Carbon Nanotubes as A High-Performance Platform for Target Delivery of Anticancer Quinones.

abstract：:Carvedilol is a nonselective β-blocker with α1-adrenergic blocking and antioxidant properties. A number of preclinical experiments and clinical trials have demonstrated that carvedilol provides prominent benefit in heart failure. However, less research has been done in the area of animal models of viral myocarditis. T...

journal_title：Current pharmaceutical design

authors： Yue-Chun L,Li-Sha G,Xue-Qiang G,Jia-Feng L

更新日期：2012-01-01 00:00:00

abstract：:Integrins alpha(1)beta(1) and alpha(2)beta(1) are highly expressed on the microvascular endothelial cells, and blocking of their adhesive properties significantly reduced the VEGF-driven neovascularization ratio and tumor growth in animal models. Hence, inhibitors of the alpha(1)beta(1) and alpha(2) beta(1) integrins,...

journal_title：Current pharmaceutical design

authors： Calvete JJ,Marcinkiewicz C,Sanz L

更新日期：2007-01-01 00:00:00

abstract：:Currently management of food allergy is mainly based on absolute avoidance of the offending food(s) and the use of rescue medication. However, the risk of severe or life-threatening reactions due to inadvertent exposure, nutritional imbalance and social isolation raises the demand of disease-modifying treatments. The ...

journal_title：Current pharmaceutical design

authors： Sabato V,Faber M,Van Gasse A,Hagendorens MM,Leysen J,Bridts CH,De Clerck LS,Ebo DG

更新日期：2014-01-01 00:00:00

abstract：:Backgound: Current drug therapy for the management of arterial hypertension and heart failure has provided substantial benefits but has also some limitations. LCZ696, a dual inhibitor of angiotensin receptor blockers and neprilysin, and finerenone, a non-steroidal mineralocorticoid receptor antagonist, are two recentl...

journal_title：Current pharmaceutical design

authors： Faselis C,Boutari C,Doumas M,Imprialos K,Stavropoulos K,Kokkinos P

更新日期：2017-01-01 00:00:00

abstract：:The prevalence of obesity is increasing globally. Rational perioperative anesthetic drug selection and administration require knowledge of how obesity interacts with those drugs. In this review, we summarize different aspects of the anesthetic agents, including pharmacokinetics (PK), pharmacodynamics (PD) and clinical...

journal_title：Current pharmaceutical design

authors： Dos Reis Falcão LF,Mc Loughlin S,Alvarez A

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Despite the limited evidence about the effect of micronutrient supplementation on the semen quality, many micronutrient supplements have been used to improve male fertility. Approximately, 40%-50% of male infertility cases in general and up to 80% in men with idiopathic infertility cases are caused by oxidat...

journal_title：Current pharmaceutical design

authors： Dimitriadis F,Tsounapi P,Zachariou A,Kaltsas A,Sokolakis I,Hatzichristodoulou G,Symeonidis EN,Kotsiris D,Gabales MR,Vlachopoulou E,Takenaka A,Sofikitis N

更新日期：2020-04-15 00:00:00

abstract：:The large conduit arteries of the thorax and abdomen are elastic while those in the arms and legs are muscular. Alterations in wall properties of elastic arteries occur over time and are usually permanent in nature; acute changes can, however, occur is response to a change in transmural pressure. Chronic alterations i...

journal_title：Current pharmaceutical design

authors： Nichols WW,Epstein BJ

更新日期：2009-01-01 00:00:00

abstract：:The prevalence of hypertension (HTN) worldwide is high and is constantly rising. HTN is considered to be a silent killer since often there are no obvious symptoms but long-term, HTN significantly increases the risk of coronary heart disease and cerebrovascular diseases. Those with diagnosed HTN or at high risk of its ...

journal_title：Current pharmaceutical design

authors： Rysz J,Franczyk B,Banach M,Gluba-Brzozka A

更新日期：2017-01-01 00:00:00

abstract：:The impact of depression on physical disability is undisputed. There is convincing evidence that depression increases the subsequent risk for physical disability and, in turn, physical disability results in increased depressive symptoms. Moreover, depression affects also the earlier stages of the disablement process (...

