Writers and Erasers of Histone Lysine methylation with Clinically Applied Modulators: Promising Target for Cancer Therapy.

abstract：:Over the last years a number of reports have described elevated numbers of regulatory T (Treg) cells inside of tumors, in close proximity of the tumor, draining lymph nodes and also in peripheral blood of patients with solid tumors and hematologic malignancies. There is increasing evidence that Treg cells can migrate ...

journal_title：Current pharmaceutical design

authors： Beyer M,Schultze JL

更新日期：2009-01-01 00:00:00

abstract：:Cardiovascular disease (CVD) is one of the major lifestyle associated disorders and leading causes of death worldwide. The incidence of CVD in diabetic patients has increased up to 3 folds and it became the major risk for diabetes associated morbidity and mortality. Insulin resistance and oxidative stress both play a ...

journal_title：Current pharmaceutical design

authors： Bagul PK,Banerjee SK

更新日期：2013-01-01 00:00:00

abstract：:Asthma is an allergic disease that affects approximately 300 million people worldwide. Two of its phenotypes routinely assessed at the clinic include airway hyperresponsiveness and IgE production. They can be measured in a non-invasive manner and have been used for genetic studies. The genetic complexity of asthma and...

journal_title：Current pharmaceutical design

authors： Kanagaratham C,Radzioch D

更新日期：2016-01-01 00:00:00

abstract：:Infections are the most common inflammatory triggers and acute and chronic infections have been associated with the development and progression of atherosclerotic disease raising interest in the infectious hypothesis of atherosclerosis. Pathogens have been identified in atherosclerotic plaques and large epidemiologica...

journal_title：Current pharmaceutical design

authors： Charakida M,Tousoulis D

更新日期：2013-01-01 00:00:00

abstract：:Nucleosides constitute an extensive group of natural and chemically modified compounds that display a wide range of structures and activities. Different biocatalysts have been developed for their preparation, but the choice of commercially available enzymes is limited. Therefore, the search of new biocatalysts is part...

journal_title：Current pharmaceutical design

authors： Lewkowicz ES,Iribarren AM

更新日期：2017-10-11 00:00:00

abstract：BACKGROUND:The use of essential oils is receiving increasing attention worldwide, as these oils are good sources of several bioactive compounds. Nowadays essential oils are preferred over synthetic preservatives thanks to their antioxidant and antimicrobial properties. Several studies highlight the beneficial effect of...

journal_title：Current pharmaceutical design

authors： Ferrentino G,Morozova K,Horn C,Scampicchio M

更新日期：2020-01-01 00:00:00

abstract：:Tumor metastasis is an important prognostic factor regarding long-term survival rate of cancer patients. At present, no imaging modality or technique is ideal for diagnosis of metastases. Molecular imaging has provided a fantastic tool for tumor metastases imaging. Based on the current medical imaging tools such as ma...

journal_title：Current pharmaceutical design

authors： Qiao R,Zhu R,Gao M

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Arterial hypertension (AH) and peripheral arterial disease (PAD) frequently coincide. While significant attention is paid to AH, PAD is often underestimated. It is known that both AH and PAD present high cardiovascular risks for ischemic events. To date, the use of the most common anti-hypertensive drugs in ...

journal_title：Current pharmaceutical design

authors： Signorelli SS

更新日期：2017-01-01 00:00:00

abstract：:Reactive oxygen species (ROS), as well as reactive nitrogen species (RNS) play either harmful or beneficial role in biological systems. Beneficial effects of ROS include physiological roles in cellular responses against infectious agents and in several cellular signalling pathways. Harmful effects are due to high conc...

journal_title：Current pharmaceutical design

authors： Balsano C,Alisi A

更新日期：2009-01-01 00:00:00

abstract：:Ras is a 21 kDa membrane-localized G protein that is coupled to receptor and non-receptor tyrosine kinase activation of downstream cytoplasmic and nuclear events. Mutated ras genes are common, and occur in a wide variety of human malignancies. These activating mutations result in constitutive signaling, thereby stimul...

