Abstract：
:Human heart has endogenous regenerative capability; however, the intrinsic repair mechanism is not sufficient to overcome the impact placed by adverse pathological conditions, such as myocardial infarction (MI). In such circumstances, the damaged tissue initiates a series of remodeling process which results in the deterioration of structural, functional, and mechanical properties of the myocardium. To address such adverse conditions, clinical approaches ranging from surgical interventions, pharmaceutical drugs, and device implantation are administered which have played significant role in reducing the mortality rate. However, these approaches do not replace the lost cardiomyocytes, or restore the degraded structure-function relationship of the myocardium. In this aspect, cell-based therapy has gained substantial interest as a potential clinical approach for myocardial regeneration; however this method is impeded by lower graft retention and poor cell viability. To overcome these limitations, biomaterials are being developed as "trojan horses", i.e., vehicles for homing and deploying cells, and as matrices for delivering specific biological, mechanical, and chemical cues intended for tissue regeneration. Similarly, several candidate drugs, potent synthetic and biological molecules, and advanced drug delivery systems are being examined to provide exogenous cues in a controlled fashion to the diseased myocardium. In this article, we review biomaterials-based drug delivery systems for myocardial regeneration, specifically on the applications of hydrogels, microgels, nanoparticles, and nanofibers in the field. The prime focus of the article is on nanofibers-based drug delivery systems that is gaining considerable attention as a biomimetic pharmacological approach. We highlight literature on fabrication methods of self-assembling and electrospun nanofibers, drug incorporation methods and release kinetics, and in vitro and in vivo outcomes from nanofiber-based drug delivery systems in cardiac regeneration.
journal_name
Curr Pharm Desjournal_title
Current pharmaceutical designauthors
Joshi J,Kothapalli CRdoi
10.2174/1381612821666150302153138subject
Has Abstractpub_date
2015-01-01 00:00:00pages
2006-20issue
15eissn
1381-6128issn
1873-4286pii
CPD-EPUB-65568journal_volume
21pub_type
杂志文章,评审abstract：:Muscarinic acetylcholine receptors mediate diverse physiological functions. At present, five receptor subtypes (M(1) - M(5)) have been identified. The odd-numbered receptors (M(1), M(3), and M(5)) are preferentially coupled to G(q/11) and activate phospholipase C, which initiates the phosphatidylinositol trisphosphate...
journal_title：Current pharmaceutical design
pub_type： 杂志文章,评审
doi：10.2174/138161206778522056
更新日期：2006-01-01 00:00:00
abstract：:The most important glycoproteins of trypanosomatids are anchored by glycoinositolphospholipids (GIPLs) to their plasma membrane. In addition, free GIPLs have been described, for instance the lipopeptidophosphoglycan (LPPG) which is a major component of the surface of T. cruzi epimastigotes. An inositolphosphoceramide ...
journal_title：Current pharmaceutical design
pub_type： 杂志文章,评审
doi：10.2174/1381612013397519
更新日期：2001-08-01 00:00:00
abstract：:Although the pathogenesis of inflammatory bowel disease (IBD) remains elusive, it appears that there is chronic activation of the immune and inflammatory cascade in genetically susceptible individuals. Current disease management guidelines have therefore focused on the use of anti-inflammatory agents, aminosalicylates...
journal_title：Current pharmaceutical design
pub_type： 杂志文章,评审
doi：10.2174/1381612033455035
更新日期：2003-01-01 00:00:00
abstract：:Adverse reactions after iodinate contrast media (ICM) administration have been observed, which can be classified as immediate (i.e., occurring within one hour after administration) and delayed or non-immediate (i.e., occurring more than one hour after administration). Even though the incidence of ICM adverse reactions...