journal_title：Current pharmaceutical design

authors： Milaneschi Y,Penninx BW

更新日期：2014-01-01 00:00:00

abstract：:Topiramate is one of the currently most promising compounds in the field of addiction medicine. This paper discusses its potential utility related to a phase model of addiction development, focusing on the assumption that addiction is a continuous process involving different neurobiological pathways, depending on the ...

journal_title：Current pharmaceutical design

authors： Thorens G,Billieux J,Manghi R,Khan R,Khazaal Y,Zullino DF

更新日期：2011-01-01 00:00:00

abstract：:The triggering receptor expressed on myeloid cells (TREM)-1 is a member of the Ig-like immunoregulatory receptor family and a major amplifier of innate immune responses. TREM- 1 has been implicated in the development and perpetuation of a number of inflammatory disorders, and soluble TREM-1 levels are a clinically val...

journal_title：Current pharmaceutical design

authors： Bosco MC,Raggi F,Varesio L

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:The last few decades have witnessed enormous advancements in the field of Pharmaceutical drug, design and delivery. One of the recent developments is the advent of 3DP technology. It has earlier been successfully employed in fields like aerospace, architecture, tissue engineering, biomedical research, medica...

journal_title：Current pharmaceutical design

authors： Mirza MA,Iqbal Z

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:Cardiovascular disease (CVD) despite the advances in medical management keeps on as the primary cause of morbidity and mortality for both genders in Western societies. Sex differences though modify the clinical picture as well as the effectiveness of treatment. METHODS AND RESULTS:In this literature review ...

journal_title：Current pharmaceutical design

authors： Oikonomou E,Tsigkou V,Lazaros G,Papamikroulis GA,Papaioannou S,Siasos G,Tousoulis D

更新日期：2016-01-01 00:00:00

abstract：:Dioxygen (O2) is an exogenously supplied gas with a number of properties that make it valuable as a biological source of energy and as a result much of life has become dependent on this molecule. Nitric oxide (NO), carbon dioxide (CO) and hydrogen sulfide (H2S) are small molecules that are sometimes in a gaseous state...

journal_title：Current pharmaceutical design

authors： Fukuto JM,Collins MD

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:Utilization of macroalgae has gained much attention in the field of pharmaceuticals, nutraceuticals, food and bioenergy. Macroalgae has been widely consumed in Asian countries as food from ancient days and proved that it has potential bioactive compounds which are responsible for its nutritional properties. ...

journal_title：Current pharmaceutical design

authors： Venkatesan J,Anil S,Rao S,Bhatnagar I,Kim SK

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Polyphenols are a family of natural antioxidants that in recent years have been studied and tested for their potential benefits towards cardiovascular diseases. OBJECTIVE:The aim of this review is to focus the attention on the presumed lipid-lowering and atheroprotective effects of polyphenols, administered...

journal_title：Current pharmaceutical design

authors： Cicero AFG,Colletti A

更新日期：2018-01-01 00:00:00

abstract：:DNA-topoisomerases, a family of DNA-processing enzymes, represent the pharmacological target of major clinically useful chemotherapeutic agents. These drugs essentially act by trapping a topoisomerase-DNA cleavable complex, an intermediate in the enzyme s catalytic cycle. Research activity in this field continues to g...

journal_title：Current pharmaceutical design

authors： Gatto B,Capranico G,Palumbo M

更新日期：1999-03-01 00:00:00

abstract：:Pulmonary surfactant, a complex of lipids and proteins, functions to keep alveoli from collapsing at expiration. Surfactant proteins A (SP-A) and D (SP-D) belong to the collectin family and play pivotal roles in the innate immunity of the lung. Pulmonary collectins directly bind with broad specificities to a variety o...

journal_title：Current pharmaceutical design

authors： Takahashi H,Sano H,Chiba H,Kuroki Y

更新日期：2006-01-01 00:00:00

abstract：:The use of the carbohydrate glucose as an energetic source is essential for an adequate function of the human body. The complex regulation of this molecule involves the coordinated action of various organs such as pancreas, liver and brain. Any disruption of this physiological balance may result in a dangerous comprom...

journal_title：Current pharmaceutical design

authors： González-Reyes RE,Aliev G,Ávila-Rodrigues M,Barreto GE

更新日期：2016-01-01 00:00:00

abstract：:A large body of evidence has accumulated indicating involvement of oxidative stress (OS) in the mode of action of various bioactive substances, including those of the immune system. The data for anticancer drugs (main and miscellaneous) are summarized herein. Although diverse origins pertain, reactive oxygen species (...

