Good Practices in Forensic Toxicology.

Abstract:

:This manuscript provides an overview for analysts, medical and scientific investigators, and laboratory administrators, the range of factors that should be considered to implement best practice forensic toxicology. These include laboratory influence over the collection of specimens, their proper transport and chain-of-custody before arrival in the laboratory. In addition, the laboratory needs to ensure properly trained staff use suitably validated and documented analytical procedures that meet the intended purpose and type of case in an accredited or suitably quality oriented management system. To assist the investigating officers laboratory results require an interpretation over their possible significance when sufficient details are available over the circumstances of the case. This requires a thorough understanding of the various factors that influence concentrations of substances and ultimately their likely physiological effect. These include consideration of the route of ingestion, influence over chronicity of usage on tissue concentrations and tolerance, possible combined drug effects or likely adverse reactions and consideration of relevant genetic factors that may have influenced pharmacokinetic or pharmacodynamic response.

journal_name

Curr Pharm Des

authors

Drummer OH

doi

10.2174/1381612823666170704123836

subject

Has Abstract

pub_date

2017-01-01 00:00:00

pages

5437-5441

issue

36

eissn

1381-6128

issn

1873-4286

pii

CPD-EPUB-84476

journal_volume

23

pub_type

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