journal_title：Current pharmaceutical design
pub_type： 杂志文章,评审
doi：10.2174/138161206778193999
更新日期：2006-01-01 00:00:00
abstract：:Catheter ablation for rhythm control in atrial fibrillation has been recognized as an established treatment. Patients with atrial fibrillation suffer from an increased risk of thromboembolic events. Long-term stroke risk and mortality have been shown to be reduced after catheter ablation, still the procedure per se is...
journal_title：Current pharmaceutical design
pub_type： 杂志文章,评审
doi：10.2174/1381612822666161205115101
更新日期：2017-01-01 00:00:00
abstract：:Cathepsin K, a cysteine protease of the papain family, was identified by sequencing complementary DNA libraries derived from osteoclasts. Cathepsin K can cleave bone proteins such as Type I collagen, osteopontin, and osteonectin. The localization and maturation of cathepsin K in activated osteoclasts have been charact...
journal_title：Current pharmaceutical design
pub_type： 杂志文章,评审
doi：10.2174/1381612003401569
更新日期：2000-01-01 00:00:00
abstract：:There is an increasing need to rapidly determine the specificity of proteases that potentially play a role in human and animal disease. Substrates for novel proteases can be discovered by testing standard protease substrates such as oxidized insulin B-chain, by screening commercially available substrates for other pro...
journal_title：Current pharmaceutical design
pub_type： 杂志文章,评审
doi：10.2174/1381612023392630
更新日期：2002-01-01 00:00:00
abstract：:Recent decades mark a great progress in the treatment of HIV infection. What was once a deadly disease is now a chronic infection. However, HIV-infected patients are prone to develop comorbidities, which severely affect their daily functions. For example, a large population of patients develop a variety of neurologica...
journal_title：Current pharmaceutical design
pub_type： 杂志文章,评审
doi：10.2174/1381612822666160726113001
更新日期：2016-01-01 00:00:00
abstract：BACKGROUND:Breast cancer is one of the leading cancers in women in the Western world. Cancer treatment, especially chemotherapy, is often associated with physical and psychosocial side effects. OBJECTIVE:To improve the quality of life and manage side effects, a new integrative mind-body-medicine group concept for brea...
journal_title：Current pharmaceutical design
pub_type： 杂志文章
doi：10.2174/1381612826666201211111122
更新日期：2020-12-10 00:00:00
abstract：BACKGROUND:Hepatocellular carcinoma (HCC) has high mortality partly due to acquiring drug resistance during chemotherapy treatment. Therefore, it is necessary to explore the underlying mechanism of drug resistance. METHODS:We used 2-DE and MALDI-TOF-MS analysis to explore the possible molecular insight into 5-FU resis...
journal_title：Current pharmaceutical design
pub_type： 杂志文章
doi：10.2174/138161282001140113125143
更新日期：2014-01-01 00:00:00
abstract：:Since identifying a transmissible agent responsible for tumorigenesis in chickens, the v-Src oncogene, significant progress has been made in determining the functions of its cellular homologue. c-Src is the product of the SRC gene and has been found both over-expressed and highly activated in a number of human cancers...
journal_title：Current pharmaceutical design
pub_type： 杂志文章,评审
doi：10.2174/1381612053507576
更新日期：2005-01-01 00:00:00
abstract：:Resveratrol (3,5,4'-trihydroxy-trans-stilbene) is a non-flavonoid polyphenol that may be present in a limited number of foodstuffs such as grapes and red wine. Resveratrol has been reported to exert a plethora of health benefits through many different mechanisms of action. This versatility and presence in the human di...
journal_title：Current pharmaceutical design
pub_type： 杂志文章,评审
doi：10.2174/13816128113199990407
更新日期：2013-01-01 00:00:00
abstract：:Although the cause of Crohn's disease remains unknown considerable progress has been made in recent years to unravel the pathogenesis of the inflammatory processes seen in chronic idiopathic inflammatory bowel diseases (IBD). Th-1 lymphocytes seem to orchestrate the inflammation through the production of pro-inflammat...