journal_title：Current pharmaceutical design

authors： Kovacic P,Osuna JA Jr

更新日期：2000-02-01 00:00:00

abstract：:Although the cause of Crohn's disease remains unknown considerable progress has been made in recent years to unravel the pathogenesis of the inflammatory processes seen in chronic idiopathic inflammatory bowel diseases (IBD). Th-1 lymphocytes seem to orchestrate the inflammation through the production of pro-inflammat...

journal_title：Current pharmaceutical design

authors： D'Haens G

更新日期：2003-01-01 00:00:00

abstract：:This review will focus on the construction, refinement, and validation of G Protein-coupled receptor models for the purpose of structure-based virtual screening. Practical tips and tricks derived from concrete modeling and virtual screening exercises to overcome the problems and pitfalls associated with the different ...

journal_title：Current pharmaceutical design

authors： de Graaf C,Rognan D

更新日期：2009-01-01 00:00:00

abstract：:Glucocorticoids are the first line medication used in the therapy of many severe inflammatory disorders. They exert their activity through binding to the glucocorticoid receptor, a ligand-dependent transcription factor, and result in either activation or repression of a large set of glucocorticoid responsive genes. Th...

journal_title：Current pharmaceutical design

authors： Schulz M,Eggert M

更新日期：2004-01-01 00:00:00

abstract：:A better knowledge of the mechanisms underlying hepatocellular carcinoma (HCC) growth and spread is essential to improve the available treatment options. So far, the only therapies available for HCC are mainly based on tumor-destructive approaches, whereas no therapies are available to consolidate these invasive thera...

journal_title：Current pharmaceutical design

authors： Antonaci S,Giannelli G

更新日期：2007-01-01 00:00:00

abstract：:Abdominal aortic aneurysm (AAA) is a devastating disease associated with high prevalence of death due to aortic rupture. Currently the therapy is restricted to surgical procedures to prevent aortic rupture, which in turn has a risk for postoperative mortality. There are no proven pharmacological therapies available to...

journal_title：Current pharmaceutical design

authors： Liu J,Daugherty A,Lu H

更新日期：2015-01-01 00:00:00

abstract：:Parkinson's disease (PD) is a common neurodegenerative disorder characterized by cardinal features of tremor, bradykinesia, rigidity and postural instability. In addition to the motor symptoms patients experience cognitive decline eventually resulting in severe disability. Pathologically PD is characterized by neurode...

journal_title：Current pharmaceutical design

authors： Thomas M,Le WD

更新日期：2004-01-01 00:00:00

abstract：:Diabetes is one of the most common endocrine non-communicable metabolic disorders which is mainly caused either due to insufficient insulin or inefficient insulin or both together and is characterized by hyperglycemia. Diabetes emerged as a serious health issue in the industrialized and developing country especially i...

journal_title：Current pharmaceutical design

authors： Prabhakar PK,Sivakumar PM

更新日期：2019-01-01 00:00:00

abstract：:The purpose of this study is to answer the following question: What are the typical features of abnormal bodily experiences (ABEs) in persons affected by acute first-episode schizophrenia? Our overall objective is to contribute to enhance early diagnosis of schizophrenia, and providing supplementary diagnostic criteri...

journal_title：Current pharmaceutical design

authors： Stanghellini G,Ballerini M,Fusar Poli P,Cutting J

更新日期：2012-01-01 00:00:00

abstract：:Bisphosphonates are widely use for pathologies such as osteoporosis, Paget's disease or bone metastasis. However, their potent antiresorptive properties open new therapeutic opportunities for other conditions associated with an increased focal or systemic bone remodelling. Moreover, apart from their antiresorptive act...

journal_title：Current pharmaceutical design

authors： Le Goff B,Berthelot JM,Maugars Y,Romas E

更新日期：2010-01-01 00:00:00

abstract：:The search for methods to control physiological levels of carbon monoxide (CO), a vasoactive molecule, and bilibrubin, an antioxidant, have improved our understanding of the protective role of heme oxygenase (HO) against oxidative injury. HO activity can assist other antioxidant systems in diminishing the overall prod...

journal_title：Current pharmaceutical design

authors： Abraham NG

更新日期：2003-01-01 00:00:00