Novel approach to cardiovascular diseases: a promising probability of (pro)renin receptor [(P)RR].

abstract：:The intracellular hydric balance is an essential process of mammalian cells. The water movement across cell membranes is driven by osmotic and hydrostatic forces and the speed of this process is dependent on the presence of specific aquaporin water channels. Since the molecular identification of the first water channe...

journal_title：Current pharmaceutical design

authors： Frigeri A,Nicchia GP,Svelto M

更新日期：2007-01-01 00:00:00

abstract：:Withdrawn by the publisher. ...

journal_title：Current pharmaceutical design

authors：

更新日期：2018-11-13 00:00:00

abstract：:Mast cells are important in the development of allergic and anaphylactic reactions, but also in acquired and innate immunity. There is also increasing evidence that mast cells participate in inflammatory diseases, where they can be activated by non-allergic triggers, such as neuropeptides and cytokines, often having s...

journal_title：Current pharmaceutical design

authors： Sismanopoulos N,Delivanis DA,Alysandratos KD,Angelidou A,Therianou A,Kalogeromitros D,Theoharides TC

更新日期：2012-01-01 00:00:00

abstract：:Erectile function is determined by tight regulation of relaxation or contraction of corpus cavernosal smooth muscle, which is the result of a long and complex chain of molecular events. Control of erectile function resides in signaling pathways of the central and peripheral nervous system, as well as intracellular eve...

journal_title：Current pharmaceutical design

authors： Seftel AD

更新日期：2005-01-01 00:00:00

abstract：:The cystic fibrosis transmembrane conductance regulator (CFTR) protein is a cAMP-regulated Cl- channel whose major function is to facilitate epithelial fluid secretion. Loss-of-function mutations in CFTR cause the genetic disease cystic fibrosis. CFTR is required for transepithelial fluid transport in certain secretor...

journal_title：Current pharmaceutical design

authors： Verkman AS,Synder D,Tradtrantip L,Thiagarajah JR,Anderson MO

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Most proteoglycans are heterogeneous molecules composed of a protein core with glycosaminoglycans (GAGs) attached. GAGs are highly negatively charged molecules that readily bind to enzymes, growth factors, cytokines etc. and as such have many functions. The role played by proteoglycans in diabetes has only r...

journal_title：Current pharmaceutical design

authors： Hiebert LM

更新日期：2017-01-01 00:00:00

abstract：:The production of autoreactive antibodies from self-reactive B cells results in the formation of immune complexes that deposit in tissue and fix complement, contributing to the pathogenesis of rheumatoid arthritis (RA). Earlier mouse models emphasize the importance of autoreactive antibodies formed against "self" prot...

journal_title：Current pharmaceutical design

authors： Low JM,Moore TL

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:New Oral Anticoagulants (NOACs) are effective and widely used to prevent and treat thromboembolic diseases, but the response to NOACs differs according to ABCB1 genotypes. OBJECTIVE:We investigated the effects of ABCB1 genotypes on the pharmacokinetics and clinical outcomes of NOACs. METHODS:We searched Pu...

journal_title：Current pharmaceutical design

authors： Xie Q,Xiang Q,Mu G,Ma L,Chen S,Zhou S,Hu K,Zhang Z,Cui Y,Jiang J

更新日期：2018-01-01 00:00:00

abstract：:Arrhythmias in left ventricular hypertrabeculation/noncompaction (LVHT) comprise sustained or non-sustained ventricular tachycardia (VT) (n=135), atrial fibrillation (AF) (n=96) AV block (n=55) and QT prolongation (n=47). The prevalence differs between children and adults. In children most frequent are WPW-syndrome (n...

journal_title：Current pharmaceutical design

authors： Stöllberger C,Finsterer J

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:At sufficient sun exposure, humans can synthesize vitamin D3 endogenously in their skin, but today's lifestyle makes the secosteroid a true vitamin that needs to be taken up by diet or supplementation with pills. The vitamin D3 metabolite 1α,25-dihydroxyvitamin D3 acts as a nuclear hormone activating the tra...

journal_title：Current pharmaceutical design

authors： Carlberg C

更新日期：2019-01-01 00:00:00

abstract：:Gene delivery, a process of introducing foreign functional nucleic acids into target cells, has proven to be a very promising tool for inducing specific gene expression in host cells. Many different technologies have been developed for efficient gene delivery. Among them, electroporation has been adopted in gene deliv...

