The Lord of the Bacteria: The Fellowship of the Leader and Other Serine Protease Inhibitors.

Abstract:

:Since antibiotics use is currently limited due to undesired side effects and the increasing antibiotic resistance of various bacteria strains, there is a pressing need to develop new strategies and methods preventing epidemic outbreaks. The virulent potency of bacteria relies on a number of different extracellularly secreted factors among which proteases considered as promising, novel drug targets are of special interest. The first evidence that bacterial cysteine, serine and metalloproteinases contributed to the progression of infection was found in the early 70's. This extracellular proteolytic system allows bacteria to penetrate into tissues, escape detection by the host's immune mechanisms and grow despite limited access to nutrition. A molecule able to selectively inhibit the activity of bacterial proteases in the spread of infection may lead to designing novel therapeutics. Moreover, due to their mechanism of action, bacterial protease inhibitors can be used to fight antibiotic-resistant strains. Herein, we undertake a review of various bacterial proteases together with the design and development of their inhibitors (excluding β-lactams) for the last ten years, and introduce the reader to a brief history of the subject.

journal_name

Curr Pharm Des

authors

Burchacka E,Sieńczyk M

doi

10.2174/1381612825666181219163922

keywords:

["Inhibitors","bacteria","bacterial serine proteases","epidemic outbreaks","metalloproteinases","potential antibiotics."]

subject

Has Abstract

pub_date

2018-01-01 00:00:00

pages

4445-4465

issue

37

eissn

1381-6128

issn

1873-4286

pii

CPD-EPUB-95336

journal_volume

24

pub_type

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