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Development of a liquid dissection technique for small-incision lenticule extraction: Clinical results and ultrastructural evaluation.

Abstract：

PURPOSE:To determine the effect of a liquid dissection technique on clinical outcomes with ultrastructural analysis of the lenticule surface in small-incision lenticule extraction (SMILE). SETTING:Zhongshan Ophthalmic Center, Guangzhou, China. DESIGN:Prospective case series. METHODS:Consecutive patients with myopia scheduled for small-incision lenticule extraction were included. The liquid dissection technique was performed in 1 eye and the traditional dissection technique was performed in the other eye by randomized assignment. Ophthalmic examinations were evaluated preoperatively and at different timepoint follow-ups after small-incision lenticule extraction. Ten human corneal lenticules were analyzed using scanning electron microscopy. RESULTS:The study comprised 29 patients (58 eyes). Uncorrected distance visual acuity (logarithm of the minimum angle of resolution) postoperative measurements at 2 and 4 hours were significantly better in the liquid dissection group than in the traditional dissection group (P < .001 and P = .001, respectively); however, there were no significant differences between the 2 groups at 1 day, 1 week, and 1 month postoperatively. Compared with the traditional dissection technique, the liquid dissection technique induced significantly fewer corneal aberrations at 2 hours and 1 month after the procedures (P = .031 and P = .016, respectively), the postoperative contrast sensitivity in the liquid dissection group was significantly higher after 1 day (P = .01). The liquid dissection samples showed smoother lenticule surfaces compared with the traditional dissection samples qualitatively and quantitatively (P = .004 and P < .001, respectively). CONCLUSION:The liquid dissection technique was helpful in facilitating better visual acuity recovery and produced smooth cuts in the early postoperative period.

journal_name

J Cataract Refract Surg

journal_title

Journal of cataract and refractive surgery

authors

Weng S,Yang X,Liu F,Lin H,Liu M,Liu Q

doi

10.1016/j.jcrs.2018.06.023

subject

Has Abstract

pub_date

2018-09-01 00:00:00

pages

1080-1089

issue

eissn

0886-3350

issn

1873-4502

pii

S0886-3350(18)30517-0

journal_volume

pub_type

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Development of a liquid dissection technique for small-incision lenticule extraction: Clinical results and ultrastructural evaluation.