Implications of the molecular basis of prostacyclin biosynthesis and signaling in pharmaceutical designs.

abstract：:Cardiovascular diseases (CVD) are considered a major health problem worldwide, being the main cause of mortality in developing and developed countries. Endothelial dysfunction, characterized by a decline in nitric oxide production and/or bioavailability, increased oxidative stress, decreased prostacyclin levels, and a...

journal_title：Current pharmaceutical design

authors： Blanco-Rivero J,Xavier FE

更新日期：2020-01-01 00:00:00

abstract：:Gene delivery, a process of introducing foreign functional nucleic acids into target cells, has proven to be a very promising tool for inducing specific gene expression in host cells. Many different technologies have been developed for efficient gene delivery. Among them, electroporation has been adopted in gene deliv...

journal_title：Current pharmaceutical design

authors： Yang Z,Chang L,Chiang CL,Lee LJ

更新日期：2015-01-01 00:00:00

abstract：:Drug-drug interactions may occur when to combine two or more drugs and may cause some adverse events such as Cardiotoxicity, Central neurotoxicity, Hepatotoxicity, etc. Although a large number of researchers who are proficient in pharmacokinetics and pharmacodynamics have been engaged in drug assays and trying to find...

journal_title：Current pharmaceutical design

authors： Huang W,Li C,Ju Y,Gao Y

更新日期：2021-01-27 00:00:00

abstract：:The complex system of molecular communications underlying cell biochemistry and function involves numerous components including kinases, phosphatases and transcription factors, which are known to be sensitive to cellular and tissue redox changes. Reactive oxygen species (ROS), whose constitutive generation in cells an...

journal_title：Current pharmaceutical design

authors： Leonarduzzi G,Sottero B,Testa G,Biasi F,Poli G

更新日期：2011-12-01 00:00:00

abstract：BACKGROUND:Absorption windows in particular segments of the small intestine can contribute to the development of orally administered drug formulations and can limit the bioavailability of released compounds. OBJECTIVE:The aim of this study was to evaluate use of wireless capsule enteroscopy regarding the disintegratio...

journal_title：Current pharmaceutical design

authors： Kvetina J,Tacheci I,Nobilis M,Kopacova M,Kunes M,Bures J

更新日期：2017-01-01 00:00:00

abstract：:The derangement of the cardiac energy substrate metabolism plays a key role in the pathogenesis of heart failure. The utilization of non-carbohydrate substrates, such as fatty acids, is the predominant metabolic pathway in the normal heart, because this provides the highest energy yield per molecule of substrate metab...

journal_title：Current pharmaceutical design

authors： Nagoshi T,Yoshimura M,Rosano GM,Lopaschuk GD,Mochizuki S

更新日期：2011-12-01 00:00:00

abstract：BACKGROUND:Inflammatory bowel disease (IBD) is a group of intestinal disorders characterised by chronic relapsing inflammation of the small intestine and colon. IBD manifests as either ulcerative colitis or Crohn's disease and increases the risk of developing colorectal cancer. METHODS:Here, we have reviewed current t...

journal_title：Current pharmaceutical design

authors： Perera AP,Kunde D,Eri R

更新日期：2017-01-01 00:00:00

abstract：:Development of effective drug delivery systems is important for medicine and healthcare. Polymer particulates (micro- and nanoparticles) have opened new opportunities in the field of drug delivery by overcoming various limitations of conventional delivery methods. The properties of polymeric particles can be readily t...

journal_title：Current pharmaceutical design

authors： Kaur H,Kumar V,Kumar K,Rathor S,Kumari P,Singh J

更新日期：2016-01-01 00:00:00

abstract：:Recent advances in the fabrication, characterization and application of micro- and nano-particles that possess a non-uniform internal structure are reviewed. The particle structures include core-shell particles, particles with multiple cores or a multi-layered structure, porous particles with both regular and random p...

journal_title：Current pharmaceutical design

authors： Čejková J,Štêpánek F

更新日期：2013-01-01 00:00:00

abstract：:The state-of-the-art in the investigation of drugs release from Silica-based ordered Mesoporous Materials (SMMs) is reviewed. First, the SMM systems used like host matrixes are described. Then, the model drugs studied until now, including their pharmacological action, structure and the mesoporous matrix employed for e...

