Current Surgical Options for Patients with Epilepsy.

abstract：:Inhibition of carbonic anhydrase (CA, EC 4.2.1.1) isoforms present in the eyes (CA I, II, IV and XII), with sulfonamides such as acetazolamide, methazolamide, ethoxzolamide and dichlorophenamide, is still widely used for the systemic treatment of glaucoma. The mechanism of action of these drugs consists in inhibition ...

journal_title：Current pharmaceutical design

authors： Mincione F,Scozzafava A,Supuran CT

更新日期：2008-01-01 00:00:00

abstract：:Over the last three decades, neoplasms have become the largest cause of human mortality due to both high tumor incidence and mortality. Chemotherapy is one of the main therapies employed to treat neoplasms. Although classical genotoxic drugs, such as cyclophosphamide, 5-FU, cisplatin and doxorubicin have been applied ...

journal_title：Current pharmaceutical design

authors： Quan C,Xiao J,Liu L,Duan Q,Yuan P,Zhu F

更新日期：2017-11-16 00:00:00

abstract：BACKGROUND:The last few decades have witnessed enormous advancements in the field of Pharmaceutical drug, design and delivery. One of the recent developments is the advent of 3DP technology. It has earlier been successfully employed in fields like aerospace, architecture, tissue engineering, biomedical research, medica...

journal_title：Current pharmaceutical design

authors： Mirza MA,Iqbal Z

更新日期：2018-01-01 00:00:00

abstract：:Severe sepsis leading to shock is the principal cause of death in intensive care units. It is a systemic inflammatory response caused by excessive secretion of pro-inflammatory mediators, such as tumor necrosis factor-alpha (TNFalpha) and reactive oxygen species (ROS), mainly induced by endotoxin (a major component of...

journal_title：Current pharmaceutical design

authors： Victor VM,Rocha M,Esplugues JV,De la Fuente M

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:Intracerebral hemorrhage is one of the most common injuries in vehicle accidents. The aim of this paper is to survey the injury mechanism of intracerebral hemorrhage in vehicle accidents, including contusion, subarachnoid hemorrhage (SAH), subdural hematoma (SDH) and diffuse axonal injury (DAI). METHODS:A c...

journal_title：Current pharmaceutical design

authors： Li F,Li H,Xiao Z,Lu R,Zhang Z,Zhu H,Ren L

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:Bacterial cellulose (BC) has recently attained greater interest in various research fields, including drug delivery for biomedical applications. BC has been studied in the field of drug delivery, such as tablet coating, controlled release systems and prodrug design. OBJECTIVE:In the current work, we tested ...

journal_title：Current pharmaceutical design

authors： Ullah H,Badshah M,Correia A,Wahid F,Santos HA,Khan T

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Although medications should only be prescribed in pregnancy if benefits to the mother outweigh the risk to the fetus, drug use in pregnancy especially prescribed and over-the-counter analgesics, is very common. OBJECTIVE:The objective of this review is to present an update on known changes in analgesic disp...

journal_title：Current pharmaceutical design

authors： Price HR,Collier AC

更新日期：2017-01-01 00:00:00

abstract：:Tamoxifen is a selective oestrogen receptor modulator (SERM). SERMs act on oestrogen receptors to inhibit oestradiol mediated negative feedback on the hypothalamic-pituitary-gonadal (HPG) axis, thereby upregulating gonadotrophin secretion and release from the pituitary. Hence, Tamoxifen is used to upregulate activatio...

journal_title：Current pharmaceutical design

authors： Dimakopoulou A,Foran D,Jayasena CN,Minhas S

更新日期：2020-02-12 00:00:00

abstract：BACKGROUND:Enhancing a compound's biological activity is the central task for lead optimization in small molecules drug discovery. However, it is laborious to perform many iterative rounds of compound synthesis and bioactivity tests. To address the issue, it is highly demanding to develop high quality in silico bioacti...

journal_title：Current pharmaceutical design

authors： Ding X,Cui C,Wang D,Zhao J,Zheng M,Luo X,Jiang H,Chen K

更新日期：2020-01-01 00:00:00

abstract：:We herein reviewed the mechanism underlying the gastric hyperemic response following barrier disruption, with a focus on cyclooxygenase (COX) isozymes, prostaglandin (PG) E2, and capsaicin-sensitive afferent neurons. Mucosal damage was induced by exposing the stomach to 20 mM taurocholate (TC) with 50 mM HCl. The TC t...

