Inhibitory effects of areca nut extract on expression of complement receptors and fc receptors in human neutrophils.

Abstract:

BACKGROUND:Chewing of areca quid increases the prevalence of periodontal diseases. Areca nut extract (ANE) inhibits the phagocytic activity of human neutrophils. This in vitro study investigates the effects of ANE on complement- and antibody-opsonized phagocytosis by neutrophils. Expression of complement receptors, Fc receptors, and F-actin in ANE-treated neutrophils is also analyzed. METHODS:The viability of ANE-treated neutrophils was determined using the propidium iodide staining method. The possible effects of ANE on the expression of complement receptors and Fc receptors were examined using an immunofluorescence staining method followed by flow cytometry and confocal laser scanning microscopy. The phagocytic activity of neutrophils against complement or immunoglobulin (Ig)G-opsonized fluorescent beads was analyzed using flow cytometry. Expression of F-actin was determined using confocal laser scanning microscopy. RESULTS:ANE significantly inhibited the production of complement receptors (CR1, CR3, and CR4) and Fc receptors (FcγRII and FcγRIII) in a concentration-dependent manner. Treatment of neutrophils with ANE significantly impaired their ability to phagocytose fluorescent beads. ANE also inhibited phagocytosis of fluorescent beads that were opsonized by complement or IgG. Moreover, expression of F-actin was inhibited after ANE treatment. CONCLUSIONS:ANE inhibits the complement- and IgG-mediated neutrophil phagocytosis that may result from reduction of the expression of complement receptors, Fc receptors, and F-actin formation after ANE treatment. The findings suggest that areca nut chewing may jeopardize the defensive functions of neutrophils and affect periodontal health.

journal_name

J Periodontol

authors

Lee YY,Lin MB,Cheng CF,Chang LY,Liu TY,Hung SL

doi

10.1902/jop.2013.130498

subject

Has Abstract

pub_date

2014-08-01 00:00:00

pages

1096-106

issue

8

eissn

0022-3492

issn

1943-3670

journal_volume

85

pub_type

杂志文章
  • Platelet-Rich Fibrin With 1.2% Rosuvastatin for Treatment of Intrabony Defects in Chronic Periodontitis: A Randomized Controlled Clinical Trial.

    abstract:BACKGROUND:Regenerative periodontal therapy encompasses use of various bioactive agents that are not only inflammomodulatory but also osteoclast-inhibitory or, rather, osteostimulative. Hypolipidemic statin drugs, particularly rosuvastatin (RSV), are known to be associated with alveolar bone formation and periodontal i...

    journal_title:Journal of periodontology

    pub_type: 杂志文章,随机对照试验

    doi:10.1902/jop.2016.160015

    authors: Pradeep AR,Garg V,Kanoriya D,Singhal S

    更新日期:2016-12-01 00:00:00

  • Detection of Actinobacillus actinomycetemcomitans but not bacteria of the red complex in aortic aneurysms by multiplex polymerase chain reaction.

    abstract:BACKGROUND:Aortic aneurysms affect an increasing number of elderly patients and cause considerable morbidity and mortality. The understanding of the mechanisms involved in the pathogenesis of aortic aneurysms is unclear and little is known about the role of microorganisms in the development of the condition. The aim of...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2005.76.4.590

    authors: Marques da Silva R,Caugant DA,Lingaas PS,Geiran O,Tronstad L,Olsen I

    更新日期:2005-04-01 00:00:00

  • Severe periodontitis is associated with diastolic blood pressure elevation in individuals with heterozygous familial hypercholesterolemia: a pilot study.

    abstract:BACKGROUND:This pilot study evaluates the association of severe periodontitis with pulse wave velocity (PWV), carotid artery intima-medial thickness (IMT), and clinical, metabolic, and atherogenic inflammatory markers in 79 subjects with heterozygous familial hypercholesterolemia (hFH). All subjects were free of previo...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2010.100496

    authors: Vieira CL,Cury PR,Miname MH,Martinez LR,Bortolotto LA,Giuliano IB,Santos RD,Caramelli B

