Faster cognitive decline in elders without dementia and decreased risk of cancer mortality: NEDICES Study.

abstract：OBJECTIVE:To assess if multifocal motor neuropathy (MMN) with and MMN without conduction block (CB) are similar or distinct diseases. METHODS:The authors reviewed the clinical features and responses to IV immunoglobulin (IVIg) treatment of patients with MMN with and without CB at diagnosis, after 4 years of follow-up ...

journal_title：Neurology

authors： Delmont E,Azulay JP,Giorgi R,Attarian S,Verschueren A,Uzenot D,Pouget J

更新日期：2006-08-22 00:00:00

abstract：:In thymomas associated with myasthenia gravis (MG), the authors found that perivascular infiltrates of memory lymphocytes and mature dendritic cells (DCs) were more frequent in patients with early improvement after thymectomy than in patients without response to thymectomy. Although these findings may be limited to pa...

journal_title：Neurology

authors： Nagane Y,Utsugisawa K,Akutsu H,Sato Y,Terayama Y

更新日期：2005-09-13 00:00:00

abstract：:We studied the cerebral effects of oxygen-derived free radicals generated from the xanthine oxidase/hypoxanthine/ADP-Fe3+ system. Xanthine oxidase/hypoxanthine/ADP-Fe3+ solution (0.1 ml) was infused into caudate putamen, and brain was frozen rapidly in situ. Brain water and sodium content increased concomitant with de...

journal_title：Neurology

authors： Chan PH,Schmidley JW,Fishman RA,Longar SM

更新日期：1984-03-01 00:00:00

abstract：:Prostaglandins B1 and B2 were topically applied to the pial vessels of mice and arteriolar constriction was observed. This constriction could be significantly increased if serotonin was added to B1, but not when norepinephrine was added. Response to B2 was not enhanced by the simultaneous addition of either serotonin ...

journal_title：Neurology

authors： Rosenblum WI

更新日期：1975-12-01 00:00:00

abstract：OBJECTIVE:-To determine whether pre-treatment cerebral microbleeds (CMBs) presence and burden are correlated with an increased risk of intracranial hemorrhage (ICH) or poor functional outcome following endovascular thrombectomy (EVT) for acute ischemic stroke (AIS). METHODS:-Consecutive patients treated by EVT for ant...

journal_title：Neurology

authors： Derraz I,Cagnazzo F,Gaillard N,Morganti R,Dargazanli C,Ahmed R,Pierre-Henri L,Riquelme C,Mourand I,Gascou G,Bonafe A,Arquizan C,Costalat V

更新日期：2021-01-25 00:00:00

abstract：:Mitoxantrone is the first drug approved for the treatment of secondary progressive multiple sclerosis (SPMS) in the United States. This assessment considers use of mitoxantrone in the treatment of MS. Mitoxantrone probably reduces the clinical attack rate and reduces attack-related MRI outcomes in patients with relaps...

journal_title：Neurology

authors： Goodin DS,Arnason BG,Coyle PK,Frohman EM,Paty DW,Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology.

更新日期：2003-11-25 00:00:00

abstract：BACKGROUND:The relationship between age-related memory decline and hippocampal anatomic changes is a matter of debate. OBJECTIVES:To investigate the relationship between age-related memory decline and MRI hippocampal anatomic changes in a cohort of healthy individuals. METHODS:In this cross-sectional study, 76 health...

journal_title：Neurology

authors： Carlesimo GA,Cherubini A,Caltagirone C,Spalletta G

更新日期：2010-01-19 00:00:00

abstract：:In 1810, two British ships, HMS Triumph and HMS Phipps, salvaged a large load of elemental mercury from a wrecked Spanish vessel near Cadiz, Spain. The bladders containing the mercury soon ruptured. The element spread about the ships in liquid and vapor forms. The sailors presented with neurologic compromises: tremor,...

journal_title：Neurology

authors： Doherty MJ

更新日期：2004-03-23 00:00:00

abstract：OBJECTIVE:Activation of the type 1 interferon (IFN1) pathway is a prominent feature of dermatomyositis (DM) muscle and may play a role in the pathogenesis of this disease. However, the relevance of the IFN1 pathway in patients with other types of myositis such as the antisynthetase syndrome (AS), immune-mediated necrot...

journal_title：Neurology

authors： Pinal-Fernandez I,Casal-Dominguez M,Derfoul A,Pak K,Plotz P,Miller FW,Milisenda JC,Grau-Junyent JM,Selva-O'Callaghan A,Paik J,Albayda J,Christopher-Stine L,Lloyd TE,Corse AM,Mammen AL

更新日期：2019-09-17 00:00:00

abstract：:Twenty-nine untreated patients diagnosed with probable AD and 15 control patients underwent two or more clinical and volumetric MRI assessments with intervals ranging from 5 months to 6 years. The change in global cerebral volume for an individual was calculated by a novel method of registration and subtraction of ser...