journal_title：Current pharmaceutical design

authors： Doadrio AL,Salinas AJ,Sánchez-Montero JM,Vallet-Regí M

更新日期：2015-01-01 00:00:00

abstract：:The use of systematic approach for the analysis of mechanism of action of drugs at different levels of biological organization of organisms is an important task in experimental and clinical pharmacology for drug designing and increasing the efficacy and safety of drugs. The analysis of published data on pharmacologica...

journal_title：Current pharmaceutical design

authors： Tarasov VV,Kudryashov NV,Chubarev VN,Kalinina TS,Barreto GE,Ashraf GM,Aliev G

更新日期：2018-01-01 00:00:00

abstract：:Diet has a high relevance in health. Hypertension is a major risk factor for cardiovascular diseases and has an important impact on public health, and consequently on countries economy. Scientific research gathered strong evidence about the role of several dietary factors either in etiology or in treatment/prevention ...

journal_title：Current pharmaceutical design

authors： Marques C,Amorim MM,Pereira JO,Pintado ME,Moura D,Calhau C,Pinheiro H

更新日期：2012-01-01 00:00:00

abstract：:Despite the significant progresses made in antiretroviral therapy, current drugs still cannot cure or prevent HIV infection. And all drugs continue to select for drug-resistant HIV strains. Consequently, new antiretroviral drugs are constantly being developed. To ensure safety, these drugs are usually designed to inhi...

journal_title：Current pharmaceutical design

authors： Provencher VM,Coccaro E,Lacasse JJ,Schang LM

更新日期：2004-01-01 00:00:00

abstract：:In the third millennium preventive medicine is becoming a corner stone in our concept of health. Colorectal cancer (CRC) fits the criteria of a disease suitable for prevention interventions. It is a prevalent disease that is associated with considerable mortality and morbidity rates, with more than 1,000,000 new cases...

journal_title：Current pharmaceutical design

authors： Boursi B,Arber N

更新日期：2007-01-01 00:00:00

abstract：:Nesfatin-1, derived from the precursor NEFA/nucleobindin2 (NUCB2), was initially identified as a feeding-suppressing neuropeptide, acting at central (mainly, hypothalamic) levels in a leptin-independent manner. However, recent experimental evidence strongly suggests that, rather than being a simple anorectic hypothala...

journal_title：Current pharmaceutical design

authors： García-Galiano D,Tena-Sempere M

更新日期：2013-01-01 00:00:00

abstract：:Histone deacetylases (HDACs) are important enzymes that effect post-translational modifications of proteins by altering the acetylation state of lysine residues. HDACs control epigenetic changes that trigger cell transformation and proliferation of transformed cells associated with many diseases. These enzymes are val...

journal_title：Current pharmaceutical design

authors： Andrews KT,Tran TN,Fairlie DP

更新日期：2012-01-01 00:00:00

abstract：:Asthma is an allergy-mediated inflammatory disease characterised by infiltration of the airway with mast cells, lymphocytes, and eosinophils. The disease is induced by co-ordination of T-helper cell type 2 (Th2) cytokines and inflammatory signal molecules. Fruits and vegetables are a rich source of polyphenolic bioact...

journal_title：Current pharmaceutical design

authors： Nyanhanda T,Gould EM,Hurst RD

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:According to the World Health Organization (WHO), diabetes mellitus is considered the 7th leading cause of death as of 2016, while almost half of all deaths related to high blood glucose occur before the age of 70. According to the 2019 American Diabetes Association's (ADA) guidelines, metformin is the first...

journal_title：Current pharmaceutical design

authors： Gillani SW,Moosvi AF

更新日期：2020-01-01 00:00:00

abstract：:Recent advances in DNA sequencing has made it possible to accurately decipher the entire genetic complement of a probiotic bacterium. Increases in sequencing capabilities have been enhanced through improved computer software that can annotate, or identify, the majority of genes encoded by the sequence. The availabilit...

journal_title：Current pharmaceutical design

authors： Callanan M

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:The prevalence of adrenal hyperandrogenism (AH), as defined by increased circulating dehydroepiandrosterone-sulfate (DHEAS) levels, ranges from 15 to 45% in women with polycystic ovary syndrome (PCOS). METHODS:The aim of this review is to update the pathogenesis and consequences of AH in PCOS, from molecula...

journal_title：Current pharmaceutical design

authors： Luque-Ramírez M,Escobar-Morreale HF

更新日期：2016-01-01 00:00:00

abstract：:More and more evidences are still accumulating rapidly on the G-protein-coupled-receptors (GPCRs) dimerization/oligomerization. Such common feature of GPCRs has called extensive attention to both pharmacologists and medicinal chemists for illustration of the pharmacological functions and therapeutic utilities of such ...

