Novel insights into c-Src.

abstract：:α-Synuclein aggregation is centrally implicated in Parkinson's disease (PD). It involves multi-step nucleated polymerization process via the formation of dimers, soluble toxic oligomers and insoluble fibrils. In the present study, we synthesized a novel compound viz., Curcumin-glucoside (Curc-gluc), a modified form of...

journal_title：Current pharmaceutical design

authors： Gadad BS,Subramanya PK,Pullabhatla S,Shantharam IS,Rao KS

更新日期：2012-01-01 00:00:00

abstract：:A better knowledge of the mechanisms underlying hepatocellular carcinoma (HCC) growth and spread is essential to improve the available treatment options. So far, the only therapies available for HCC are mainly based on tumor-destructive approaches, whereas no therapies are available to consolidate these invasive thera...

journal_title：Current pharmaceutical design

authors： Antonaci S,Giannelli G

更新日期：2007-01-01 00:00:00

abstract：:Mast cells are important in the development of allergic and anaphylactic reactions, but also in acquired and innate immunity. There is also increasing evidence that mast cells participate in inflammatory diseases, where they can be activated by non-allergic triggers, such as neuropeptides and cytokines, often having s...

journal_title：Current pharmaceutical design

authors： Sismanopoulos N,Delivanis DA,Alysandratos KD,Angelidou A,Therianou A,Kalogeromitros D,Theoharides TC

更新日期：2012-01-01 00:00:00

abstract：:The complex system of molecular communications underlying cell biochemistry and function involves numerous components including kinases, phosphatases and transcription factors, which are known to be sensitive to cellular and tissue redox changes. Reactive oxygen species (ROS), whose constitutive generation in cells an...

journal_title：Current pharmaceutical design

authors： Leonarduzzi G,Sottero B,Testa G,Biasi F,Poli G

更新日期：2011-12-01 00:00:00

abstract：BACKGROUND:Breast cancer is the most frequently diagnosed malignancy in women worldwide. Breast cancer tends to metastasize to bone. Around 70% of the breast cancer patients eventually develop bone metastasis. After the bone invasion, metastatic cells disrupt the balance between osteoblastic and osteoclastic activities...

journal_title：Current pharmaceutical design

authors： Irshad I,Varamini P

更新日期：2018-01-01 00:00:00

abstract：:The present review discusses the mechanism of late stent thrombosis and its distinction from restenosis and summarizes the advisory note issued by FDA on the proper usage of different treatments available for atherosclerosis. In light of the latest developments, a plethora of new stents have been and continue to be de...

journal_title：Current pharmaceutical design

authors： Rastogi A,Stavchansky S

更新日期：2008-01-01 00:00:00

abstract：:Monoclonal antibodies have undergone a radical evolutionary journey over the last 25 years, with advances in molecular biology, process development and drug formulation underpinning their rise to becoming one of the most efficacious and economically important class of drug today. The success of antibodies for the trea...

journal_title：Current pharmaceutical design

authors： Lowe DC,Vaughan TJ

更新日期：2015-01-01 00:00:00

abstract：:The derangement of the cardiac energy substrate metabolism plays a key role in the pathogenesis of heart failure. The utilization of non-carbohydrate substrates, such as fatty acids, is the predominant metabolic pathway in the normal heart, because this provides the highest energy yield per molecule of substrate metab...

journal_title：Current pharmaceutical design

authors： Nagoshi T,Yoshimura M,Rosano GM,Lopaschuk GD,Mochizuki S

更新日期：2011-12-01 00:00:00

abstract：BACKGROUND:Origanum vulgare is used in Armenian cuisine as well as in folk medicine. The aim of this investigation was to determine the peculiarities of the chemical composition of Armenian flora's oregano essential oil (EO) and ethanol extract (EE) and to characterize mainly antioxidant and antibacterial properties in...

journal_title：Current pharmaceutical design

authors： Moghrovyan A,Sahakyan N,Babayan A,Chichoyan N,Petrosyan M,Trchounian A

更新日期：2019-01-01 00:00:00

abstract：:The survival of patients with pulmonary arterial hypertension is closely related with right ventricular function. During the progression of right ventricular remodeling, energetic metabolism shifts from oxidative mitochondrial metabolism to glycolysis. In normal physiological conditions, cardiomyocytes use major sourc...