journal_title：Current pharmaceutical design
pub_type： 杂志文章,评审
doi：10.2174/1381612033391982
更新日期：2003-01-01 00:00:00
abstract：:In recent years, combination of different types of therapies using nanoparticles has emerged as an advanced strategy for cancer treatment. Most of all, combination of chemotherapeutic drug and siRNA in nanoformulation has shown a great potential, because siRNA-mediated specific gene silencing can compensate for the in...
journal_title：Current pharmaceutical design
pub_type： 杂志文章,评审
doi：10.2174/1381612821666150531165059
更新日期：2015-01-01 00:00:00
abstract：:Myelodysplastic syndromes (MDS) are a group of aquired hematopoietic disorders characterized by ineffective hematopoiesis, and increased risk of progression of acute myeloid leukemia. For a long period of time, the standard therapy for MDS was hematopoietic stem cell transplantation, however DNA methyltransferase inhi...
journal_title：Current pharmaceutical design
pub_type： 杂志文章,评审
doi：10.2174/1381612811209023204
更新日期：2012-01-01 00:00:00
abstract：BACKGROUND/OBJECTIVE:KRAS-mutant colorectal cancers (CRC) are tumors that are associated with poor prognosis. However, no effective treatments are available to target them. Therefore, we designed and synthesized novel chalcone analogs, small organic molecules, to investigate their effects on KRAS-mutant CRC cells. MET...
journal_title：Current pharmaceutical design
pub_type： 杂志文章
doi：10.2174/1381612826666200206095400
更新日期：2020-01-01 00:00:00
abstract：:Colorectal cancer (CRC) is one of the most common cancers globally and is associated with a high mortality rate. The transforming growth factor beta (TGF-β) signaling pathway plays an important role in normal intestinal tissue function, but has also been implicated in the development of CRC. MicroRNAs (miRNAs) have al...
journal_title：Current pharmaceutical design
pub_type： 杂志文章,评审
doi：10.2174/1381612825666190110150705
更新日期：2018-01-01 00:00:00
abstract：:Thiopurines are widely used in the treatment of inflammatory bowel disease (IBD). However, in clinical practice azathioprine (AZA) or 6-mercaptopurine (6-MP) are not effective in one-third of patients and up to one-fifth of patients discontinue thiopurine therapy due to adverse reactions. The observed interindividual ...
journal_title：Current pharmaceutical design
pub_type： 杂志文章,评审
doi：10.2174/138161210790112773
更新日期：2010-01-01 00:00:00
abstract：:The majority of pharmaceutical formulations for the treatment of ocular pathologies are for topical administration. However, this kind of ophthalmic formulations has disadvantages such as low bioavailability and, consequently, a reduced therapeutic effect. This happens due to the anatomical and physiological specifici...
journal_title：Current pharmaceutical design
pub_type： 杂志文章,评审
doi：10.2174/1381612821666150923095155
更新日期：2015-01-01 00:00:00
abstract：:Obesity, a chronic low-grade inflammation disorder characterized by an expansion in adipose tissue mass, is rapidly expanding worldwide leading to an increase in the incidence of comorbidities such as insulin resistance, type 2 diabetes and cardiovascular diseases. This has led to a renewed interest in the adipose tis...
journal_title：Current pharmaceutical design
pub_type： 杂志文章,评审
doi：10.2174/1381612822666151109111958
更新日期：2016-01-01 00:00:00
abstract：:While it is well documented that the mitogenic actions of estrogens are critical in the development and progression of human breast and some gynecologic cancers, only latest data demonstrate a crucial involvement of estrogen-signaling in the carcinogenesis of non-classical estrogen target tissues, as colon, prostate, ...
journal_title：Current pharmaceutical design
pub_type： 杂志文章,评审
doi：10.2174/138161212800626139
更新日期：2012-01-01 00:00:00
abstract：:Parkinson's disease (PD) is one of common neurodegenerative diseases, which shows motor symptoms including tremor, bradykinesia, rigidity and postural instability. It also involves non-motor symptoms such as cognitive impairment, mental manifestation, autonomic disorder and sensory disturbance. Although treatments to ...
