Abstract:
:Currently management of food allergy is mainly based on absolute avoidance of the offending food(s) and the use of rescue medication. However, the risk of severe or life-threatening reactions due to inadvertent exposure, nutritional imbalance and social isolation raises the demand of disease-modifying treatments. The aim of the different treatments is to allow patients to safely ingest the offending food(s). However this unresponsiveness can be transient and requires continued treatment (desensitization) and has to be permanent and sustained also after stopping the treatment (tolerance). This review focuses on non-allergen specific (anti-IgE, Chinese herbal formula, etc..) and allergen specific treatments for food allergy. The anti-IgE treatment is at the moment the only non-allergen-specific therapy, for which some data on a temporarily clinical efficacy have been provided. Regarding allergen-specific treatments, different protocols (oral, sublingual, subcutaneous and epicutaneous) with natural, heat treated or recombinant food allergens have been investigated. Although promising, results of the different clinical trials are heterogeneous. In particular data on long-term effects are lacking. At the moment food specific immunotherapy can be considered an experimental interventional strategy, limited to research, and not yet ready for routine use.
journal_name
Curr Pharm Desjournal_title
Current pharmaceutical designauthors
Sabato V,Faber M,Van Gasse A,Hagendorens MM,Leysen J,Bridts CH,De Clerck LS,Ebo DGdoi
10.2174/13816128113199990045subject
Has Abstractpub_date
2014-01-01 00:00:00pages
964-72issue
6eissn
1381-6128issn
1873-4286pii
CPD-EPUB-20130517-3journal_volume
20pub_type
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