journal_title：Current pharmaceutical design

authors： Yang Z,Chang L,Chiang CL,Lee LJ

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:The population with autism spectrum disorder (ASD) has been increasing and is currently estimated to be 1 in 58 births. The increased prevalence of ASD together with the lack of knowledge on the processes of aging in this population, the support needed at this stage of life, and the associated risk factors, ...

journal_title：Current pharmaceutical design

authors： Ruggieri V,Gómez JLC,Martínez MM,Arberas C

更新日期：2019-01-01 00:00:00

abstract：:DAP12 is a novel immunoreceptor tyrosine-based activation motifs (ITAM)-bearing transmembrane adapter molecule. This molecule, together with its partner receptor complex molecules including the killer cell activating receptors (KARs), myeloid DAP12 associating lectin-1 (MDL-1), triggering receptor expressed on myeloid...

journal_title：Current pharmaceutical design

authors： Aoki N,Kimura S,Xing Z

更新日期：2003-01-01 00:00:00

abstract：:Propofol (2, 6-diisopropylphenol) is a potent intravenous hypnotic agent which is widely used for the induction and maintenance of anesthesia and for sedation in the intensive care unit. Propofol is an oil at room temperature and insoluble in aqueous solution. Present formulations consists of 1% or 2% (w/v) propofol, ...

journal_title：Current pharmaceutical design

authors： Marik PE

更新日期：2004-01-01 00:00:00

abstract：:Nonalcoholic fatty liver disease (NAFLD) is rapidly becoming the most common cause of chronic liver disease worldwide. This is primarily driven by the global epidemic of obesity and diabetes as well as the aging of the general population. Most of the epidemiology data of NAFLD for North America are published from stud...

journal_title：Current pharmaceutical design

authors： Arshad T,Golabi P,Henry L,Younossi ZM

更新日期：2020-01-01 00:00:00

abstract：:Sulphur mustard (SM; (2, 2'-dichloroethylsulfide)) was used for the first time in 1917, during the World War I. SM mainly induces DNA damage, oxidative stress, and inflammation. This compound injures the respiratory system, eyes, skin and the endocrine, gastrointestinal, and hematopoietic systems. However, due to the ...

journal_title：Current pharmaceutical design

authors： Panahi Y,Shahbazi A,Naderi M,Jadidi K,Sahebkar A

更新日期：2018-01-01 00:00:00

abstract：:Vascular smooth muscle cells (VSMC) respond to arterial wall injury by intimal proliferation and play a key role in atherogenesis by proliferating and migrating excessively in response to repeated injury, such as hypertension and atherosclerosis. In contrast, fully differentiated, quiescent VSMC allow arterial vasodil...

journal_title：Current pharmaceutical design

authors： Isenović ER,Soskić S,Trpković A,Dobutović B,Popović M,Gluvić Z,Putniković B,Marche P

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:A high dietary intake of polyphenols has been associated with a reduced cardiovascular mortality, due to their antioxidant properties. However, growing evidence suggests that counteracting oxidative stress in cardiovascular disease might also reduce sympathetic nervous system overactivity. METHODS:This arti...

journal_title：Current pharmaceutical design

authors： Bruno RM,Ghiadoni L

更新日期：2018-01-01 00:00:00

abstract：:Muscarinic acetylcholine receptors mediate diverse physiological functions. At present, five receptor subtypes (M(1) - M(5)) have been identified. The odd-numbered receptors (M(1), M(3), and M(5)) are preferentially coupled to G(q/11) and activate phospholipase C, which initiates the phosphatidylinositol trisphosphate...

journal_title：Current pharmaceutical design

authors： Ishii M,Kurachi Y

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:Loss of olfaction can cause noticeable reduction in general quality of life. Only a small portion of patients with olfactory loss respond to current medications. Thus, development of novel therapeutic strategies seems to be necessary. Looking into traditional medical knowledge can be of great value in addres...

journal_title：Current pharmaceutical design

authors： Sinaei F,Emami SA,Sahebkar A,Javadi B

更新日期：2017-01-01 00:00:00

abstract：:Electropulsation (electroporation) is a physical method for delivery of various molecules into the cells in vitro and in vivo. It is an expanding field due to its applicability in cancer therapy, where combined application of electric pulses and chemotherapeutic drugs is used for treatment of cutaneous and subcutaneou...

