Regulatory T cells: major players in the tumor microenvironment.

abstract：BACKGROUND:Tissue engineering (TE) is a promising solution for orthopaedic diseases such as bone or cartilage defects and bone metastasis. Cell culture in vitro and scaffold fabrication are two main parts of TE, but these two methods both have their own limitations. The static cell culture medium is unable to achieve m...

journal_title：Current pharmaceutical design

authors： Wang L,Jiang D,Wang Q,Wang Q,Hu H,Jia W

更新日期：2018-01-01 00:00:00

abstract：:All common contributing factors to epilepsy such as trauma, malignancies and infections are accompanied by different levels of central nervous system inflammation that in turn have been associated with the occurrence of seizure. Emerging data from human brain tissue and experimental models of epilepsy support the prop...

journal_title：Current pharmaceutical design

authors： Lorigados Pedre L,Morales Chacón LM,Orozco Suárez S,Pavón Fuentes N,Estupiñán Díaz B,Serrano Sánchez T,García Maeso I,Rocha Arrieta L

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Cancer is a set of diseases formed by abnormal growth of cells leading to the formation of the tumor. The diagnosis can be made through symptoms' evaluation or imaging tests, however, the techniques are limited and the tumor detection may be late. Thus, pharmaceutical nanotechnology has emerged to optimize t...

journal_title：Current pharmaceutical design

authors： do Nascimento T,Tavares M,Monteiro MSSB,Santos-Oliveira R,Todeschini AR,de Souza VT,Ricci-Júnior E

更新日期：2020-01-01 00:00:00

abstract：:The mechanisms and factors causing or influencing degenerative diseases require tailor-made solutions. Natural polysaccharides are among the most versatile building units of the novel drug delivery systems. Their properties can be easily tailored to specific needs because they depend not only on the first-order struct...

journal_title：Current pharmaceutical design

authors： Karewicz A,Bielska D,Nowakowska M

更新日期：2012-01-01 00:00:00

abstract：:In the early 1980s, an "atypical" beta-adrenergic receptor was discovered and subsequently called the beta (3)-adrenoceptor (beta(3)-AR). Agonists of the beta(3)-AR were observed to simultaneously increase lipolysis, fat oxidation, energy expenditure and insulin action leading to the belief that this receptor might se...

journal_title：Current pharmaceutical design

authors： de Souza CJ,Burkey BF

更新日期：2001-09-01 00:00:00

abstract：:Development of effective drug delivery systems is important for medicine and healthcare. Polymer particulates (micro- and nanoparticles) have opened new opportunities in the field of drug delivery by overcoming various limitations of conventional delivery methods. The properties of polymeric particles can be readily t...

journal_title：Current pharmaceutical design

authors： Kaur H,Kumar V,Kumar K,Rathor S,Kumari P,Singh J

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:According to the World Health Organization (WHO), diabetes mellitus is considered the 7th leading cause of death as of 2016, while almost half of all deaths related to high blood glucose occur before the age of 70. According to the 2019 American Diabetes Association's (ADA) guidelines, metformin is the first...

journal_title：Current pharmaceutical design

authors： Gillani SW,Moosvi AF

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:Neuroanatomical abnormalities, including cingulate cortex volume abnormalities, are a common feature in psychosis. However, the extent to which these are related to a vulnerability to psychosis, as opposed to the disorder per se, is less certain. AIM UND HYPOTHESES: The aim of the present study is to compare...

journal_title：Current pharmaceutical design

authors： Röthlisberger M,Riecher-Rössler A,Aston J,Fusar-Poli P,Radü EW,Borgwardt S

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Dietary supplements have been widely used among the United States of America (USA) and the European Union (EU) population not only as a form of nutrition but also for medicinal purposes. Still, the legislation regulating these supplements remains unclear due to the fact that they can be considered as foodstu...

journal_title：Current pharmaceutical design

authors： Pereira C,Barros L,Ferreira ICFR

更新日期：2017-01-01 00:00:00

abstract：:Inflammation is a complex pathological condition associated with exaggerated human immune system involving various activated immune cells and bio-molecules. Treatment of inflammatory diseases particularly chronic inflammatory diseases such as rheumatoid arthritis, inflammatory bowel disease etc. has been a big challen...

