Cell therapy for the treatment of chronic ischemic heart disease.

abstract：:Mesenchymal Stem Cells (MSCs) are a population of adherent cells that can differentiate into mesenchymal lineage populations (cartilage, bone and fat tissue). In addition, they seem to be able to differentiate also into a broader type of lineages other than the original mesodermal germ layer. Bone marrow MSCs are a st...

journal_title：Current pharmaceutical design

authors： Mariani E,Facchini A

更新日期：2012-01-01 00:00:00

abstract：:Pro-rich antimicrobial peptides are a group of linear peptides of innate immunity isolated from mammals and invertebrates, and characterised by a high content of proline residues (up to 50%). Members of this group are predominantly active against Gram-negative bacterial species which they kill by a non-lytic mechanism...

journal_title：Current pharmaceutical design

authors： Gennaro R,Zanetti M,Benincasa M,Podda E,Miani M

更新日期：2002-01-01 00:00:00

abstract：:Clopidogrel, in combination wih aspirin, is currently the drug of choice to prevent thrombosis after coronary stent implantation. Currently, clopidogrel is administered to the vast majority of patients without any assessment of platelet inhibition. Response variability and resistance, however, definitely occur to clop...

journal_title：Current pharmaceutical design

authors： Gurbel PA,Lau WC,Bliden KP,Tantry US

更新日期：2006-01-01 00:00:00

abstract：:Opiates lack potent analgesic efficacy in neuropathic pain although it is now generally accepted that the poor effect of these drugs reflects a reduction in their potency. Reduction of morphine antinociceptive potency was postulated to be due to the fact that nerve injury altered the activity of opioid systems or opio...

journal_title：Current pharmaceutical design

authors： Przewlocki R,Przewlocka B

更新日期：2005-01-01 00:00:00

abstract：:Alzheimer disease (AD) is the leading cause of dementia among elderly. Currently, no effective treatment is available for AD. Analysis of transgenic mouse models of AD has facilitated our understanding of disease mechanisms and provided valuable tools for evaluating potential therapeutic strategies. In this review, we...

journal_title：Current pharmaceutical design

authors： Kitazawa M,Medeiros R,Laferla FM

更新日期：2012-01-01 00:00:00

abstract：:G protein receptor kinase 2 (GRK2) has been for years mainly considered the negative regulator of the cardiac β adrenergic signaling. However GRK2 is a ubiquitous molecule and its kinase activity and scaffold properties brought to several investigations which have evidenced its involvement in pathophysiology of extra-...

journal_title：Current pharmaceutical design

authors： Ciccarelli M,Cipolletta E,Iaccarino G

更新日期：2012-01-01 00:00:00

abstract：:Natural products, or their synthetic derivatives are a treasure trove to find potential candidates for novel drugs for human treatment. The selection of diamonds from the huge pile of worthless stone is a critical--and difficult--stage in the discovery pipeline. Of all the factors to be considered, perhaps the most im...

journal_title：Current pharmaceutical design

authors： Wrzesinski K,Fey SJ

更新日期：2015-01-01 00:00:00

abstract：:An integrative synthesis of concepts and an explosion of experimental and epidemiological findings allow new insights as to how the interactions of genetic, environmental, dietary, cultural (social, psychological, economic) factors can influence the aging and diseases of aging processes. Although the net effect of the...

journal_title：Current pharmaceutical design

authors： Trosko JE

更新日期：2008-01-01 00:00:00

abstract：:Atherosclerosis is a multifactorial and long-lasting process in humans. Therefore, animal models where more rapid changes occur can be useful for the study of this process. Among such models are the apolipoprotein (apo) E knock out mice. Apo E deficient mice show impaired clearing of plasma lipoproteins and they devel...

journal_title：Current pharmaceutical design

authors： Kolovou G,Anagnostopoulou K,Mikhailidis DP,Cokkinos DV

更新日期：2008-01-01 00:00:00

abstract：:Alzheimer's disease (AD) is the most common form of dementia in the elderly. Research focused on identifying compounds that restore cognition and memory in AD patients is a very active investigational pursuit, but unfortunately, it has been only successful in terms of developing symptomatic treatments. Aβ deposition a...

