and in several cellular signalling pathways. Harmful effects are due to high conc...

journal_title：Current pharmaceutical design

authors： Balsano C,Alisi A

更新日期：2009-01-01 00:00:00

abstract：:In the classical renin angiotensin system (RAS), angiotensin II Ang IIplays many important roles in cardiovascular disease and in kidney, brain, and other organs via the Ang II type 1 receptor (AT1). The RAS consists of many angiotensin peptides, including Ang (1-7), Ang (1-9), Ang (2-8), and Ang IV. Ang (1-7), produc...

journal_title：Current pharmaceutical design

authors： Ohishi M,Yamamoto K,Rakugi H

更新日期：2013-01-01 00:00:00

abstract：:In this review, the antimicrobial properties of a number of peptides are described. We first deal with helical linear peptides such as the well-known gramicidin, magainins, melittin, and other less well-known or more recently discovered peptides. Then, beta-sheet peptides (defensins isolated from insects and also from...

journal_title：Current pharmaceutical design

authors： Duclohier H

更新日期：2010-01-01 00:00:00

abstract：:α-Synuclein aggregation is centrally implicated in Parkinson's disease (PD). It involves multi-step nucleated polymerization process via the formation of dimers, soluble toxic oligomers and insoluble fibrils. In the present study, we synthesized a novel compound viz., Curcumin-glucoside (Curc-gluc), a modified form of...

journal_title：Current pharmaceutical design

authors： Gadad BS,Subramanya PK,Pullabhatla S,Shantharam IS,Rao KS

更新日期：2012-01-01 00:00:00

abstract：:The development of targeted therapy drugs acting on tumor growth and progression is greatly expanding these last years. Among them kinase inhibitors have a prominent position and have demonstrated efficacy and clinical benefits in solid and hematologic malignancies. Compared to conventional systemic cytotoxic chemothe...

journal_title：Current pharmaceutical design

authors： Levade M,Severin S,Gratacap MP,Ysebaert L,Payrastre B

更新日期：2016-01-01 00:00:00

abstract：:Parkinson's disease (PD) is one of common neurodegenerative diseases, which shows motor symptoms including tremor, bradykinesia, rigidity and postural instability. It also involves non-motor symptoms such as cognitive impairment, mental manifestation, autonomic disorder and sensory disturbance. Although treatments to ...

journal_title：Current pharmaceutical design

authors： Miyazaki I,Asanuma M

更新日期：2017-01-01 00:00:00

abstract：:Inhibition of the renin-angiotensin system (RAS) has been shown to have beneficial effects in cardiovascular disease prognosis and therapy.Discovery of (pro)renin receptor [(P)RR] revealed that (P)RR upon binding to both renin or prorenin in their proenzyme inactive form made them enzymatically active, thus aiding the...

journal_title：Current pharmaceutical design

authors： Ando T,Ichihara A

更新日期：2014-01-01 00:00:00

abstract：: ...

journal_title：Current pharmaceutical design

authors： Sukhorukov VN,Orekhov AN

更新日期：2019-01-01 00:00:00

abstract：:Methicillin-resistant Staphylococcus aureus (MRSA) remains the single biggest challenge in infectious disease in the civilized world. Moreover, vancomycin resistance is also spreading, leading to fears of untreatable infections as were common in ancient times. Molecular microbiology and bioinformatics have revealed ma...

journal_title：Current pharmaceutical design

authors： Magana M,Ioannidis A,Magiorkinis E,Ursu O,Bologa CG,Chatzipanagiotou S,Hamblin MR,Tegos GP

更新日期：2015-01-01 00:00:00

abstract：:Recent progresses in the development of fluorescent technologies become a reliable device for drug discovery research. The fluorescence tools offer attractive options for an opportunity to visualize the effects of drug candidates in the cells. The fluorescent tools, such as fluorescent protein, are regularly used in a...