journal_title：Current pharmaceutical design

authors： Takeuchi K,Takeeda M,Amagase K,Nakashima M

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Inhibition of hepatic fibrosis is an attainable objective in managing the chronic liver disease. The present study aimed to investigate possible defensive effects of metformin on the activities of antioxidant enzymes, hydroxyproline content, and biochemical factors in bile duct ligation (BDL)-induced cholest...

journal_title：Current pharmaceutical design

authors： Mansourian M,Sadeghi H,Doustimotlagh AH

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Oxidative stress and inflammation are key parameters in developing metabolic disorders. Hence, antioxidant intake might be an appropriate approach. Several studies have evaluated the effect of coenzyme Q10 (CoQ10) supplementation on lipid profile among patients with metabolic diseases, though f...

journal_title：Current pharmaceutical design

authors： Sharifi N,Tabrizi R,Moosazadeh M,Mirhosseini N,Lankarani KB,Akbari M,Chamani M,Kolahdooz F,Asemi Z

更新日期：2018-01-01 00:00:00

abstract：:The use of the carbohydrate glucose as an energetic source is essential for an adequate function of the human body. The complex regulation of this molecule involves the coordinated action of various organs such as pancreas, liver and brain. Any disruption of this physiological balance may result in a dangerous comprom...

journal_title：Current pharmaceutical design

authors： González-Reyes RE,Aliev G,Ávila-Rodrigues M,Barreto GE

更新日期：2016-01-01 00:00:00

abstract：:Today, in spite of being older than a century (born in 1911), the Pictet-Spengler two component reaction (PS-2CR) is still one of the most popular reactions, not only for the synthesis of tetrahydroisoquinolines (THIQs), tetrahydro-β-carbolines (THBCs), or more complex structures containing these two privileged moieti...

journal_title：Current pharmaceutical design

authors： Ingallina C,D'Acquarica I,Delle Monache G,Ghirga F,Quaglio D,Ghirga P,Berardozzi S,Markovic V,Botta B

更新日期：2016-01-01 00:00:00

abstract：:Reducing sugars can react non-enzymatically with amino groups of proteins and lipids to form irreversibly cross-linked macroprotein derivatives called as advanced glycation end products (AGEs). Cross-linking modification of extracellular matrix proteins by AGEs deteriorate their tertiary structural integrity and funct...

journal_title：Current pharmaceutical design

authors： Yamagishi SI,Matsui T,Ishibashi Y,Isami F,Abe Y,Sakaguchi T,Higashimoto Y

更新日期：2017-01-01 00:00:00

abstract：:Fever of Unknown Origin, or FUO, is a challenging condition for patients and clinicians. In up to 50% of cases, no diagnosis is established. Patient workup begins with comprehensive history, physical examination and laboratory tests. Radionuclide imaging has been a second-line procedure. Gallium-67 citrate, which accu...

journal_title：Current pharmaceutical design

authors： Palestro CJ,Love C

更新日期：2018-01-01 00:00:00

abstract：:Catheter ablation for rhythm control in atrial fibrillation has been recognized as an established treatment. Patients with atrial fibrillation suffer from an increased risk of thromboembolic events. Long-term stroke risk and mortality have been shown to be reduced after catheter ablation, still the procedure per se is...

journal_title：Current pharmaceutical design

authors： Vrachatis DA,Giannopoulos G,Kossyvakis C,Panagopoulou V,Vavuranakis M,Papaioannou TG,Pagoni S,Pyrgakis VN,Cleman MW,Deftereos SG

更新日期：2017-01-01 00:00:00

abstract：OBJECTIVE:High prevalence of Dental and periodontal problems during the gestation period may have a negative effect on oral health-related quality of life (OHRQoL) in pregnant women. This systematic review aimed to perform a quality assessment and provide a critical overview of the current research available on OHRQoL ...

journal_title：Current pharmaceutical design

authors： Fakheran O,Saied-Moallemi Z,Khademi A,Sahebkar A

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:Cyclodextrins (CDs), as one type of the novel pharmaceutical excipients, have been widely used in drug delivery and pharmaceutical industry. Over the past decades, a large amount of molecular modeling studies in CDs were reported for profound understanding of structural, dynamic and energetic features of CDs...

journal_title：Current pharmaceutical design

authors： Zhao Q,Zhang W,Wang R,Wang Y,Ouyang D

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:Absorption windows in particular segments of the small intestine can contribute to the development of orally administered drug formulations and can limit the bioavailability of released compounds. OBJECTIVE:The aim of this study was to evaluate use of wireless capsule enteroscopy regarding the disintegratio...

