Gender Differences in Non-Obstructive Coronary Artery Disease.

abstract：:Recent advances in DNA sequencing has made it possible to accurately decipher the entire genetic complement of a probiotic bacterium. Increases in sequencing capabilities have been enhanced through improved computer software that can annotate, or identify, the majority of genes encoded by the sequence. The availabilit...

journal_title：Current pharmaceutical design

authors： Callanan M

更新日期：2005-01-01 00:00:00

abstract：:Chloride channels play important roles in vital cellular signalling processes contributing to homeostasis in both excitable and non-excitable cells. Since 1987, more than ten ion channel genes have been identified as causing human hereditary diseases among them the genes for the voltage-dependent chloride channel ClC-...

journal_title：Current pharmaceutical design

authors： Becq F

更新日期：2006-01-01 00:00:00

abstract：:Resveratrol (3,5,4'-trihydroxy-trans-stilbene) is a non-flavonoid polyphenol that may be present in a limited number of foodstuffs such as grapes and red wine. Resveratrol has been reported to exert a plethora of health benefits through many different mechanisms of action. This versatility and presence in the human di...

journal_title：Current pharmaceutical design

authors： Tomé-Carneiro J,Larrosa M,González-Sarrías A,Tomás-Barberán FA,García-Conesa MT,Espín JC

更新日期：2013-01-01 00:00:00

abstract：:Backgound: Current drug therapy for the management of arterial hypertension and heart failure has provided substantial benefits but has also some limitations. LCZ696, a dual inhibitor of angiotensin receptor blockers and neprilysin, and finerenone, a non-steroidal mineralocorticoid receptor antagonist, are two recentl...

journal_title：Current pharmaceutical design

authors： Faselis C,Boutari C,Doumas M,Imprialos K,Stavropoulos K,Kokkinos P

更新日期：2017-01-01 00:00:00

abstract：:Emerging evidence has shown that microRNAs (miRNAs) can act as oncogenes in the initiation and progression of leukemia and lymphoma. Aberrant expression of oncogenic miRNAs, including miR-155, miR-17-92, miR-21, miR-125b, miR-93, miR-143-p3, miR-196b, and miR-223 promotes leukemogenesis through increasing the leukemic...

journal_title：Current pharmaceutical design

authors： Pan Y,Meng M,Zhang G,Han H,Zhou Q

更新日期：2014-01-01 00:00:00

abstract：:Nanogels are nanosized hydrogel particles formed by physical or chemical cross-linked polymer networks. The advantageous properties of nanogels related to the ability of retaining considerable amount of water, the biocompatibility of the polymers used, the ability to encapsulate and protect a large quantity of payload...

journal_title：Current pharmaceutical design

authors： Maya S,Sarmento B,Nair A,Rejinold NS,Nair SV,Jayakumar R

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Heat shock proteins are powerful endogenous cytoprotective proteins which help cells to survive recurrent cellular stress events. Identifying the underlying molecular mechanisms and molecular targets is especially interesting since it may help to develop new therapeutic strategies for the treatment of diseas...

journal_title：Current pharmaceutical design

authors： Golenhofen N,Bartelt-Kirbach B

更新日期：2016-01-01 00:00:00

abstract：:Diterpenes present complex structure and due to their unique carbon skeleton and interesting biological activities, have been the focus of continuous studies for the development of new anticancer agents. Phorbol esters have been known for their activity against skin malignancies since ancient times. Taxol was first st...

journal_title：Current pharmaceutical design

authors： Prieto JM,Silveira D

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:The population with autism spectrum disorder (ASD) has been increasing and is currently estimated to be 1 in 58 births. The increased prevalence of ASD together with the lack of knowledge on the processes of aging in this population, the support needed at this stage of life, and the associated risk factors, ...

journal_title：Current pharmaceutical design

authors： Ruggieri V,Gómez JLC,Martínez MM,Arberas C

更新日期：2019-01-01 00:00:00

abstract：:Vascular disorders, resulting from endothelial cell dysfunction, may be caused by various stimuli, including infectious pathogens, cytotoxic reagents, and pathophysiological mechanisms mediated by immune responses. Endothelial cell dysfunction characterized by apoptosis and abnormal immune activation is, at least in p...