journal_title：Current pharmaceutical design

authors： Solas M,Puerta E,Ramirez MJ

更新日期：2015-01-01 00:00:00

abstract：:Ghrelin as a human natural hormone is involved in fundamental regulatory processes of eating and energy balance. Ghrelin signals the nutrient availability from the gastrointestinal tract to the central nervous system, up-regulates food intake and lowers energy expenditure mainly through hypothalamic mediators acting b...

journal_title：Current pharmaceutical design

authors： Strasser F

更新日期：2012-01-01 00:00:00

abstract：:Cumulative recent evidence from clinical trials, observational studies and case reports has shown that subcutaneous administration of immunoglobulin (SCIg) exerts similar immunomodulatory capacity than intravenous immunoglobulin (IVIg) in autoimmune neurological diseases. Besides the beneficial clinical effects, the p...

journal_title：Current pharmaceutical design

authors： Sanchez-Ramon S,Corbi AL,Fidalgo AG,Dominguez-Soto A

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Spice and spice-derived compounds have been identified and explored for their health benefits since centuries. One of the spice long pepper has been traditionally used to treat chronic bronchitis, asthma, constipation, gonorrhea, paralysis of the tongue, diarrhea, cholera, malaria, viral hepatitis, respirato...

journal_title：Current pharmaceutical design

authors： Prasad S,Tyagi AK

更新日期：2016-01-01 00:00:00

abstract：:Neurodegenerative disorders are one of the most critical public health concerns of our times. Regrettably, therapeutic interventions currently available have shown only partial benefits to patients affected by one of these disorders. Although the important advances made during the last decades, several questions regar...

journal_title：Current pharmaceutical design

authors： Bastias-Candia S,Garrido A N,Zolezzi JM,Inestrosa NC

更新日期：2016-01-01 00:00:00

abstract：:Alzheimer's disease (AD) is the most common neurodegenerative disorder that affects the elderly. The increase of life-expectancy is transforming AD into a major health-care problem. AD is characterized by a progressive impairment of memory and other cognitive skills leading to dementia. The major pathogenic factor ass...

journal_title：Current pharmaceutical design

authors： Agostinho P,Cunha RA,Oliveira C

更新日期：2010-01-01 00:00:00

abstract：:Psoriasis is an immune-mediated, chronic and recurrent inflammatory skin disease, prevalent worldwide, and represents an important burden in life quality of patients. The most common clinical variant is termed as psoriasis vulgaris or plaque psoriasis, which with an individualized and carefully monitored therapy can d...

journal_title：Current pharmaceutical design

authors： Bruschi ML,da Silva JB,Rosseto HC

更新日期：2019-01-01 00:00:00

abstract：:Nanogels are nanosized hydrogel particles formed by physical or chemical cross-linked polymer networks. The advantageous properties of nanogels related to the ability of retaining considerable amount of water, the biocompatibility of the polymers used, the ability to encapsulate and protect a large quantity of payload...

journal_title：Current pharmaceutical design

authors： Maya S,Sarmento B,Nair A,Rejinold NS,Nair SV,Jayakumar R

更新日期：2013-01-01 00:00:00

abstract：:The last decade, the number of health economic evaluations has increased substantially in the field of child psychiatry. The objective of the present paper is to offer an overview of economic evaluations of child psychiatric drug treatment. Major electronic databases, as well as abstract booklets from international cl...

journal_title：Current pharmaceutical design

authors： Schlander M

更新日期：2010-01-01 00:00:00

abstract：:The number of protein 3D structures without function annotation in Protein Data Bank (PDB) has been steadily increased. Many of these proteins are relevant for Pharmaceutical Design because they may be enzymes of different classes that could become drug targets. This fact has led in turn to an increment of demand for ...

journal_title：Current pharmaceutical design

authors： Concu R,Podda G,Ubeira FM,González-Díaz H

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:A mobile health application is an exciting, fast-paced domain that is likely to improve prenatal care. METHODS:In this narrative review, we summarise the use of mobile health applications in this setting with a special emphasis on both the benefits of remote monitoring devices and the potential pitfalls of ...

journal_title：Current pharmaceutical design

authors： Gyselaers W,Lanssens D,Perry H,Khalil A

更新日期：2019-01-01 00:00:00

abstract：:Metabolic syndrome is an aggregation of conditions and associated with an increased risk of developing diabetes, obesity and cardiovascular diseases (CVD). Edible mushrooms are widely consumed in many countries and are valuable components of the diet because of their attractive taste, aroma, and nutritional value. Med...

