Abstract:
:Many therapeutically active medications have significant side effects, some of which can compromise the intended therapeutic goal. The development of plasma lipid abnormalities or a dyslipidemia as the result of a medication intended for an unrelated effect has been reported. Human immunodeficiency virus (HIV) infection can cause dyslipidemia as can the medications used to treat this infection. Such dyslipidemia can be a significant problem made more relevant by the already increased risk of cardiovascular (CV) disease faced by these patients. Some hypoglycemic medications used to treat diabetes can also be associated with dyslipidemia, most notably rosiglitazone. Antihypertensive medications are intended to decrease CV risk but are not free of dyslipidemia problems with thiazides able to cause hypertriglyceridemia and older beta-blockers without an alpha-blocking effect associated with moderate plasma lipid abnormalities and altered glucose metabolism. Estrogen administered orally can be associated with a severe hypertriglyceridemia. Currently-used antipsychotic medications have a significant association with hypertriglyceridemia. Clinicians must be aware of the dyslipidemias caused by these medications and know how to manage them, even treating a secondary dyslipidemia with another medication as in the case of HIV infection rather than trying to switch treatment of the infection in many cases. Mention is also made of lipid lowering effects of medications intended for other purposes (e.g. angiotensin receptor blockers and orlistat).
journal_name
Curr Pharm Desjournal_title
Current pharmaceutical designauthors
Whayne TF,Mukherjee Ddoi
10.2174/1381612820666140620163023subject
Has Abstractpub_date
2014-01-01 00:00:00pages
6325-38issue
40eissn
1381-6128issn
1873-4286pii
CPD-EPUB-61084journal_volume
20pub_type
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journal_title:Current pharmaceutical design
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doi:10.2174/1381612013398491
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journal_title:Current pharmaceutical design
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journal_title:Current pharmaceutical design
pub_type: 杂志文章,评审
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journal_title:Current pharmaceutical design
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journal_title:Current pharmaceutical design
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journal_title:Current pharmaceutical design
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journal_title:Current pharmaceutical design
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journal_title:Current pharmaceutical design
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更新日期:2007-01-01 00:00:00
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journal_title:Current pharmaceutical design
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更新日期:2011-01-01 00:00:00
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journal_title:Current pharmaceutical design
pub_type: 杂志文章,评审
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更新日期:2004-01-01 00:00:00
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journal_title:Current pharmaceutical design
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journal_title:Current pharmaceutical design
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doi:10.2174/1381612825666190621155718
更新日期:2019-01-01 00:00:00
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journal_title:Current pharmaceutical design
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更新日期:2009-01-01 00:00:00
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journal_title:Current pharmaceutical design
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更新日期:2005-01-01 00:00:00
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journal_title:Current pharmaceutical design
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更新日期:2020-01-01 00:00:00
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journal_title:Current pharmaceutical design
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更新日期:2013-01-01 00:00:00
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journal_title:Current pharmaceutical design
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更新日期:2013-01-01 00:00:00
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journal_title:Current pharmaceutical design
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journal_title:Current pharmaceutical design
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doi:
更新日期:2013-01-01 00:00:00
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journal_title:Current pharmaceutical design
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更新日期:2019-01-01 00:00:00
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更新日期:2014-01-01 00:00:00
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更新日期:2006-01-01 00:00:00
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journal_title:Current pharmaceutical design
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abstract::The number of protein 3D structures without function annotation in Protein Data Bank (PDB) has been steadily increased. Many of these proteins are relevant for Pharmaceutical Design because they may be enzymes of different classes that could become drug targets. This fact has led in turn to an increment of demand for ...
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更新日期:2010-01-01 00:00:00