journal_title：Current pharmaceutical design

authors： Zhang R,Jing ZC

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Cardiovascular disease has been the leading cause of death in both sexes in developed countries for decades. In general, men and women share the same cardiovascular risk factors. However, in recent trials including both men and women sexspecific analyses have raised awareness of sex differences in cardiovasc...

journal_title：Current pharmaceutical design

authors： Pedersen LR,Frestad D,Michelsen MM,Mygind ND,Rasmusen H,Suhrs HE,Prescott E

更新日期：2016-01-01 00:00:00

abstract：:Single-agent therapy with molecularly targeted agents has shown limited success in tumor growth control, mainly because escape or resistance mechanisms are activated once a signalling molecule is inhibited. Rational combinations of target-specific agents could counteract this response providing a useful strategy in ca...

journal_title：Current pharmaceutical design

authors： Porcelli L,Quatrale AE,Mantuano P,Silvestris N,Rolland JF,Biancolillo L,Paradiso A,Azzariti A

更新日期：2013-01-01 00:00:00

abstract：:Despite the development of strong antibiotics, the pneumonia death is increasing all over the world in these decades. Among the people who died of pneumonia, the majority were 65 years old or over. Although pneumonia is recently categorized into several entities, aspiration pneumonia includes all entities. Therefore, ...

journal_title：Current pharmaceutical design

authors： Ebihara S,Ebihara T,Gui P,Osaka K,Sumi Y,Kohzuki M

更新日期：2014-01-01 00:00:00

abstract：:Macrophage migration inhibitory factor (MIF) is a pro-inflammatory cytokine released from T-cells and macrophages, and is a key molecule in inflammation. Although a detailed understanding of the biological functions of MIF has not yet been found, it is known that MIF catalyzes the tautomerization of phenylpyruvate and...

journal_title：Current pharmaceutical design

authors： Orita M,Yamamoto S,Katayama N,Fujita S

更新日期：2002-01-01 00:00:00

abstract：:Opioids constitute the basis for pharmacological treatment of moderate to severe pain in cancer pain and non-cancer pain patients. Their action is mediated by the activation of opioid receptors, which integrates the pain modulation system with other effects in the central nervous system including cognition resulting i...

journal_title：Current pharmaceutical design

authors： Højsted J,Kurita GP,Kendall S,Lundorff L,de Mattos Pimenta CA,Sjøgren P

更新日期：2012-01-01 00:00:00

abstract：:Ras is a 21 kDa membrane-localized G protein that is coupled to receptor and non-receptor tyrosine kinase activation of downstream cytoplasmic and nuclear events. Mutated ras genes are common, and occur in a wide variety of human malignancies. These activating mutations result in constitutive signaling, thereby stimul...

journal_title：Current pharmaceutical design

authors： Adjei AA

更新日期：2001-11-01 00:00:00

abstract：:Cancer disease is one of the leading causes of morbidity and mortality worldwide, with approximately 14 million new cases and around 8 million cancer-related deaths yearly. Estimates expect to increase these figures over the next few years. Therefore, it is very important to develop more effective and targeted therapi...

journal_title：Current pharmaceutical design

authors： Caro C,Pozo D

更新日期：2015-01-01 00:00:00

abstract：:Dengue is one of the most important arboviral infections worldwide, infecting up to 390 million people and causing 25,000 deaths annually. Although a licensed dengue vaccine is available, it is not efficacious against dengue serotypes that infect people living in South East Asia, where dengue is an endemic disease. He...

journal_title：Current pharmaceutical design

authors： Reginald K,Chan Y,Plebanski M,Poh CL

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:Polycystic ovary syndrome (PCOS) is a frequent female reproductive endocrine disease. It has been associated with a number of severe reproductive and metabolic abnormalities. However, there are still open questions especially regarding the best long-term management. METHODS:We summarized the literature focu...

journal_title：Current pharmaceutical design

authors： Ruan X,Li M,Mueck AO

更新日期：2018-01-01 00:00:00

abstract：:The final aim/target of Pharmaceutical Sciences is to design successful dosage forms for effective therapy, considering individual patient needs and compliance. Development of new drug entities, particularly using peptides and proteins, is growing in importance and attracting increased interest, as they are specifical...

