Abstract:
BACKGROUND:Abundant evidence indicate the increased levels of oxidative stress in patients with autism. Advanced glycation end products and advanced lipoxidation end products and their precursors play a major role in increased oxidative stress in numerous metabolic and neurologic diseases. Carnosine is a natural dipeptide with antiglycation effects. The aim of this trial was to examine the effects of carnosine supplementation on the advanced glycation end products and the precursors of advanced lipoxidation end products in patients with autism. METHOD:This randomized double-blind, placebo-controlled clinical trial was conducted on 36 autistic children, 18 in the carnosine group and 18 in the placebo group. The groups received a daily supplement of 500 mg carnosine or placebo for two months, respectively. Plasma concentrations of glycation and precursors of lipoxidation markers were evaluated by enzyme-linked immunosorbent assay method. RESULTS:In all, 63.9% of the autistic children had normal nutritional status. Carnosine supplementation did not significantly alter plasma concentrations of advanced glycation end products and precursors of advanced lipoxidation end products in autistic children. CONCLUSION:The findings indicate that supplementation of carnosine could not change advanced glycation end products and precursor of advanced lipoxidation end products in autistic children.
journal_name
Ann Clin Biochemjournal_title
Annals of clinical biochemistryauthors
Ghodsi R,Kheirouri S,Nosrati Rdoi
10.1177/0004563218796860subject
Has Abstractpub_date
2019-01-01 00:00:00pages
148-154issue
1eissn
0004-5632issn
1758-1001journal_volume
56pub_type
杂志文章,随机对照试验abstract::This paper summarises the views of the authors on the provision of a prolactin assay service. We discuss the pathophysiology of prolactin secretion and the clinical indications that arise from that. We cover the rather complex issue of the definition of normal and elevated prolactin levels. From these considerations, ...
journal_title:Annals of clinical biochemistry
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abstract::A real time data processing system for a group of three clinical chemistry laboratories (one base and two satellite) has been developed as a successor to one used previously. This paper describes both the inadequacies of the previous worksheet-based system and the advantages of the new system, including flexibility, f...
journal_title:Annals of clinical biochemistry
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journal_title:Annals of clinical biochemistry
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journal_title:Annals of clinical biochemistry
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journal_title:Annals of clinical biochemistry
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journal_title:Annals of clinical biochemistry
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journal_title:Annals of clinical biochemistry
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journal_title:Annals of clinical biochemistry
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abstract::In monocytes at the secretory (oestrogen-progesterone dominant) phase of the menstrual cycle, expression of c-fms and macrophage colony-stimulating factor (M-CSF) receptor and activity of tyrosine kinase (TK) were increased by oestradiol with or without progesterone. In vivo, oestrogen may induce expression of c-fms a...
journal_title:Annals of clinical biochemistry
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journal_title:Annals of clinical biochemistry
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journal_title:Annals of clinical biochemistry
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abstract::Ethylene glycol in plasma, urine or dialysis fluid is analysed as the phenylboronate derivative by mixing with acetonitrile/acidified 2,2-dimethoxypropane containing phenylboronic acid. After centrifugation, a portion of the supernatant is analysed directly by gas-liquid chromatography using a 3% OV-101 column at 150 ...
journal_title:Annals of clinical biochemistry
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journal_title:Annals of clinical biochemistry
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journal_title:Annals of clinical biochemistry
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journal_title:Annals of clinical biochemistry
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journal_title:Annals of clinical biochemistry
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journal_title:Annals of clinical biochemistry
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journal_title:Annals of clinical biochemistry
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journal_title:Annals of clinical biochemistry
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journal_title:Annals of clinical biochemistry
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journal_title:Annals of clinical biochemistry
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