journal_title：Current pharmaceutical design

authors： Kulkarni RG,Achaiah G,Sastry GN

更新日期：2006-01-01 00:00:00

abstract：:Alzheimer's disease (AD) is the most common form of dementia in the elderly. Research focused on identifying compounds that restore cognition and memory in AD patients is a very active investigational pursuit, but unfortunately, it has been only successful in terms of developing symptomatic treatments. Aβ deposition a...

journal_title：Current pharmaceutical design

authors： Solas M,Puerta E,Ramirez MJ

更新日期：2015-01-01 00:00:00

abstract：:The triggering receptor expressed on myeloid cells (TREM)-1 is a member of the Ig-like immunoregulatory receptor family and a major amplifier of innate immune responses. TREM- 1 has been implicated in the development and perpetuation of a number of inflammatory disorders, and soluble TREM-1 levels are a clinically val...

journal_title：Current pharmaceutical design

authors： Bosco MC,Raggi F,Varesio L

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Familial Hypercholesterolaemia (FH) is an autosomal-dominant genetic disease and represents the most common genetic disorder: heterozygous 1/250 births, homozygous 1/300, 000 births. FH is characterized by high to very high low-density lipoprotein cholesterol (LDL-C), which is the main cause of increased inc...

journal_title：Current pharmaceutical design

authors： Viigimaa M,Heinsar S,Lovic D,Katsimardou A,Piperidou A,Duishvili D

更新日期：2018-01-01 00:00:00

abstract：:CD1 molecules are a family of non-polymorphic, class I antigen-presenting glycoproteins, which bind and present amphiphilic lipid antigens for recognition to T cells. Two groups of CD1 molecules are involved in presentation of self and foreign lipid antigens: group 1 (CD1a, CD1b and CD1c) and group 2 (CD1d). Crystal s...

journal_title：Current pharmaceutical design

authors： Schiefner A,Wilson IA

更新日期：2009-01-01 00:00:00

abstract：:Inhibition of carbonic anhydrase (CA, EC 4.2.1.1) isoforms present in the eyes (CA I, II, IV and XII), with sulfonamides such as acetazolamide, methazolamide, ethoxzolamide and dichlorophenamide, is still widely used for the systemic treatment of glaucoma. The mechanism of action of these drugs consists in inhibition ...

journal_title：Current pharmaceutical design

authors： Mincione F,Scozzafava A,Supuran CT

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:Neglected tropical diseases (NTDs) represent a serious problem in a number of countries around the world and especially in Africa and South America, affecting mostly the poor population which has limited access to the healthcare system. The drugs currently used for the treatment of NTDs are dated many decade...

journal_title：Current pharmaceutical design

authors： Chazapi E,Magoulas GE,Prousis KC,Calogeropoulou T

更新日期：2020-12-09 00:00:00

abstract：:Doxorubicin has been a constituent of antitumor drug protocols for a broad spectrum of cancers for more than two decades. Side effects and resistance continue to be important limitations. Drug targets responsible for both side effects and anti-tumor activity are cell membrane receptors, cell membrane lipids, nucleic a...

journal_title：Current pharmaceutical design

authors： Taatjes DJ,Fenick DJ,Gaudiano G,Koch TH

更新日期：1998-06-01 00:00:00

abstract：:Cardiovascular disease (CVD) is one of the major lifestyle associated disorders and leading causes of death worldwide. The incidence of CVD in diabetic patients has increased up to 3 folds and it became the major risk for diabetes associated morbidity and mortality. Insulin resistance and oxidative stress both play a ...

journal_title：Current pharmaceutical design

authors： Bagul PK,Banerjee SK

更新日期：2013-01-01 00:00:00

abstract：:The most important glycoproteins of trypanosomatids are anchored by glycoinositolphospholipids (GIPLs) to their plasma membrane. In addition, free GIPLs have been described, for instance the lipopeptidophosphoglycan (LPPG) which is a major component of the surface of T. cruzi epimastigotes. An inositolphosphoceramide ...

journal_title：Current pharmaceutical design

authors： Lederkremer RM,Bertello LE

更新日期：2001-08-01 00:00:00

abstract：:Growth factors (GFs) are extracellular signaling polypeptides regulating cell proliferation, differentiation and survival. They exert a wide spectrum of biological activities selectively binding to and activating specific membrane receptors which then transfer the message to cell interior inducing specific biochemical...