journal_title：Current pharmaceutical design

authors： Kvetina J,Tacheci I,Nobilis M,Kopacova M,Kunes M,Bures J

更新日期：2017-01-01 00:00:00

abstract：:Nanoparticles have gained ground in several fields. However, it is important to consider their potentially hazardous effects on humans, flora, and fauna. Human exposure to nanomaterials can occur unintentionally in daily life or in industrial settings, and the continuous exposure of the biological components (cells, r...

journal_title：Current pharmaceutical design

authors： Mitarotonda R,Giorgi E,Desimone MF,De Marzi MC

更新日期：2019-01-01 00:00:00

abstract：:Tissue-engineered oral mucosal equivalents have been developed for in vitro studies for a few years now. However, the usefulness of currently available models is still limited by many factors, mainly the lack of a physiological extracellular matrix (ECM) and the use of cell populations that do not reflect the properly...

journal_title：Current pharmaceutical design

authors： Bucchieri F,Fucarino A,Marino Gammazza A,Pitruzzella A,Marciano V,Paderni C,De Caro V,Siragusa MG,Lo Muzio L,Holgate ST,Davies DE,Farina F,Zummo G,Kudo Y,Giannola IL,Campisi G

更新日期：2012-01-01 00:00:00

abstract：:Diet has a high relevance in health. Hypertension is a major risk factor for cardiovascular diseases and has an important impact on public health, and consequently on countries economy. Scientific research gathered strong evidence about the role of several dietary factors either in etiology or in treatment/prevention ...

journal_title：Current pharmaceutical design

authors： Marques C,Amorim MM,Pereira JO,Pintado ME,Moura D,Calhau C,Pinheiro H

更新日期：2012-01-01 00:00:00

abstract：:Protein palmitoylation is a fundamental and reversible post-translational lipid modification that involves a series of biological processes. Although a large number of experimental studies have explored the molecular mechanism behind the palmitoylation process, the computational methods has attracted much attention fo...

journal_title：Current pharmaceutical design

authors： Li Y,Pu F,Wang J,Zhou Z,Zhang C,He F,Ma Z,Zhang J

更新日期：2020-11-12 00:00:00

abstract：:Macrolides have broad antibacterial spectrum and proven efficacy in the management of respiratory tract infections. Over the past decade there has been progressive interest in these agents for their potential role as tissue modifying, anti-inflammatory agents. Increasingly, the effect of macrolides on numerous cell ty...

journal_title：Current pharmaceutical design

authors： Martinez FJ,Simon RH

更新日期：2004-01-01 00:00:00

abstract：:The heart is a sophisticated endocrine gland synthesizing a family of peptide hormones by three different genes. These cardiac hormones are stored as 3 prohormones, i.e. atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP) and C-type natriuretic peptide (CNP) prohormones. Within the ANP prohormones are 4 ...

journal_title：Current pharmaceutical design

authors： Vesely DL

更新日期：2010-01-01 00:00:00

abstract：:Stimulation of β-adrenergic receptors in the heart is the most effective endogenous way to increase the mechanical performance of cardiac tissues to meet the requirements of a fight-or-flight situation or stress. On the other hand, sustained activation of cardiac β-receptors initiates maladaptive remodeling of the myo...

journal_title：Current pharmaceutical design

authors： Szentmiklosi AJ,Szentandrássy N,Hegyi B,Horvath B,Magyar J,Bányász T,Nanasi PP

更新日期：2015-01-01 00:00:00

abstract：:The activation of Corticotrophin Releasing-Factor (CRF) receptors in the brain is well established to coordinate the endocrine, behavioral, autonomic and visceral responses to stress. In addition, CRF receptors are also expressed within the gut where they exert biological actions and play a role in modulating stress-r...

journal_title：Current pharmaceutical design

authors： Czimmer J,Tache Y

更新日期：2017-01-01 00:00:00

abstract：:Viral infections are important causes of morbidity and mortality in hematopoietic stem cell transplant (HSCT) recipients. Some viruses, such as the respiratory and gastrointestinal viruses, are acquired from the healthcare or community in the midst of or after HSCT. Other viruses, such as the herpes-virus family, esta...

journal_title：Current pharmaceutical design

authors： Anderson EJ

更新日期：2008-01-01 00:00:00

abstract：:Current antiretroviral therapy has had a significant impact on HIV associated morbidity and mortality. Despite these positive outcomes current antiretroviral regimens have significant deficiencies which include multiple drug-drug interactions, high pill burdens, and considerable financial expense. Perhaps the greatest...

journal_title：Current pharmaceutical design

authors： Romanelli F,Hoven AD

更新日期：2006-01-01 00:00:00