journal_title：Current pharmaceutical design

authors： Chakraborty C,Hsu CH,Wen ZH,Lin CS

更新日期：2009-01-01 00:00:00

abstract：:Prostacyclin (PGI(2)) is one of the major vascular protectors against thrombosis and vasoconstriction, caused by thromboxane A(2). Understanding the molecular mechanisms of PGI(2) biosynthesis and signaling is crucial to the development of therapeutic approaches to regulate PGI(2) functions. This review provides infor...

journal_title：Current pharmaceutical design

authors： Ruan KH,Dogné JM

更新日期：2006-01-01 00:00:00

abstract：:Donkey's milk is the best substitute of human milk for its content in lactose, proteins, minerals, and omega-3 fatty acids. Here, we have evaluated the effects of colostrum and milk from donkeys (Martina Franca breed) on the function of human peripheral blood mononuclear cells (PBMCs) at different intervals from lacta...

journal_title：Current pharmaceutical design

authors： Tafaro A,Magrone T,Jirillo F,Martemucci G,D'Alessandro AG,Amati L,Jirillo E

更新日期：2007-01-01 00:00:00

abstract：:Gene therapy, currently, represents one of the new therapies that have emerged for the treatment of different diseases. Between the different approaches that can be chosen concerning this therapy, gene delivery with non-viral systems has focused the attention during the past decades, because of the reduced toxicity co...

journal_title：Current pharmaceutical design

authors： Urbiola K,Blanco-Fernandez L,de Ilarduya CT

更新日期：2015-01-01 00:00:00

abstract：:microRNAs (miRNAs) comprise a recently discovered class of non-coding RNAs with regulatory functions in post-transcriptional gene expression control. Many miRNAs are located in genomic regions that are frequently deleted in cancer, or are subject to epigenetic and transcriptional deregulation in cancer cells. The miRN...

journal_title：Current pharmaceutical design

authors： Schmid CA,Craig VJ,Müller A,Flori M

更新日期：2013-01-01 00:00:00

abstract：:Reduction strategies of blood pressure, as a modifiable cardiovascular risk, are currently based on office assessment of brachial artery blood pressure. However, antihypertensive treatment based on brachial BP values reduces cardiovascular risk but cannot completely reverse the hypertension-induced risk of morbidity e...

journal_title：Current pharmaceutical design

authors： Rinaldi ER,Yannoutsos A,Borghi C,Safar ME,Blacher J

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:The objective of this study was to apply Quality by Design (QbD) principles on process parameter optimization for the development of hybrid delivery system (combination of (SLNs) and In-situ gelling system) for hydrophilic drug Moxifloxacin Hydrochloride (MOX) to achieve its controlled delivery, which otherw...

journal_title：Current pharmaceutical design

authors： Khurana LK,Singh R,Singh H,Sharma M

更新日期：2018-01-01 00:00:00

abstract：:Fever of Unknown Origin, or FUO, is a challenging condition for patients and clinicians. In up to 50% of cases, no diagnosis is established. Patient workup begins with comprehensive history, physical examination and laboratory tests. Radionuclide imaging has been a second-line procedure. Gallium-67 citrate, which accu...

journal_title：Current pharmaceutical design

authors： Palestro CJ,Love C

更新日期：2018-01-01 00:00:00

abstract：:Surgery for epilepsy dates back to 1886 and has undergone significant developments. Today it is considered a key treatment modality in patients who are resistant to pharmacological intervention. It improves seizure control, cognition and quality of life. New technologies, advances in surgical technique and progress in...

journal_title：Current pharmaceutical design

authors： Rasul FT,Bal J,Pereira EA,Tisdall M,Themistocleous M,Haliasos N

更新日期：2017-01-01 00:00:00

abstract：BACKGROUNDS:Targeted therapy is the foundation of personalized medicine in cancer, which is often understood as the right patient using the right drug. Thinking from the viewpoint of determinants during personalized drug treatment, the genetics, epigenetics and metagenomics would provide individual-specific biological ...

journal_title：Current pharmaceutical design

authors： Wang L,Yu X,Zhang C,Zeng T

更新日期：2018-01-01 00:00:00

abstract：:A new controlled delivery system has been developed for ropinirole (RP) for the treatment of Parkinson´s Disease (PD) consisting in PLGA microparticles (MPs) which exhibited in vitro constant release of RP (78.23 µg/day/10 mg MPs) for 19 days. The neuroprotective effects of RP released from MPs were evaluated in SKN-A...