    更新日期:2011-05-01 00:00:00

  • Traumatic lesions of the gingiva: a case series.

    abstract:BACKGROUND:The most recent classification of periodontal diseases includes a new section on traumatic gingival lesions. Traumatic lesions of the gingiva are thought to be highly prevalent, yet the periodontal literature contains few references on the topic. The purpose of this article is to present a broad spectrum of ...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2004.75.5.762

    authors: Rawal SY,Claman LJ,Kalmar JR,Tatakis DN

    更新日期:2004-05-01 00:00:00

  • Guided bone regeneration for dehiscence and fenestration defects on implants using an absorbable polymer barrier.

    abstract:BACKGROUND:Guided bone regeneration (GBR) using a non-absorbable barrier has provided clinicians the ability to place implants in sites compromised by insufficient bone, including immediate extraction sites. Recent evidence suggests that successful GBR outcomes may be possible using bioabsorbable polymer barriers. MET...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2001.72.2.250

    authors: Rosen PS,Reynolds MA

    更新日期:2001-02-01 00:00:00

  • Effective periodontal treatment in a patient with type IIA von Willebrand's disease: report of a case.

    abstract::von Willebrand's disease (vWD) is one of the most common hereditary hemorrhagic disorders. A mild to moderate deficiency of factor VIII and von Willebrand factor (vWf) often is associated with gingival bleeding. In this case report, the periodontal treatment of a patient with vWD is described. A 45-year-old woman with...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.1999.70.5.548

    authors: Izumi Y,Taniguchi T,Maruyama Y,Sueda T

    更新日期:1999-05-01 00:00:00

  • Combining host modulation and topical antimicrobial therapy in the management of moderate to severe periodontitis: a randomized multicenter trial.

    abstract:BACKGROUND:Previous studies showed that host modulation therapy (HMT) or topical antimicrobial therapy (TAT) provided significant adjunctive benefits to scaling and root planing (SRP) in the treatment of chronic periodontitis (CP). The purpose of this study was to evaluate a combination therapy involving SRP, HMT, and ...

    journal_title:Journal of periodontology

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1902/jop.2008.070237

    authors: Novak MJ,Dawson DR 3rd,Magnusson I,Karpinia K,Polson A,Polson A,Ryan ME,Ciancio S,Drisko CH,Kinane D,Powala C,Bradshaw M

    更新日期:2008-01-01 00:00:00

  • Immediate functional loading of edentulous maxilla: a 5-year retrospective study of 388 titanium implants.

    abstract:BACKGROUND:Immediate functional loading is a new surgical-prosthetic technique that can be used extensively in implant placement. Because of a lack of experimental reports regarding edentulous maxilla, we decided to evaluate the survival rate of immediately loaded dental implants in this area. METHODS:Forty-three pati...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2005.76.6.1016

    authors: Degidi M,Piattelli A,Felice P,Carinci F

    更新日期:2005-06-01 00:00:00

  • Local antibody responses in periodontal diseases.

    abstract::The relationship between local and systemic host antibody responses, colonization of subgingival plaque by periodontal disease-associated microorganisms and the progression of periodontal disease was assessed in 61 patients. Serum antibody levels to a battery of oral microorganisms were determined by an enzyme-linked ...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.1985.56.11s.51

    authors: Ebersole JL,Taubman MA,Smith DJ

    更新日期:1985-11-01 00:00:00

  • Effect of implant cleaning on titanium particle dissolution and cytocompatibility.

    abstract:BACKGROUND:Peri-implantitis treatments are mainly based on protocols for teeth but have not shown favorable outcomes for implants. The potential role of titanium dissolution products in peri-implantitis necessitate the consideration of material properties in devising treatment protocols. We assessed implant cleaning in...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1002/JPER.20-0186

    authors: Kotsakis GA,Black R,Kum J,Berbel L,Sadr A,Karoussis I,Simopoulou M,Daubert D