journal_title：Current pharmaceutical design
pub_type： 杂志文章,评审
doi：10.2174/1381612823666170710163731
更新日期：2017-01-01 00:00:00
abstract：:Obesity, insulin resistance, glucose intolerance/type 2 diabetes and hypertension are clustered in the metabolic syndrome representing critical risk factors for increased incidence cardio-cerebro-vascular diseases, kidney failure and cancer. Ectopic fat accumulation, i.e., accumulation in the mediastinum, liver and th...
journal_title：Current pharmaceutical design
pub_type： 杂志文章,评审
doi：10.2174/138161211798157720
更新日期：2011-01-01 00:00:00
abstract：BACKGROUND:There is a strong rationale for usage of anti-angiogenic agents in epithelial ovarian cancer. Bevacizumab is the most widely investigated anti-VEGF agent and has shown promising results in recent clinical trials. OBJECTIVE:To review the rationale and usage of bevacizumab in advanced epithelial ovarian cance...
journal_title：Current pharmaceutical design
pub_type： 杂志文章
doi：10.2174/138161212802002689
更新日期：2012-01-01 00:00:00
abstract：:Since antibiotics use is currently limited due to undesired side effects and the increasing antibiotic resistance of various bacteria strains, there is a pressing need to develop new strategies and methods preventing epidemic outbreaks. The virulent potency of bacteria relies on a number of different extracellularly s...
journal_title：Current pharmaceutical design
pub_type： 杂志文章,评审
doi：10.2174/1381612825666181219163922
更新日期：2018-01-01 00:00:00
abstract：BACKGROUND:In spite of considerable efforts of researchers the cancer deseases remain to be incurable and a percentage of cancer deseases in the structure of mortality increases every year. At that, high systemic toxicity of antitumor drugs hampers their effective use. Because of this fact, the development of nanosyste...
journal_title：Current pharmaceutical design
pub_type： 杂志文章,评审
doi：10.2174/1381612825666190117095132
更新日期：2018-01-01 00:00:00
abstract：:Marine plants, animals and microorganisms display steady growth in the ocean and are abundant carbohydrate resources. Specifically, natural polysaccharides obtained from brown algae have been drawing increasing attention owing to their great potential in pharmaceutical applications. This review describes the structura...
journal_title：Current pharmaceutical design
pub_type： 杂志文章,评审
doi：10.2174/1381612825666190618143952
更新日期：2019-01-01 00:00:00
abstract：:Active pharmaceutical ingredients (APIs) can exist in different polymorphic forms as well as in amorphous state. Polymorphic and amorphous forms of APIs can differ in physicochemical properties which in turn can significantly influence their therapeutic safety and effectiveness of the treatment. This review focuses on...
journal_title：Current pharmaceutical design
pub_type： 杂志文章,评审
doi：10.2174/1381612822666160804100036
更新日期：2016-01-01 00:00:00
abstract：:Separating emotions from cognition seems impossible in everyday experiences of a human being. Emotional processes have an impact on the ability of planning and solving problems, or decision-making skills. They are a valuable source of information about ourselves, our partners in interactions and the surrounding world....
journal_title：Current pharmaceutical design
pub_type： 杂志文章,评审
doi：10.2174/1381612822666151230110738
更新日期：2016-01-01 00:00:00
abstract：:In the last two decades the development of efficient plant-based expression strategies and new concepts for the purification of recombinant proteins prompted the application of plant-derived vaccines for veterinary purposes. The expression of recombinant proteins in plants possesses advantages over conventional eukary...
journal_title：Current pharmaceutical design
pub_type： 杂志文章,评审
doi：10.2174/1381612811319310014
更新日期：2013-01-01 00:00:00
