Drug eluting stents and beyond.

Abstract:

:The present review discusses the mechanism of late stent thrombosis and its distinction from restenosis and summarizes the advisory note issued by FDA on the proper usage of different treatments available for atherosclerosis. In light of the latest developments, a plethora of new stents have been and continue to be developed globally. Hence, there is a need to review the available methodology to control their quality and to understand the delivery of drugs to the lesion. This can be achieved by systematically reviewing the novelties in each type. The article evaluates upcoming drugs, biocompatible coatings, and new concepts. We have also provided the latest update on the three new promising drug eluting stents (DES) - Medtronic's Endeavor, Abbott's Xience, and Conor Medsystem's CoStar. In addition, the article also summarizes other DES in horizon.

journal_name

Curr Pharm Des

authors

Rastogi A,Stavchansky S

doi

10.2174/138161208785294573

subject

Has Abstract

pub_date

2008-01-01 00:00:00

pages

2111-20

issue

21

eissn

1381-6128

issn

1873-4286

journal_volume

14

pub_type

杂志文章,评审
  • Regulatory T cells and tolerogenic dendritic cells as critical immune modulators in atherogenesis.

    abstract::Innate and adaptive immunity has been shown to be critically involved in the pathogenesis of atherosclerosis. In particular, immune suppression mediated by regulatory T cells (Tregs) or tolerogenic dendritic cells (DCs) serves as a vital mechanism for regulating pathogenic chronic inflammation in atherogensis, suggest...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章,评审

    doi:10.2174/1381612820666141013142518

    authors: Sasaki N,Yamashita T,Kasahara K,Takeda M,Hirata K

    更新日期:2015-01-01 00:00:00

  • Cardiac applications for human pluripotent stem cells.

    abstract::Human embryonic stem cells (hESCs) and induced pluripotent stem cells (hiPSCs) can self-renew indefinitely, while maintaining the capacity to differentiate into useful somatic cell types, including cardiomyocytes. As such, these stem cell types represent an essentially inexhaustible source of committed human cardiomyo...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章,评审

    doi:10.2174/138161209788923804

    authors: Shiba Y,Hauch KD,Laflamme MA

    更新日期:2009-01-01 00:00:00

  • State of the art and perspectives in food allergy (part II): therapy.

    abstract::Currently management of food allergy is mainly based on absolute avoidance of the offending food(s) and the use of rescue medication. However, the risk of severe or life-threatening reactions due to inadvertent exposure, nutritional imbalance and social isolation raises the demand of disease-modifying treatments. The ...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章,评审

    doi:10.2174/13816128113199990045

    authors: Sabato V,Faber M,Van Gasse A,Hagendorens MM,Leysen J,Bridts CH,De Clerck LS,Ebo DG

    更新日期:2014-01-01 00:00:00

  • Beneficial effects of the Mediterranean diet on metabolic syndrome.

    abstract::The metabolic syndrome (MetS) represents a cluster of medical disorders, such as hyperglycemia, dyslipidemia, hypertension, and abdominal obesity that, when occurring together, increase the risk of developing cardiovascular disease. The role of food and nutrients in the aetiology of chronic diseases has become clearer...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章,评审

    doi:10.2174/1381612819666131206112144

    authors: Grosso G,Mistretta A,Marventano S,Purrello A,Vitaglione P,Calabrese G,Drago F,Galvano F

    更新日期:2014-01-01 00:00:00

  • Ras signaling pathway proteins as therapeutic targets.

    abstract::Ras is a 21 kDa membrane-localized G protein that is coupled to receptor and non-receptor tyrosine kinase activation of downstream cytoplasmic and nuclear events. Mutated ras genes are common, and occur in a wide variety of human malignancies. These activating mutations result in constitutive signaling, thereby stimul...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章,评审

    doi:10.2174/1381612013397258

    authors: Adjei AA

    更新日期:2001-11-01 00:00:00

  • GABA uptake inhibitors. Design, molecular pharmacology and therapeutic aspects.

    abstract::In the mid seventies a drug design programme using the Amanita muscaria constituent muscimol (7) as a lead structure, led to the design of guvacine (23) and (R)-nipecotic acid (24) as specific GABA uptake inhibitors and the isomeric compounds isoguvacine (10) and isonipecotic acid (11) as specific GABAA receptor agoni...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章,评审

    doi:10.2174/1381612003399608

    authors: Krogsgaard-Larsen P,Frølund B,Frydenvang K

    更新日期:2000-08-01 00:00:00

  • Immunological properties of donkey's milk: its potential use in the prevention of atherosclerosis.