    更新日期:2020-08-26 00:00:00

  • The relationship between periodontitis and the maxillary sinus.

    abstract::This article presents a short review of the literature describing the relationship of periodontal disease and the maxillary sinus. This is followed by two case reports which demonstrate a close physical relationship between molar roots and the sinus and suggest that a sinusitis may develop from the extension of period...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.1984.55.8.477

    authors: Lane JJ,O'Neal RB

    更新日期:1984-08-01 00:00:00

  • Suggested solutions for common problems in clinical periodontics.

    abstract::This short report offers solutions for three common clinical problems. Based on their experience, the authors suggest using a "spoon" type partial denture for the temporary replacement of maxillary anterior teeth. The denture is unique in that it has no clasps and does not contact the marginal gingiva. Also, conventio...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.1984.55.6.341

    authors: O'Leary TJ,Kepic TJ,Detamore RJ

    更新日期:1984-06-01 00:00:00

  • Responses of four tooth and site groupings to periodontal therapy.

    abstract::The responses of four tooth/site groupings to periodontal therapy were evaluated. Eighty-two patients with periodontitis were treated in a split mouth design with coronal scaling, root planing, modified Widman surgery, and flap with osseous resectional surgery. Patients were evaluated prior to therapy, 4 weeks post-Ph...

    journal_title:Journal of periodontology

    pub_type: 临床试验,杂志文章

    doi:10.1902/jop.1990.61.3.173

    authors: Kaldahl WB,Kalkwarf KL,Patil KD,Molvar MP

    更新日期:1990-03-01 00:00:00

  • Individual predisposition and the intricate interplay between systemic biomarkers and periodontal risk in a general population.

    abstract:BACKGROUND:Increasing age is associated with systemic diseases as well as with periodontal diseases. We wondered whether a biological age score constructed exclusively from systemic biomarkers would reflect periodontal risk factors at baseline and tooth loss as well as periodontal outcome during 10 years follow-up. ME...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1002/JPER.20-0591

    authors: Meisel P,Nauck M,Kocher T

    更新日期:2020-12-14 00:00:00

  • Porphyromonas gingivalis Lipopolysaccharide Stimulation of Vascular Smooth Muscle Cells Activates Proliferation and Calcification.

    abstract:BACKGROUND:Porphyromonas gingivalis (Pg) is a major etiologic agent of periodontitis, whose virulence has been attributed to different factors, including lipopolysaccharide (LPS). Vascular ectopic calcification as a well-known major risk factor for adverse cardiovascular diseases is a highly prevalent vascular pathophe...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2016.150602

    authors: Liu G,Deng J,Zhang Q,Song W,Chen S,Lou X,Zhang P,Pan K

    更新日期:2016-07-01 00:00:00

  • Effect of low-protein diet on alveolar bone loss in streptozotocin-induced diabetic rats.

    abstract::The present study demonstrated that hyperglycemic diabetic rats fed a low-protein (8%) diet maintained an alveolar bone height similar to controls; in contrast, those fed a standard protein diet (24%) had reduced alveolar bone height (P less than 0.05). Euglycemic diabetic and untreated control rats fed low-protein di...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.1989.60.5.264

    authors: Johnson RB,Thliveris JA

    更新日期:1989-05-01 00:00:00

  • Adjunctive effects of laser therapy on somatosensory function and vasomotor regulation of periodontal tissues in patients with periodontitis: A randomized controlled clinical trial.

    abstract:BACKGROUND:The purpose of this prospective study was to compare the changes in periodontal somatosensory function and microcirculation in patients with periodontitis following initial treatment with scaling and root planing (SRP) with or without adjuvant laser therapy. METHODS:Twenty-four patients suffering from perio...