journal_title：Current pharmaceutical design

authors： Liu Z,Zhang J,Zhang A

更新日期：2009-01-01 00:00:00

abstract：:Inflammation is part of an important mechanism triggered by the innate immune response that rapidly responds to invading microorganisms and tissue injury. One important elicitor of the inflammatory response is the Gram-negative bacteria component lipopolysaccharide (LPS), which induces the activation of innate immune ...

journal_title：Current pharmaceutical design

authors： de Almeida OP Jr,Toledo TR,Rossi D,Rossetto Dde B,Watanabe TF,Galvão FC,Medeiros AI,Zanelli CF,Valentini SR

更新日期：2014-01-01 00:00:00

abstract：:Natural products, or their synthetic derivatives are a treasure trove to find potential candidates for novel drugs for human treatment. The selection of diamonds from the huge pile of worthless stone is a critical--and difficult--stage in the discovery pipeline. Of all the factors to be considered, perhaps the most im...

journal_title：Current pharmaceutical design

authors： Wrzesinski K,Fey SJ

更新日期：2015-01-01 00:00:00

abstract：:α-Synuclein aggregation is centrally implicated in Parkinson's disease (PD). It involves multi-step nucleated polymerization process via the formation of dimers, soluble toxic oligomers and insoluble fibrils. In the present study, we synthesized a novel compound viz., Curcumin-glucoside (Curc-gluc), a modified form of...

journal_title：Current pharmaceutical design

authors： Gadad BS,Subramanya PK,Pullabhatla S,Shantharam IS,Rao KS

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Cyclodextrins (CDs), as one type of the novel pharmaceutical excipients, have been widely used in drug delivery and pharmaceutical industry. Over the past decades, a large amount of molecular modeling studies in CDs were reported for profound understanding of structural, dynamic and energetic features of CDs...

journal_title：Current pharmaceutical design

authors： Zhao Q,Zhang W,Wang R,Wang Y,Ouyang D

更新日期：2017-01-01 00:00:00

abstract：:Despite the development of strong antibiotics, the pneumonia death is increasing all over the world in these decades. Among the people who died of pneumonia, the majority were 65 years old or over. Although pneumonia is recently categorized into several entities, aspiration pneumonia includes all entities. Therefore, ...

journal_title：Current pharmaceutical design

authors： Ebihara S,Ebihara T,Gui P,Osaka K,Sumi Y,Kohzuki M

更新日期：2014-01-01 00:00:00

abstract：:Many of the most debilitating symptoms for psychiatric disorders such as schizophrenia remain poorly treated. As such, the development of novel treatments is urgently needed. Unfortunately, the costs associated with high failure rates for investigational compounds as they enter clinical trials has led to pharmaceutica...

journal_title：Current pharmaceutical design

authors： Wylie KP,Smucny J,Legget KT,Tregellas JR

更新日期：2016-01-01 00:00:00

abstract：:Depression is one of the leading causes of disability in the world. Current pharmaceutical treatment for depression remains unsatisfactory due to its limited therapeutic efficacy and undesirable side effects. There is increasing interest in looking for alternative strategies from diet for the treatment of depressive d...

journal_title：Current pharmaceutical design

authors： Wang X,Zhao F,Wang X,Niu Y,Niu L,Wang C

更新日期：2018-01-01 00:00:00

abstract：:The Hereditary Spastic Paraparesis (HSP) or Strumpell-Lorrain disease is a heterogeneous neurodegenerative disease of the spinal cord. It is genetically transmitted and characterized by a progressive muscle weakness, spasticity of the lower limbs and awkward gain. There is no specific pharmacological treatment. The ph...

journal_title：Current pharmaceutical design

authors： Riccardo M,Angela L,Angela D,Vita P,Giulio L,Pietroq F,Giancarlo I,Marisa M

更新日期：2016-01-01 00:00:00

abstract：:While it is well documented that the mitogenic actions of estrogens are critical in the development and progression of human breast and some gynecologic cancers, only latest data demonstrate a crucial involvement of estrogen-signaling in the carcinogenesis of non-classical estrogen target tissues, as colon, prostate, ...

journal_title：Current pharmaceutical design

authors： Gallo D,De Stefano I,Grazia Prisco M,Scambia G,Ferrandina G

更新日期：2012-01-01 00:00:00