    abstract::Donkey's milk is the best substitute of human milk for its content in lactose, proteins, minerals, and omega-3 fatty acids. Here, we have evaluated the effects of colostrum and milk from donkeys (Martina Franca breed) on the function of human peripheral blood mononuclear cells (PBMCs) at different intervals from lacta...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章

    doi:10.2174/138161207783018590

    authors: Tafaro A,Magrone T,Jirillo F,Martemucci G,D'Alessandro AG,Amati L,Jirillo E

    更新日期:2007-01-01 00:00:00

  • A Combination of Ulinastatin and Xuebijing Amplifies Neuroprotection after Transient Cerebral Ischemia via Attenuating Apoptosis Signal Pathways in Hippocampus.

    abstract:BACKGROUND:Ulinastatin (UTI) plays the beneficial roles in modifying cerebral ischemic injury evoked by cardiac arrest (CA). XueBiJing (XBJ), comprised of extracts from Chinese herbals, has been used for the treatment of sepsis and ischemic disorders linked to multiple organ dysfunction syndromes. The current study was...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章

    doi:10.2174/1381612825666190206224134

    authors: Ma C,Han DF,Jin H,Cheng YY,Hu HX,Wang X

    更新日期:2018-01-01 00:00:00

  • The role of hyperglycaemia and the hypercoagulable state in the pathogenesis of cardiovascular events in diabetes mellitus: implications for hypertension management.

    abstract::Population studies have identified diabetes mellitus as a risk factor for cardiac and vascular events, with a common association with hypertension. Observational studies have consistently demonstrated blood glucose as a continuous cardiovascular risk factor. Experimental studies suggest that elevated blood glucose, th...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章,评审

    doi:10.2174/138161206776843322

    authors: Lim HS,MacFadyen RJ,Bakris G,Lip GY

    更新日期:2006-01-01 00:00:00

  • An Updated Review of Disulfiram: Molecular Targets and Strategies for Cancer Treatment.

    abstract::Repurposing already approved drugs as new anticancer agents is a promising strategy considering the advantages such as low costs, low risks and less time-consumption. Disulfiram (DSF), as the first drug for antialcoholism, was approved by the U.S. Food and Drug Administration (FDA) over 60 years ago. Increasing eviden...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章,评审

    doi:10.2174/1381612825666190816233755

    authors: Yang Q,Yao Y,Li K,Jiao L,Zhu J,Ni C,Li M,Dou QP,Yang H

    更新日期:2019-01-01 00:00:00

  • Repurposing Drugs for the Management of Patients with Confirmed Coronavirus Disease 2019 (COVID-19).

    abstract:BACKGROUND:Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), termed coronavirus disease 2019 (COVID-19) by the World Health Organization, is a newly emerging zoonotic agent that emerged in China in December 2019. No specific treatment for COVID-19 is currently available. Usual palliative treatment includes ...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章

    doi:10.2174/1381612826666200707121636

    authors: Lovato ECW,Barboza LN,Wietzikoski S,de Souza ANV,Auth PA,Junior AG,Dos Reis Lívero FA

    更新日期:2020-07-07 00:00:00

  • An overview of the mechanisms of marine fungi-derived antiinflammatory and anti-tumor agents and their novel role in drug targeting.

    abstract::Marine fungi with their successful pharmacological effects were considered to be the treasure of ocean medicines concerning the striking ability of their secondary metabolites. Literature over literature has been published on fungi derived bioactive molecules to probe its therapeutic potential. Marine fungi have an im...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章

    doi:10.2174/1381612826666200728142244

    authors: Shams Ul Hassan S,Ishaq M,Zhang WD,Jin HZ

    更新日期:2020-07-28 00:00:00

  • An Update on the Immunological, Metabolic and Genetic Mechanisms in Drug Hypersensitivity Reactions.

    abstract::Drug hypersensitivity reactions (DHRs) represent a major burden on the healthcare system since their diagnostic and management are complex. As they can be influenced by individual genetic background, it is conceivable that the identification of variants in genes potentially involved could be used in genetic testing fo...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章,评审

    doi:10.2174/1381612825666191105122414

    authors: Mayorga C,Montañez MI,Jurado-Escobar R,Gil-Ocaña V,Cornejo-García JA

    更新日期:2019-01-01 00:00:00

  • The role of food addiction in clinical research.

    abstract::Recent research has uncovered neurobiological and behavioral similarities between substance dependence and excess consumption of highly processed foods. These findings have led to the theory that food addiction may play a role in obesity and disordered eating. The inclusion of validated food addiction measures in clin...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章,评审

    doi:10.2174/138161211795656800

    authors: Gearhardt AN,Corbin WR

    更新日期:2011-01-01 00:00:00

  • Ion Channel and Neurotransmitter Modulators as Electroceutical Approaches to the Control of Cancer.