    journal_title:Journal of periodontology

    pub_type: 杂志文章,随机对照试验

    doi:10.1002/JPER.19-0562

    authors: Gou H,Fan R,Chen X,Li L,Wang X,Xu Y,Svensson P,Wang K

    更新日期:2020-10-01 00:00:00

  • Repair of Class II furcation defects after a reparative tissue graft obtained from extraction sockets treated with growth factors: a histologic and histometric study in dogs.

    abstract:BACKGROUND:Reparative tissue of extraction sockets was proposed as grafting material in the treatment of periodontal defects. Our hypothesis was that the addition of growth factors to extraction sockets improves the regenerative potential of this tissue when used as a graft. The objective of the present study was to an...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2005.76.10.1681

    authors: Soares FP,Hayashi F,Yorioka CW,Pannuti CM,Gioso MA,de Lima LA,Romito GA,Pustiglioni FE

    更新日期:2005-10-01 00:00:00

  • Tissue response to titanium implants in the rat maxilla: ultrastructural and histochemical observations of the bone-titanium interface.

    abstract:BACKGROUND:The detailed mechanism of osseointegration, the most appropriate implant-bone interface, remains unclear in jaw tissues at the ultrastructural level in contrast to the many reports using long bones. The present study reports on tissue response to titanium-implantation on an animal model using rat maxilla. M...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2000.71.2.287

    authors: Futami T,Fujii N,Ohnishi H,Taguchi N,Kusakari H,Ohshima H,Maeda T

    更新日期:2000-02-01 00:00:00

  • Characterization of mandibular bone in a mouse model of chronic kidney disease.

    abstract:BACKGROUND:Chronic kidney disease (CKD) is a worldwide health problem with increasing prevalence and poor outcomes, including severe cardiovascular disease and renal osteodystrophy. With advances in medical treatment, patients with CKD are living longer and require oral care. The aim of this study is to determine the e...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2009.090379

    authors: Lee MM,Chu EY,El-Abbadi MM,Foster BL,Tompkins KA,Giachelli CM,Somerman MJ

    更新日期:2010-02-01 00:00:00

  • Inhibitory effects of azithromycin on the adherence ability of Porphyromonas gingivalis.

    abstract:BACKGROUND:Porphyromonas gingivalis is a major pathogen and has a high detection rate in periodontal disease. Fimbriae and hemagglutinin are expressed by P. gingivalis, and these play an important role in the adherence of the bacteria to periodontal tissue and biofilm formation. The aim of this study was to investigate...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1002/JPER.18-0559

    authors: Kan P,Sasaki H,Inaba K,Watanabe K,Hamada N,Minabe M

    更新日期:2019-08-01 00:00:00

  • Treatment of dehiscence-type defects with collagen matrix and/or enamel matrix derivative: Histomorphometric study in minipigs.

    abstract:BACKGROUND:This study aimed to evaluate, histomorphometrically, the use of collagen matrix (CM) and/or enamel matrix derivative (EMD) for the treatment of dehiscence-type recession defects in minipigs. METHODS:Eight healthy, male, young BR-1 minipigs, with no periodontal disease were treated. Bilateral dehiscence-type...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1002/JPER.19-0107

    authors: França-Grohmann IL,Sangiorgio JPM,Bueno MR,Casarin RCV,Silvério Ruiz KG,Nociti FH Jr,Casati MZ,Sallum EA

    更新日期:2020-07-01 00:00:00

  • Coronally advanced flap procedure for root coverage. Treatment of root surface: root planning versus polishing.

    abstract::This clinical study was designed to determine if mechanical instrumentation (root planing) of the exposed root is useful in treating gingival recession caused by traumatic toothbrushing following a coronally advanced flap (CAF). Ten patients with high levels of oral hygiene (full-mouth plaque score <20%), from 25 to 5...

    journal_title:Journal of periodontology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1902/jop.1999.70.9.1064

    authors: Pini-Prato G,Baldi C,Pagliaro U,Nieri M,Saletta D,Rotundo R,Cortellini P