journal_title：Neurology

authors： Fox NC,Scahill RI,Crum WR,Rossor MN

更新日期：1999-05-12 00:00:00

abstract：BACKGROUND:In patients with multiple sclerosis (MS), contrast-enhancing lesions (CELs) on postcontrast MRI are considered markers of the inflammatory responses associated with blood-brain barrier breakdown. Based upon shape, CELs may be defined as nodular (nCEL) or ring (rCEL) lesions. Several short-term studies pointe...

journal_title：Neurology

authors： Davis M,Auh S,Riva M,Richert ND,Frank JA,McFarland HF,Bagnato F

更新日期：2010-03-09 00:00:00

abstract：BACKGROUND:Hereditary neuralgic amyotrophy (HNA) is an autosomal dominant disorder that manifests as recurrent, episodic, painful brachial neuropathies. A gene for HNA maps to chromosome 17q25.3 where mutations in SEPT9, encoding the septin-9 protein, have been identified. OBJECTIVE:To determine the frequency and type...

journal_title：Neurology

authors： Hannibal MC,Ruzzo EK,Miller LR,Betz B,Buchan JG,Knutzen DM,Barnett K,Landsverk ML,Brice A,LeGuern E,Bedford HM,Worrall BB,Lovitt S,Appel SH,Andermann E,Bird TD,Chance PF

更新日期：2009-05-19 00:00:00

abstract：:Prompted by the observation that a fellow medical student sneezed at about the same time in class every morning, we recorded the time of each of the 118 sneezes she made on 69 days over a 6.5-month period. Analysis of the sneeze times with the goodness-of-fit test revealed a highly nonuniform distribution (p < 0.0001)...

journal_title：Neurology

authors： Grant AC,Roter EP

更新日期：1994-03-01 00:00:00

abstract：OBJECTIVE:To investigate whether plasma interleukin-6 (IL-6) is cross-sectionally related to poorer cognitive function and whether a baseline plasma IL-6 measurement can predict risk for decline in cognitive function in longitudinal follow-up of a population-based sample of nondisabled elderly people. METHODS:A prospe...

journal_title：Neurology

authors： Weaver JD,Huang MH,Albert M,Harris T,Rowe JW,Seeman TE

更新日期：2002-08-13 00:00:00

abstract：OBJECTIVE:To evaluate possible abnormal increase in thalamic glutamate/glutamine levels for restless legs syndrome (RLS) indicating increased glutamatergic activity producing arousal that at night disrupts and shortens sleep. METHODS:(1)H MRS of the right thalamus was performed using a 1.5 T GE MRI scanner and the PRO...

journal_title：Neurology

authors： Allen RP,Barker PB,Horská A,Earley CJ

更新日期：2013-05-28 00:00:00

abstract：:Two patients with similar courses of neurologic impairment and subsequent recovery after cerebral air embolism complicating cardiac ablation procedures are described. Hyperbaric oxygen therapy, combined with aggressive resuscitative efforts, appears to have contributed to each patient's recovery. ...

journal_title：Neurology

authors： Hinkle DA,Raizen DM,McGarvey ML,Liu GT

更新日期：2001-03-27 00:00:00

abstract：:A 27-year-old man, recent visitor to the Middle East, presented with 6-week history of fever (up to 102°F) followed by altered behavior and left hemiparesis. CSF was acellular with raised protein (138 mg/dL). CSF bacterial culture was sterile; adenosine deaminase normal (3 U/L); cryptococcal antigen, Venereal Disease ...

journal_title：Neurology

authors： Rajan R,Khurana D,Kesav P

更新日期：2013-01-15 00:00:00

abstract：OBJECTIVE:To investigate whether sex and race differences exist in dementia diagnosis risk associated with traumatic brain injury (TBI) among older veterans. METHODS:Using Fine-Gray regression models, we investigated incident dementia diagnosis risk with TBI exposure by sex and race. RESULTS:After the exclusion of ba...

journal_title：Neurology

authors： Kornblith E,Peltz CB,Xia F,Plassman B,Novakovic-Apopain T,Yaffe K

更新日期：2020-09-29 00:00:00

abstract：:The authors examined the neural function of a postmeningitic deaf-blind patient who regained his hearing with a multichannel cochlear implant. Auditory stimuli activated the temporal cortices of both sides in a manner similar to that of controls, reflecting the successful recruitment of the auditory cortex after impla...

journal_title：Neurology

authors： Osaki Y,Takasawa M,Doi K,Nishimura H,Iwaki T,Imaizumi M,Oku N,Hatazawa J,Kubo T

更新日期：2006-09-12 00:00:00

abstract：:Fatigue is a common but poorly understood symptom in Parkinson's disease (PD). Using previously validated scales, we asked 58 nondemented PD patients and 58 controls to fill out questionnaires assessing fatigue and depression and found that PD patients were more depressed and more fatigued than age-matched controls. A...

journal_title：Neurology

authors： Friedman J,Friedman H

更新日期：1993-10-01 00:00:00

abstract：OBJECTIVE:To explore the causal relationships between sleep, major depressive disorder (MDD), and Alzheimer disease (AD). METHODS:We conducted bidirectional 2-sample Mendelian randomization analyses. Genetic associations were obtained from the largest genome-wide association studies currently available in UK Biobank (...