journal_title：Current pharmaceutical design

authors： Cemazar M,Golzio M,Sersa G,Rols MP,Teissié J

更新日期：2006-01-01 00:00:00

abstract：:The organ shortage for kidney transplantation remains a challenging issue worldwide. Incompatibility between donor-recipient pairs, commonly occurring among transplant candidates who were sensitized from prior antigen exposure, serves as a significant barrier to kidney transplantation. In efforts to overcome this obst...

journal_title：Current pharmaceutical design

authors： Mustian MN,Locke JE

更新日期：2020-01-01 00:00:00

abstract：:Bisphosphonates are widely use for pathologies such as osteoporosis, Paget's disease or bone metastasis. However, their potent antiresorptive properties open new therapeutic opportunities for other conditions associated with an increased focal or systemic bone remodelling. Moreover, apart from their antiresorptive act...

journal_title：Current pharmaceutical design

authors： Le Goff B,Berthelot JM,Maugars Y,Romas E

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Bio-soft material, a class of derivatives of the natural or synthetic material, is getting more and more prevalent in biomedical researches and applications due to the advantages such as in-vivo biodegradation, good water solubility and designable targeting ability. With the presence of bio-sof...

journal_title：Current pharmaceutical design

authors： Chen N,Su T,Cheng Z,An F

更新日期：2018-01-01 00:00:00

abstract：:Resveratrol (3,5,4'-trihydroxy-trans-stilbene) is a non-flavonoid polyphenol that may be present in a limited number of foodstuffs such as grapes and red wine. Resveratrol has been reported to exert a plethora of health benefits through many different mechanisms of action. This versatility and presence in the human di...

journal_title：Current pharmaceutical design

authors： Tomé-Carneiro J,Larrosa M,González-Sarrías A,Tomás-Barberán FA,García-Conesa MT,Espín JC

更新日期：2013-01-01 00:00:00

abstract：:CD1 molecules are a family of non-polymorphic, class I antigen-presenting glycoproteins, which bind and present amphiphilic lipid antigens for recognition to T cells. Two groups of CD1 molecules are involved in presentation of self and foreign lipid antigens: group 1 (CD1a, CD1b and CD1c) and group 2 (CD1d). Crystal s...

journal_title：Current pharmaceutical design

authors： Schiefner A,Wilson IA

更新日期：2009-01-01 00:00:00

abstract：:Effective blood pressure control with a large arsenal of conventional antihypertensive drugs, such as diuretics, beta-adrenergic blockers, and calcium channel blockers, significantly reduce the morbidity and mortality associated with cardiovascular disease. However, blood pressure control with these drugs does not red...

journal_title：Current pharmaceutical design

authors： Igic R,Behnia R

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:Stroke represent one of the most devastating of all neurological diseases, affecting about 15 million people per year and is an important cause of morbidity and mortality worldwide and currently the leading cause of adult disability in developed countries. Blood pressure and heart rate may undergo several mo...

journal_title：Current pharmaceutical design

authors： Maida C,Tuttolomondo A,Di Raimondo D,Daidone M,Pinto A

更新日期：2017-01-01 00:00:00

abstract：:The review examines the multifaceted interactions between cholinergic transmission and beta-amyloid suggesting a continuum in the action of the peptide that at low concentrations (picomolar-low nanomolar) may directly stimulate nicotinic cholinergic receptor while desensitizing them at increasing concentrations (high ...

journal_title：Current pharmaceutical design

authors： Govoni S,Mura E,Preda S,Racchi M,Lanni C,Grilli M,Zappettini S,Salamone A,Olivero G,Pittaluga A,Marchi M

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Radix Stephaniae Tetrandrine (RST), known as FangJi (Pinyin name) in Chinese, is the dried root of Stephania tetrandra S.Moore, and has been prescribed in combination with other herbs to treat cardiovascular diseases and breast cancer in traditional Chinese medicine (TCM) clinical trials. OBJECTIVE:The aim ...

journal_title：Current pharmaceutical design

authors： Guo Y,Chen B,Pei X,Zhang D

更新日期：2020-01-01 00:00:00