The potential interest of topiramate in addiction.

Abstract:

:Topiramate is one of the currently most promising compounds in the field of addiction medicine. This paper discusses its potential utility related to a phase model of addiction development, focusing on the assumption that addiction is a continuous process involving different neurobiological pathways, depending on the stage of addiction. A specific emphasis will be made on the development of dysfunctional automatic behaviors in late stage of addiction and the central role of glutamate and AMPA receptors. The aim is to propose that if a too broad effect of anti-addiction medication is expected (such as anti-craving, anti-relapse and preventive effects), the results might be disappointing. The speculative specific efficacy of topiramate in addiction is described.

journal_name

Curr Pharm Des

authors

Thorens G,Billieux J,Manghi R,Khan R,Khazaal Y,Zullino DF

doi

10.2174/138161211796150864

subject

Has Abstract

pub_date

2011-01-01 00:00:00

pages

1410-5

issue

14

eissn

1381-6128

issn

1873-4286

pii

BSP/CPD/E-Pub/000453

journal_volume

17

pub_type

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