journal_title：Current pharmaceutical design

authors： Negro S,Boeva L,Slowing K,Fernandez-Carballido A,Garcia-García L,Barcia E

更新日期：2017-01-01 00:00:00

abstract：:Resveratrol (3,5,4'-trihydroxy-trans-stilbene) is a non-flavonoid polyphenol that may be present in a limited number of foodstuffs such as grapes and red wine. Resveratrol has been reported to exert a plethora of health benefits through many different mechanisms of action. This versatility and presence in the human di...

journal_title：Current pharmaceutical design

authors： Tomé-Carneiro J,Larrosa M,González-Sarrías A,Tomás-Barberán FA,García-Conesa MT,Espín JC

更新日期：2013-01-01 00:00:00

abstract：:The intracellular hydric balance is an essential process of mammalian cells. The water movement across cell membranes is driven by osmotic and hydrostatic forces and the speed of this process is dependent on the presence of specific aquaporin water channels. Since the molecular identification of the first water channe...

journal_title：Current pharmaceutical design

authors： Frigeri A,Nicchia GP,Svelto M

更新日期：2007-01-01 00:00:00

abstract：:Tissue-engineered oral mucosal equivalents have been developed for in vitro studies for a few years now. However, the usefulness of currently available models is still limited by many factors, mainly the lack of a physiological extracellular matrix (ECM) and the use of cell populations that do not reflect the properly...

journal_title：Current pharmaceutical design

authors： Bucchieri F,Fucarino A,Marino Gammazza A,Pitruzzella A,Marciano V,Paderni C,De Caro V,Siragusa MG,Lo Muzio L,Holgate ST,Davies DE,Farina F,Zummo G,Kudo Y,Giannola IL,Campisi G

更新日期：2012-01-01 00:00:00

abstract：:About 50 peptides, and a similar number of peptide receptors, are known to be present in the gut and this amount is likely to rise significantly over the next few years. While there has been a massive research effort to define their functions and their anatomical distribution in the central nervous system (CNS), the u...

journal_title：Current pharmaceutical design

authors： Motilva V,Talero E,Calvo JR,Villegas I,Alarcón-de-la-Lastra C,Sánchez-Fidalgo S

更新日期：2008-01-01 00:00:00

abstract：:Synaptic transmission through descending motor pathways to lumbar motoneurons and then to leg muscles is essential for walking in humans and rats. Spinal cord injury (SCI), even when incomplete, results in diminished transmission to motoneurons and very limited recovery of motor function. Neurotrophins have emerged as...

journal_title：Current pharmaceutical design

authors： Arvanian V

更新日期：2013-01-01 00:00:00

abstract：:Histone lysine methylation can be modified by various writers and erasers. Different from other epigenetic modifications, mono-, di, and tri- methylation distinctly modulate chromatin structure and thereby contribute to the regulation of DNA-based nuclear processes such as transcription, replication and repair on thei...

journal_title：Current pharmaceutical design

authors： Zheng YC,Ma JL,Liu Y,Liu HM

更新日期：2016-01-01 00:00:00

abstract：:The mechanisms of beneficial preventive and therapeutic effects achieved by traditional and complementary medicine are currently being deciphered in molecular medicine. Curcumin, a yellow-colored polyphenol derived from the rhizome of turmeric (Curcuma longa), influences a wide variety of cellular processes through th...

journal_title：Current pharmaceutical design

authors： Troselj KG,Kujundzic RN

更新日期：2014-01-01 00:00:00

abstract：:The number of protein 3D structures without function annotation in Protein Data Bank (PDB) has been steadily increased. Many of these proteins are relevant for Pharmaceutical Design because they may be enzymes of different classes that could become drug targets. This fact has led in turn to an increment of demand for ...

journal_title：Current pharmaceutical design

authors： Concu R,Podda G,Ubeira FM,González-Díaz H

更新日期：2010-01-01 00:00:00