Clinical implications of macrolide therapy in chronic sinopulmonary diseases.

Abstract:

:Macrolides have broad antibacterial spectrum and proven efficacy in the management of respiratory tract infections. Over the past decade there has been progressive interest in these agents for their potential role as tissue modifying, anti-inflammatory agents. Increasingly, the effect of macrolides on numerous cell types has been documented. Preliminary data have suggested a beneficial clinical role of chronic macrolide therapy in selected patients with chronic rhinosinusitis, chronic obstructive pulmonary disease, cystic fibrosis, non-cystic fibrosis bronchiectasis and asthma. This review presents the biological rationale and the available clinical data of chronic macrolide therapy in chronic respiratory tract diseases. When available, the data addressing the presumed mechanisms underlying clinical benefits are presented.

journal_name

Curr Pharm Des

authors

Martinez FJ,Simon RH

doi

10.2174/1381612043383304

subject

Has Abstract

pub_date

2004-01-01 00:00:00

pages

3095-110

issue

25

eissn

1381-6128

issn

1873-4286

journal_volume

10

pub_type

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