Development of Peptide Vaccines in Dengue.

Abstract:

:Dengue is one of the most important arboviral infections worldwide, infecting up to 390 million people and causing 25,000 deaths annually. Although a licensed dengue vaccine is available, it is not efficacious against dengue serotypes that infect people living in South East Asia, where dengue is an endemic disease. Hence, there is an urgent need to develop an efficient dengue vaccine for this region. Data from different clinical trials indicate that a successful dengue vaccine must elicit both neutralizing antibodies and cell mediated immunity. This can be achieved by designing a multi-epitope peptide vaccine comprising B, CD8+ and CD4+ T cell epitopes. As recognition of T cell epitopes are restricted by human leukocyte antigens (HLA), T cell epitopes which are able to recognize several major HLAs will be preferentially included in the vaccine design. While peptide vaccines are safe, biocompatible and cost-effective, it is poorly immunogenic. Strategies to improve its immunogenicity by the use of long peptides, adjuvants and nanoparticle delivery mechanisms are discussed.

journal_name

Curr Pharm Des

authors

Reginald K,Chan Y,Plebanski M,Poh CL

doi

10.2174/1381612823666170913163904

subject

Has Abstract

pub_date

2018-01-01 00:00:00

pages

1157-1173

issue

11

eissn

1381-6128

issn

1873-4286

pii

CPD-EPUB-85764

journal_volume

24

pub_type

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