    abstract::The activities of individual cells must be tightly coordinated in order to build and maintain complex 3- dimensional body structures during embryogenesis and regeneration. Thus, one way to view cancer is within systems biology as a network disorder affecting the ability of cells to properly interact with a morphodynam...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章,评审

    doi:10.2174/1381612823666170530105837

    authors: Tuszynski J,Tilli TM,Levin M

    更新日期:2017-01-01 00:00:00

  • The effect of Endovascular Aneurysm Repair on Renal Function in Patients Treated for Abdominal Aortic Aneurysm.

    abstract:AIM:The effect of endovascular aneurysm repair in patients treated for abdominal aortic aneurysm has not been clearly defined. The objective of the present article was to provide a contemporary literature review and perform an analysis to determine the effect of EVAR on renal function in the early post-operative period...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章

    doi:10.2174/1381612825666191129094923

    authors: Nana P,Kouvelos G,Brotis A,Spanos K,Giannoukas A,Matsagkas M

    更新日期:2019-01-01 00:00:00

  • Serotonergic system and its role in epilepsy and neuropathic pain treatment: a review based on receptor ligands.

    abstract::The serotonergic system is involved in pathomechanisms of both epilepsy and neuropathic pain. So far, participation in the epileptogenesis and maintenance of epilepsy was proved for 5-HT1A, 5-HT2C, 5-HT3, 5-HT4 and 5-HT7 receptors as well as 5-HTT serotonin transporter. Depending on the receptor type or its localizati...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章,评审

    doi:10.2174/1381612821666141121114917

    authors: Panczyk K,Golda S,Waszkielewicz A,Zelaszczyk D,Gunia-Krzyzak A,Marona H

    更新日期:2015-01-01 00:00:00

  • Understanding the Binding Mechanism of Amyloid-β Inhibitors from Molecular Simulations.

    abstract::In recent years, Aβ aggregation prevention, one of the most concerned strategies in drug development has been carefully assessed to treat Alzheimer's disease. Aβ peptides can transform structurally from random coil monomer into β-stranded protofibril via multiple oligomeric states. Among the various Aβ species, the id...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章,评审

    doi:10.2174/1381612824666180813093420

    authors: Tran L

    更新日期:2018-01-01 00:00:00

  • Leptin and the OB-receptor as anti-obesity target: recent in silico advances in the comprehension of the protein-protein interaction and rational drug design of anti- obesity lead compounds.

    abstract::The OB-receptor or leptin receptor (LR) is crucial for energy homeostasis and regulation of food uptake. Leptin is a 16 kDa hormone that is mainly secreted by fat cells into the bloodstream. Under normal circumstances, circulating leptin levels are proportionate to the fat body mass. Sensing of elevated leptin levels ...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章,评审

    doi:10.2174/13816128113196660743

    authors: Tutone M,Lauria A,Almerico AM

    更新日期:2014-01-01 00:00:00

  • Pro-rich antimicrobial peptides from animals: structure, biological functions and mechanism of action.

    abstract::Pro-rich antimicrobial peptides are a group of linear peptides of innate immunity isolated from mammals and invertebrates, and characterised by a high content of proline residues (up to 50%). Members of this group are predominantly active against Gram-negative bacterial species which they kill by a non-lytic mechanism...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章,评审

    doi:10.2174/1381612023395394

    authors: Gennaro R,Zanetti M,Benincasa M,Podda E,Miani M

    更新日期:2002-01-01 00:00:00

  • Marine-derived Polyaromatic Butenolides - Isolation, Synthesis and Biological Evaluations.

    abstract::Marine invertebrates, especially tunicates, are a lucrative resource for the discovery of new lead compounds for the development of clinically utilized drugs. This review describes the isolation, synthesis and biological activities of several classes of marine-derived butenolide natural products, namely rubrolides and...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章

    doi:10.2174/1381612826666200518110617

    authors: Bracegirdle J,Keyzers RA

    更新日期:2020-01-01 00:00:00

  • Ectopic ATP synthase in endothelial cells: a novel cardiovascular therapeutic target.

    abstract::Adenosine triphosphate (ATP) synthase produces ATP in cells and is found on the inner membrane of mitochondria or the cell plasma membrane (ectopic ATP synthase). Here, we summarize the functions of ectopic ATP synthase in vascular endothelial cells (ECs). Ectopic ATP synthase is involved in adenosine metabolism on th...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章,评审

    doi:10.2174/138161210794519219

    authors: Fu Y,Zhu Y

    更新日期:2010-01-01 00:00:00

  • Traditional Risk Factors are Causally Related to Carotid Intima-Media Thickness Progression: Inferences from Observational Cohort Studies and Interventional Trials.