journal_title：Current pharmaceutical design

authors： Lin YS,Lin CF,Lei HY,Liu HS,Yeh TM,Chen SH,Liu CC

更新日期：2004-01-01 00:00:00

abstract：:Protein stability of hypoxia-inducible factor (HIF)alpha subunits is regulated by the oxygen-sensing prolyl-4-hydroxylase domain (PHD) enzymes. Under oxygen-limited conditions, HIFalpha subunits are stabilized and form active HIF transcription factors that induce a large number of genes involved in adaptation to hypox...

journal_title：Current pharmaceutical design

authors： Wenger RH,Camenisch G,Stiehl DP,Katschinski DM

更新日期：2009-01-01 00:00:00

abstract：:Strontium ranelate is composed of an organic moiety (ranelic acid) and of two atoms of stable non-radioactive strontium. In vitro, strontium ranelate increases collagen and non-collagenic proteins synthesis by mature osteoblast enriched cells. The effects of strontium ranelate on bone formation were confirmed as stron...

journal_title：Current pharmaceutical design

authors： Reginster JY

更新日期：2002-01-01 00:00:00

abstract：:Molecular Mechanics (MM) force fields are the methods of choice for protein simulations, which are essential in the study of conformational flexibility. Given the importance of protein flexibility in drug binding, MM is involved in most if not all Computational Structure-Based Drug Discovery (CSBDD) projects. This pap...

journal_title：Current pharmaceutical design

authors： Vanommeslaeghe K,Guvench O,MacKerell AD Jr

更新日期：2014-01-01 00:00:00

abstract：:Protein palmitoylation is a fundamental and reversible post-translational lipid modification that involves a series of biological processes. Although a large number of experimental studies have explored the molecular mechanism behind the palmitoylation process, the computational methods has attracted much attention fo...

journal_title：Current pharmaceutical design

authors： Li Y,Pu F,Wang J,Zhou Z,Zhang C,He F,Ma Z,Zhang J

更新日期：2020-11-12 00:00:00

abstract：:A positive relationship between stress tolerance and longevity has been observed in several model systems. That the same correlation is applicable in humans and that it may be open to experimental manipulation for extending human lifespan requires studies on association of stress genes with longevity. The involvement ...

journal_title：Current pharmaceutical design

authors： Singh R,Kølvraa S,Bross P,Christensen K,Bathum L,Gregersen N,Tan Q,Rattan SI

更新日期：2010-01-01 00:00:00

abstract：:A growing body of evidence shows that gamma-hydroxybutyric acid (GHB) is an addictive substance. Its precursors gammabutyrolactone (GBL) and 1,4-butanediol (1,4-BD) show the same properties and may pose even more risks due to different pharmacokinetics. There are indications that problematic GHB use is increasing in t...

journal_title：Current pharmaceutical design

authors： Brunt TM,van Amsterdam JG,van den Brink W

更新日期：2014-01-01 00:00:00

abstract：:Antimicrobial photodynamic therapy (aPDT) is an emerging alternative to antibiotics motivated by growing problems with multi-drug resistant pathogens. aPDT uses non-toxic dyes or photosensitizers (PS) in combination with harmless visible of the correct wavelength to be absorbed by the PS. The excited state PS can form...

journal_title：Current pharmaceutical design

authors： Sharma SK,Dai T,Kharkwal GB,Huang YY,Huang L,De Arce VJ,Tegos GP,Hamblin MR

更新日期：2011-01-01 00:00:00

abstract：:Psychoneuroimmunology is a relatively young field of research that investigates interactions between central nervous and immune system. The brain modulates the immune system by the endocrine and autonomic nervous system. Vice versa, the immune system modulates brain activity including sleep and body temperature. Based...

journal_title：Current pharmaceutical design

authors： Ziemssen T

更新日期：2012-01-01 00:00:00

abstract：:The mechanisms underlying neurodegeneration in amyotrophic lateral sclerosis (ALS) are multifactorial and include genetic and environmental factors. Nowadays, it is well accepted that neuronal loss is driven by non-cell autonomous toxicity. Non-neuronal cells, such as astrocytes, have been described to significantly c...

journal_title：Current pharmaceutical design

authors： Johann S

更新日期：2017-01-01 00:00:00

abstract：:Invasive fungal infections are a major cause of morbidity and mortality in immunosuppressed patients with fatality rates ranging from 30 % to 80 % in neutropenic patients. This results at least partly in difficulties obtaining a reliable and early diagnosis, followed by the fact that clinical symptoms are unspecific a...

