Mesenchymal stem/stromal cells: a new ''cells as drugs'' paradigm. Efficacy and critical aspects in cell therapy.

Abstract:

:Mesenchymal stem cells (MSCs) were first isolated more than 50 years ago from the bone marrow. Currently MSCs may also be isolated from several alternative sources and they have been used in more than a hundred clinical trials worldwide to treat a wide variety of diseases. The MSCs mechanism of action is undefined and currently under investigation. For in vivo purposes MSCs must be produced in compliance with good manufacturing practices and this has stimulated research on MSCs characterization and safety. The objective of this review is to describe recent developments regarding MSCs properties, physiological effects, delivery, clinical applications and possible side effects.

journal_name

Curr Pharm Des

authors

de Girolamo L,Lucarelli E,Alessandri G,Avanzini MA,Bernardo ME,Biagi E,Brini AT,D'Amico G,Fagioli F,Ferrero I,Locatelli F,Maccario R,Marazzi M,Parolini O,Pessina A,Torre ML,Italian Mesenchymal Stem Cell Group

doi

10.2174/1381612811319130015

subject

Has Abstract

pub_date

2013-01-01 00:00:00

pages

2459-73

issue

13

eissn

1381-6128

issn

1873-4286

pii

CPD-EPUB-20121226-10

journal_volume

19

pub_type

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