journal_title：Current pharmaceutical design

authors： D'Andrea LD,Del Gatto A,De Rosa L,Romanelli A,Pedone C

更新日期：2009-01-01 00:00:00

abstract：AIM:The effect of endovascular aneurysm repair in patients treated for abdominal aortic aneurysm has not been clearly defined. The objective of the present article was to provide a contemporary literature review and perform an analysis to determine the effect of EVAR on renal function in the early post-operative period...

journal_title：Current pharmaceutical design

authors： Nana P,Kouvelos G,Brotis A,Spanos K,Giannoukas A,Matsagkas M

更新日期：2019-01-01 00:00:00

abstract：:Nonalcoholic fatty liver disease (NAFLD) affects about 20%-30% of the general population, and its clinical relevance arises from the fact that 20%-30% of these subjects develop non-alcoholic steatohepatitis (NASH), a condition at risk of cirrhosis progression. In addition NAFLD, and in particular NASH patients, are al...

journal_title：Current pharmaceutical design

authors： Petta S,Handberg A,Craxì A

更新日期：2013-01-01 00:00:00

abstract：:There is extensive evidence that changes in immune system activation accompany the pathological changes of Alzheimer's disease (AD), but a mechanistic understanding of how the immune system actually participates in disease pathogenesis is still largely lacking. Because of the complexity of the immunological response, ...

journal_title：Current pharmaceutical design

authors： Nelson RB

更新日期：2005-01-01 00:00:00

abstract：:The integrin family of cell surface receptors were principally thought to be involved in cell adhesion. Intense study has shown that these glycoproteins also regulate a diverse range of physiological processes. Inappropriate activation of integrins has been implicated in many pathological processes. Recent studies hav...

journal_title：Current pharmaceutical design

authors： Robertson JH,Iga AM,Sales KM,Winslet MC,Seifalian AM

更新日期：2008-01-01 00:00:00

abstract：:Severe asthma is a complex heterogeneous disease with substantial unmet clinical need. Understanding the immunopathogenesis is likely to provide insights into potential novel therapies. To date researchers have focussed primarily at a single scale for example genome, cell or whole organ physiology. In this review we s...

journal_title：Current pharmaceutical design

authors： Brightling CE,Gupta S,Hollins F,Sutcliffe A,Amrani Y

更新日期：2011-01-01 00:00:00

abstract：:Parkinson's disease (PD) is a common neurodegenerative disorder characterized by cardinal features of tremor, bradykinesia, rigidity and postural instability. In addition to the motor symptoms patients experience cognitive decline eventually resulting in severe disability. Pathologically PD is characterized by neurode...

journal_title：Current pharmaceutical design

authors： Thomas M,Le WD

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND:Casein kinase II (CK2) is a pro-oncogenic protein, which is emerging as a promising therapeutic target in cancer. Recent studies have revealed an important role for CK2 in tumorigenesis. High levels of CK2 are noted in many malignancies including leukemia. Use of CK2 inhibitors in various malignancies includ...

journal_title：Current pharmaceutical design

authors： Gowda C,Sachdev M,Muthusami S,Kapadia M,Petrovic-Dovat L,Hartman M,Ding Y,Song C,Payne JL,Tan BH,Dovat S

更新日期：2017-01-01 00:00:00

abstract：:Oncology remains an increasingly important focus of therapeutic development yet there remain many scientific and operational bottlenecks to deliver optimum treatments efficiently. Radiopharmaceuticals constitute a group of methodologies able to support the many stages of drug development. Methods such as [(18)F]-FDG-P...

journal_title：Current pharmaceutical design

authors： Murphy PS,Bergström M

更新日期：2009-01-01 00:00:00

abstract：:1, 2-Distearoyl-sn-glycero-3-phosphoethanolamine-Poly(ethylene glycol) (DSPE- PEG) is a widely used phospholipids-polymer conjugate in drug delivery applications. It is a biocompatible, biodegradable and amphiphilic material which can also be functionalized with various biomolecules for specific functions. With the em...

journal_title：Current pharmaceutical design

authors： Che J,Okeke CI,Hu ZB,Xu J

更新日期：2015-01-01 00:00:00

abstract：:Colchicine is a lipophilic alkaloid drug, which exhibits ant-inflammatory and anti-fibrotic properties. Cardinal mechanisms of action of colchicine are the disruption of the microtubule system and the inhibition of neutrophil adhesion and recruitment. Colchicine is indicated in the prevention and treatment of gouty ar...

journal_title：Current pharmaceutical design

authors： Marinaki S,Skalioti C,Boletis JN

更新日期：2018-01-01 00:00:00