journal_title：Current pharmaceutical design

authors： Lackner M,Lass-Flörl C

更新日期：2013-01-01 00:00:00

abstract：:Naturally occurring and chemically modified ribonucleosides have interesting bioactive effects. Dietary ribonucleosides are ingested mainly as nucleoproteins and are converted in the course of intestinal digestion to monomeric compounds. Different bioactive effects of dietary ribonucleosides have been described, inclu...

journal_title：Current pharmaceutical design

authors： Martin D,Meisel H

更新日期：2007-01-01 00:00:00

abstract：AIM:The effect of endovascular aneurysm repair in patients treated for abdominal aortic aneurysm has not been clearly defined. The objective of the present article was to provide a contemporary literature review and perform an analysis to determine the effect of EVAR on renal function in the early post-operative period...

journal_title：Current pharmaceutical design

authors： Nana P,Kouvelos G,Brotis A,Spanos K,Giannoukas A,Matsagkas M

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:The integrin family receptors stimulate the cellular proliferation and migration through the focal adhesion pathway by the activation of PTK2, VASP and TSP1 proteins. The purpose of this study was to investigate the integrin-ligated motifs through the activation of focal adhesion pathway. METHODS:A chimeric...

journal_title：Current pharmaceutical design

authors： Khosravi M,Kakavandi N,Rezaee S,Shabani M,Najafi M

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:The 3' repair exonuclease 1 (TREX1) gene is the major DNA-specific 3'-5 'exonuclease of mammalian cells which reduces single- and double-stranded DNA (ssDNA and dsDNA) to prevent undue immune activation mediated by the nucleic acid. TREX1 is also a crucial suppressor of selfrecognition that pr...

journal_title：Current pharmaceutical design

authors： Tao SS,Wu GC,Zhang Q,Zhang TP,Leng RX,Pan HF,Ye DQ

更新日期：2019-01-01 00:00:00

abstract：:Systemic hypersensitivity (HS) to corticosteroids (CS) is paradoxical but does exist. Some patients with a previous contact allergy to topical CS may develop a systemic contact dermatitis (SCD) while receiving CS orally or intravenously. However, a previous contact sensitization is not mandatory for developing a syste...

journal_title：Current pharmaceutical design

authors： Barbaud A,Waton J

更新日期：2016-01-01 00:00:00

abstract：:Phosphodiesterase 2 (PDE2) is a ubiquitous enzyme whose major role is to hydrolyze the important second messengers cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP). In the central nervous system, pharmacological inhibition of PDE2 results in boosted cAMP and/or cGMP signaling, which is r...

journal_title：Current pharmaceutical design

authors： Zhang C,Yu Y,Ruan L,Wang C,Pan J,Klabnik J,Lueptow L,Zhang HT,O'Donnell JM,Xu Y

更新日期：2015-01-01 00:00:00

abstract：:Our current understanding of cancer suggests that every tumour has individual features. Approaches to cancer treatment require thorough comprehension of the mechanisms triggering genomic instability and protecting cancer cells from therapeutic treatments. Base excision repair (BER) is a frontline DNA repair system tha...

journal_title：Current pharmaceutical design

authors： Poletto M,Legrand AJ,Dianov GL

更新日期：2017-01-01 00:00:00

abstract：:HIV infection remains incurable although several anti-HIV drugs have been identified and developed. Among these the nucleoside analogues were and remain in the forefront of anti-HIV chemotherapeutic regimens. Most of these nucleoside analogues are modified mainly in the sugar moiety. In general, they lack a free hydro...

journal_title：Current pharmaceutical design

authors： el Kouni MH

更新日期：2002-01-01 00:00:00

abstract：:Angiogenesis, the development of new capillaries form pre-existing vessels, requires the coordinate activation of endothelial cells, which migrate and proliferate in response to growth factors to form functional vessels. Therapeutic angiogenesis is proposed to restore tissue integrity and function following damage and...

journal_title：Current pharmaceutical design

authors： Morbidelli L,Donnini S,Ziche M

更新日期：2003-01-01 00:00:00

abstract：:The disappointing results in long-term survival of patients affected by non-small cell lung cancer (NSCLC) may be attributed, at least in part, to the lack of knowledge on the way by which genetic characteristics in normal and neoplastic cells affect responsiveness as well as metabolism of chemotherapy and new targete...

journal_title：Current pharmaceutical design

authors： Galvani E,Toffalorio F,Peters GJ,De Pas T,Giovannetti E

更新日期：2014-01-01 00:00:00