    更新日期:1999-09-01 00:00:00

  • Differential effects of amelogenin on mineralization of cementoblasts and periodontal ligament cells.

    abstract:BACKGROUND:Amelogenin is a major component of developing extracellular enamel matrix proteins and plays a crucial role during the formation of tooth enamel. In addition, amelogenins are suggested to exert biologic functions as signaling molecules through cell-surface receptors. The purpose of this study is to examine t...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2011.110408

    authors: Tanimoto K,Kunimatsu R,Tanne Y,Huang YC,Michida M,Yoshimi Y,Miyauchi M,Takata T,Tanne K

    更新日期:2012-05-01 00:00:00

  • Effect of selected beta-blockers on supragingival calculus formation.

    abstract::Supragingival plaque and calculus indices, salivary flow rates, pH, ionic and total calcium concentrations, total phosphate concentration, and the number of cervical restorations and caries lesions were measured in 29 subjects using systemic beta-(beta) blockers and in 28 subjects who were not taking any systemic medi...

    journal_title:Journal of periodontology

    pub_type: 临床试验,杂志文章

    doi:10.1902/jop.1996.67.4.428

    authors: Breuer MM,Mboya SA,Moroi H,Turesky SS

    更新日期:1996-04-01 00:00:00

  • The use of blade implants in a selected population of partially edentulous adults. A five-year report.

    abstract::Based on the findings observed after the insertion of 33 blade implants in 23 patients, ages 31 to 74, for periods up to 60 months, the following conclusions can be made: (1) The blade implant is a technically feasible procedure which can be maintained in the mouth for period up to 5 years, although some degree of bon...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.1976.47.1.19

    authors: Smithloff M,Fritz ME

    更新日期:1976-01-01 00:00:00

  • Effects of chlorhexidine gel in a group of maintenance-care patients with poor oral hygiene.

    abstract::An intraindividual double-blind crossover study was designed in order to see if a 1% chlorhexidine gel used twice a day could substitute for ordinary toothpaste in group of maintenance-care patients with poor oral hygiene. Twenty patients from a student clinic participated, each with a long history of maintenance-care...

    journal_title:Journal of periodontology

    pub_type: 临床试验,杂志文章

    doi:10.1902/jop.1986.57.6.364

    authors: Lie T,Enersen M

    更新日期:1986-06-01 00:00:00

  • The effects of a calorie-reduced diet on periodontal inflammation and disease in a non-human primate model.

    abstract:BACKGROUND:Low-calorie diets are commonplace for reducing body weight. However, no information is available on the effects of a reduced-calorie diet on periodontal inflammation and disease. The purpose of this study was to evaluate the clinical effects of a long-term calorie-restriction (CR) diet on periodontitis in an...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2008.070629

    authors: Branch-Mays GL,Dawson DR,Gunsolley JC,Reynolds MA,Ebersole JL,Novak KF,Mattison JA,Ingram DK,Novak MJ

    更新日期:2008-07-01 00:00:00

  • Tissue interactions with dentin specimens after demineralization using tetracycline.

    abstract::Greater cell attachment to demineralized dentin has been associated with subsequent development of a fiber attachment system. The purpose of this study was to evaluate tissue interactions to dentin demineralized with different concentrations of tetracycline solution. Dentin specimens were obtained from beneath root su...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.1988.59.11.714

    authors: Frantz B,Polson A

    更新日期:1988-11-01 00:00:00

  • Loss of periodontal attachment in HIV-seropositive military personnel.

    abstract::The cross-sectional relationship between severe loss of periodontal attachment (LPA) and worsening immune status due to HIV infection was evaluated in 474 HIV-infected subjects (416 men, 58 women) aged 18 to 49 years who had been classified at stages 1 through 6 of the Walter Reed Army Institute of Research (WR) Stagi...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.1995.66.6.421

    authors: Tomar SL,Swango PA,Kleinman DV,Burt BA

    更新日期:1995-06-01 00:00:00