journal_title：Current pharmaceutical design

authors： Adjei AA

更新日期：2001-11-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:The 3' repair exonuclease 1 (TREX1) gene is the major DNA-specific 3'-5 'exonuclease of mammalian cells which reduces single- and double-stranded DNA (ssDNA and dsDNA) to prevent undue immune activation mediated by the nucleic acid. TREX1 is also a crucial suppressor of selfrecognition that pr...

journal_title：Current pharmaceutical design

authors： Tao SS,Wu GC,Zhang Q,Zhang TP,Leng RX,Pan HF,Ye DQ

更新日期：2019-01-01 00:00:00

abstract：:Biochemical biomarkers are important candidates for the diagnosis and prognosis of neurological diseases of autoimmune etiology, since they may reflect the presence, nature and intensity of certain immune responses caused by both genetic and environmental processes. Different body fluids such as cerebrospinal fluid (C...

journal_title：Current pharmaceutical design

authors： Tumani H,Brettschneider J

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Discovery and development of BCS class 1 drugs through high throughput screening is one of the biggest challenge faced by formulation scientist. METHODS:There are a number of approaches that have been exploited to enhance the solubility and permeability of drugs. Among them, development of nanosuspension ha...

journal_title：Current pharmaceutical design

authors： Arora D,Khurana B,Rath G,Nanda S,Goyal AK

更新日期：2018-01-01 00:00:00

abstract：:In recent years several new drugs (oxcarbazepine, lamotrigine, topiramate, gabapentin, zonisamide, tiagabine, fosphenytoin, vigabatrin and felbamate) have been added to the therapeutic armamentarium against epilepsy. Some of these represent structural modifications of pre-existing compounds, others were developed with...

journal_title：Current pharmaceutical design

authors： Gatti G,Bonomi I,Jannuzzi G,Perucca E

更新日期：2000-05-01 00:00:00

abstract：:Agitation is commonly seen in acute schizophrenic patients and core symptoms include a wide range of symptom. It requires rapid and effective treatment approaches in order to protect patient and caregiver from potential injury. Clinician's decision of pharmacological treatment should be individualized to the needs and...

journal_title：Current pharmaceutical design

authors： San L,Arranz B,Escobar R

更新日期：2005-01-01 00:00:00

abstract：:Cyclooxygenase-1 (COX-1) derived eicosanoids promote gastroprotective mucosal defenses and induce platelet aggregation. By sparing COX-1, COX-2 specific inhibitors provide effective anti-inflammatory and analgesic activity while substantially reducing the risk of peptic ulcer disease and GI bleeding compared to dual C...

journal_title：Current pharmaceutical design

authors： Scheiman JM

更新日期：2003-01-01 00:00:00

abstract：:Gene delivery, a process of introducing foreign functional nucleic acids into target cells, has proven to be a very promising tool for inducing specific gene expression in host cells. Many different technologies have been developed for efficient gene delivery. Among them, electroporation has been adopted in gene deliv...

journal_title：Current pharmaceutical design

authors： Yang Z,Chang L,Chiang CL,Lee LJ

更新日期：2015-01-01 00:00:00

abstract：PURPOSE:The emerging evidence has recently shown an evident dependence between recently identified salusin peptides and atherosclerosis, and their important roles as endogenous modulators of atherogenesis. It was reported that the development of atherosclerosis could also be affected by endogenous salusin- β overproduc...

journal_title：Current pharmaceutical design

authors： Kołakowska U,Kuroczycka-Saniutycz E,Olański W,Wasilewska A

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:Nuts have been an indispensable component of the human diet for hundreds because of their unique nutrient composition and are thought to play a beneficial part in the prevention of cardiovascular diseases. OBJECTIVE:To evaluate the extent, validity and presence of evidence for studies investigating the impa...

journal_title：Current pharmaceutical design

authors： Schwingshackl L,Hoffmann G,Missbach B,Stelmach-Mardas M,Boeing H

更新日期：2017-01-01 00:00:00

abstract：:No-reflow, i.e., the lack of distal myocardial perfusion to fully recover following recanalization of an acutely occluded coronary artery, is not only a mere consequence of ischemic injury, as substantial microvascular alterations may also develop subsequently, after initial restoration of perfusion. Since part of per...