journal_title：Neurology

authors： Huang J,Zuber V,Matthews PM,Elliott P,Tzoulaki J,Dehghan A

更新日期：2020-10-06 00:00:00

abstract：OBJECTIVE:To examine the diagnostic accuracy of nerve ultrasound in a prospective cohort of consecutive patients with a clinical suspicion of chronic inflammatory neuropathies, including chronic inflammatory demyelinating polyneuropathy, Lewis-Sumner syndrome, and multifocal motor neuropathy, and to determine the added...

journal_title：Neurology

authors： Herraets IJT,Goedee HS,Telleman JA,van Eijk RPA,van Asseldonk JT,Visser LH,van den Berg LH,van der Pol WL

更新日期：2020-04-07 00:00:00

abstract：:The authors examined the influence of APOE and human leukocyte antigen-DRB1-DQB1 polymorphisms on the course of multiple sclerosis in 871 patients, 773 with relapsing and 98 with primary progressive disease, and 348 control subjects. The risk of the primary progressive course was increased (odds ratio = 6.81, p = 0.00...

journal_title：Neurology

authors： Cocco E,Sotgiu A,Costa G,Murru MR,Mancosu C,Murru R,Lai M,Contu P,Marrosu MG

更新日期：2005-02-08 00:00:00

abstract：:Capecitabine is used to treat advanced breast and gastrointestinal malignancies. A single case of encephalopathy and three cases of peripheral neuropathy are the only neurotoxicities reported. The authors report five additional cases of capecitabine-induced multifocal leukoencephalopathy. ...

journal_title：Neurology

authors： Videnovic A,Semenov I,Chua-Adajar R,Baddi L,Blumenthal DT,Beck AC,Simuni T,Futterer S,Gradishar W,Tellez C,Raizer JJ

更新日期：2005-12-13 00:00:00

abstract：BACKGROUND:In multifocal motor neuropathy (MMN), high dose of IV immunoglobulin (IVIg) is the only established treatment. Subcutaneous self-infusion with immunoglobulin G (IgG) (SCIG) increases patient autonomy and treatment flexibility, and might be associated with fewer side effects due to lower peak IgG levels. In a...

journal_title：Neurology

authors： Harbo T,Andersen H,Jakobsen J

更新日期：2010-10-12 00:00:00

abstract：:Hoarding behavior associated with focal brain injury is rarely reported. The authors report a 46-year-old man with pathologic collecting behavior after a left orbitofrontal and caudate injury from an aneurysmal rupture of anterior communicating artery. His hoarding, an impulse control disorder or an ego-syntonic compu...

journal_title：Neurology

authors： Hahm DS,Kang Y,Cheong SS,Na DL

更新日期：2001-02-13 00:00:00

abstract：:We report a family with Machado-Joseph disease (MJD) that was previously diagnosed with dentatorubral-pallidoluysian atrophy (DRPLA), on the basis of the neuropathologic findings. Because the clinical and pathologic reevaluation strongly suggested a diagnosis of MJD, we conducted a genetic study in the family. Two pat...

journal_title：Neurology

authors： Sakai T,Antoku Y,Kawakami H,Maruyama H,Nakamura S,Tanaka K

更新日期：1996-04-01 00:00:00

abstract：OBJECTIVE:Identifying an intriguing mechanism for unmasking recessive hereditary spastic paraplegias. METHOD:Herein, we describe 4 novel homozygous FA2H mutations in 4 nonconsanguineous families detected by whole-exome sequencing or a targeted gene panel analysis providing high coverage of all known hereditary spastic...

journal_title：Neurology

authors： Soehn AS,Rattay TW,Beck-Wödl S,Schäferhoff K,Monk D,Döbler-Neumann M,Hörtnagel K,Schlüter A,Ruiz M,Pujol A,Züchner S,Riess O,Schüle R,Bauer P,Schöls L

更新日期：2016-07-12 00:00:00

abstract：OBJECTIVE:To examine the relation of nonsteroidal anti-inflammatory drugs (NSAIDs) to incident Alzheimer disease (AD), change in cognition, and AD pathology. METHODS:Participants were 1,019 older Catholic clergy followed up annually for up to 12 years (mean baseline age = 75.0 years, education = 18.1 years, Mini-Menta...

journal_title：Neurology

authors： Arvanitakis Z,Grodstein F,Bienias JL,Schneider JA,Wilson RS,Kelly JF,Evans DA,Bennett DA

更新日期：2008-06-03 00:00:00

abstract：:A 50-year-old woman with a history of metastatic malignant thymoma presented with diffuse neuropathic pain involving the extremities and torso prior to chemotherapy and radiation. She also developed episodic diarrhea, diaphoresis, fevers, insomnia, and encephalopathy. Examination revealed rippling muscles (video on th...

journal_title：Neurology

authors： Lukas RV,Rezania K,Malec M,Salgia R

更新日期：2013-01-29 00:00:00