journal_title：Current pharmaceutical design

authors： Degim IT,Celebi N

更新日期：2007-01-01 00:00:00

abstract：:Stimulation of β-adrenergic receptors in the heart is the most effective endogenous way to increase the mechanical performance of cardiac tissues to meet the requirements of a fight-or-flight situation or stress. On the other hand, sustained activation of cardiac β-receptors initiates maladaptive remodeling of the myo...

journal_title：Current pharmaceutical design

authors： Szentmiklosi AJ,Szentandrássy N,Hegyi B,Horvath B,Magyar J,Bányász T,Nanasi PP

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Compounds and extracts derived from natural sources continue to stand in the spotlight of drug design owing to their versatile interaction with enzymes, receptors and metabolic pathways. Nanomedicine offers an operative tool for the efficient delivery of natural products, in terms of increased bioavailabilit...

journal_title：Current pharmaceutical design

authors： Simona AD,Florina A,Rodica CA,Evelyne O,Maria-Corina S

更新日期：2017-01-01 00:00:00

abstract：: ...

journal_title：Current pharmaceutical design

authors： Deb PK

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:A substantial part of literature has been centered on sex differences in the clinical aspects of ischemic heart disease (IHD). Many reports have documented differences in the presentation and risk profile between women and men. Such differences drive sex-related inequalities in the referral and treatment of ...

journal_title：Current pharmaceutical design

authors： Cenko E,Bugiardini R

更新日期：2016-01-01 00:00:00

abstract：:Oxidative stress is often considered as a causative factor in carcinogenesis. In addition, current knowledge recognizes oxidative stress as a mechanism by which various cancer therapies act against cancer. To ameliorate the side effects of cancer therapy, many of the patients suffering from cancer are subject to adjuv...

journal_title：Current pharmaceutical design

authors： Milkovic L,Siems W,Siems R,Zarkovic N

更新日期：2014-01-01 00:00:00

abstract：:Drug designing targeting protein-protein interactions is challenging. Because structural elucidation and computational analysis have revealed the importance of hot spot residues in stabilizing these interactions, there have been on-going efforts to develop drugs which bind the hot spots and out-compete the native prot...

journal_title：Current pharmaceutical design

authors： Ma B,Nussinov R

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Utilization of macroalgae has gained much attention in the field of pharmaceuticals, nutraceuticals, food and bioenergy. Macroalgae has been widely consumed in Asian countries as food from ancient days and proved that it has potential bioactive compounds which are responsible for its nutritional properties. ...

journal_title：Current pharmaceutical design

authors： Venkatesan J,Anil S,Rao S,Bhatnagar I,Kim SK

更新日期：2019-01-01 00:00:00

abstract：:Regeneration of bone requires the coordinated processes of angiogenesis and osteogenesis. These repair mechanisms are closely linked through both direct cell-cell contact and indirect paracrine signaling among osteoblasts, endothelial cells, and other cell types. The vasculature provides a source of nutrients, oxygen,...

journal_title：Current pharmaceutical design

authors： Segar CE,Ogle ME,Botchwey EA

更新日期：2013-01-01 00:00:00

abstract：:There is a plausible role for cytokines, brain-derived neurotrophic factor (BDNF), and their interaction in major depressive disorder's (MDD) etiology. This review includes (i) briefly defining cytokines, (ii) a discussion of theories for why they may affect brain function, (iii) cross-sectional associations between c...

journal_title：Current pharmaceutical design

authors： Lotrich F

更新日期：2012-01-01 00:00:00

abstract：:Stroke remains a major cause of death in the US and around the world. Despite major scientific advances in our understanding of stroke pathology, the only FDA-approved drug for ischemic stroke is tissue plasminogen activator (tPA). Moreover, the therapeutic window for tPA is confined to the acute phase of stroke, ther...

journal_title：Current pharmaceutical design

authors： Tajiri N,Lau T,Glover LE,Shinozuka K,Kaneko Y,van Loveren H,Borlongan CV

更新日期：2012-01-01 00:00:00