journal_title：Current pharmaceutical design

authors： Tritto I,Zuchi C,Vitale S,Ambrosio G

更新日期：2013-01-01 00:00:00

abstract：:Several diseases of the heart have been linked to an insufficient ability to generate enough energy (ATP) to sustain proper heart function. Hyperpolarized magnetic resonance (MR) is a novel technique that can visualize and quantify myocardial energy metabolism. Hyperpolarization enhances the MR signal from a biologica...

journal_title：Current pharmaceutical design

authors： Lauritzen MH,Sogaard LV,Madsen PL,Ardenkjaer-Larsen JH

更新日期：2014-01-01 00:00:00

abstract：:Inhibition of carbonic anhydrase (CA, EC 4.2.1.1) isoforms present in the eyes (CA I, II, IV and XII), with sulfonamides such as acetazolamide, methazolamide, ethoxzolamide and dichlorophenamide, is still widely used for the systemic treatment of glaucoma. The mechanism of action of these drugs consists in inhibition ...

journal_title：Current pharmaceutical design

authors： Mincione F,Scozzafava A,Supuran CT

更新日期：2008-01-01 00:00:00

abstract：:Psychoneuroimmunology is a relatively young field of research that investigates interactions between central nervous and immune system. The brain modulates the immune system by the endocrine and autonomic nervous system. Vice versa, the immune system modulates brain activity including sleep and body temperature. Based...

journal_title：Current pharmaceutical design

authors： Ziemssen T

更新日期：2012-01-01 00:00:00

abstract：:The concept that the gut microbiota plays a major role in the development of pouchitis in ulcerative colitis patients after restorative proctocolectomy with ileal pouch-anal anastomosis, is widely accepted and supported by a widespread use of some antibiotics (metronidazole and/or ciprofloxacin, rifaximin) to treat th...

journal_title：Current pharmaceutical design

authors： Guslandi M

更新日期：2014-01-01 00:00:00

abstract：:Virtual screening, especially the structure-based virtual screening, has emerged as a reliable, cost-effective and time-saving technique for the discovery of lead compounds. Here, the basic ideas and computational tools for virtual screening have been briefly introduced, and emphasis is placed on aspects of recent dev...

journal_title：Current pharmaceutical design

authors： Hou T,Xu X

更新日期：2004-01-01 00:00:00

abstract：:Cardiovascular diseases remain the leading cause of morbidity and mortality among postmenopausal women in western societies. There are still no specific and highly efficient methods of preservation of women's vascular health in modern preventive medicine. For many years physicians have assumed that hormone replacement...

journal_title：Current pharmaceutical design

authors： Sobenin IA,Myasoedova VA,Orekhov AN

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:In the field of forensic toxicology, the quality of analytical methods is of great importance to ensure the reliability of results and to avoid unjustified legal consequences. A key to high quality analytical methods is a thorough method development. METHODS:The presented article will provide an overview on...

journal_title：Current pharmaceutical design

authors： Peters FT,Wissenbach DK,Busardo FP,Marchei E,Pichini S

更新日期：2017-01-01 00:00:00

abstract：:Marine fungi with their successful pharmacological effects were considered to be the treasure of ocean medicines concerning the striking ability of their secondary metabolites. Literature over literature has been published on fungi derived bioactive molecules to probe its therapeutic potential. Marine fungi have an im...

journal_title：Current pharmaceutical design

authors： Shams Ul Hassan S,Ishaq M,Zhang WD,Jin HZ

更新日期：2020-07-28 00:00:00

abstract：:Many therapeutically active medications have significant side effects, some of which can compromise the intended therapeutic goal. The development of plasma lipid abnormalities or a dyslipidemia as the result of a medication intended for an unrelated effect has been reported. Human immunodeficiency virus (HIV) infecti...

journal_title：Current pharmaceutical design

authors： Whayne TF,Mukherjee D

更新日期：2014-01-01 00:00:00

abstract：:The present mini review offers a brief overview on the preparation and modification of gold nanomaterials (AuNMs) designed for biomedical applications, including biosensors, bioimaging, phototherapy and importantly gene/drug delivery. As biocompatibility is a prerequisite for safe pharmaceutical application, the poten...

journal_title：Current pharmaceutical design

authors： Rossi M,Pina CD,Falletta E

更新日期：2016-01-01 00:00:00