Abstract:
BACKGROUND:Breast cancer is one of the leading cancers in women in the Western world. Cancer treatment, especially chemotherapy, is often associated with physical and psychosocial side effects. OBJECTIVE:To improve the quality of life and manage side effects, a new integrative mind-body-medicine group concept for breast cancer patients receiving chemotherapy was developed and pilot tested. METHODS:Breast cancer patients participated in a 66 hours mind-body-medicine group program tailored to the needs of cancer patients during chemotherapy. The program was integrated into standard care encompassing mindfulness training, yoga, moderate exercise, nutrition, complementary self-help strategies, cognitive restructuring, and acupuncture. Quality of life (EORTC QLQ-C30), depression and anxiety (HADS), stress (PSS-10), and fatigue (BFI) were assessed before and after the program as well as satisfaction and safety. Analyses were carried out exploratory with paired samples t-tests. RESULTS:Fifty-seven female patients, 51.3±10.5 years, with breast cancer diagnoses were enrolled. After completing the program, global EORTC quality of life was improved (Δ=9.5; 95%-CI=[2.9|16.1]; p=.005), although the EORTC-symptom scales fatigue (Δ=9.9; 95%-CI=[1|18.8]; p=.030), nausea (Δ=7.1; 95%-CI=[0.6|13.6]; p=.031), and dyspnea (Δ=12.5; 95%- CI=[2.9|22.1]; p=.011) increased. Stress (Δ=-3.5; 95%-CI=[-5|-2.1]; p=.000), anxiety (Δ=-3.8; 95%-CI=[-4.9|-2.7]; p=.000), and depression (Δ=-3.9; 95%-CI=[-4.9|-2.8]; p=.000) were also significantly reduced. Regarding intensity of (Δ=0.2; 95%- CI=[-0.8|0.5]; p=.644) and the impairment through fatigue (Δ=0.1; 95%-CI=[-0.8|0.6]; p=.696), no significant worsening was observed. Patients were satisfied with the program. No serious adverse events were reported. CONCLUSION:Breast cancer patients benefit from an integrative mind-body-medicine group program during chemotherapy regarding the quality of life and psychological symptoms. Randomized controlled trials are warranted.
journal_name
Curr Pharm Desjournal_title
Current pharmaceutical designauthors
Haller H,Choi KE,Lange S,Kümmel S,Paul A,Cramer H,Dobos G,Voiss Pdoi
10.2174/1381612826666201211111122subject
Has Abstractpub_date
2020-12-10 00:00:00eissn
1381-6128issn
1873-4286pii
CPD-EPUB-112351pub_type
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