journal_title：Current pharmaceutical design

authors： Tung YT,Pan CH,Chien YW,Huang HY

更新日期：2020-01-01 00:00:00

abstract：:Human heart has endogenous regenerative capability; however, the intrinsic repair mechanism is not sufficient to overcome the impact placed by adverse pathological conditions, such as myocardial infarction (MI). In such circumstances, the damaged tissue initiates a series of remodeling process which results in the det...

journal_title：Current pharmaceutical design

authors： Joshi J,Kothapalli CR

更新日期：2015-01-01 00:00:00

abstract：:It is generally accepted that mitochondrial dysfunction and endoplasmic reticulum (ER) stress are related to insulin resistance and type 2 diabetes. Mitochondria use substrates from lipid and glucose metabolism in order to generate ATP, and when mitochondrial O2 consumption is decreased due to an altered metabolism th...

journal_title：Current pharmaceutical design

authors： Rocha M,Diaz-Morales N,Rovira-Llopis S,Escribano-Lopez I,Bañuls C,Hernandez-Mijares A,Diamanti-Kandarakis E,Victor VM

更新日期：2016-01-01 00:00:00

abstract：:The plants of the Colchicum family were known during the archaic period in Greece for their deleterious properties. Later on, they were used for the treatment of podagra. The treatment was introduced by the ancient Greek physicians and passed on to the Byzantine and Arabian physicians to endure until nowadays. The fir...

journal_title：Current pharmaceutical design

authors： Tsoucalas G,Papaioannou T,Panayiotakopoulos G,Saridaki Z,Vrachatis DA,Karamanou M

更新日期：2018-01-01 00:00:00

abstract：:More and more evidences are still accumulating rapidly on the G-protein-coupled-receptors (GPCRs) dimerization/oligomerization. Such common feature of GPCRs has called extensive attention to both pharmacologists and medicinal chemists for illustration of the pharmacological functions and therapeutic utilities of such ...

journal_title：Current pharmaceutical design

authors： Liu Z,Zhang J,Zhang A

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:R. Schofield (1978) proposed a hypothesis of hematopoietic stem cells (HSCs) niche (specialized cell microenvironment). An existence of osteoblastic and vascular niches for HSCs has been postulated since 2003. At the same time, the discussion about the existence and functioning of niche for multipotent mesen...

journal_title：Current pharmaceutical design

authors： Khlusov IA,Litvinova LS,Khlusova MY,Yurova KA

更新日期：2018-01-01 00:00:00

abstract：:The development of radioligands to image beta-amyloid (A beta) plaques and neurofibrillary tangles (NFTs) in vivo in the aging human brain is an important and active area of radiopharmaceutical design. When used in combination with positron emission tomography (Pet) or single photon emission computed tomography (spect...

journal_title：Current pharmaceutical design

authors： Mathis CA,Wang Y,Klunk WE

更新日期：2004-01-01 00:00:00

abstract：:ABO-incompatible (ABO-I) liver transplantation (LT) has been limited due to the increased rate of complications, including severe cellular and antibody-mediated rejection, hepatic necrosis, hepatic artery thrombosis, and biliary complications. However, several strategies for reducing preformed anti-donor ABO antibodie...

journal_title：Current pharmaceutical design

authors： Cheng CH,Lee CF,Wang YC,Wu TH,Wu TJ,Chou HS,Chan KM,Lee WC

更新日期：2020-01-01 00:00:00

abstract：:Membrane disrupting lytic peptides are abundant in nature and serve insects, invertebrates, vertebrates and humans as defense molecules. Initially, these peptides attracted attention as antimicrobial agents; later, the sensitivity of tumor cells to lytic peptides was discovered. In the last decade intensive research h...

journal_title：Current pharmaceutical design

authors： Leuschner C,Hansel W

更新日期：2004-01-01 00:00:00

abstract：:High molecular weight kininogen (HK) is a plasma protein that is cleaved by plasma kallikrein in the clinical settings of sepsis and chronic inflammatory diseases such as rheumatoid arthritis and Crohn's disease. This proteolytic event results in a nonapeptide, bradykinin (BK), and a kinin-free derivative of HK, namel...

journal_title：Current pharmaceutical design

authors： Colman RW

更新日期：2006-01-01 00:00:00