    abstract::In the present review, associations between traditional vascular risk factors (VRFs) and carotid intimamedial thickness progression (C-IMTp) as well as the effects of therapies for VRFs control on C-IMTp were appraised to infer causality between each VRF and C-IMTp. Cohort studies indicate that smoking, binge drinking...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章,评审

    doi:10.2174/1381612825666191213120339

    authors: Frigerio B,Werba JP,Amato M,Ravani A,Sansaro D,Coggi D,Vigo L,Tremoli E,Baldassarre D

    更新日期:2020-01-01 00:00:00

  • Estrogen receptor beta in cancer: an attractive target for therapy.

    abstract::While it is well documented that the mitogenic actions of estrogens are critical in the development and progression of human breast and some gynecologic cancers, only latest data demonstrate a crucial involvement of estrogen-signaling in the carcinogenesis of non-classical estrogen target tissues, as colon, prostate, ...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章,评审

    doi:10.2174/138161212800626139

    authors: Gallo D,De Stefano I,Grazia Prisco M,Scambia G,Ferrandina G

    更新日期:2012-01-01 00:00:00

  • Platelet-neutrophil interactions as a target for prevention and treatment of transfusion-related acute lung injury.

    abstract::Transfusion-related acute lung injury (TRALI) is a major cause of morbidity and mortality in transfused hosts and like other causes of acute lung injury, there is no effective pharmacologic treatment. The pathophysiology of TRALI is still being defined, but neutrophils have a major role in the pathogenesis of both hum...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章,评审

    doi:10.2174/1381612811209023260

    authors: Caudrillier A,Looney MR

    更新日期:2012-01-01 00:00:00

  • Regulation of GABA Neurotransmission by Glutamic Acid Decarboxylase (GAD).

    abstract::Control of GABA neurotransmission at the pre-synaptic site occurs substantially through the activation of the glutamic acid decarboxylase (GAD) enzymes GAD65 and GAD67. Concentrations of GAD65 and GAD67 are controlled either by transcription or by mRNA splicing and importantly the activities of these key enzymes are r...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章

    doi:10.2174/1381612821666150917094343

    authors: Modi JP,Prentice H,Wu JY

    更新日期:2015-01-01 00:00:00

  • Unmasking the Many Faces of Giloy (Tinospora cordifolia L.): A fresh look on its phytochemical and medicinal properties.

    abstract:BACKGROUND:Plants have been used to treat health disorders and prevent diseases since antiquity in all civilizations including the Indian and Chinse civilizations. Giloy (Tinospora cordifolia L.) is one of the most important medicinal plants in Indian folk medicine and is commonly known as the "Heart-leaved Moonseed" o...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章

    doi:10.2174/1381612826666200625111530

    authors: Verma DK,Goyal K,Kumar P,El-Shazly M

    更新日期:2020-06-25 00:00:00

  • Regulatory mechanism of the gastric hyperemic response following barrier disruption: roles of cyclooxygenase-1, the prostaglandin E2/EP1 receptor and sensory neurons.

    abstract::We herein reviewed the mechanism underlying the gastric hyperemic response following barrier disruption, with a focus on cyclooxygenase (COX) isozymes, prostaglandin (PG) E2, and capsaicin-sensitive afferent neurons. Mucosal damage was induced by exposing the stomach to 20 mM taurocholate (TC) with 50 mM HCl. The TC t...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章,评审

    doi:10.2174/1381612821666150514105248

    authors: Takeuchi K,Takeeda M,Amagase K,Nakashima M

    更新日期:2015-01-01 00:00:00

  • The association between cannabis use and earlier age at onset of schizophrenia and other psychoses: meta-analysis of possible confounding factors.

    abstract::A recent meta-analysis showed that the mean age of onset of psychosis among cannabis users was almost three years earlier than that of non-cannabis users. However, because cannabis users usually smoke tobacco, the use of tobacco might independently contribute to the earlier onset of psychosis. We aimed to use meta-ana...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章,meta分析

    doi:10.2174/138161212802884816

    authors: Myles N,Newall H,Nielssen O,Large M

    更新日期:2012-01-01 00:00:00

  • Targeting the cell cycle in the pursuit of novel chemotherapies against parasitic protozoa.

    abstract::Protozoan parasites, such as those responsible for malaria and African Sleeping Sickness, represent a huge burden to the developing world. Current chemotherapy to combat these diseases is inadequate: antiquated, toxic and increasingly ineffective due to drug resistance. In this article, the potential usefulness of tar...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章,评审

    doi:10.2174/138161208784041042

    authors: Grant KM

    更新日期:2008-01-01 00:00:00