Abstract:
BACKGROUND:Anticoagulation in patients with pulmonary embolism. OBJECTIVE:To identify how non-vitamin K antagonist oral anticoagulants are associated with multiple outcomes in patients with pulmonary embolism. METHODS:We performed a systematic search of systematic reviews via multiple electronic databases from inception to August 19th, 2019, without language restriction. Two authors independently extracted data and assessed the methodological quality of the included systematic reviews using the ROBIS tool. RESULTS:We found twelve systematic reviews. Eleven SRs collected their data from randomized clinical trials and one from observational studies. All the included studies were published between 2014 and 2019 in English. The methodological quality of the 12 systematic reviews was low to high. None of the systematic reviews, which are included in our overview of systematic reviews, has evaluated the overall quality of evidence outcome using the Grading of Recommendations Assessments, Development and Evaluation (GRADE) approach. CONCLUSION:This is the first effort to summarize evidence about non-vitamin K antagonist oral anticoagulants in an overview of systematic reviews focusing exclusively on patients with pulmonary embolism. The evidence suggests that the non-vitamin K antagonist oral anticoagulants seem to be more effective and safer than a dualdrug approach with LMWH- VKA.
journal_name
Curr Pharm Desjournal_title
Current pharmaceutical designauthors
Doundoulakis I,Antza C,Karvounis H,Giannakoulas Gdoi
10.2174/1381612826666200506114450subject
Has Abstractpub_date
2020-01-01 00:00:00pages
2686-2691issue
23eissn
1381-6128issn
1873-4286pii
CPD-EPUB-106417journal_volume
26pub_type
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